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A rare case of Philadelphia-positive (P210BCR-ABL1) T-cell acute lymphoblastic leukemia/lymphoma associated with minimal residual disease persistence after intensive chemotherapeutic approaches
We present a case of adult Ph+ T-ALL/LBL with a likely history of antecedent CML. Initially thought to be a case of chronic-phase CML, a diagnostic quandary led to the pursuit of a lymph node biopsy that established the diagnosis of Ph+ T-LBL or T lymphoblastic blast crisis of CML, a clinical presentation extremely rare and only the second of its kind from our review of the literature. The patient was treated with an intensive chemotherapy regimen for over a year due to persistent minimal residual disease (MRD) positivity indicating aggressive disease.PMID:38572397 | PMC:PMC10987326 | DOI:10.1016/j.lrr.2024.100456 (Source: Cell Research)
Source: Cell Research - April 4, 2024 Category: Cytology Authors: Shruti Shah Rupayan Kundu Rahul Mishra Sudipto Mukherjee Abhay Singh Source Type: research

CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research

Biomarkers of bleeding and venous thromboembolism in patients with acute leukemia
CONCLUSIONS: Our study shows alterations in several biomarkers in acute leukemia and identifies biomarkers associated with risk of bleeding and DVT.PMID:38574862 | DOI:10.1016/j.jtha.2024.03.020 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Yohei Hisada Sierra J Archibald Karan Bansal Yanjun Chen Chen Dai Sindhu Dwarampudi Nora Balas Lindsey Hageman Nigel S Key Smita Bhatia Ravi Bhatia Nigel Mackman Radhika Gangaraju Source Type: research

Honokiol induces apoptosis and autophagy in dexamethasone-resistant T-acute lymphoblastic leukemia CEM-C1 cells
Conclusion: The combination of honokiol and DEX were better than DEX alone in DEX-resistant CEM-C1 cell lines. Honokiol may regulate T-ALL-related dexamethasone resistance by affecting c-Myc.PMID:38573223 | DOI:10.1080/16078454.2024.2337307 (Source: Hematology)
Source: Hematology - April 4, 2024 Category: Hematology Authors: Yang Liu Suqian Zhang Yajuan Tan Source Type: research

The IKAROS Transcription Factor Gene IKZF1 as a Critical Regulator in the Pathogenesis of Childhood Acute Lymphoblastic Leukemia: Insights from a Bangladeshi Population
This study investigated whether two specific IKZF1 variants, rs10272724 (T > C) and rs4132601 (T > G), are potential risk factors for childhood ALL among Bangladeshi children. In this study, we found that ALL occurs with a significantly greater frequency in male children than in female children, shedding light on potential sex-specific susceptibility patterns. Subsequent association analyses u tilizing codominant, dominant, and recessive inheritance models demonstrated that rs10272724 is associated with a 2.36-fold increased risk of ALL development according to the codominant model, a 3.6-fold increased ri...
Source: Indian Journal of Clinical Biochemistry - April 4, 2024 Category: Biochemistry Source Type: research

CXCR6 defines therapeutic subtypes of CD4 < sup > + < /sup > cytotoxic T cell lineage for adoptive cell transfer therapy in pediatric B cell acute lymphoblastic leukemia
Int Immunopharmacol. 2024 Apr 2;132:111972. doi: 10.1016/j.intimp.2024.111972. Online ahead of print.ABSTRACTThe potential of cytotoxic CD4+ T cells and tissue resident memory T cells (Trm) in achieving adult leukemia remission have been highlighted [1,2]. We hypothesized that CXCR6 could serve as a marker for cytotoxic CD4+ Trm cells in the bone marrow (BM) of pediatric B-ALL patients. Flow cytometry (FCM) and published single cell RNA sequencing (scRNA-seq) datasets were employed to characterize CXCR6+CD4+ T cells in the BM and peripheral blood (PB) of pediatric B-ALL patients and healthy donors. FCM, scRNA-seq and co-cu...
Source: International Immunopharmacology - April 3, 2024 Category: Allergy & Immunology Authors: Shaojie Shi Haiyan Xing Xiangping Xu Jinquan Chai Zixuan Lu Jianyong Wang Bin Wang Source Type: research

EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia
The EP300-ZNF384 fusion gene is an oncogenic driver in B-cell acute lymphoblastic leukemia (B-ALL). In the present study, we demonstrated that EP300-ZNF384 substantially induces the transcription of IL3RA and the... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 2, 2024 Category: Molecular Biology Authors: Zhijie Hou, Yifei Ren, Xuehong Zhang, Dan Huang, Fanzhi Yan, Wentao Sun, Wenjuan Zhang, Qingqing Zhang, Xihui Fu, Zhenghui Lang, Chenyang Chu, Boyang Zou, Beibei Gao, Bilian Jin, Zhijie Kang, Quentin Liu & hellip; Tags: Research Source Type: research