Acute Lymphoblastic Leukemia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The CNS microenvironment promotes leukemia cell survival by disrupting tumor suppression and cell cycle regulation in pediatric T-cell acute lymphoblastic leukemia
Exp Cell Res. 2024 Mar 30:114015. doi: 10.1016/j.yexcr.2024.114015. Online ahead of print.ABSTRACTA major obstacle in improving survival in pediatric T-cell acute lymphoblastic leukemia is understanding how to predict and treat leukemia relapse in the CNS. Leukemia cells are capable of infiltrating and residing within the CNS, primarily the leptomeninges, where they interact with the microenvironment and remain sheltered from systemic treatment. These cells can survive in the CNS, by hijacking the microenvironment and disrupting normal functions, thus promoting malignant transformation. While the protective effects of the ...
Source: Experimental Cell Research - April 1, 2024 Category: Cytology Authors: Sabina Enlund Indranil Sinha Christina Neofytou Amanda Ramilo Amor Konstantinos Papadakis Anna Nilsson Qingfei Jiang Ola Hermanson Frida Holm Source Type: research

The CNS microenvironment promotes leukemia cell survival by disrupting tumor suppression and cell cycle regulation in pediatric T-cell acute lymphoblastic leukemia
Exp Cell Res. 2024 Mar 30:114015. doi: 10.1016/j.yexcr.2024.114015. Online ahead of print.ABSTRACTA major obstacle in improving survival in pediatric T-cell acute lymphoblastic leukemia is understanding how to predict and treat leukemia relapse in the CNS. Leukemia cells are capable of infiltrating and residing within the CNS, primarily the leptomeninges, where they interact with the microenvironment and remain sheltered from systemic treatment. These cells can survive in the CNS, by hijacking the microenvironment and disrupting normal functions, thus promoting malignant transformation. While the protective effects of the ...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: Sabina Enlund Indranil Sinha Christina Neofytou Amanda Ramilo Amor Konstantinos Papadakis Anna Nilsson Qingfei Jiang Ola Hermanson Frida Holm Source Type: research

Ponatinib-Related Vasospastic Angina
We report 3 cases of Ponatinib-related vasospastic angina, in which prophylactic administration of nitrates or calcium channel blockers was effective.PMID:38556342 | DOI:10.1536/ihj.23-355 (Source: International Heart Journal)
Source: International Heart Journal - March 31, 2024 Category: Cardiology Authors: Michiho Shindo Chinatsu Komiyama Tetsuo Yamaguchi Kosei Kageyama Hisashi Yamamoto Yo Fujimoto Naoyuki Uchida Takahide Kodama Source Type: research

"Characterization of residential proximity to sources of environmental carcinogens in clusters of Acute Lymphoblastic Leukemia in San Luis Potosi, Mexico"
CONCLUSIONS: This study has a limited source and amount of available data on ALL cases, so selection bias is present as well as the inability to rule out residual confounding factors, since covariates were not included. However, in this study, children living in environments with high vehicular density, gas stations, brick kilns, incinerators, commercial establishments burning biomass, or near industrial zones may be at higher risk for ALL.PMID:38555983 | DOI:10.1016/j.envres.2024.118790 (Source: Environmental Research)
Source: Environmental Research - March 31, 2024 Category: Environmental Health Authors: Lizet Jarquin-Ya ñez Monica Imelda Martinez-Acu ña Ivan Lopez-Arevalo Jaqueline Calderon Hernandez Source Type: research