Acute Lymphoblastic Leukemia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Outcome of infants with acute lymphoblastic leukemia treated with the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia 2015 study protocol
Haematologica. 2024 Apr 18. doi: 10.3324/haematol.2024.285201. Online ahead of print.ABSTRACTNot available.PMID:38634141 | DOI:10.3324/haematol.2024.285201 (Source: Haematologica)
Source: Haematologica - April 18, 2024 Category: Hematology Authors: Alex Wk Leung Jiaoyang Cai Zhi Wan Jiefen Qin Yongjun Fang Lirong Sun Jiashi Zhu Shaoyan Hu Ningling Wang Pan Gao Xin Tian Xiaofan Zhu Fen Zhou Xuedong Wu Xiuli Ju Xiaowen Zhai Hua Jiang Qun Hu Changda Liang Liangchun Yang Hui Zhang Jingyan Tang Ju Gao Ch Source Type: research

Associations of granulocyte colony-stimulating factor with toxicities and efficacy of chimeric antigen receptor T-cell therapy in relapsed or refractory B-cell acute lymphoblastic leukemia
In conclusion, our results showed that G-CSF administration was not associated with the incidence or severity of CRS in patients with low BM tumor burden, but the incidence o f CRS was higher after G-CSF administration in patients with high BM tumor burden. The duration of CRS was prolonged in G-CSF group. G-CSF administration was not associated with the efficacy of CAR T-cell therapy. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - April 17, 2024 Category: Cancer & Oncology Source Type: research

Chemo-free treatment of adult patients with Ph-positive acute lymphoblastic leukemia: latest updates from the 2023 ASH annual meeting
The chemo-free concept represents a new direction for managing adult patients with Ph-positive acute lymphoblastic leukemia (Ph + ALL). The tyrosine kinase inhibitors (TKIs), blinatumomab and venetoclax serve ... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - April 16, 2024 Category: Hematology Authors: Ting Shi and Hong-Hu Zhu Tags: Correspondence Source Type: research

Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency
While therapies targeting CD19 by antibodies, chimeric antigen receptor T cells (CAR-T), and T cell engagers have improved the response rates in B cell malignancies, the emergence of resistant cell populations with low CD19 expression can lead to relapsed disease. We developed an in vitro model of adaptive resistance facilitated by chronic exposure of leukemia cells to a CD19 immunotoxin. Single-cell RNA-Seq (scRNA-Seq) showed an increase in transcriptionally distinct CD19lo populations among resistant cells. Mass cytometry demonstrated that CD22 was also decreased in these CD19lo-resistant cells. An assay for transposase-...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Sarah Aminov, Orsi Giricz, David T. Melnekoff, R. Alejandro Sica, Veronika Polishchuk, Cristian Papazoglu, Bonnie Yates, Hao-Wei Wang, Srabani Sahu, Yanhua Wang, Shanisha Gordon-Mitchell, Violetta V. Leshchenko, Carolina Schinke, Kith Pradhan, Srinivas Al Source Type: research

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. Mutations in IL7R have been analyzed genetically, but downstream effector functions such as STAT5A and STAT5B hyperactivation are poorly understood. Here, we studied the most frequent and clinically challenging STAT5BN642H driver in T cell development and immature T cell cancer onset and compared it with STAT5A hyperactive variants in transgenic mice. Enhanced STAT5 activity caused disrupted T cell development and promoted an early T cell progenitor–ALL phenotype, with upregulation of genes involved in T cell receptor (TCR) signaling, ev...
Source: Journal of Clinical Investigation - April 15, 2024 Category: Biomedical Science Authors: Tobias Suske, Helena Sorger, Gabriele Manhart, Frank Ruge, Nicole Prutsch, Mark W. Zimmerman, Thomas Eder, Diaaeldin I. Abdallah, Barbara Maurer, Christina Wagner, Susann Schönefeldt, Katrin Spirk, Alexander Pichler, Tea Pemovska, Carmen Schweicker, Dani Source Type: research

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia
ConclusionOverall, these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - April 15, 2024 Category: Research Source Type: research

Adult survivors ’ perception of their childhood and the influences of being treated for acute lymphoblastic leukaemia with allogenic hematopoietic stem cell transplantation as a child: a phenomenographic study
Adults who had acute lymphoblastic leukaemia (ALL) as children and were treated with allogeneic hematopoietic stem cell transplantation (aHSCT) may have been affected in their lives due to several long-term complications. From a clinical point of view, it is of interest to study how survivors describe their perceptions of their childhood today. The aim was therefore to describe how adults perceived their childhood and the influences of being treated for ALL with aHSCT as a child. (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - April 15, 2024 Category: Cancer & Oncology Authors: Susann Arvidsson, Elisabeth Brobeck, Jens Nygren, Marianne Jarfelt, Katarina Aili, Maria Olsson Source Type: research

Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis
To study the shared genetic structure between autoimmune diseases and B-cell acute lymphoblastic leukemia (B-ALL) and identify the shared risk loci and genes and genetic mechanisms involved. (Source: BMC Medicine)
Source: BMC Medicine - April 15, 2024 Category: Internal Medicine Authors: Xinghao Yu, Yiyin Chen, Jia Chen, Yi Fan, Huimin Lu, Depei Wu and Yang Xu Tags: Research article Source Type: research

Frontline combination of dasatinib and low-intensity chemotherapy in adults with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia
CONCLUSIONS: Our results suggest that dasatinib-based low-intensity chemotherapy is safe and effective as an induction strategy in the Chinese population. Allo-HSCT plays a crucial role in the long-term outcomes of patients with Ph+ ALL.CLINICAL TRIAL REGISTRATION: The trial was registered at ClinicalTrials.gov as NCT02690922.PMID:38616308 | DOI:10.1080/17474086.2024.2343885 (Source: Expert Review of Hematology)
Source: Expert Review of Hematology - April 14, 2024 Category: Hematology Authors: Yizhou Peng Jinjin Huang Jin Yin Fankai Meng Yang Cao Liang Huang Dengju Li Yicheng Zhang Donghua Zhang Li Meng Zhiqiang Han Zhenya Hong Source Type: research

Three-year outcomes of valoctocogene roxaparvovec gene therapy for hemophilia A
CONCLUSIONS: Hemostatic efficacy was maintained, and safety remained unchanged from previous years.PMID:38614387 | DOI:10.1016/j.jtha.2024.04.001 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 13, 2024 Category: Hematology Authors: Bella Madan Margareth C Ozelo Priyanka Raheja Emily Symington Doris V Quon Andrew D Leavitt Steven W Pipe Gillian Lowe Gili Kenet Mark T Reding Jane Mason Michael Wang Annette von Drygalski Robert Klamroth Susan Shapiro Herv é Chambost Amy L Dunn Johanne Source Type: research

GSE243667 Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities
Contributors : Richard L Frock ; Valeria Rangel ; Jason N Sterrenberg ; Nicholas R PannunzioSeries Type : OtherOrganism : Homo sapiensActivation-induced cytidine deaminase (AID) is a B cell-specific base editor required during class switch recombination and somatic hypermutation for B cell maturation and antibody diversification. However, it has also been implicated as a factor in the etiology of several B cell malignancies. Evaluating the AID-induced mutation load in patients at-risk for certain types of blood cancers is critical in assessing disease severity and treatment options. Here, we have developed a digital PCR (...
Source: GEO: Gene Expression Omnibus - April 13, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil
Bone Marrow Transplantation, Published online: 13 April 2024; doi:10.1038/s41409-024-02283-6Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - April 13, 2024 Category: Hematology Authors: Camila D. Donadel Gil C. De Santis Thiago E. Gon çalves Bruno G. Pires Leonardo C. Palma Flavia Gava Renato Luiz Guerino-Cunha Joana T. B. Faria Gabriela V. A. Silva Luiz Guilherme Darrigo-Junior Giancarlo Fatobene Vanderson Rocha Dimas T. Covas Rodrigo Source Type: research