Acute Lymphoblastic Leukemia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatment outcomes, relapses still pose significant risks of mortality and long-term complicati... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 28, 2024 Category: Research Authors: Adri án Mosquera Orgueira, Olga Krali, Carlos Pérez Míguez, Andrés Peleteiro Raíndo, José Ángel Díaz Arias, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Manuel Fernández Sanmartín, Daniel Sinnet, Mats Heyman, Gudmar Lönnerholm, Ul Tags: Research Source Type: research

Involvement of the ABCB1 C3435T Variant but Not the MTHFR C677T or MTHFR A1298C Variant in High-Dose Methotrexate-Induced Toxicity in Pediatric Acute Lymphoblastic Leukemia Patients in China
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - March 27, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research

Detection of terminal deoxynucleotidyl transferase activity based on self-mediated nucleic acid elongation and elemental labeling inductively coupled plasma-mass spectrometry
Talanta. 2024 Mar 22;274:125979. doi: 10.1016/j.talanta.2024.125979. Online ahead of print.ABSTRACTTerminal deoxynucleotidyl transferase (TdT), a specialized DNA polymerase, is recognized as a promising biomarker for acute leukemia. Herein, taking the advantage of the self-mediated strand elongation property of TdT, a simple and sensitive method for TdT activity assay was developed based on gold nanoparticles (AuNPs) labeling inductively coupled plasma mass spectrometry (ICP-MS). In the presence of TdT, the primer DNA on magnetic beads is elongated with an adenine-rich single stranded long chain that can label poly-thymine...
Source: Talanta - March 27, 2024 Category: Chemistry Authors: Yuwei Liu Beibei Chen Man He Bin Hu Source Type: research

Acute Lymphoblastic Leukemia With Near-haploid Karyotype and Philadelphia Chromosome
CONCLUSION: The coexistence of the BCR::ABL1 chimera and near-haploidy in the same cytogenetic clone suggested a possible synergistic role in leukemogenesis, with the former activating signaling pathways and the latter disrupting gene dosage balance.PMID:38537997 | DOI:10.21873/anticanres.16935 (Source: Cell Research)
Source: Cell Research - March 27, 2024 Category: Cytology Authors: Ioannis Panagopoulos Kristin Andersen Hilde Skuterud Wik Maren Randi Tands æther Source Type: research

SOHO State of the Art Updates and Next Questions | Novel Agents and the Diminishing Role of Allogeneic Stem Cell Transplant in B-Acute Lymphoblastic Leukemia
We present our approach to newly diagnosed patients with B-ALL and illustrate how the incorporation of novel agents and use of high-sensitivity MRD assays can abrogate the need for allo-SCT in most patients with B-ALL.PMID:38538495 | DOI:10.1016/j.clml.2024.02.017 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - March 27, 2024 Category: Cancer & Oncology Authors: Wei-Ying Jen Elias Jabbour Hagop M Kantarjian Nicholas J Short Source Type: research

Pharmacokinetics of PEGasparaginase in Infants with Acute Lymphoblastic Leukemia
ConclusionThe pharmacokinetics of PEGasparaginase in infants diagnosed under one year of age with ALL is comparable to that of older children (1 –18 years). We recommend a PEGasparaginase dosing at 1,500 IU/m2 for infants without dose adaptations according to age, and implementing therapeutic drug monitoring as standard practice. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 27, 2024 Category: Drugs & Pharmacology Source Type: research

Prophylaxis with enoxaparin and antithrombin III in drug-induced coagulation alterations in childhood leukemia: a retrospective experience of 20 years
Thromboembolic complications are well known in the treatment of childhood acute lymphoblastic leukemia. Over the years it has not been possible to reach a consensus on a possible prophylaxis of thromboembolic ... (Source: Thrombosis Journal)
Source: Thrombosis Journal - March 27, 2024 Category: Hematology Authors: Christina Salvador, Robert Salvador, Gabriele Kropshofer, Bernhard Meister, Marie Rock, Petra Obexer, Benjamin Hetzer, Evelyn Rabensteiner and Roman Crazzolara Tags: Research Source Type: research

Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity
CONCLUSION: DNR induces Cyr61 production in B-ALL cells, and increased Cyr61 levels reduce the chemosensitivity of B-ALL cells. Consequently, targeting Cyr61 or related ATM signaling pathway may present a promising treatment strategy to enhance the chemosensitivity of patients with B-ALL.PMID:38530432 | DOI:10.1007/s00432-024-05692-8 (Source: Cell Research)
Source: Cell Research - March 26, 2024 Category: Cytology Authors: Pengchong Shi Zhen Lin Yanfang Song Zhaozhong Li Menglu Zeng Li Luo Yingping Cao Xianjin Zhu Source Type: research

Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity
ConclusionDNR induces Cyr61 production in B-ALL cells, and increased Cyr61 levels reduce the chemosensitivity of B-ALL cells. Consequently, targeting Cyr61 or related ATM signaling pathway may present a promising treatment strategy to enhance the chemosensitivity of patients with B-ALL. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 26, 2024 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 16, Pages 1288: Asciminib Maintains Antibody-Dependent Cellular Cytotoxicity against Leukemic Blasts
Märklin B cell acute lymphoblastic leukemia (B-ALL) is characterized by an accumulation of malignant precursor cells. Treatment consists of multiagent chemotherapy followed by allogeneic stem cell transplantation in high-risk patients. In addition, patients bearing the BCR-ABL1 fusion gene receive concomitant tyrosine kinase inhibitor (TKI) therapy. On the other hand, monoclonal antibody therapy is increasingly used in both clinical trials and real-world settings. The introduction of rituximab has improved the outcomes in CD20 positive cases. Other monoclonal antibodies, such as tafasitamab (anti-CD19), obinutuzumab (...
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Samuel J. Holzmayer Joseph Kauer Jonas Mauermann Tobias Roider Melanie M ärklin Tags: Article Source Type: research

Evaluation of childhood malignancies presenting with musculoskeletal manifestations from two different divisions: a multicenter study
CONCLUSIONS: Malignancies may present with only MSK system complaints in childhood. Therefore, malignancies should be included in the differential diagnosis of patients presenting with MSK complaints.PMID:38523382 | DOI:10.24953/turkjped.2023.446 (Source: The Turkish Journal of Pediatrics)
Source: The Turkish Journal of Pediatrics - March 25, 2024 Category: Pediatrics Authors: Şengül Çağlayan Beg üm Şirin Koç Özge Baba Esra Ba ğlan Bur çak Kurucu Deniz Gezgin Y ıldırım Aylin Canbolat Ayhan Mustafa Çakan G ülçin Otar Yener K übra Öztürk Figen Çakmak Hafize Emine S önmez Nuray Aktay Ayaz Ay şenur Paç Kısaa Source Type: research

Outcomes and adverse events in older acute lymphoblastic Leukemia patients treated with a pediatric-inspired protocol with Pegylated or native Asparaginase
Hematology. 2024 Dec;29(1):2329027. doi: 10.1080/16078454.2024.2329027. Epub 2024 Mar 25.ABSTRACTThis retrospective report presents the outcomes and adverse events (AEs) observed in 73 patients aged 60 years or older diagnosed with Philadelphia Chromosome-negative Acute Lymphoblastic Leukemia (Ph-negative ALL) treated with a pediatric-inspired protocol incorporating either Pegylated (PEG-ASP) or Native Asparaginase (EC-ASP). Notably, 61% of patients experienced AEs of Grade III-IV severity. The most prevalent AEs included thrombosis (35.6%), febrile neutropenia (38.4%), and transaminitis (34.2%). AEs did not translate into...
Source: Hematology - March 25, 2024 Category: Hematology Authors: Maria Agustina Perusini Claire Andrews Eshetu G Atenafu Vikas Gupta Dawn Maze Andre C Schuh Karen Wl Yee Aniket Bankar Marta B Davidson Guillaume Richard-Carpentier Steven M Chan Jad Sibai Aaron D Schimmer Mark D Minden Hassan Sibai Source Type: research

Long Non-coding RNA RP11-252C15.1 is a Potential Biomarker of Prognosis and Hallmark for Leukemogenesis in Children with B-cell Precursor Acute Lymphoblastic Leukemia
CONCLUSION: LncRNA RP11-252C15.1 is a potential oncogene in BCP-ALL pathogenesis and a prognostic biomarker in children with BCP-ALL.PMID:38527424 | DOI:10.1159/000535461 (Source: Acta Haematologica)
Source: Acta Haematologica - March 25, 2024 Category: Hematology Authors: Lili Pan Yongzhi Zheng Hao Zheng Source Type: research