Acute Lymphoblastic Leukemia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Response to apheretic platelet transfusion in children of acute lymphoblastic leukemia receiving induction chemotherapy: a cross-sectional study from Bangladesh
CONCLUSIONS: Significant improvement in bleeding status and platelet count was observed following apheretic platelet transfusion.PMID:38463129 | PMC:PMC10923282 | DOI:10.1097/MS9.0000000000001780 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Sushanta Kumar Basak Mohammad Azmain Iktidar Romana Chowdhury Ayesha Khatun Atiar Rahman Sonia Shormin Miah Sheikh Saiful Islam Shaheen Sudeshna Mazumder Source Type: research

Dynamic evolution of bone marrow adipocyte in B cell acute lymphoblastic leukemia: insights from diagnosis to post-chemotherapy
Cancer Biol Ther. 2024 Dec 31;25(1):2323765. doi: 10.1080/15384047.2024.2323765. Epub 2024 Mar 11.ABSTRACTAdipocyte is a unique and versatile component of bone marrow microenvironment (BMM). However, the dynamic evolution of Bone Marrow (BM) adipocytes from the diagnosis of B cell Acute Lymphoblastic Leukemia (B-ALL) to the post-treatment state, and how they affect the progression of leukemia, remains inadequately explicated. Primary patient-derived xenograft models (PDXs) and stromal cell co-culture system are employed in this study. We show that the dynamic evolution of BM adipocytes from initial diagnosis of B-ALL to th...
Source: Cancer Biology and Therapy - March 11, 2024 Category: Cancer & Oncology Authors: Xi Jia Naying Liao Yunqian Yao Xutao Guo Kai Chen Pengcheng Shi Source Type: research

Regulating TKT activity inhibits proliferation of human acute lymphoblastic leukemia cells
In this study, we treated T-ALL cells with different doses of niclosamide and primary T-ALL PBMCs were analyzed by RNA sequencing. T-ALL cells treated with niclosamide were analyzed with the Western blotting and TKT activity assay. Metabolism of T-ALL cells was evaluated by ATP assay and seahorse analyses. Lastly, we used a T-ALL xenograft murine model to determine effects of TKT knockdown on T-ALL tumor growth. Tumor samples were analyzed by H&E and IHC stainings. We found that niclosamide reduced T-ALL cell viability, and reduced expressions of TKT, Transketolase-Like Protein 1/2 (TKTL1/2) and transaldolase. In addit...
Source: Cell Research - March 8, 2024 Category: Cytology Authors: Fang-Liang Huang Yao-Ming Chang Cheng-Yung Lin Sheng-Jie Yu Jing-Tong Fu Ting-Yu Chou Sih-Wen Yeh En-Chih Liao Chia-Ling Li Source Type: research

ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia
Sci Adv. 2024 Mar 8;10(10):eadj8803. doi: 10.1126/sciadv.adj8803. Epub 2024 Mar 8.ABSTRACTPhiladelphia chromosome-positive B cell acute lymphoblastic leukemia (B-ALL), characterized by the BCR::ABL1 fusion gene, remains a poor prognosis cancer needing new therapeutic approaches. Transcriptomic profiling identified up-regulation of oncogenic transcription factors ERG and c-MYC in BCR::ABL1 B-ALL with ERG and c-MYC required for BCR::ABL1 B-ALL in murine and human models. Profiling of ERG- and c-MYC-dependent gene expression and analysis of ChIP-seq data established ERG and c-MYC coordinate a regulatory network in BCR::ABL1 B...
Source: Cancer Control - March 8, 2024 Category: Cancer & Oncology Authors: Kira Behrens Natalie Brajanovski Zhen Xu Elizabeth M Viney Ladina DiRago Soroor Hediyeh-Zadeh Melissa J Davis Richard B Pearson Elaine Sanij Warren S Alexander Ashley P Ng Source Type: research

ERG and c-MYC regulate a critical gene network in BCR::ABL1-driven B cell acute lymphoblastic leukemia
Sci Adv. 2024 Mar 8;10(10):eadj8803. doi: 10.1126/sciadv.adj8803. Epub 2024 Mar 8.ABSTRACTPhiladelphia chromosome-positive B cell acute lymphoblastic leukemia (B-ALL), characterized by the BCR::ABL1 fusion gene, remains a poor prognosis cancer needing new therapeutic approaches. Transcriptomic profiling identified up-regulation of oncogenic transcription factors ERG and c-MYC in BCR::ABL1 B-ALL with ERG and c-MYC required for BCR::ABL1 B-ALL in murine and human models. Profiling of ERG- and c-MYC-dependent gene expression and analysis of ChIP-seq data established ERG and c-MYC coordinate a regulatory network in BCR::ABL1 B...
Source: Adv Data - March 8, 2024 Category: Epidemiology Authors: Kira Behrens Natalie Brajanovski Zhen Xu Elizabeth M Viney Ladina DiRago Soroor Hediyeh-Zadeh Melissa J Davis Richard B Pearson Elaine Sanij Warren S Alexander Ashley P Ng Source Type: research

Pre-transplant blinatumomab improves outcomes in B-cell acute lymphoblastic leukemia patients who undergo allogeneic hematopoietic cell transplantation
Acute lymphoblastic leukemia (ALL) is the most common cancer in children.1 It carries an excellent prognosis with 5-year overall survival (OS) rates of up to 90%.2 Pediatric-inspired intensive regimens are also used to treat adolescents and young adults age 15 –39 (AYA), with an estimated 3-year OS in this group of 73%.3 (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - March 8, 2024 Category: Hematology Authors: Ayman Sayyed, Carol Chen, Armin Gerbitz, Dennis Dong Hwan Kim, Rajat Kumar, Wilson Lam, Arjun Datt Law, Jeffrey H. Lipton, Fotios V. Michelis, Igor Novitzky-Basso, Auro Viswabandya, Jonas Mattsson, Ivan Pasic Source Type: research

Inotuzumab in Older Patients with Newly Diagnosed Acute Lymphoblastic Leukemia —A Podcast
AbstractOlder patients with acute lymphoblastic leukemia (ALL) have historically had poor outcomes (5-year survival rate, 20%) with standard intensive and dose-adjusted chemotherapy regimens, due to a high incidence of adverse biologic features including high-risk cytogenetics, presence ofTP53 mutations, and poor tolerance to intensive therapy. Thus, there is an unmet medical need in this patient population. Inotuzumab ozogamicin is a humanized antibody –drug conjugate that targets CD22-positive leukemic blasts. It is approved for the treatment of relapsed or refractory ALL and has been shown to be effective and tolerabl...
Source: Targeted Oncology - March 8, 2024 Category: Cancer & Oncology Source Type: research

Integrated analysis of transcriptome and genome variations in pediatric T cell acute lymphoblastic leukemia: data from north Indian tertiary care center
T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease with poor prognosis and inferior outcome. Although multiple studies have been perform on genomics of T-ALL, data from Indian s... (Source: BMC Cancer)
Source: BMC Cancer - March 8, 2024 Category: Cancer & Oncology Authors: Minu Singh, Pankaj Sharma, Prateek Bhatia, Amita Trehan, Rozy Thakur and Sreejesh Sreedharanunni Tags: Research Source Type: research

Pretransplant Blinatumomab Improves Outcomes in B Cell Acute Lymphoblastic Leukemia Patients Who Undergo Allogeneic Hematopoietic Cell Transplantation
Acute lymphoblastic leukemia (ALL) is the most common cancer in children [1]. It carries an excellent prognosis with 5-year overall survival (OS) rates of up to 90% [2]. Pediatric-inspired intensive regimens are also used to treat adolescents and young adults age 15 to 39 (AYA), with an estimated 3-year OS in this group of 73% [3]. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - March 8, 2024 Category: Hematology Authors: Ayman Sayyed, Carol Chen, Armin Gerbitz, Dennis Dong Hwan Kim, Rajat Kumar, Wilson Lam, Arjun Datt Law, Jeffrey H. Lipton, Fotios V. Michelis, Igor Novitzky-Basso, Auro Viswabandya, Jonas Mattsson, Ivan Pasic Tags: Full-length article Source Type: research

Incidence and outcome of central nervous system relapse after hematopoietic stem cell transplantation in patients suffering from acute myeloid leukemia and acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Haematologica. 2024 Mar 7. doi: 10.3324/haematol.2023.284858. Online ahead of print.ABSTRACTNot available.PMID:38450525 | DOI:10.3324/haematol.2023.284858 (Source: Haematologica)
Source: Haematologica - March 7, 2024 Category: Hematology Authors: Sabine Blum Yves Chalandon Myriam Labopin J ürgen Finke Tobias Gedde-Dahl Tarek Ben Othman Jan J Cornelissen Pavel Jindra H élène Labussière-Wallet Matthew Collin Stig Lenhoff Guido Kobbe Norma C Guti érrez Arnon Nagler Mohamad Mohty Source Type: research

Epidemiology and risk factors of bloodstream infections among adolescents and young adults with acute lymphoblastic leukaemia: An 11-year retrospective cohort study
In this study, we analysed these aspects in AYAs patients and compared similarities and differences with children (<15 years old) and older adults (>39 years old). We analysed the pathogenic epidemiology, antibiotic resistance and BSI risk factors of 73 children, 180 AYAs, and 110 older adults with ALL in three comprehensive hospitals from January 2010 to August 2021. The data on BSIs in AYAs were compared to that of the other two groups. In this study, the epidemiology of BSIs in AYAs was similar to that of older adult patients. Concerning clinical characteristics, most AYAs and older adults with BSIs were in a rela...
Source: Clinical and Experimental Pharmacology and Physiology - March 7, 2024 Category: Drugs & Pharmacology Authors: Longlong Xue Yishu Tang Liwen Wang Cong Xu Qian Cheng Xin Li Source Type: research