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Pretransplant Blinatumomab Improves Outcomes in B Cell Acute Lymphoblastic Leukemia Patients Who Undergo Allogeneic Hematopoietic Cell Transplantation
Acute lymphoblastic leukemia (ALL) is the most common cancer in children [1]. It carries an excellent prognosis with 5-year overall survival (OS) rates of up to 90% [2]. Pediatric-inspired intensive regimens are also used to treat adolescents and young adults age 15 to 39 (AYA), with an estimated 3-year OS in this group of 73% [3]. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - March 8, 2024 Category: Hematology Authors: Ayman Sayyed, Carol Chen, Armin Gerbitz, Dennis Dong Hwan Kim, Rajat Kumar, Wilson Lam, Arjun Datt Law, Jeffrey H. Lipton, Fotios V. Michelis, Igor Novitzky-Basso, Auro Viswabandya, Jonas Mattsson, Ivan Pasic Tags: Full-length article Source Type: research

Incidence and outcome of central nervous system relapse after hematopoietic stem cell transplantation in patients suffering from acute myeloid leukemia and acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Haematologica. 2024 Mar 7. doi: 10.3324/haematol.2023.284858. Online ahead of print.ABSTRACTNot available.PMID:38450525 | DOI:10.3324/haematol.2023.284858 (Source: Haematologica)
Source: Haematologica - March 7, 2024 Category: Hematology Authors: Sabine Blum Yves Chalandon Myriam Labopin J ürgen Finke Tobias Gedde-Dahl Tarek Ben Othman Jan J Cornelissen Pavel Jindra H élène Labussière-Wallet Matthew Collin Stig Lenhoff Guido Kobbe Norma C Guti érrez Arnon Nagler Mohamad Mohty Source Type: research

Epidemiology and risk factors of bloodstream infections among adolescents and young adults with acute lymphoblastic leukaemia: An 11-year retrospective cohort study
In this study, we analysed these aspects in AYAs patients and compared similarities and differences with children (<15 years old) and older adults (>39 years old). We analysed the pathogenic epidemiology, antibiotic resistance and BSI risk factors of 73 children, 180 AYAs, and 110 older adults with ALL in three comprehensive hospitals from January 2010 to August 2021. The data on BSIs in AYAs were compared to that of the other two groups. In this study, the epidemiology of BSIs in AYAs was similar to that of older adult patients. Concerning clinical characteristics, most AYAs and older adults with BSIs were in a rela...
Source: Clinical and Experimental Pharmacology and Physiology - March 7, 2024 Category: Drugs & Pharmacology Authors: Longlong Xue Yishu Tang Liwen Wang Cong Xu Qian Cheng Xin Li Source Type: research