Chimeric antigen T cell receptor treatment in hematological malignancies.
Authors: Ali N, FCPS Haematology PMID: 31309082 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Follicular lymphoma with prominent Dutcher body formation after liver transplantation.
Authors: Sung YN, Huh J PMID: 31309083 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Simultaneous presentation of plasma cell myeloma and hairy cell leukemia.
Authors: Carulli G, Sammuri P, Ottaviano V PMID: 31309084 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Evans syndrome diagnosed after traumatic subdural hemorrhage.
Authors: Hong CS, Landreneau MM, Grant RA PMID: 31309085 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Role of redox iron towards an increase in mortality among patients: a systemic review and meta-analysis.
In conclusion, iron mediated mortality may not be mediated by redox iron among multi-transfused and iron overloaded patients. PMID: 31309086 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Enhanced polo-like kinase 1 expression in myelodysplastic syndromes.
This study aimed to investigate the transcript dynamics of PLK1 and determine its role in the pathophysiology of MDS. Methods: PLK1 mRNA obtained from the bone marrow samples of 67 patients with MDS, 16 patients with secondary acute myeloid leukemia (sAML), and 10 healthy controls were analyzed using quantitative real-time PCR and compared according to various clinical parameters. Results: The median PLK1 expression levels differed slightly, but not significantly, between MDS and sAML patients [661.21 (range, 29.38-8,987.31) vs. 1,462.05 (32.22-5,734.09), respectively], but were significantly higher (P
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Safety and efficacy of bendamustine in the conditioning regimen for autologous stem cell transplantation in patients with relapsed/refractory lymphoma.
Conclusion: Our study showed that bendamustine is a potentially toxic agent in the conditioning regimen for autologous SCT, resulting in significant liver, kidney, and gastrointestinal toxicity. Further studies are required to assess its safety and efficacy at reduced doses. PMID: 31309088 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Clinical significance of cell-free DNA as a prognostic biomarker in patients with diffuse large B-cell lymphoma.
Authors: Eskandari M, Manoochehrabadi S, Pashaiefar H, Zaimy MA, Ahmadvand M Abstract Background: Cell-free DNA (cfDNA) has the potential to serve as a non-invasive prognostic biomarker in some types of neoplasia. The investigation of plasma concentration of cfDNA may reveal its use as a valuable biomarker for risk stratification of diffuse large B-cell lymphoma (DLBCL). The present prognostic value of plasma cfDNA has not been widely confirmed in DLBCL subjects. Here, we evaluated cfDNA plasma concentration and assessed its potential prognostic value as an early DLBCL diagnostic tool. Methods: cfDNA concentrat...
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Determining the risk factors associated with the development of Clostridium difficile infection in patients with hematological diseases.
Authors: Lee-Tsai YL, Luna-Santiago R, Demichelis-Gómez R, Ponce-de-León A, Ochoa-Hein E, Tamez-Torres KM, Bourlon MT, Bourlon C Abstract Background: Clostridium difficile infection (CDI) is a nosocomial condition prevalent in patients with hematological disorders. We aimed to identify the risk factors associated with the development of CDI and assess the mortality rate at 15 and 30 days among hematologic patients admitted to a tertiary care center. Methods: We conducted a retrospective case-control study from January 2010 to December 2015. Forty-two patients with hematologic malignancy and CDI, a...
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

The top 10 things to know about transfusion medicine before intern year: an evidence-based course for graduating medical students.
Authors: Peedin AR, Perjar I, Mazepa MA, Rollins-Raval MA, Park YA, Raval JS Abstract Background: Transfusion medicine (TM) knowledge varies widely among physician trainees. In addition, there have been few instances in which curricular changes have been meaningfully assessed for TM education in medical school. Methods: We created and presented a novel lecture to improve TM knowledge for graduating medical students using eight objectives designed to reinforce critical information about blood management. Each objective was coded according to unique color schemes, fonts, and graphics to create visual associations...
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Treatment of autoimmune hemolytic anemia: real world data from a reference center in Mexico.
Conclusion: Outcomes of w-AIHA treatment were considerably heterogeneous. Low rituximab doses plus high dexamethasone doses were effective for refractory disease. PMID: 31309092 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Comparison of quality of life and depression between hematopoietic stem cell transplantation survivors and their spouse caregivers.
Conclusion: This study found that there were no significant differences in QoL or level of depression between HSCT survivors and their spouse caregivers. Family income, gender, and co-morbidities showed significant association with spouse caregiver distress. PMID: 31309093 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

An investigation of methylation pattern changes in the IKZF1 promoter in patients with childhood B-cell acute lymphoblastic leukemia.
Authors: Rahmani M, Fardi M, Farshdousti Hagh M, Hosseinpour Feizi AA, Talebi M, Solali S Abstract Background: Ikaros family zinc finger 1 (IKZF1) is a transcription factor with an important role in controlling hematopoietic proliferation and function, particularly lymphoid cell differentiation. It was previously shown that various mechanisms and expression patterns of Ikaros are linked to a variety of cancers. We hypothesized that aberrant methylation (hypomethylation) of the IKZF1 promoter region might be one of the causes of B-cell acute lymphoblastic leukemia (B-ALL). In B-ALL patients, an increased expression ...
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

False elevations of vitamin B12 levels due to assay errors in a patient with pernicious anemia.
Authors: Iltar U, Göçer M, Kurtoğlu E PMID: 31309095 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

First case report of latent tuberculosis reactivation complicating treatment with nilotinib in chronic myeloid leukemia.
Authors: Kim DJ, Jeong S, Kong SG, Lee HS PMID: 31309096 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

What is the most appropriate regimen for untreated Waldenstr öm macroglobulinemia? - An updated analysis of rituximab and half-dose CHOP therapy and cost effectiveness.
What is the most appropriate regimen for untreated Waldenström macroglobulinemia? - An updated analysis of rituximab and half-dose CHOP therapy and cost effectiveness. Blood Res. 2019 Jun;54(2):153-156 Authors: Sekiguchi N, Hamano A, Kitagawa T, Ito K, Hirano K, Yamada K PMID: 31309097 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Erratum: Breast implant-associated anaplastic large cell lymphoma.
Authors: Abstract [This corrects the article on p. 3 in vol. 54, PMID: 30956955.]. PMID: 31309098 [PubMed - in process] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Erratum: Evaluation of thrombocytopenia in the hematology clinic: a case series from a large tertiary care center.
Authors: Abstract [This corrects the article on p. 166 in vol. 53, PMID: 29963525.]. PMID: 31309099 [PubMed - in process] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Recurrent bilateral deep vein thrombosis after cava vein resection in a patient with leiomyosarcoma.
Authors: Lucia OO, Pablo DR, Sandra PR, Jorge DT PMID: 30956953 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Hemophagocytosis by blasts in acute lymphoblastic leukemia.
Authors: Klein E, Derrieux C, Dulucq S PMID: 30956954 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Breast implant-associated anaplastic large cell lymphoma.
Authors: Baseggio L, Travers-Glehen A, Bachy E, Laurent C PMID: 30956955 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Organ-specific considerations for marginal zone lymphomas in Korea, based on Consortium for Improving Survival of Lymphoma (CISL) and Korean clinical studies.
Authors: Oh SY, Suh C PMID: 30956956 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Cord blood 2.0: state of the art and future directions in transplant medicine.
Authors: Wagner JE PMID: 30956957 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Molecular perspective of iron uptake, related diseases, and treatments.
Authors: Shokrgozar N, Golafshan HA Abstract Iron deficiency anemia and anemia of chronic disorders are the most common types of anemia. Disorders of iron metabolism lead to different clinical scenarios such as iron deficiency anemia, iron overload, iron overload with cataract and neurocognitive disorders. Regulation of iron in the body is a complex process and different regulatory proteins are involved in iron absorption and release from macrophages into hematopoietic tissues. Mutation in these regulatory genes is the most important cause of iron refractory iron deficiency anemia (IRIDA). This review provides a gl...
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: a study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology.
Authors: Lee YK, Kim HJ, Lee K, Park SH, Song SH, Seong MW, Kim M, Han JY Abstract Genetic hemoglobin disorders are caused by mutations and/or deletions in the α-globin or β-globin genes. Thalassemia is caused by quantitative defects and hemoglobinopathies by structural defect of hemoglobin. The incidence of thalassemia and hemoglobinopathy is increased in Korea with rapid influx of people from endemic areas. Thus, the awareness of the disease is needed. α-thalassemias are caused by deletions in α-globin gene, while β-thalassemias are associated with decreased synthesis of β-globin ...
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Efficacy of parenteral glutamine supplementation in adult hematopoietic stem cell transplantation patients.
Conclusion: Results showed that the glutamine group had less clinically documented infection and 100-days mortality than the non-glutamine group, but the other outcomes did not show significant differences. The extended duration of glutamine supplementation according to the period of total parenteral nutrition and mucositis should be considered. PMID: 30956960 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Biochemical effects and safety of Gum arabic (Acacia Senegal) supplementation in patients with sickle cell anemia.
Conclusion: GA may alter the disease severity in SCA as demonstrated by its ability to decrease direct bilirubin and urea levels in the serum. PMID: 30956961 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Microcytosis in children and adolescents with the sickle cell trait in Basra, Iraq.
Conclusion: Despite the frequent occurrence of iron deficiency in SCT subjects, co-inheritance of alpha-thalassemia seemed to be the cause of low MCV in non-iron deficient individuals with microcytosis. Genetic analysis is required to understand the genetic basis of this phenomenon. PMID: 30956962 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Outcome and prognostic factors of children with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib followed by allogeneic hematopoietic cell transplantation in first remission.
Authors: Shin J, Lee NY, Kim S, Lee JW, Jang PS, Chung NG, Cho B Abstract Background: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is a subset of ALL with poor prognosis. Here, we analyzed the outcomes and prognostic factors of children with Ph+ ALL who received imatinib and chemotherapy followed by allogeneic hematopoietic cell transplantation (HCT) in first complete remission (CR). Methods: Thirty-one Ph+ ALL patients (female 10) diagnosed from January 2005 to December 2016 were included in the study. All patients were treated with imatinib and chemotherapy before HCT. Bone marrow (...
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Analysis of hematologic parameters of donors, patients, and granulocyte concentrates to predict successful granulocyte transfusion.
This study was performed in 281 donors, with their granulocyte concentrates being collected through apheresis, and in 54 severe neutropenic patients who had various hematologic diseases. Complete blood cell counts of donors pre- and post-apheresis, granulocyte concentrates, and patients pre- and post-GTx were analyzed. Patients were divided into two groups according to survival at discharge (Group S, survival; Group D, dead) to compare various factors including age, infection status, pre- and post-GTx total white blood cell counts (TWBCC) and absolute neutrophil counts (ANC), total number of GTx, infused TWBCC and ANC per ...
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

ABCB1 and BMI1 mRNA expression in patients with chronic myeloid leukemia: impact on imatinib efficacy.
Conclusion: ABCB1 mRNA expression may serve as a predictor of the optimal response to imatinib treatment in patients with CML. BMI1 expression was higher in the accelerated and blastic crisis phases of CML and associated with a shorter PFS. PMID: 30956965 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Biphenotypic acute leukemia or acute leukemia of ambiguous lineage in childhood: clinical characteristics and outcome.
Conclusion: Due to the rarity of the cases, future multicenter, prospective studies incorporating large number of cases are urgently warranted to identify the clinical, biologic, and molecular markers for the prediction of prognosis and determine the best tailored therapy for each patient. PMID: 30956966 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

A case of immune thrombocytopenia associated with invasive thymoma successfully treated with eltrombopag.
Authors: Yoon JK, Jang HR, Park JH, Kim KH, Roh EY, Byun JM PMID: 30956967 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Coexistence of BCR/ABL1-positive chronic myeloid leukemia and JAK2 V617F-mutated myelofibrosis successfully treated with dasatinib and ruxolitinib.
Authors: Yi JH, Kim HR PMID: 30956968 [PubMed] (Source: Blood Research)
Source: Blood Research - April 10, 2019 Category: Hematology Tags: Blood Res Source Type: research

Cytoplasmic azurophilic inclusion bodies in reactive plasmacytosis.
Authors: Gupta A, Tripathi P, Tyagi S PMID: 30588458 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Small cell variant of T-cell prolymphocytic leukemia with atypical presentation.
Authors: Park J PMID: 30588459 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Clonal villous lymphocytes and plasma cells in splenic marginal zone lymphoma with plasmacytic differentiation.
Authors: Souto Filho JTD, de Morais RA, Oliveira Silveira AL, Lacerda AP, Fassbender IPB, Chaves Ribeiro JMM, de Sales LR PMID: 30588460 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Methotrexate-induced myelodysplasia mimicking myelodysplastic syndrome.
Authors: Kawase Y, Ohe M, Shida H, Horita T, Furuya K, Hashino S PMID: 30588461 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Comparison of mean platelet volume levels in coronary artery ectasia and healthy people: systematic review and meta-analysis.
Authors: Moghadam RH, Shahmohammadi A, Asgari N, Azizi K, Mansour SM, Roozbahani M Abstract Coronary artery ectasia (CAE) is defined as the dilation of a segment of a coronary vessel to at least 1.5 times the diameter of its normal adjacent segment. Mean platelet volume (MPV) plays a role in acute coronary syndromes, with high MPV correlating to poor prognosis for acute thrombotic events and CAE. Several studies investigated the relationship between MPV and CAE, resulting in conflicting results. These results led us to systematically review all studies investigating the relationship between MPV and ectatic heart di...
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Clinicohematological parameters and outcomes in a cohort of chronic lymphocytic leukemia patients with Deletion 17p from Pakistan.
Conclusion: Del 17p is relatively common in Pakistan, and patients harboring this deletion had poor treatment response and survival outcomes. PMID: 30588463 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Detection of bone marrow involvement with FDG PET/CT in patients with newly diagnosed lymphoma.
Conclusion: Our results suggest that BMI should not be decided solely based PET/CT or BMB findings. It is reasonable to use both diagnostic assays along with clinical and laboratory findings. PET/CT result, clinical and laboratory findings could be useful for predicting BMI in patient for whom BMB is contraindicated. PMID: 30588464 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Treatment and clinical outcomes of patients relapsing after allogeneic hematopoietic cell transplantation for myelodysplastic syndrome.
Conclusion: Outcomes of MDS patients relapsing after allogeneic HCT were disappointing. Some patients could be saved using DLI or second HCT. PMID: 30588465 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype.
Conclusion: Higher IDO expression in CN-AML patients may be associated with an increased Treg phenotype which may promote disease progression and lead to poor prognosis of CN-AML patients. PMID: 30588466 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Neutrophil oxidative burst as a diagnostic indicator of IgG-mediated anaphylaxis.
Authors: Won DI, Kim S, Lee EH Abstract Background: IgG-mediated anaphylaxis occurs after infusion of certain monoclonal antibody-based therapeutics. New in vitro tests are urgently needed to diagnose such reactions. We investigated whether allergens trigger neutrophil oxidative burst (OB) and if neutrophil OB occurs due to allergen-specific IgG (sIgG). Methods: Neutrophil OB was measured by dihydrorhodamine 123 flow cytometry using a leukocyte suspension spiked with a very small patch of the allergen crude extract, Dermatophagoides farinae (Der f). The mean fluorescence intensity ratio of stimulated to unstimu...
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Clinical presentation and treatment outcomes of primary ocular adnexal MALT lymphoma in Thailand.
Conclusion: We revealed that POML has good response to treatment, especially radiotherapy, with excellent long-term outcome. PMID: 30588468 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Relationship between liver iron concentration determined by R2-MRI, serum ferritin, and liver enzymes in patients with thalassemia intermedia.
Authors: Al-Momen H, Jasim SK, Hassan QA, Ali HH Abstract Background: Iron overload is a risk factor affecting all patients with thalassemia intermedia (TI). We aimed to determine whether there is a relationship of serum ferritin (SF) and alanine aminotransferase (ALT) with liver iron concentration (LIC) determined by R2 magnetic resonance imaging (R2-MRI), to estimate the most relevant degree of iron overload and best time to chelate in patients with TI. Methods: In this cross-sectional study, 119 patients with TI (mean age years) were randomly selected and compared with 120 patients who had a diagnosis of tha...
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Altered expression of MALAT1 lncRNA in chronic lymphocytic leukemia patients, correlation with cytogenetic findings.
Conclusion: Altered expression of MALAT1 is associated with CLL development. Further investigations are required to assess the relationship between this long non-coding RNA and CLL patient survival and prognosis. PMID: 30588470 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Effective sickle hemoglobin reduction by automated red cell exchange using Spectra Optia in three Emirati patients with sickle cell disease before allogeneic hematopoietic stem cell transplantation.
Authors: Choi SJ, Cho H, Eom KS, Lee JW, Kim Y, Lim J PMID: 30588471 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Epstein-Barr virus-positive mucocutaneous ulcer colliding with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (malt lymphoma) that developed in the palatine tonsils of an immunocompetent patient after gastric lymphoma relapse.
Authors: Lee YM, Kim JM PMID: 30588472 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research

Price of PRICE (Protection, Rest, Ice, Compression, and Elevation) redefined: a case of entrapment neuropathy in an individual with hemophilia.
Authors: Patra PC, Mandal PK, Gantait D, Bhowmik A, Chakrabarti P PMID: 30588473 [PubMed] (Source: Blood Research)
Source: Blood Research - December 29, 2018 Category: Hematology Tags: Blood Res Source Type: research