Impact of CYP1A1 variants on the risk of acute lymphoblastic leukemia: evidence from an updated meta-analysis
CONCLUSION: Our comprehensive analysis indicates that the T3801 and A2455G polymorphisms of CYP1A1 may increase the risk of ALL depending on ethnicity. Therefore, both variants should be considered promising biomarkers for ALL risk. Further large-scale investigations are necessary to assess other factors, such as gene-gene or gene-environment interactions.PMID:38485870 | PMC:PMC10917727 | DOI:10.1007/s44313-024-00007-9 (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Imen Frikha Rim Frikha Moez Medhaffer Hanen Charfi Fatma Turki Moez Elloumi Source Type: research

Effectiveness and safety of blinatumomab for pediatric B cell acute lymphoblastic leukemia with Loeffler ’s endocarditis
(Source: Annals of Hematology)
Source: Annals of Hematology - March 15, 2024 Category: Hematology Source Type: research

Cancers, Vol. 16, Pages 1164: PAX5 Alterations in a Consecutive Childhood B-Cell Acute Lymphoblastic Leukemia Cohort Treated Using the ALL IC-BFM 2009 Protocol
In conclusion, this study provides valuable insights into the presence, frequency, and prognostic significance of diverse PAX5 alterations in B-ALL patients, highlighting the complexity of genetic factors and their impact on patient outcomes. (Source: Cancers)
Source: Cancers - March 15, 2024 Category: Cancer & Oncology Authors: Klementina Črepinšek Nika Klobu čar Tine Tesovnik Robert Šket Barbara Jenko Jenko Bizjan Jernej Kova č Marko Kav čič Toma ž Prelog Lidija Kitanovski Janez Jazbec Maru ša Debeljak Tags: Article Source Type: research

In-hospital psychoeducation for family caregivers of Nigerian children with cancer (The RESCUE Study)
This study aimed to determine the impact of a structured psychoeducation program on caregivers' outcomes relating to preparedness to provide care, burden of caregiving, and quality of life (QoL).METHODS: This quasi-experimental (pre-and-posttest) design, involved family caregivers of children on admission for cancer treatment in 4 Nigerian tertiary hospitals. Eligible participants received 2 structured, psychoeducational training sessions delivered by a multidisciplinary oncology team, focusing on the management of patients' condition, spiritual care, self-care, and support.RESULTS: Subjects were mainly female (79.5%) and ...
Source: Palliative and Supportive Care - March 14, 2024 Category: Palliative Care Authors: Tonia Chinyelu Onyeka Ifeoma Emodi Alhassan Datti Mohammed Akinyemi Olugbenga Ofakunrin Adewumi Alabi Justus Uchenna Onu Nneka Iloanusi Jude Ohaeri Agnes Anarado Musa Usman Umar Gbenro Olukiran Anthonia Sowunmi Adeseye Akinsete Bolanle Adegboyega Ijeoma N Source Type: research

SOHO State of the Art Updates and Next Questions, Measurable Residual Disease in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Clin Lymphoma Myeloma Leuk. 2024 Feb 21:S2152-2650(24)00081-8. doi: 10.1016/j.clml.2024.02.009. Online ahead of print.ABSTRACTAssessment of measurable residual disease (MRD) provides important prognostic information and can inform decision-making about appropriate consolidative therapy in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Many contemporary treatment protocols for Ph+ ALL achieve high rates of MRD negativity, and several analyses suggest that allogeneic hematopoietic stem cell transplant in first remission can be safely deferred in most patients who achieve MRD negativity...
Source: Clinical Lymphoma and Myeloma - March 14, 2024 Category: Cancer & Oncology Authors: Nicholas J Short Elias Jabbour Hagop Kantarjian Source Type: research

In-hospital psychoeducation for family caregivers of Nigerian children with cancer (The RESCUE Study)
This study aimed to determine the impact of a structured psychoeducation program on caregivers' outcomes relating to preparedness to provide care, burden of caregiving, and quality of life (QoL).METHODS: This quasi-experimental (pre-and-posttest) design, involved family caregivers of children on admission for cancer treatment in 4 Nigerian tertiary hospitals. Eligible participants received 2 structured, psychoeducational training sessions delivered by a multidisciplinary oncology team, focusing on the management of patients' condition, spiritual care, self-care, and support.RESULTS: Subjects were mainly female (79.5%) and ...
Source: Palliative and Supportive Care - March 14, 2024 Category: Palliative Care Authors: Tonia Chinyelu Onyeka Ifeoma Emodi Alhassan Datti Mohammed Akinyemi Olugbenga Ofakunrin Adewumi Alabi Justus Uchenna Onu Nneka Iloanusi Jude Ohaeri Agnes Anarado Musa Usman Umar Gbenro Olukiran Anthonia Sowunmi Adeseye Akinsete Bolanle Adegboyega Ijeoma N Source Type: research

In-hospital psychoeducation for family caregivers of Nigerian children with cancer (The RESCUE Study)
This study aimed to determine the impact of a structured psychoeducation program on caregivers' outcomes relating to preparedness to provide care, burden of caregiving, and quality of life (QoL).METHODS: This quasi-experimental (pre-and-posttest) design, involved family caregivers of children on admission for cancer treatment in 4 Nigerian tertiary hospitals. Eligible participants received 2 structured, psychoeducational training sessions delivered by a multidisciplinary oncology team, focusing on the management of patients' condition, spiritual care, self-care, and support.RESULTS: Subjects were mainly female (79.5%) and ...
Source: Palliative and Supportive Care - March 14, 2024 Category: Palliative Care Authors: Tonia Chinyelu Onyeka Ifeoma Emodi Alhassan Datti Mohammed Akinyemi Olugbenga Ofakunrin Adewumi Alabi Justus Uchenna Onu Nneka Iloanusi Jude Ohaeri Agnes Anarado Musa Usman Umar Gbenro Olukiran Anthonia Sowunmi Adeseye Akinsete Bolanle Adegboyega Ijeoma N Source Type: research

In-hospital psychoeducation for family caregivers of Nigerian children with cancer (The RESCUE Study)
This study aimed to determine the impact of a structured psychoeducation program on caregivers' outcomes relating to preparedness to provide care, burden of caregiving, and quality of life (QoL).METHODS: This quasi-experimental (pre-and-posttest) design, involved family caregivers of children on admission for cancer treatment in 4 Nigerian tertiary hospitals. Eligible participants received 2 structured, psychoeducational training sessions delivered by a multidisciplinary oncology team, focusing on the management of patients' condition, spiritual care, self-care, and support.RESULTS: Subjects were mainly female (79.5%) and ...
Source: Palliative and Supportive Care - March 14, 2024 Category: Palliative Care Authors: Tonia Chinyelu Onyeka Ifeoma Emodi Alhassan Datti Mohammed Akinyemi Olugbenga Ofakunrin Adewumi Alabi Justus Uchenna Onu Nneka Iloanusi Jude Ohaeri Agnes Anarado Musa Usman Umar Gbenro Olukiran Anthonia Sowunmi Adeseye Akinsete Bolanle Adegboyega Ijeoma N Source Type: research

In-hospital psychoeducation for family caregivers of Nigerian children with cancer (The RESCUE Study)
This study aimed to determine the impact of a structured psychoeducation program on caregivers' outcomes relating to preparedness to provide care, burden of caregiving, and quality of life (QoL).METHODS: This quasi-experimental (pre-and-posttest) design, involved family caregivers of children on admission for cancer treatment in 4 Nigerian tertiary hospitals. Eligible participants received 2 structured, psychoeducational training sessions delivered by a multidisciplinary oncology team, focusing on the management of patients' condition, spiritual care, self-care, and support.RESULTS: Subjects were mainly female (79.5%) and ...
Source: Palliative and Supportive Care - March 14, 2024 Category: Palliative Care Authors: Tonia Chinyelu Onyeka Ifeoma Emodi Alhassan Datti Mohammed Akinyemi Olugbenga Ofakunrin Adewumi Alabi Justus Uchenna Onu Nneka Iloanusi Jude Ohaeri Agnes Anarado Musa Usman Umar Gbenro Olukiran Anthonia Sowunmi Adeseye Akinsete Bolanle Adegboyega Ijeoma N Source Type: research