Classification of acute myeloid leukemia.
Authors: Hwang SM Abstract The World Health Organization (WHO) Classification of Tumors of Hematopoietic and Lymphoid Tissues was revised in 2017 on the basis of recent high-throughput sequencing and gene expression data on hematologic malignancies. This review explores the current WHO classification of acute myeloid leukemia (AML) and related precursor neoplasms, highlighting the changes made in the current edition and focusing on the diagnosis of AML. PMID: 32719169 [PubMed] (Source: Blood Research)
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Treatments for children and adolescents with AML.
Authors: Kim H Abstract In recent decades, survival rates for childhood acute myeloid leukemia have remarkably improved, owing to chemotherapy intensification, allogeneic hematopoietic stem cell transplantation, and improved supportive care. Furthermore, treatment protocols have evolved and are currently better matched to prognostic factors and treatment responses. Recently, new molecular prognostic factors were discovered via leukemia genomic studies. Moreover, new tumor subtypes with independent gene expression profiles have been characterized. To broaden the therapeutic options for patients with poor prognoses, ...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

New agents in acute myeloid leukemia (AML).
Authors: Park S, Cho BS, Kim HJ Abstract Despite expanding knowledge in the molecular landscape of acute myeloid leukemia (AML) and an increasing understanding of leukemogenic pathways, little has changed in the treatment of AML in the last 40 years. Since introduction in the 1970s, combination chemotherapy consisting of anthracycline and cytarabine has been the mainstay of treatment, with major therapeutic advances based on improving supportive care rather than the introduction of novel therapeutics. Over the last decades, there have been extensive efforts to identify specific target mutations or pathways with the...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Minimal residual disease in acute lymphoblastic leukemia: technical aspects and implications for clinical interpretation.
Authors: Kim IS Abstract Minimal residual disease (MRD) monitoring has proven to be one of the fundamental independent prognostic factors for patients with acute lymphoblastic leukemia (ALL). Sequential monitoring of MRD using sensitive and specific methods, such as real-time quantitative polymerase chain reaction (qPCR) or flow cytometry (FCM), has improved the assessment of treatment response and is currently used for therapeutic stratification and early detection. Although both FCM and qPCR yield highly consistent results with sensitivities of 10‒4, each method has several limitations. For example, qPCR is tim...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Optimal therapy for adolescents and young adults with acute lymphoblastic leukemia-current perspectives.
Authors: Lee JW Abstract Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) have worse prognosis than children. Differing biology of ALL may account for some of this disparity in outcome, with AYA patients having far lower incidence of good risk cytogenetic abnormalities, and higher proportion of patients with genetic lesions associated with inferior survival such as Ph-like ALL. Actual chemotherapy may also contribute to differences in outcome. Retrospective studies have shown that AYA patients treated on pediatric-based regimens had higher survival than those treated with adult regimens; t...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Current treatment strategies for Philadelphia chromosome-positive adult acute lymphoblastic leukemia.
Authors: Park HS Abstract Acute lymphoblastic leukemia (ALL) is an aggressive hematological disease. The incorporation of tyrosine kinase inhibitors (TKIs) into the standard treatment regimen for Philadelphia (Ph)-positive ALL significantly improved clinical outcomes. TKI-based induction chemotherapy, followed by allogeneic hematopoietic cell transplantation (HCT) during the first complete remission (CR), is the standard of care for ALL patients. However, treatment with TKIs alone or TKIs plus low-intensity chemotherapy can achieve CR in some patients. Although this strategy is not enough to induce a deeper molecul...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Frontline therapy for newly diagnosed patients with multiple myeloma.
Authors: Jung SH, Jo JC, Song GY, Ahn SY, Yang DH, Ahn JS, Kim HJ, Lee JJ Abstract Since the introduction of an alkylator to the treatment of multiple myeloma (MM), new effective agents have been developed, such as immunomodulatory drugs including thalidomide, lenalidomide, and pomalidomide; proteasome inhibitors including bortezomib, carfilzomib, and ixazomib; monoclonal antibodies including daratumumab and elotuzumab; and deacetylase inhibitors including panobinostat. Numerous regimens with these new agents have been developed and they have contributed in improving survival outcomes in MM patients. In addition, t...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Treatment of relapsed and refractory multiple myeloma.
Authors: Lee JH, Kim SH Abstract The therapeutic strategy for relapsed and refractory multiple myeloma (RRMM) integrates a holistic approach regarding patient, disease, and drug-related factors. Patient-related factors include age, frailty status, and underlying comorbidities, especially cardiovascular and renal diseases and peripheral neuropathies that affect tolerability to multiple drug combinations or transplantations. Disease-related factors encompass these multiple patient-related factors, particularly the aggressiveness of the disease and cytogenetics. Regarding drug-related factors, the approval of novel pr...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

AL amyloidosis: advances in diagnosis and management.
Authors: Koh Y Abstract Light chain (AL) amyloidosis is a disease in which malignant plasma cell clones affect multiple organs including the heart and kidney. The mechanism for organ function deterioration in AL amyloidosis differs from multiple myeloma. Thus, not all agents used to treat multiple myeloma shows similar efficacy in AL amyloidosis. In AL amyloidosis, both hematologic and organ responses after treatment are important to improve the clinical outcome. Especially, improving heart function is one of the key aspects in the treatment of AL amyloidosis. With recent advances in the understanding of the pathop...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Recent advances in the management of primary central nervous system lymphoma.
Authors: Choi YS Abstract Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal lymphoma primarily involving the brain, spinal cord, or leptomeninges. PCNSL is associated with a relatively poor prognosis compared to other extranodal diffuse large B-cell lymphomas. However, methotrexate-based induction chemotherapy followed by consolidative chemotherapy or high-dose therapy and autologous stem cell transplantation has improved the survival outcome, together with reduced neurotoxicity. Recent studies found that aberrant activation of the B-cell receptor-signaling pathway and activation of th...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Extranodal NK/T cell lymphoma.
Authors: Jeong SH Abstract Extranodal natural killer (NK)/T cell lymphoma (ENKTL) is a distinct subtype of Non-Hodgkin's lymphoma mainly involving the nasal area. Since the entity was first recognized, treatment strategies have been evolving from anthracycline-based chemotherapy and radiotherapy to L-asparaginase containing regimens and recently immune checkpoint inhibitors. With the currently used combined chemotherapy and radiotherapy, more than 70% of patients with localized disease can be cured. L-asparaginase containing regimens have significantly improved treatment outcomes among patients with advanced diseas...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Recent advances in chronic lymphocytic leukemia therapy.
Authors: Uhm J Abstract Chronic lymphocytic leukemia is a genetically heterogeneous disease, and a complex set of genetic alterations is associated with its pathogenesis. CLL is the most common leukemia in the western countries, whereas it is rare in Asia, including Korea. The prognostic models integrate the traditional staging systems developed by Rai et al. and Binet et al. with biochemical and genetic markers. With the advent of molecular biology, a variety of targeted agents, including anti-CD20 antibodies, inhibitors of BCR signaling pathway, and BCL-2 inhibitors, have been introduced, which has changed the la...
Source: Blood Research - July 29, 2020 Category: Hematology Tags: Blood Res Source Type: research

Coronavirus disease-19 and its hematological manifestations.
Authors: Kim HR, Lee YE, Kang MG, Lee SY, Lee JH, Shin MG PMID: 32595169 [PubMed] (Source: Blood Research)
Source: Blood Research - July 2, 2020 Category: Hematology Tags: Blood Res Source Type: research

Immune checkpoint inhibitors in patients with pretreated Hodgkin Ês lymphoma: a Korean single-center, retrospective study.
Conclusion: In this study, pembrolizumab and nivolumab both demonstrated clinical efficacy and tolerability in patients with cHL who failed previous chemotherapy or ASCT. PMID: 32595170 [PubMed] (Source: Blood Research)
Source: Blood Research - July 2, 2020 Category: Hematology Tags: Blood Res Source Type: research

An interesting story of a clone.
Authors: Juneja R, Veetil KK, Gupta G, Dange P, Pati H PMID: 32595171 [PubMed] (Source: Blood Research)
Source: Blood Research - July 2, 2020 Category: Hematology Tags: Blood Res Source Type: research

Chronicles of blood morphology associated with steroid use.
Authors: PMID: 32595172 [PubMed] (Source: Blood Research)
Source: Blood Research - July 2, 2020 Category: Hematology Tags: Blood Res Source Type: research

Pulmonary hypertension in patients with Philadelphia-negative myeloproliferative neoplasms: a single-center retrospective analysis of 225 patients.
Conclusion: PH is common in patients with Ph⎺ MPNs and hence, careful screening for PH is warranted. PMID: 32429621 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 22, 2020 Category: Hematology Tags: Blood Res Source Type: research

Natural soluble human leukocyte antigen class I in donor serum neutralizes donorspecific HLA alloantibodies in recipient serum.
Conclusions: Using inhibition FCXM, we verified that natural sHLA class I in donor serum neutralizes DSAs in recipient serum. However, no neutralizing effects of sHLA class II were revealed in this study. These potentially beneficial effects of sHLA infused via blood-derived products should be considered when desensitizing highly HLA-sensitized patients. PMID: 32429622 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 22, 2020 Category: Hematology Tags: Blood Res Source Type: research

Response of multifocal acquired demyelinating sensorimotor neuropathy associated with atypical chronic lymphocytic leukemia to rituximab therapy.
Authors: Jain A, Prasad P, Chaudhry S, Gupta DK, Saluja S PMID: 32429623 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 22, 2020 Category: Hematology Tags: Blood Res Source Type: research

Adult T-cell leukemia/lymphoma and Glucose-6-phosphate dehydrogenase deficiency rapidly diagnosed through blood smear examination.
Authors: Marie C, Derrieux C PMID: 32429624 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 22, 2020 Category: Hematology Tags: Blood Res Source Type: research

Apparent diffusion coefficient as a valuable quantitative parameter for predicting clinical outcomes in patients with newly diagnosed primary CNS lymphoma.
Conclusion: ADC demonstrated significant prognostic value for long-term survival in patients with newly diagnosed PCNSL. Low ADC was an independent unfavorable prognostic factor, suggesting that ADC obtained from MRI can improve the current prognostic scoring system. PMID: 32408414 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 16, 2020 Category: Hematology Tags: Blood Res Source Type: research

Impact of using genotyping to predict SERF negative phenotype in Thai blood donor populations.
Conclusion: This study is the first to distinguish the predicted SERF phenotypes from genotyping results obtained using in-house PCR-SSP, confirming that the CROM*01.-12 allele frequency ranged from 0.007 to 0.010 in three Thai populations. This helps identify the SERF(-) phenotype among donors and patients, ultimately preventing adverse transfusion reactions. PMID: 32408415 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 16, 2020 Category: Hematology Tags: Blood Res Source Type: research

Atypical presentation of hairy cell leukemia: a report and comprehensive review.
Authors: Pattnaik SA, Padhi S, Chhabra G, Panigrahi MK, Das PK, Bhola RK, Mishra S PMID: 32408416 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 16, 2020 Category: Hematology Tags: Blood Res Source Type: research

Chronic phase of chronic myeloid leukemia presenting with myeloid sarcoma in an adolescent.
Authors: Lee HJ, Gu MJ, Kong E, Lee JM PMID: 32375463 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 9, 2020 Category: Hematology Tags: Blood Res Source Type: research

Large granular lymphocytes (LGL) in primary Sj ögren syndrome (pSS): immunophenotype and review on the pathological role of T cells in pSS.
Large granular lymphocytes (LGL) in primary Sjögren syndrome (pSS): immunophenotype and review on the pathological role of T cells in pSS. Blood Res. 2020 May 07;: Authors: Tavarozzi R, Carulli G, Manzato E, Sammuri P, Ciabatti E, Petrini M PMID: 32375464 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 9, 2020 Category: Hematology Tags: Blood Res Source Type: research

Lineage switch from B lymphoblastic leukemia with KMT2A-rearranged to mixed-phenotype acute leukemia under daratumumab.
Authors: Marco-Ayala J, Vicente AI, Such E, Luna I, Andreu R, Sempere A, Romero S, Peris MLS PMID: 32375465 [PubMed - as supplied by publisher] (Source: Blood Research)
Source: Blood Research - May 9, 2020 Category: Hematology Tags: Blood Res Source Type: research

Bibliometric analysis of studies about acute myeloid leukemia conducted globally from 1999 to 2018.
This study aimed to investigate AML research networks and to conduct a trend-related keyword analysis. We analyzed 48,202 studies about AML published from 1999 to 2019 in the Web of Science Core Collection. The network analysis was conducted using the R&R studio software. The journal Blood had the highest number of published articles with an h-index of 410. The USA had the highest number of total publications (18,719, 38.3%) and research funded by the government, institutions, and pharmaceutical companies (5,436, 10.8%). The institute with the largest number of publications was the MD Anderson Cancer Center. Kantarjian...
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

A general view of CD33+ leukemic stem cells and CAR-T cells as interesting targets in acute myeloblatsic leukemia therapy.
Authors: Fathi E, Farahzadi R, Sheervalilou R, Sanaat Z, Vietor I Abstract Acute myeloblastic leukemia (AML) is the most frequent acute leukemia in adulthood with very poor overall survival rates. In the past few decades, significant progresses had led to the findings of new therapeutic approaches and the better understanding of the molecular complexity of this hematologic malignancy. Leukemic stem cells (LSCs) play a key role in the initiation, progression, regression, and drug resistance of different types of leukemia. The cellular and molecular characteristics of LSCs and their mechanism in the development of le...
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Characteristics of DNMT3A mutations in acute myeloid leukemia.
Conclusion: We characterized DNMT3A mutations in AML and revealed the association between the DNMT3A mutation and CDKN2B expression and clinical outcome. PMID: 32269971 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Similar transplant outcomes between haploidentical and unrelated donors after reduced-intensity conditioning with busulfan, fludarabine, and anti-thymocyte globulin in patients with acute leukemia or myelodysplastic syndrome.
Conclusion: T-cell replete HCT from HIDs using an ATG-containing reduced intensity conditioning regimen may be a reasonable option in the absence of matched related donors in patients with acute leukemia or myelodysplastic syndrome. PMID: 32269972 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Human platelet lysate efficiency, stability, and optimal heparin concentration required in culture of mammalian cells.
Conclusion: The HPL prepared by the mechanical activation of platelets may serve as an efficient alternative to FBS in cell culture process. PMID: 32269973 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Thromboprophylaxis after bariatric surgery.
Conclusion: Extended thromboprophylaxis after bariatric surgery appears to be an effective and safe strategy for VTE prevention. Large prospective studies are needed to evaluate the optimal thromboprophylaxis regimen after bariatric surgery. PMID: 32269974 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

HIV-negative plasmablastic lymphoma: report of 8 cases and a comprehensive review of 394 published cases.
Conclusion: HIV-negative PBL is a distinct entity with a predilection for elderly and immunosuppressed individuals. Intensive chemotherapy had no apparent survival benefits over the CHOP regimen in terms of OS; the prognosis of this disease is poor with current chemotherapy methods, and treatment remains a challenge. PMID: 32269975 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Mantle cell lymphoma relapsed after autologous stem cell transplantation: a single-center experience.
Conclusion: Our findings suggest that ibrutinib can achieve relatively prolonged control of MCL progressing after autoSCT. PMID: 32269976 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Clinical significance of myeloproliferative neoplasms with JAK2V617F mutations and major BCR-ABL1 translocations: a literature review with case presentation.
Authors: Kim B, Lee KT, Yoon YA, Choi YJ PMID: 32269977 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Daratumumab in dialysis-dependent multiple myeloma.
Authors: Jeyaraman P, Bhasin A, Dayal N, Pathak S, Naithani R PMID: 32269978 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Molecular screening for an underlying myeloproliferative neoplasm in patients with stroke: who and how?
Authors: Langabeer SE PMID: 32269979 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Response to the letter by Langabeer on "Retrospective screening for Philadelphia-negative myeloproliferative neoplasms in patients with cerebral infarctions as revealed using the revised 2016 World Health Organization diagnostic criteria".
Response to the letter by Langabeer on "Retrospective screening for Philadelphia-negative myeloproliferative neoplasms in patients with cerebral infarctions as revealed using the revised 2016 World Health Organization diagnostic criteria". Blood Res. 2020 Mar;55(1):68 Authors: Song IC PMID: 32269980 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Helicobacter pylori testing in a population of Korean patients with pernicious anemia.
Authors: Song IC, Lee MW, Baek SW, Ryu H, Choi YS, Jo DY PMID: 32269981 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Chronic lymphocytic leukemia with unusual cytoplasmic anomalies.
Authors: Athanase N PMID: 31915647 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Recurred breast cancer presenting with autoimmune hemolytic anemia.
Authors: Park J PMID: 31915648 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Do not jump to hasty conclusions: all gamma delta T-cells neoplasms are not aggressive!
Authors: Vergez F, Largeaud L, Oberic L, Rieu JB PMID: 31915649 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Clinical impacts of inflammatory markers and clinical factors in patients with relapsed or refractory diffuse large B-cell lymphoma.
Authors: Kim DY, Song MK, Chung JS, Shin HJ, Yang DH, Lim SN, Oh SY Abstract Background: Systemic inflammatory response can be associated with the prognosis of diffuse large B cell lymphoma (DLBCL). We investigated the systemic factors significantly related to clinical outcome in relapsed/refractory DLBCL. Methods: In 242 patients with DLBCL, several factors, including inflammatory markers were analyzed. We assessed for the correlation between the survivals [progression-free survival (PFS) and overall survival (OS)] and prognostic factors. Results: In these patients, a high derived neutrophil/lymphocyte rat...
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells.
Conclusion: The exposure of BM-MSCs to FR induced remarkable alterations in cellular biology and the proteome, allowing for identification of novel biomarkers for FR exposure. Furthermore, AHR antagonists might be able to prevent cellular damage due to FR exposure. PMID: 31915651 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Evaluating the effect of donor anxiety levels and lifestyle characteristics on the activation of platelet concentrates.
Conclusion: The quality of apheresis platelets is not affected by anxiety levels and lifestyle characteristics of blood donors. There is no need to organize apheresis blood donor pool considering with these subjects. PMID: 31915652 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

The increasing trend of blood donation in Iran.
Conclusion: The results of the current study showed that there is a recent increasing trend toward blood donation in Iran. Furthermore, the largest share of donations is related to regular donors. The increasing proportion of regular and repeated donors has led to the improvement in the quality and consequently health level of donated blood. PMID: 31915653 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Clinical significance of T cell receptor excision circle (TREC) quantitation after allogenic HSCT.
Conclusion: Age and nature of disease determine the TREC levels, which are related to relapse. PMID: 31915654 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

EBV reactivation mimicking a lymphoproliferative disorder associated with ruxolitinib therapy for myelofibrosis.
Authors: Prem S, Loach D, Lipton J, Kumar R, Gupta V PMID: 31915655 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Retrospective screening for Philadelphia-negative myeloproliferative neoplasms in patients with cerebral infarctions as revealed using the revised 2016 World Health Organization diagnostic criteria.
Authors: Song IC, Choi YS, Shin JW, Song HJ, Kim J, Jo DY PMID: 31915656 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research

Beta-2 microglobulin as a prognostic factor of primary central nervous system lymphoma.
Authors: Hyung J, Hong JY, Kim S, Ryu JS, Huh J, Suh C PMID: 31915657 [PubMed] (Source: Blood Research)
Source: Blood Research - January 10, 2020 Category: Hematology Tags: Blood Res Source Type: research