Acute Lymphoblastic Leukemia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

GSE243667 Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities
Contributors : Richard L Frock ; Valeria Rangel ; Jason N Sterrenberg ; Nicholas R PannunzioSeries Type : OtherOrganism : Homo sapiensActivation-induced cytidine deaminase (AID) is a B cell-specific base editor required during class switch recombination and somatic hypermutation for B cell maturation and antibody diversification. However, it has also been implicated as a factor in the etiology of several B cell malignancies. Evaluating the AID-induced mutation load in patients at-risk for certain types of blood cancers is critical in assessing disease severity and treatment options. Here, we have developed a digital PCR (...
Source: GEO: Gene Expression Omnibus - April 13, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil
Bone Marrow Transplantation, Published online: 13 April 2024; doi:10.1038/s41409-024-02283-6Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 13, 2024 Category: Hematology Authors: Camila D. Donadel Gil C. De Santis Thiago E. Gon çalves Bruno G. Pires Leonardo C. Palma Flavia Gava Renato Luiz Guerino-Cunha Joana T. B. Faria Gabriela V. A. Silva Luiz Guilherme Darrigo-Junior Giancarlo Fatobene Vanderson Rocha Dimas T. Covas Rodrigo Source Type: research

Understanding hemoglobin contribution to high-dose methotrexate disposition —population pharmacokinetics in pediatric patients with hematological malignancies
ConclusionThe developed population pharmacokinetic model can contribute to the therapy optimization during HDMTX in pediatric patients with ALL and NHL. In addition to renal function and body weight, it describes the influence of hemoglobin on CL, allowing better understanding of its contribution to the disposition of HDMTX. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Source Type: research

RuZn NPs with electroactivity and oxidase-like property for dual-mode anti-cancer drug monitoring
Talanta. 2024 Apr 8;274:126075. doi: 10.1016/j.talanta.2024.126075. Online ahead of print.ABSTRACT6-mercaptopurine (6-MP) as the effective anti-cancer drug was used for the treatment of Crohn's disease and acute lymphoblastic leukaemia, but the response to maintenance therapy was variable with individual differences. In order to control the dosage and decrease the side effects of 6-MP, a sensitive and stable assay was urgently needed for 6-MP monitoring. Herein, RuZn NPs with electrochemical oxidation property and oxidase-like activity was proposed for dual-mode 6-MP monitoring. Burr-like RuZn NPs were prepared and explore...
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Zhao Jin Fang Peng Qiaodan Du Dan Liang Yuan Zhao Source Type: research

RuZn NPs with electroactivity and oxidase-like property for dual-mode anti-cancer drug monitoring
Talanta. 2024 Apr 8;274:126075. doi: 10.1016/j.talanta.2024.126075. Online ahead of print.ABSTRACT6-mercaptopurine (6-MP) as the effective anti-cancer drug was used for the treatment of Crohn's disease and acute lymphoblastic leukaemia, but the response to maintenance therapy was variable with individual differences. In order to control the dosage and decrease the side effects of 6-MP, a sensitive and stable assay was urgently needed for 6-MP monitoring. Herein, RuZn NPs with electrochemical oxidation property and oxidase-like activity was proposed for dual-mode 6-MP monitoring. Burr-like RuZn NPs were prepared and explore...
Source: Talanta - April 11, 2024 Category: Chemistry Authors: Zhao Jin Fang Peng Qiaodan Du Dan Liang Yuan Zhao Source Type: research

Emergency Department Visits Before Cancer Diagnosis Among Women at Mayo Clinic
CONCLUSION: Patient characteristics identified in this study offer opportunities to provide cancer risk assessment and health navigation, particularly among individuals with comorbidities and limited health care access.PMID:38596167 | PMC:PMC11002794 | DOI:10.1016/j.mayocpiqo.2024.03.002 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 10, 2024 Category: Cancer & Oncology Authors: Sally K Stauder Shalmali R Borkar Amy E Glasgow Tage L Runkle Mark E Sherman Aaron C Spaulding Michael M Mohseni Christopher C DeStephano Source Type: research

The DMT1 isoform lacking the iron ‐response element regulates normal and malignant hematopoiesis via NOTCH pathway activation
In this report, we investigated the function of DMT1 nonIRE in normal and malignant hematopoiesis. Knockdown of Dmt1 nonIRE in mice showed that it has non-canonical functions in hematopoietic stem cell differentiation: its knockdown suppressed development along the myeloid and lymphoid lineages, while promoting the production of platelets. These phenotypic effects on the hematopoietic system induced by Dmt1 nonIRE knockdown were linked to suppression of Notch/Myc pathway activity. Conversely, our data indicate a non-canonical function for DMT1 nonIRE overexpression in boosting NOTCH pathway activity in T-cell leukemia home...
Source: FEBS Letters - April 10, 2024 Category: Biochemistry Authors: Judith Hounjet, Linde Van Aerschot, Kim De Keersmaecker, Marc Vooijs, Kim R. Kampen Tags: Research Letter Source Type: research

GSE254783 Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment [HiChIP]
Contributors : Kashi Raj Bhattarai ; Robert J Mobley ; Kelly R Barnett ; Daniel C Ferguson ; Jonathan D Diedrich ; Brennan P Bergeron ; Satoshi Yoshimura ; Wenjian Yang ; Kristine R Crews ; Elias Jabbour ; Christopher S Manring ; Elisabeth Paietta ; Steven M Kornblau ; Wendy Stock ; Hiroto Inaba ; Sima Jeha ; Ching-Hon Pui ; Cheng Cheng ; Mary V Relling ; William E Evans ; Jun J Yang ; Daniel SavicSeries Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensAlthough acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer, there is limited understa...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research

GSE225263 Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment [MPRA]
Contributors : Kashi Raj Bhattarai ; Robert J Mobley ; Kelly R Barnett ; Daniel C Ferguson ; Jonathan D Diedrich ; Brennan P Bergeron ; Wenjian Yang ; Kristine R Crews ; Elias Jabbour ; Christopher S Manring ; Elisabeth Paietta ; Steven M Kornblau ; Wendy Stock ; Hiroto Inaba ; Sima Jeha ; Ching-Hon Pui ; Cheng Cheng ; Mary V Relling ; William E Evans ; Jun J Yang ; Daniel SavicSeries Type : OtherOrganism : Homo sapiens ; synthetic constructAlthough acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer, there is limited understanding of the contribution of inherited genetic variation on inter-...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens synthetic construct Source Type: research

GSE224956 Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment [ChIP-Seq]
Contributors : Kashi R Bhattarai ; Robert J Mobley ; Kelly R Barnett ; Daniel C Ferguson ; Jonathan D Diedrich ; Brennan P Bergeron ; Wenjian Yang ; Kristine R Crews ; Elias Jabbour ; Christopher S Manring ; Elisabeth Paietta ; Steven M Kornblau ; Wendy Stock ; Hiroto Inaba ; Sima Jeha ; Ching-Hon Pui ; Cheng Cheng ; Mary V Relling ; William E Evans ; Jun J Yang ; Daniel SavicSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAlthough acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer, there is limited understanding of the contribution of inh...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE224530 Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment [ATAC-seq]
Contributors : Kashi R Bhattarai ; Robert J Mobley ; Kelly R Barnett ; Daniel C Ferguson ; Jonathan D Diedrich ; Brennan P Bergeron ; Wenjian Yang ; Kristine R Crews ; Elias Jabbour ; Christopher S Manring ; Elisabeth Paietta ; Steven M Kornblau ; Wendy Stock ; Hiroto Inaba ; Sima Jeha ; Ching-Hon Pui ; Cheng Cheng ; Mary V Relling ; William E Evans ; Jun J Yang ; Daniel SavicSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensAlthough acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer, there is limited understanding of the contribution of inh...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE224204 Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiens ; synthetic constructThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens synthetic construct Source Type: research

GSE224203 Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment [HiC]
Contributors : Kashi R Bhattarai ; Robert J Mobley ; Kelly R Barnett ; Daniel C Ferguson ; Jonathan D Diedrich ; Brennan P Bergeron ; Wenjian Yang ; Kristine R Crews ; Elias Jabbour ; Christopher S Manring ; Elisabeth Paietta ; Steven M Kornblau ; Wendy Stock ; Hiroto Inaba ; Sima Jeha ; Ching-Hon Pui ; Cheng Cheng ; Mary V Relling ; William E Evans ; Jun J Yang ; Daniel SavicSeries Type : OtherOrganism : Homo sapiensAlthough acute lymphoblastic leukemia (ALL) is the most prevalent childhood cancer, there is limited understanding of the contribution of inherited genetic variation on inter-individual differences in...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research