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No Relapse of Calcineurin Inhibitor-Associated Thrombotic Microangiopathy after Discontinuation of Eculizumab.
WH PMID: 29136616 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 15, 2017 Category: Hematology Authors: Neumann T, Plis A, Weigel M, Stracke S, Friesecke S, Stecher SS, Schneidewind L, Busemann C, Schmidt CA, Krüger WH Tags: Acta Haematol Source Type: research

Hepcidin in Iron Homeostasis: Diagnostic and Therapeutic Implications in Type 2 Diabetes Mellitus Patients.
Abstract The prevalence of type 2 diabetes is increasing in epidemic proportions worldwide. Evidence suggests body iron overload is frequently linked and observed in patients with type 2 diabetes. Body iron metabolism is based on iron conservation and recycling by which only a part of the daily need is replaced by duodenal absorption. The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism. It directly binds to ferroportin, the sole iron exporter, resulting in the internalization and degradation of ferroportin. However, inappropriate production of hepcidin has been shown to...
Source: Acta Haematologica - November 15, 2017 Category: Hematology Authors: Ambachew S, Biadgo B Tags: Acta Haematol Source Type: research

No Relapse of Calcineurin Inhibitor-Associated Thrombotic Microangiopathy after Discontinuation of Eculizumab
Acta Haematol 2017;138:194-197 (Source: Acta Haematologica)
Source: Acta Haematologica - November 14, 2017 Category: Hematology Source Type: research

Hepcidin in Iron Homeostasis: Diagnostic and Therapeutic Implications in Type 2 Diabetes Mellitus Patients
The prevalence of type 2 diabetes is increasing in epidemic proportions worldwide. Evidence suggests body iron overload is frequently linked and observed in patients with type 2 diabetes. Body iron metabolism is based on iron conservation and recycling by which only a part of the daily need is replaced by duodenal absorption. The principal liver-produced peptide called hepcidin plays a fundamental role in iron metabolism. It directly binds to ferroportin, the sole iron exporter, resulting in the internalization and degradation of ferroportin. However, inappropriate production of hepcidin has been shown to play a role in th...
Source: Acta Haematologica - November 14, 2017 Category: Hematology Source Type: research

Observational Monitoring of Patients with Aplastic Anemia and Low/Intermediate-1 Risk of Myelodysplastic Syndromes Complicated with Iron Overload
Conclusion: The transfusion amount was more reliable at predicting IOL in patients with AA than in those with MDS. Adequate iron chelation can decrease serum ferritin levels and may improve hepatic T2*, cardiac T2*, and LVEF levels. A decrease in serum ferritin, even in the absence of chelation, may also benefit patients.Acta Haematol 2017;138:119-128 (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

Autoimmune Myelofibrosis: Clinical Features, Course, and Outcome
Conclusions: AIMF contributes to cytopenias in the subset of patients with various autoimmune disorders. The majority of patients with AIMF experience an improvement in cytopenias with immunosuppressive therapy.Acta Haematol 2017;138:129-137 (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

Improved Drug Adherence in Patients with Chronic Myeloid Leukemia in the Chronic Phase by Switching to Second-Generation Tyrosine Kinase Inhibitors
Acta Haematol 2017;138:140-142 (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

IDH1 Mutation Is an Independent Inferior Prognostic Indicator for Patients with Myelodysplastic Syndromes
Background: Genomic sequencing technologies have identified isocitrate dehydrogenase (IDH) mutations in haematological malignancies. The prognostic implications of somaticIDH mutation (mIDH) in myelodysplastic syndromes (MDS) remain controversial.Methods: Mutations inIDH1 andIDH2were detected using genomic sequencing technologies in 97 patients with MDS.Results: Seven (7.2%) mutations were identified: 3 inIDH1 (all R132C) and 4 inIDH2 (3 R140Q and 1 R140L). The frequency of mutation was 16.6% (2/12) in refractory anaemia with excess blasts (RAEB)-1 and 14.7% (5/34) in RAEB-2.IDH1/2 mutations were closely associated with hi...
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

Switching-On Adherence in Chronic Myeloid Leukemia
Acta Haematol 2017;138:138-139 (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

Delayed Development of Hemolytic Anemia with Fragmented Red Blood Cells and Cardiac and Renal Impairments after High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation for Malignant Lymphoma
Among 42 consecutive patients with malignant lymphoma who underwent high-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (AHSCT), 5 developed hemolytic anemia with fragmented red blood cells (HA-FrRBCs) on days 87-125 (median 107) of AHSCT. Nadir Hb levels ranged between 5.0 and 6.4 g/dL with 2.2-5.6% FrRBCs. All patients developed grade ≥3 hypoxia and heart failure, and 4 developed grade ≥3 hypertension. The ejection fraction of the left ventricle assessed by echocardiography was significantly reduced in 3 patients. Peak creatinine levels were>4 times above the baseline and ...
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

Reticulocytes Are an Enriched Source of the RUVBL1 Protein
Acta Haematol 2017;138:162-165 (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

Pregnancy Outcome among Women with Beta-Thalassemia Major in North Sardinia
Acta Haematol 2017;138:166-167 (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

Very-Low-Dose Decitabine Is Effective in Treating Intermediate- or High-Risk Myelodysplastic Syndrome
In conclusion, very-low-dose decitabine showed relatively good efficacy, good tolerance, and low medical cost in the treatment of intermediate- or high-risk MDS. Elderly patients with more than 1 complication or pati ents with a higher proportion of blast cells may be the most suitable candidates for this regimen.Acta Haematol 2017;138:168-174 (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

CD34+CD38-CD123+ Cells Are Present in Virtually All Acute Myeloid Leukaemia Blasts: A Promising Single Unique Phenotype for Minimal Residual Disease Detection
Conclusion: The CD34+CD38-CD123+ phenotype is present in virtually all AML blasts and it may be used as a unique single phenotype for MRD detection in AML patients.Acta Haematol 2017;138:175-181 (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Source Type: research

CD34+CD38-CD123+ Cells Are Present in Virtually All Acute Myeloid Leukaemia Blasts: A Promising Single Unique Phenotype for Minimal Residual Disease Detection.
CONCLUSION: The CD34+CD38-CD123+ phenotype is present in virtually all AML blasts and it may be used as a unique single phenotype for MRD detection in AML patients. PMID: 29065396 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - October 25, 2017 Category: Hematology Authors: Al-Mawali A, Pinto AD, Al-Zadjali S Tags: Acta Haematol Source Type: research

CD34+CD38-CD123+ Cells Are Present in Virtually All Acute Myeloid Leukaemia Blasts: A Promising Single Unique Phenotype for Minimal Residual Disease Detection
Conclusion: The CD34+CD38-CD123+ phenotype is present in virtually all AML blasts and it may be used as a unique single phenotype for MRD detection in AML patients.Acta Haematol 2017;138:175-181 (Source: Acta Haematologica)
Source: Acta Haematologica - October 24, 2017 Category: Hematology Source Type: research

Very-Low-Dose Decitabine Is Effective in Treating Intermediate- or High-Risk Myelodysplastic Syndrome.
In conclusion, very-low-dose decitabine showed relatively good efficacy, good tolerance, and low medical cost in the treatment of intermediate- or high-risk MDS. Elderly patients with more than 1 complication or patients with a higher proportion of blast cells may be the most suitable candidates for this regimen. PMID: 29045939 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - October 19, 2017 Category: Hematology Authors: Li H, Wang L, Wu Y, Su L, Zhao H, Zhang Y, Wang Z, Huang D, Huang Z, Wu X, Li X, Ye F, Yu F, Liu H, Wang JW, Cong J, Sun W, Chen HR, Wang J, Han B Tags: Acta Haematol Source Type: research

Very-Low-Dose Decitabine Is Effective in Treating Intermediate- or High-Risk Myelodysplastic Syndrome
In conclusion, very-low-dose decitabine showed relatively good efficacy, good tolerance, and low medical cost in the treatment of intermediate- or high-risk MDS. Elderly patients with more than 1 complication or pati ents with a higher proportion of blast cells may be the most suitable candidates for this regimen.Acta Haematol 2017;138:168-174 (Source: Acta Haematologica)
Source: Acta Haematologica - October 18, 2017 Category: Hematology Source Type: research

Pregnancy Outcome among Women with Beta-Thalassemia Major in North Sardinia
Acta Haematol 2017;138:166-167 (Source: Acta Haematologica)
Source: Acta Haematologica - October 10, 2017 Category: Hematology Source Type: research

Pregnancy Outcome among Women with Beta-Thalassemia Major in North Sardinia.
PMID: 28992618 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - October 10, 2017 Category: Hematology Authors: Fozza C, Asara MA, Vacca N, Caggiari S, Monti A, Zaccheddu F, Capobianco G, Dessole S, Dore F, Antonucci R Tags: Acta Haematol Source Type: research

Reticulocytes Are an Enriched Source of the RUVBL1 Protein.
PMID: 28982102 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - October 6, 2017 Category: Hematology Authors: Baron BW, Baron RM, Baron JM Tags: Acta Haematol Source Type: research

Reticulocytes Are an Enriched Source of the RUVBL1 Protein
Acta Haematol 2017;138:162-165 (Source: Acta Haematologica)
Source: Acta Haematologica - October 5, 2017 Category: Hematology Source Type: research

Delayed Development of Hemolytic Anemia with Fragmented Red Blood Cells and Cardiac and Renal Impairments after High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation for Malignant Lymphoma.
Abstract Among 42 consecutive patients with malignant lymphoma who underwent high-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (AHSCT), 5 developed hemolytic anemia with fragmented red blood cells (HA-FrRBCs) on days 87-125 (median 107) of AHSCT. Nadir Hb levels ranged between 5.0 and 6.4 g/dL with 2.2-5.6% FrRBCs. All patients developed grade ≥3 hypoxia and heart failure, and 4 developed grade ≥3 hypertension. The ejection fraction of the left ventricle assessed by echocardiography was significantly reduced in 3 patients. Peak creatinine levels were>4 times above...
Source: Acta Haematologica - October 4, 2017 Category: Hematology Authors: Iioka F, Toda Y, Nagai Y, Akasaka T, Shimomura D, Tsuda K, Nakamura F, Ohno H Tags: Acta Haematol Source Type: research

Delayed Development of Hemolytic Anemia with Fragmented Red Blood Cells and Cardiac and Renal Impairments after High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation for Malignant Lymphoma
Among 42 consecutive patients with malignant lymphoma who underwent high-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (AHSCT), 5 developed hemolytic anemia with fragmented red blood cells (HA-FrRBCs) on days 87-125 (median 107) of AHSCT. Nadir Hb levels ranged between 5.0 and 6.4 g/dL with 2.2-5.6% FrRBCs. All patients developed grade ≥3 hypoxia and heart failure, and 4 developed grade ≥3 hypertension. The ejection fraction of the left ventricle assessed by echocardiography was significantly reduced in 3 patients. Peak creatinine levels were>4 times above the baseline and ...
Source: Acta Haematologica - October 3, 2017 Category: Hematology Source Type: research

IDH1 Mutation Is an Independent Inferior Prognostic Indicator for Patients with Myelodysplastic Syndromes
Background: Genomic sequencing technologies have identified isocitrate dehydrogenase (IDH) mutations in haematological malignancies. The prognostic implications of somaticIDH mutation (mIDH) in myelodysplastic syndromes (MDS) remain controversial.Methods: Mutations inIDH1 andIDH2were detected using genomic sequencing technologies in 97 patients with MDS.Results: Seven (7.2%) mutations were identified: 3 inIDH1 (all R132C) and 4 inIDH2 (3 R140Q and 1 R140L). The frequency of mutation was 16.6% (2/12) in refractory anaemia with excess blasts (RAEB)-1 and 14.7% (5/34) in RAEB-2.IDH1/2 mutations were closely associated with hi...
Source: Acta Haematologica - September 6, 2017 Category: Hematology Source Type: research

Switching-On Adherence in Chronic Myeloid Leukemia.
PMID: 28873366 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - September 6, 2017 Category: Hematology Authors: Leader A, Raanani P Tags: Acta Haematol Source Type: research

IDH1 Mutation Is an Independent Inferior Prognostic Indicator for Patients with Myelodysplastic Syndromes.
Abstract BACKGROUND: Genomic sequencing technologies have identified isocitrate dehydrogenase (IDH) mutations in haematological malignancies. The prognostic implications of somatic IDH mutation (mIDH) in myelodysplastic syndromes (MDS) remain controversial. METHODS: Mutations in IDH1 and IDH2 were detected using genomic sequencing technologies in 97 patients with MDS. RESULTS: Seven (7.2%) mutations were identified: 3 in IDH1 (all R132C) and 4 in IDH2 (3 R140Q and 1 R140L). The frequency of mutation was 16.6% (2/12) in refractory anaemia with excess blasts (RAEB)-1 and 14.7% (5/34) in RAEB-2. IDH1/2 muta...
Source: Acta Haematologica - September 6, 2017 Category: Hematology Authors: Wang N, Wang F, Shan N, Sui X, Xu H Tags: Acta Haematol Source Type: research

< b > < i > IDH1 < /i > < /b > Mutation Is an Independent Inferior Prognostic Indicator for Patients with Myelodysplastic Syndromes
Background: Genomic sequencing technologies have identified isocitrate dehydrogenase (IDH) mutations in haematological malignancies. The prognostic implications of somaticIDH mutation (mIDH) in myelodysplastic syndromes (MDS) remain controversial.Methods: Mutations inIDH1 andIDH2were detected using genomic sequencing technologies in 97 patients with MDS.Results: Seven (7.2%) mutations were identified: 3 inIDH1 (all R132C) and 4 inIDH2 (3 R140Q and 1 R140L). The frequency of mutation was 16.6% (2/12) in refractory anaemia with excess blasts (RAEB)-1 and 14.7% (5/34) in RAEB-2.IDH1/2 mutations were closely associated with hi...
Source: Acta Haematologica - September 5, 2017 Category: Hematology Source Type: research

Switching-On Adherence in Chronic Myeloid Leukemia
Acta Haematol 2017;138:138-139 (Source: Acta Haematologica)
Source: Acta Haematologica - September 5, 2017 Category: Hematology Source Type: research

Improved Drug Adherence in Patients with Chronic Myeloid Leukemia in the Chronic Phase by Switching to Second-Generation Tyrosine Kinase Inhibitors.
PMID: 28869927 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - September 5, 2017 Category: Hematology Authors: Maeda Y, Okamoto A, Kawaguchi SI, Konishi A, Yamamoto K, Eguchi G, Kanai Y, Yamaguchi T Tags: Acta Haematol Source Type: research

Improved Drug Adherence in Patients with Chronic Myeloid Leukemia in the Chronic Phase by Switching to Second-Generation Tyrosine Kinase Inhibitors
Acta Haematol 2017;138:140-142 (Source: Acta Haematologica)
Source: Acta Haematologica - September 4, 2017 Category: Hematology Source Type: research

Observational Monitoring of Patients with Aplastic Anemia and Low/Intermediate-1 Risk of Myelodysplastic Syndromes Complicated with Iron Overload.
CONCLUSION: The transfusion amount was more reliable at predicting IOL in patients with AA than in those with MDS. Adequate iron chelation can decrease serum ferritin levels and may improve hepatic T2*, cardiac T2*, and LVEF levels. A decrease in serum ferritin, even in the absence of chelation, may also benefit patients. PMID: 28866669 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - September 2, 2017 Category: Hematology Authors: Du Y, Long Z, Chen M, Han B, Hou B, Feng F Tags: Acta Haematol Source Type: research

Autoimmune Myelofibrosis: Clinical Features, Course, and Outcome.
CONCLUSIONS: AIMF contributes to cytopenias in the subset of patients with various autoimmune disorders. The majority of patients with AIMF experience an improvement in cytopenias with immunosuppressive therapy. PMID: 28866671 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - September 2, 2017 Category: Hematology Authors: Piatek CI, Vergara-Lluri ME, Pullarkat V, Siddiqi IN, O'Connell C, Brynes RK, Feinstein DI Tags: Acta Haematol Source Type: research

Autoimmune Myelofibrosis: Clinical Features, Course, and Outcome
Conclusions: AIMF contributes to cytopenias in the subset of patients with various autoimmune disorders. The majority of patients with AIMF experience an improvement in cytopenias with immunosuppressive therapy.Acta Haematol 2017;138:129-137 (Source: Acta Haematologica)
Source: Acta Haematologica - September 1, 2017 Category: Hematology Source Type: research

Observational Monitoring of Patients with Aplastic Anemia and Low/Intermediate-1 Risk of Myelodysplastic Syndromes Complicated with Iron Overload
Conclusion: The transfusion amount was more reliable at predicting IOL in patients with AA than in those with MDS. Adequate iron chelation can decrease serum ferritin levels and may improve hepatic T2*, cardiac T2*, and LVEF levels. A decrease in serum ferritin, even in the absence of chelation, may also benefit patients.Acta Haematol 2017;138:119-128 (Source: Acta Haematologica)
Source: Acta Haematologica - September 1, 2017 Category: Hematology Source Type: research

Association of Plasminogen Activator Inhibitor-1 Gene Polymorphisms and Methylene Tetrahydrofolate Reductase Polymorphisms with Spontaneous Miscarriages.
The objective of this study was to investigate a possible correlation between the plasminogen activator inhibitor-1 (PAI-1) and methylene tetrahydrofolate reductase (MTHFR) polymorphisms and unexplained spontaneous miscarriages (SM). MATERIALS AND METHODS: PAI-1 polymorphisms were evaluated in 150 women with pregnancy in their history. One hundred women with a history of SM formed the study group and 50 women with normal pregnancies served as the control group. Also, the combination of PAI-1 and MTHFR polymorphisms were evaluated in 138 women out of a total of 150, which included 92 women with SM in their history comp...
Source: Acta Haematologica - September 1, 2017 Category: Hematology Authors: Bubalo P, Buterin I, Šalek Z, Ðogić V, Zupančić-Šalek S Tags: Acta Haematol Source Type: research

Intracranial Hemorrhage in Patients Newly Diagnosed with Acute Myeloid Leukemia and Hyperleukocytosis.
PMID: 28858876 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - September 1, 2017 Category: Hematology Authors: Lieberman F, Villgran V, Normolle D, Boyiadzis M Tags: Acta Haematol Source Type: research

Intracranial Hemorrhage in Patients Newly Diagnosed with Acute Myeloid Leukemia and Hyperleukocytosis
Acta Haematol 2017;138:116-118 (Source: Acta Haematologica)
Source: Acta Haematologica - August 31, 2017 Category: Hematology Source Type: research

Association of Plasminogen Activator Inhibitor-1 Gene Polymorphisms and Methylene Tetrahydrofolate Reductase Polymorphisms with Spontaneous Miscarriages
The objective of this study was to investigate a possible correlation between the plasminogen activator inhibitor-1 (PAI-1) and methylene tetrahydrofolate reductase (MTHFR) polymorphisms and unexplained spontaneous miscarriages (SM).Materials and Methods: PAI-1 polymorphisms were evaluated in 150 women with pregnancy in their history. One hundred women with a history of SM formed the study group and 50 women with normal pregnancies served as the control group. Also, the combination of PAI-1 and MTHFR polymorphisms were evaluated in 138 women out of a total of 150, which included 92 women with SM in their history compared t...
Source: Acta Haematologica - August 31, 2017 Category: Hematology Source Type: research

Epinephrine Stimulates Cell Proliferation and Induces Chemoresistance in Myeloma Cells through the β-Adrenoreceptor in vitro.
CONCLUSIONS: Our results reveal that epinephrine stimulates myeloma cell growth in vitro while the β-blocker propranolol has an antiproliferative effect, indicating that stress hormones may trigger the progression of myeloma. PMID: 28848082 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - August 29, 2017 Category: Hematology Authors: Liu Y, Yu X, Zhuang J Tags: Acta Haematol Source Type: research

Epinephrine Stimulates Cell Proliferation and Induces Chemoresistance in Myeloma Cells through the β-Adrenoreceptor in vitro
Conclusions: Our results reveal that epinephrine stimulates myeloma cell growth in vitro while the β-blocker propranolol has an antiproliferative effect, indicating that stress hormones may trigger the progression of myeloma.Acta Haematol 2017;138:103-110 (Source: Acta Haematologica)
Source: Acta Haematologica - August 28, 2017 Category: Hematology Source Type: research

Anemia in the Elderly in Northeastern Thailand: A Community-Based Study Investigating Prevalence, Contributing Factors, and Hematologic Features.
Abstract This community-based study investigated anemia prevalence and certain hematologic features and their possible relationships to thalassemia and iron deficiency (ID) in a population of older people in Northeastern Thailand. Participants included 319 apparently healthy individuals ranging in age from 60 to 98 years, whose current health status was assessed by means of personal interviews. Blood samples were also collected to determine the following parameters: red blood cell indices, serum ferritin, C-reactive protein, hemoglobin profiles, and the α0-thalassemia gene. Based upon established WHO criteri...
Source: Acta Haematologica - August 19, 2017 Category: Hematology Authors: Deeruksa L, Sanchaisuriya K Tags: Acta Haematol Source Type: research

Anemia in the Elderly in Northeastern Thailand: A Community-Based Study Investigating Prevalence, Contributing Factors, and Hematologic Features
This community-based study investigated anemia prevalence and certain hematologic features and their possible relationships to thalassemia and iron deficiency (ID) in a population of older people in Northeastern Thailand. Participants included 319 apparently healthy individuals ranging in age from 60 to 98 years, whose current health status was assessed by means of personal interviews. Blood samples were also collected to determine the following parameters: red blood cell indices, serum ferritin, C-reactive protein, hemoglobin profiles, and the α0-thalassemia gene. Based upon established WHO criteria, the overall pre...
Source: Acta Haematologica - August 18, 2017 Category: Hematology Source Type: research

Arterial and Venous Thrombosis in Haemophilia Patients: Experiences from a Danish Haemophilia Centre.
PMID: 28817815 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - August 18, 2017 Category: Hematology Authors: Larsen JB, Nielsen KBJ, Poulsen LH, Bor MV Tags: Acta Haematol Source Type: research

Arterial and Venous Thrombosis in Haemophilia Patients: Experiences from a Danish Haemophilia Centre
Acta Haematol 2017;138:91-95 (Source: Acta Haematologica)
Source: Acta Haematologica - August 17, 2017 Category: Hematology Source Type: research

Green Inclusions in Neutrophils and Monocytes Are an Indicator of Acute Liver Injury and High Mortality.
PMID: 28813697 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - August 17, 2017 Category: Hematology Authors: Patel N, Hoffman CM, Goldman BI, Bentley K, Burack WR, Evans AG Tags: Acta Haematol Source Type: research

Green Inclusions in Neutrophils and Monocytes Are an Indicator of Acute Liver Injury and High Mortality
Acta Haematol 2017;138:85-90 (Source: Acta Haematologica)
Source: Acta Haematologica - August 16, 2017 Category: Hematology Source Type: research

Microvessel Density as a Surrogate Prognostic Marker in Patients with Multiple Myeloma: A Meta-Analysis.
Abstract BACKGROUND/AIMS: Bone marrow (BM) angiogenesis is considered a hallmark of multiple myeloma (MM) development and progression, and can be quantified with the use of microvessel density (MVD). The purpose of this study is to provide a review and a meta-analysis of the current literature regarding the prognostic value of MVD in the overall survival (OS) of MM patients. METHODS: MEDLINE was screened for studies evaluating the OS of MM patients with regard to their MVD count in BM trephine. The pooled hazard ratio (HR) and its associated 95% confidence interval (CI) among MM patients with a high and low M...
Source: Acta Haematologica - August 11, 2017 Category: Hematology Authors: Ntellas P, Perivoliotis K, Dadouli K, Koukoulis GK, Ioannou M Tags: Acta Haematol Source Type: research

Pleural Effusion in Multiple Myeloma: Characteristics and Practice Patterns.
Abstract In many Asian countries battling with the double burden of increasing noninfectious diseases on top of infectious diseases, multiple myeloma (MM) patients presenting with pleural effusion (PE) pose a great diagnostic challenge. Thus, we aimed to analyze the clinical features and practice patterns of such patients. This is a multicenter retrospective study of newly diagnosed MM patients between January 2011 and December 2015. Among 575 MM patients diagnosed during the study period, 80 (13.9%) that were associated with PE were identified and analyzed. The most common cause of PE was parapneumonic (25%), fol...
Source: Acta Haematologica - August 11, 2017 Category: Hematology Authors: Byun JM, Kim KH, Choi IS, Park JH, Kim JS, Shin DY, Koh Y, Kim I, Yoon SS, Lim HJ Tags: Acta Haematol Source Type: research

Microvessel Density as a Surrogate Prognostic Marker in Patients with Multiple Myeloma: A Meta-Analysis
Background/Aims: Bone marrow (BM) angiogenesis is considered a hallmark of multiple myeloma (MM) development and progression, and can be quantified with the use of microvessel density (MVD). The purpose of this study is to provide a review and a meta-analysis of the current literature regarding the prognostic value of MVD in the overall survival (OS) of MM patients.Methods: MEDLINE was screened for studies evaluating the OS of MM patients with regard to their MVD count in BM trephine. The pooled hazard ratio (HR) and its associated 95% confidence interval (CI) among MM patients with a high and low MVD count was the primary...
Source: Acta Haematologica - August 10, 2017 Category: Hematology Source Type: research