Acute Lymphoblastic Leukemia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia
Leukemia, Published online: 10 April 2024; doi:10.1038/s41375-024-02241-7Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia (Source: Leukemia)
Source: Leukemia - April 10, 2024 Category: Hematology Authors: Hayden L. Bell Helen J. Blair Samantha J. Jepson Gosling Martin Galler Daniel Astley Anthony V. Moorman Olaf Heidenreich Gareth J. Veal Frederik W. van Delft John Lunec Julie A. E. Irving Source Type: research

Characterization of brain development with neuroimaging in a female mouse model of chemotherapy treatment of acute lymphoblastic leukemia
CONCLUSIONS: The results demonstrate feasibility of modeling pediatric ALL treatment in a preclinical model and highlight the potential of using preclinical neuroimaging models to gain insight into brain development throughout survivorship.PMID:38590373 | PMC:PMC10998997 | DOI:10.21037/tp-23-458 (Source: Cancer Control)
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Kellen Gandy Timothy R Koscik Tyler Alexander Jeffrey D Steinberg Kevin R Krull Ellen van der Plas Source Type: research

Clinicopathological and Immunophenotypic Characteristics of Series of ZNF384 Re-arranged Acute Leukemias
We present the clinic-pathological and immunophenotypic findings in a series of five cases of acute leukemia withZNF384-r reported in our Institute between September 2020 to September 2023. Notably, whileTCF3::ZNF384 fusion was the most frequently encountered abnormality, the fusion partner was not identified in two patients withZNF384-r BCP-ALL. Immunophenotypically, patients presenting as B-cell precursor acute lymphoblastic leukemia (BCP-ALL) had a distinct profile characterized by weak or absent CD10 expression and the presence of myeloid markers such as CD13/CD33. Our findings underscore the importance of recognizing ...
Source: Indian Journal of Hematology and Blood Transfusion - April 9, 2024 Category: Hematology Source Type: research

Significance and implications of FHIT gene expression and promoter hypermethylation in acute lymphoblastic leukemia (ALL)
ConclusionThe present study conclude thatFHIT gene hypermethylation and its altered expression may be linked in the pathogenesis of ALL and provide an evidence for the role ofFHIT in the development of ALL. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 8, 2024 Category: Cancer & Oncology Source Type: research

A review of immunotargeted therapy for Philadelphia chromosome positive acute lymphoblastic leukaemia: making progress in chemotherapy-free regimens
Hematology. 2024 Dec;29(1):2335856. doi: 10.1080/16078454.2024.2335856. Epub 2024 Apr 6.ABSTRACTPhiladelphia chromosome-positive acute lymphoblastic leukemia (PH + ALL) is the most common cytogenetic abnormality of B-ALL in adults and is associated with poor prognosis. Previously, the only curative treatment option in PH + ALL was allogeneic hematopoietic stem cell transplantation (Allo-HSCT). Since 2000, targeted therapy combined with chemotherapy, represented by the tyrosine kinase inhibitor Imatinib, has become the first-line treatment for PH + ALL. Currently, the remission rate and survival rate of Imatinib are superio...
Source: Hematology - April 6, 2024 Category: Hematology Authors: Zhen-Yu Xiong Yao-Jia Shen Shi-Zhong Zhang Hong-Hu Zhu Source Type: research

Insufficient secretion of pancreatic FGF21 is the toxicological mechanism and therapeutic target of asparaginase-associated pancreatitis
In this study, we found that the decrease of FGF21 in pancreas is closely related to AAP. Pegaspargase (1 IU/g) induces widespread edema and inflammatory infiltration in the pancreas of rats/mice. The specific expression of FGF21 in the acinar tissue of AAP rats was significantly downregulated. Asparaginase caused dysregulation of the ATF4/ATF3/FGF21 axis in acinar tissue or cells, and thus mediated the decrease of FGF21. It greatly activated ATF3 in the acinar, which competed with ATF4 for the Fgf21 promoter, thereby inhibiting the expression of FGF21. Pharmacological replacement of FGF21 (1 mg/kg) or PERK inhibitors (GSK...
Source: Toxicology and Applied Pharmacology - April 6, 2024 Category: Toxicology Authors: Jiang He Yajing Chen Wen Zhong Lu Jun Dong Chen Hui Cheng Wang Mei Source Type: research

Wiskott Aldrich syndrome protein (WASp)-deficient Th1 cells promote R-loop-driven transcriptional insufficiency and transcription-coupled nucleotide excision repair factor (TC-NER)-driven genome-instability in the pathogenesis of T cell acute lymphoblastic leukemia
CONCLUSION: Our findings present a provocative possibility of resetting R-loops as a therapeutic intervention to correct both immune deficiency and malignancy in T-cell acute lymphoblastic leukemia patients and a novel role of WASp in the epigenetic regulation of T helper cell differentiation in T-ALL patients, anticipating WASp's requirement for the suppression of T-ALL progression.PMID:38582251 | DOI:10.1016/j.clim.2024.110204 (Source: Clinical Immunology)
Source: Clinical Immunology - April 6, 2024 Category: Allergy & Immunology Authors: R Pradeep Sudeshna Rakshit Geetha Shanmugam Melvin George Koustav Sarkar Source Type: research

INSPIRED Symposium Part 5: Expanding the Use of CAR T cells in Children and Young Adults
Chimeric antigen receptor (CAR) T cell therapies have shown remarkable efficacy in the treatment of relapsed/refractory (r/r) B cell malignancies, including in children and young adults with B cell acute lymphoblastic leukemia (ALL).1-7 However, the efficacy that CAR T cell therapies have shown in B cell malignancies has not yet translated to equivalent success in non-B cell hematologic malignancies, central nervous system (CNS) tumors, and non-CNS solid tumors. Emerging strategies to enhance CAR T cell efficacy and safety for other malignancies have begun to show promise in early-phase clinical trials. (Source: Biology of...
Source: Biology of Blood and Marrow Transplantation - April 6, 2024 Category: Hematology Authors: Aimee C. Talleur, Vanessa A. Fabrizio, Richard Aplenc, Stephan A. Grupp, Crystal Mackall, Robbie Majzner, Rosa Nguyen, Rayne Rouce, Amy Moskop, Kevin O. McNerney Source Type: research

Epidemiological characteristics and influencing factors of acute leukemia in children and adolescents and adults: a large population-based study
CONCLUSION: From 2000 to 2016, the incidence rates of AL in children and adolescents and adults were increasing. Children and adolescents with AL had significantly better OS than adults with AL, and OS declined with age in both children and adolescents and adults with ALL, AML and AUL.PMID:38578123 | DOI:10.1080/16078454.2024.2327916 (Source: Hematology)
Source: Hematology - April 5, 2024 Category: Hematology Authors: Shuojie Liu Bin Hu Jiaqin Zhang Source Type: research