Soluble NKG2D Ligands Are Potential Biomarkers and Sentinels of Immune-Mediated Bone Marrow Injury in Bone Marrow Failure Syndromes
Immune-mediated processes are considered important in the pathogenesis of bone marrow failure syndromes (BFS). We previously reported that natural killer group 2D (NKG2D) ligands were expressed on pathological blood cells of patients with BFS and that NKG2D immunity may be involved in bone marrow failure. In addition to membranous NKG2D ligands on the cell surface, soluble NKG2D ligands can exist in plasma. We therefore examined the relationship between soluble NKG2D ligands and blood cell counts in 86 patients with BFS, including aplastic anemia, myelodysplastic syndrome with single lineage dysplasia, and paroxysmal noctu...
Source: Acta Haematologica - June 19, 2019 Category: Hematology Source Type: research

Soluble NKG2D Ligands Are Potential Biomarkers and Sentinels of Immune-Mediated Bone Marrow Injury in Bone Marrow Failure Syndromes.
Abstract Immune-mediated processes are considered important in the pathogenesis of bone marrow failure syndromes (BFS). We previously reported that natural killer group 2D (NKG2D) ligands were expressed on pathological blood cells of patients with BFS and that NKG2D immunity may be involved in bone marrow failure. In addition to membranous NKG2D ligands on the cell surface, soluble NKG2D ligands can exist in plasma. We therefore examined the relationship between soluble NKG2D ligands and blood cell counts in 86 patients with BFS, including aplastic anemia, myelodysplastic syndrome with single lineage dysplasia, an...
Source: Acta Haematologica - June 19, 2019 Category: Hematology Authors: Murata S, Mushino T, Hosoi H, Kuriyama K, Nishikawa A, Nagakura S, Horikawa K, Yonemura Y, Nakakuma H, Sonoki T, Hanaoka N Tags: Acta Haematol Source Type: research

The Association of Circulating T Follicular Helper Cells and Regulatory Cells with Acute Myeloid Leukemia Patients
Conclusion: There was a significantly higher percentage of cTfr cells in AML patients. cTfr cells may have a potential association with the pathogenesis of AML patients.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 18, 2019 Category: Hematology Source Type: research

The Association of Circulating T Follicular Helper Cells and Regulatory Cells with Acute Myeloid Leukemia Patients.
This study aims to investigate the association of circulating T follicular helper (cTfh) cells and T follicular regulatory (cTfr) cells with acute myeloid leukemia (AML) patients. METHODS: A total of 22 newly diagnosed, untreated AML patients as well as 26 healthy controls were enrolled. Percentages of cTfh and cTfr cells were detected using flow cytometry. RESULTS: Compared to healthy controls, a significantly higher percentage of cTfr cells was observed in AML patients (4.10 ± 11.18 vs. 0.63 ± 0.38%) (p
Source: Acta Haematologica - June 18, 2019 Category: Hematology Authors: Guo Z, Chen Z, Xu Y, Zhang Y, Hu L, Yu F, Chai J, Liu L, Ren X Tags: Acta Haematol Source Type: research

Extranodal Marginal-Zone Lymphomas: An Entity with Significant Heterogeneity at Different Anatomic Sites
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 17, 2019 Category: Hematology Source Type: research

A Unique Case of Primary Extranodal Marginal Zone Lymphoma of the Anal Canal
Marginal zone lymphomas represent approximately 10 –12% of all B-cell lymphomas. Extranodal marginal zone lymphomas (EMZL) or mucosa-associated lymphoid tissue (MALT) lymphomas are the most common subtype. Almost half of all MALT lymphomas arise in the gastrointestinal (GI) tract and, while the stomach is the most common site of GI involvement, th e small and large intestines can also be involved. Rare cases of MALT lymphoma involving the rectum have been reported; however, to our knowledge, involvement of the anal canal has never been reported in the literature. Here, we describe a unique case of MALT lymphoma of th...
Source: Acta Haematologica - June 17, 2019 Category: Hematology Source Type: research

A Unique Case of Primary Extranodal Marginal Zone Lymphoma of the Anal Canal.
Abstract Marginal zone lymphomas represent approximately 10-12% of all B-cell lymphomas. Extranodal marginal zone lymphomas (EMZL) or mucosa-associated lymphoid tissue (MALT) lymphomas are the most common subtype. Almost half of all MALT lymphomas arise in the gastrointestinal (GI) tract and, while the stomach is the most common site of GI involvement, the small and large intestines can also be involved. Rare cases of MALT lymphoma involving the rectum have been reported; however, to our knowledge, involvement of the anal canal has never been reported in the literature. Here, we describe a unique case of MALT lymp...
Source: Acta Haematologica - June 17, 2019 Category: Hematology Authors: Diamantopoulos P, Dryllis G, Tsourouflis G, Petevi K, Boutsikas G, Rondogianni P, Boutsis D, Korkolopoulou P, Konstantopoulos K, Angelopoulou MK, Meletis J, Kanellis G, Vassilakopoulos TP Tags: Acta Haematol Source Type: research

Extranodal Marginal-Zone Lymphomas: An Entity with Significant Heterogeneity at Different Anatomic Sites.
PMID: 31207602 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - June 17, 2019 Category: Hematology Authors: Kalpadakis C, Pangalis GA Tags: Acta Haematol Source Type: research

Transfusional Iron Chelation Inches Forward
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 12, 2019 Category: Hematology Source Type: research

Analysis of Post-Sample Collection EDTA Effects on Mean Platelet Volume Values in Relation to Overweight and Obese Patient Status
Conclusions: K3-EDTA use alters platelet volume. The time from collection to measurement should be standardized to reduce MPV value variance. MPV should be determined within 1 h of collection to avoid anticoagulant use-related interference.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 12, 2019 Category: Hematology Source Type: research

Transfusional Iron Chelation Inches Forward.
PMID: 31189159 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - June 12, 2019 Category: Hematology Authors: Hagar RW Tags: Acta Haematol Source Type: research

Analysis of Post-Sample Collection EDTA Effects on Mean Platelet Volume Values in Relation to Overweight and Obese Patient Status.
CONCLUSIONS: K3-EDTA use alters platelet volume. The time from collection to measurement should be standardized to reduce MPV value variance. MPV should be determined within 1 h of collection to avoid anticoagulant use-related interference. PMID: 31189163 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - June 12, 2019 Category: Hematology Authors: Pinto RVL, Rodrigues G, Simões RL, Porto LC Tags: Acta Haematol Source Type: research

Shiga-Like Toxin-Producing < b > < i > Escherichia coli < /i > < /b > Inducing Diarrhea in Patients with Multiple Myeloma Diagnosed by BioFire PCR-Film Array
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 11, 2019 Category: Hematology Source Type: research

Shiga-Like Toxin-Producing Escherichia coli Inducing Diarrhea in Patients with Multiple Myeloma Diagnosed by BioFire PCR-Film Array.
PMID: 31185477 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - June 11, 2019 Category: Hematology Authors: Kreiniz N, Abu-Ahmad A, Golan-Shany O, Paz A, Tadmor T Tags: Acta Haematol Source Type: research

Low Platelet Counts at Diagnosis Predict Better Survival for Patients with Intermediate-Risk Acute Myeloid Leukemia
Conclusion: PLT count at diagnosis predicts survival for patients with intermediate-risk AML.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 5, 2019 Category: Hematology Source Type: research

Safety-Related Postmarketing Modifications of Drugs for Hematological Malignancies
The prevalence of safety-related postmarketing label modifications of medications for hematological malignancies is unknown. We identified 35 new drugs indicated for hematological malignancies approved by the US Food and Drug Administration between January 1999 and December 2014. Characteristics of supporting trials and safety-related label modifications from approval to December 2017 were collected from drug labels. Regulatory review and approval pathways were also collected. New drug approvals were supported by trials with a median of 167 patients (interquartile range 115 –316). All drugs were approved based on sur...
Source: Acta Haematologica - June 5, 2019 Category: Hematology Source Type: research

Thrombotic Thrombocytopenic Purpura Cases and Consumption of Large Quantities of Energy Drink: Related or Coincidence?
In this report we present 2 acquired TTP cases involving the consumption of a large amount of energy drink.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 5, 2019 Category: Hematology Source Type: research

Pregnancy with Chuvash Polycythaemia and Other Congenital Erythrocytosis
This original report describes the management of a pregnant woman with congenital erythrocytosis (Chuvash polycythaemia) and reviews the scarce data available in the literature. Therapy consisted of low-dose aspirin and phlebotomies to maintain haematocrit #x3c;50% while monitoring iron stores to avoid severe deficiency detrimental to the foetus. Despite normal initial foetal growth, the pregnancy was complicated by preterm birth due to chorioamnionitis. The placenta showed no signs of thrombotic events. The published reports cover 13 pregnancies in 8 patients, showing 1 first-trimester miscarriage, 5 infants with intraute...
Source: Acta Haematologica - June 5, 2019 Category: Hematology Source Type: research

Safety-Related Postmarketing Modifications of Drugs for Hematological Malignancies.
Abstract The prevalence of safety-related postmarketing label modifications of medications for hematological malignancies is unknown. We identified 35 new drugs indicated for hematological malignancies approved by the US Food and Drug Administration between January 1999 and December 2014. Characteristics of supporting trials and safety-related label modifications from approval to December 2017 were collected from drug labels. Regulatory review and approval pathways were also collected. New drug approvals were supported by trials with a median of 167 patients (interquartile range 115-316). All drugs were approved b...
Source: Acta Haematologica - June 5, 2019 Category: Hematology Authors: Gafter-Gvili A, Tibau A, Raanani P, Shepshelovich D Tags: Acta Haematol Source Type: research

Pregnancy with Chuvash Polycythaemia and Other Congenital Erythrocytosis.
Abstract This original report describes the management of a pregnant woman with congenital erythrocytosis (Chuvash polycythaemia) and reviews the scarce data available in the literature. Therapy consisted of low-dose aspirin and phlebotomies to maintain haematocrit
Source: Acta Haematologica - June 5, 2019 Category: Hematology Authors: Dewarrat N, Kaiser J, Baud D, Alberio L, Gavillet M Tags: Acta Haematol Source Type: research

Thrombotic Thrombocytopenic Purpura Cases and Consumption of Large Quantities of Energy Drink: Related or Coincidence?
In this report we present 2 acquired TTP cases involving the consumption of a large amount of energy drink. PMID: 31167181 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - June 5, 2019 Category: Hematology Authors: Göçer M, Iltar U, Aykaş F, Aslan V, Nizam İ, Çelik M, Kurtoğlu E Tags: Acta Haematol Source Type: research

Low Platelet Counts at Diagnosis Predict Better Survival for Patients with Intermediate-Risk Acute Myeloid Leukemia.
Abstract BACKGROUND: Aggressive growth of primitive and immature cells in the bone marrow results in reductions in megakaryocyte and platelet (PLT) counts, leading to thrombocytopenia in acute myeloid leukemia (AML). However, not all AML patients show thrombocytopenia at the time of diagnosis, and the association of PLT count with patient survival is largely unknown. METHODS: A retrospective study was performed to determine PLT counts at diagnosis in the peripheral blood in 291 newly diagnosed AML patients and assess the association of PLT counts with the overall survival (OS) and disease-free survival (DFS) ...
Source: Acta Haematologica - June 5, 2019 Category: Hematology Authors: Zhang Y, Gu H, Chen Q, Zhang Y, Cheng H, Yang J, Wang J, Hu X Tags: Acta Haematol Source Type: research

Interruption or Discontinuation of Tyrosine Kinase Inhibitor Treatment in Chronic Myeloid Leukaemia: A Retrospective Cohort Study (SPARKLE) in Belgium
Conclusion: Although TKIs are used for long-term CML treatment, physicians sometimes recommend interruptions/discontinuations. In this study, interruptions/discontinuations were mainly caused by side effects or intolerance, rather than TFR attempts.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 4, 2019 Category: Hematology Source Type: research

The Biological Function and Clinical Significance of miR-886-5p in Multiple Myeloma
Conclusion: miR-886-5p triggered MM cell growth and may act as a diagnostic plasma biomarker for MM, potentially contributing to resistance to chemotherapy.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - June 4, 2019 Category: Hematology Source Type: research

The Biological Function and Clinical Significance of miR-886-5p in Multiple Myeloma.
CONCLUSION: miR-886-5p triggered MM cell growth and may act as a diagnostic plasma biomarker for MM, potentially contributing to resistance to chemotherapy. PMID: 31163428 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - June 4, 2019 Category: Hematology Authors: Xiang P, Liu Y, Liu L, Lin Q, Liu X, Zhang H, Xu J, Fang B Tags: Acta Haematol Source Type: research

Interruption or Discontinuation of Tyrosine Kinase Inhibitor Treatment in Chronic Myeloid Leukaemia: A Retrospective Cohort Study (SPARKLE) in Belgium.
CONCLUSION: Although TKIs are used for long-term CML treatment, physicians sometimes recommend interruptions/discontinuations. In this study, interruptions/discontinuations were mainly caused by side effects or intolerance, rather than TFR attempts. PMID: 31163431 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - June 4, 2019 Category: Hematology Authors: Devos T, Verhoef G, Steel E, Mazure D, Lewalle P, Bron D, Berneman Z, Benghiat FS, Mineur P, Theunissen K, Zachée P, Doyen C, Put N, Lejeune M, Van Eygen K, Havelange V, Reusens M, Pluymers W, Peeters K Tags: Acta Haematol Source Type: research

Sirt1 in the Regulation of Interferon Gamma in Severe Aplastic Anemia
In conclusion, the defective Sirt1 may be correlated to the abnormal IFN γ expression in SAA patients, and activation of Sirt1 signaling may help improve the inflammatory status of SAA.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - May 29, 2019 Category: Hematology Source Type: research

Sirt1 in the Regulation of Interferon Gamma in Severe Aplastic Anemia.
In this study, we investigated the role of Sirt1 in the regulation of IFNγ in patients with SAA. A significant decrease in relative SIRT1 (p
Source: Acta Haematologica - May 29, 2019 Category: Hematology Authors: Lin X, Liu C, Wang T, Wang H, Shao Z Tags: Acta Haematol Source Type: research

A Case of Acquired Amegakaryocytic Thrombocytopenia with Anti-c-mpl Autoantibody: Comparison with Idiopathic Thrombocytopenic Purpura
We report the case of a 60-year-old woman diagnosed with AAMT, who presented with severe thrombocytopenia, gastroin ­testinal bleeding, and significantly reduced bone marrow megakaryocytes. The patient was treated with methylprednisolone, cyclosporin, and intravenous immunoglobulin. After 2 weeks of treatment, her platelet count started to increase, and her bone marrow megakaryocyte count had normalized 3 months after diagnosis. At the time of diagnosis, the patient was seropositive for anti-c-mpl antibody but was seen to be seronegative once the platelet count recovered. In contrast, anti-c-mpl antibodies were not det...
Source: Acta Haematologica - May 27, 2019 Category: Hematology Source Type: research

A Case of Acquired Amegakaryocytic Thrombocytopenia with Anti-c-mpl Autoantibody: Comparison with Idiopathic Thrombocytopenic Purpura.
We report the case of a 60-year-old woman diagnosed with AAMT, who presented with severe thrombocytopenia, gastroin-testinal bleeding, and significantly reduced bone marrow megakaryocytes. The patient was treated with methylprednisolone, cyclosporin, and intravenous immunoglobulin. After 2 weeks of treatment, her platelet count started to increase, and her bone marrow megakaryocyte count had normalized 3 months after diagnosis. At the time of diagnosis, the patient was seropositive for anti-c-mpl antibody but was seen to be seronegative once the platelet count recovered. In contrast, anti-c-mpl antibodies were not detected...
Source: Acta Haematologica - May 27, 2019 Category: Hematology Authors: Son B, Park HS, Han HS, Kim HK, Baek SW, Yang Y, Lee KH, Kwon J Tags: Acta Haematol Source Type: research

Proteomic Profiling of Signaling Networks Modulated by G-CSF/Plerixafor/Busulfan-Fludarabine Conditioning in Acute Myeloid Leukemia Patients in Remission or with Active Disease prior to Allogeneic Stem Cell Transplantation
To characterize intracellular signaling in peripheral blood (PB) cells of acute myeloid leukemia (AML) patients undergoing pretransplant conditioning with CXCR4 inhibitor plerixafor, granulocyte colony-stimulating factor (G-CSF), and busulfan plus fludarabine (Bu+Flu) chemotherapy, we profiled 153 proteins in 33 functional groups using reverse phase protein array. CXCR4 inhibition mobilized AML progenitors and clonal AML cells, and this was associated with molecular markers of cell cycle progression. G-CSF/plerixafor and G-CSF/plerixafor/Bu+Flu modulated distinct signaling networks in AML blasts of patients undergoing cond...
Source: Acta Haematologica - May 21, 2019 Category: Hematology Source Type: research

Therapeutic Outcomes and Toxicity of High-Dose Methotrexate-Based Chemotherapy for Elderly Patients with Primary Central Nervous System Lymphoma: A Report on Six Cases
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - May 21, 2019 Category: Hematology Source Type: research

Atypical Chronic Myeloid Leukemia in a Patient with Aplastic Anemia
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - May 21, 2019 Category: Hematology Source Type: research

Can Chronic-Phase Chronic Myeloid Leukemia Patients Achieve Optimal and Durable Responses after Two Failed TKI Treatments? Real-World Evidence Data
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - May 21, 2019 Category: Hematology Source Type: research

Hemoglobin Saint Etienne Found in a Chinese Family
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - May 21, 2019 Category: Hematology Source Type: research

Proteomic Profiling of Signaling Networks Modulated by G-CSF/Plerixafor/Busulfan-Fludarabine Conditioning in Acute Myeloid Leukemia Patients in Remission or with Active Disease prior to Allogeneic Stem Cell Transplantation.
Abstract To characterize intracellular signaling in peripheral blood (PB) cells of acute myeloid leukemia (AML) patients undergoing pretransplant conditioning with CXCR4 inhibitor plerixafor, granulocyte colony-stimulating factor (G-CSF), and busulfan plus fludarabine (Bu+Flu) chemotherapy, we profiled 153 proteins in 33 functional groups using reverse phase protein array. CXCR4 inhibition mobilized AML progenitors and clonal AML cells, and this was associated with molecular markers of cell cycle progression. G-CSF/plerixafor and G-CSF/plerixafor/Bu+Flu modulated distinct signaling networks in AML blasts of patien...
Source: Acta Haematologica - May 21, 2019 Category: Hematology Authors: Zeng Z, Liu W, Benton CB, Konoplev S, Lu H, Wang RY, Chen J, Shpall E, Baggerly KA, Champlin R, Konopleva M Tags: Acta Haematol Source Type: research

Therapeutic Outcomes and Toxicity of High-Dose Methotrexate-Based Chemotherapy for Elderly Patients with Primary Central Nervous System Lymphoma: A Report on Six Cases.
PMID: 31112947 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - May 21, 2019 Category: Hematology Authors: Tempaku A, Takahashi Y, Kamada H Tags: Acta Haematol Source Type: research

Hemoglobin Saint Etienne Found in a Chinese Family.
PMID: 31112948 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - May 21, 2019 Category: Hematology Authors: Xu JX, Gao HH Tags: Acta Haematol Source Type: research

Can Chronic-Phase Chronic Myeloid Leukemia Patients Achieve Optimal and Durable Responses after Two Failed TKI Treatments? Real-World Evidence Data.
PMID: 31112953 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - May 21, 2019 Category: Hematology Authors: Breccia M Tags: Acta Haematol Source Type: research

Atypical Chronic Myeloid Leukemia in a Patient with Aplastic Anemia.
ona F PMID: 31112981 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - May 21, 2019 Category: Hematology Authors: Santopietro M, Miano M, Palumbo G, Zhang K, Cardarelli L, Chiaretti S, Peragine N, Nanni M, Diverio D, Mancini F, Testi AM, Moleti ML, Foà R, Giona F Tags: Acta Haematol Source Type: research

A Novel Mutation at HBB: c.91delA (Codon 30, –A) Causing β-Thalassemia in a Chinese Family
β-Thalassemia is a genetic disease characterized by the defective synthesis of the hemoglobin tetramer β-globin chains. So far, a number of mutations have been identified and associated with this genetic disease. A high incidence of thalassemia has been found in Guangxi (China). Herein, we report a case of a patient with slightly increased HbA2 levels (4.6%). Based on the clinical data and laboratory findings, the patient was diagnosed with β-thalassemia. Routine genetic screening tests were negative. Sequencing revealed an A deletion at codon 30 (HBB: c.91delA) and the genotype of this patient was βCD3...
Source: Acta Haematologica - May 20, 2019 Category: Hematology Source Type: research

Decreased Bleeding Incidence with Direct Oral Anticoagulants Compared to Vitamin K Antagonist and Low-Molecular-Weight Heparin in Patients with Sickle Cell Disease and Venous Thromboembolism
Conclusion: There was no difference between VTE recurrence and choice of anticoagulation in SCD patients with VTE. Bleeding events were lower for DOACs compared to VKA or LMWH.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - May 20, 2019 Category: Hematology Source Type: research

A Novel Mutation at HBB: c.91delA (Codon 30, -A) Causing β-Thalassemia in a Chinese Family.
A Novel Mutation at HBB: c.91delA (Codon 30, -A) Causing β-Thalassemia in a Chinese Family. Acta Haematol. 2019 May 20;:1-4 Authors: Jia W, Wang W, Zhu H, Chen P Abstract β-Thalassemia is a genetic disease characterized by the defective synthesis of the hemoglobin tetramer β-globin chains. So far, a number of mutations have been identified and associated with this genetic disease. A high incidence of thalassemia has been found in Guangxi (China). Herein, we report a case of a patient with slightly increased HbA2 levels (4.6%). Based on the clinical data and laboratory findings, the pati...
Source: Acta Haematologica - May 20, 2019 Category: Hematology Authors: Jia W, Wang W, Zhu H, Chen P Tags: Acta Haematol Source Type: research

Decreased Bleeding Incidence with Direct Oral Anticoagulants Compared to Vitamin K Antagonist and Low-Molecular-Weight Heparin in Patients with Sickle Cell Disease and Venous Thromboembolism.
Abstract BACKGROUND: Venous thromboembolism (VTE) is a recognized complication of sickle cell disease (SCD), yet the optimal pharmacologic anticoagulant is unknown. METHODS: A retrospective single-institution cohort study of patients with SCD complicated by first VTE from January 2009 through July 2017 was performed using ICD 9/10 codes. Data collected included the anticoagulant used, VTE recurrence, and incidence of bleeding. RESULTS: 109 patients with VTE were identified. SCD genotypes included HbSS in 92 (84%), HbSC in 13 (12%), and HbS-β+ thalassemia in 4 (4%). After the initial VTE event, 32 pa...
Source: Acta Haematologica - May 20, 2019 Category: Hematology Authors: Patel A, Williams H, Baer MR, Zimrin AB, Law JY Tags: Acta Haematol Source Type: research

Responses to Dasatinib as a Second- and Third-Line Tyrosine Kinase Inhibitor in Chronic Phase Chronic Myeloid Leukaemia Patients
We retrospectively evaluated the efficacy and safety of dasatinib among 48 Chinese patients with chronic phase chronic myeloid leukaemia. The proportions of patients achieving the optimal molecular responses at 3, 6, and 12  months, a major molecular response (MMR) rate and a complete cytogenetic response (CCyR) rate were 87.0, 87.0, 72.2, 45.8, and 72.7% for patients with dasatinib as second-line therapy, and 34.8, 34.8, 33.3, 20.8, and 46.2% as third-line therapy, respectively. A BCR-ABL1 transcript level on the Int ernational Scale (BCR-ABL1IS) of ≤10% at the initiation of ­dasatinib treatment was found to b...
Source: Acta Haematologica - May 17, 2019 Category: Hematology Source Type: research

C-X-C Chemokine Receptor 4 in Diffuse Large B Cell Lymphoma: Achievements and Challenges
Diffuse large B cell lymphoma (DLBCL), an aggressive cancer of the B cells, is the most common subtype of non-Hodgkin lymphoma (NHL) worldwide. In China, the cases of DLBCL increase yearly. C-X-C chemokine receptor 4 (CXCR4) has been implicated in the migration and trafficking of malignant B cells in several hematological malignancies, and only a few reports have been published on the role of CXCR4 in the metastasis of DLBCL. This review summarizes the relevant perspectives on the functional mechanism, prognostic significance, and therapeutic applications of the CXCL12/CXCR4 axis in DLBCL, in particular DLBCL with bone mar...
Source: Acta Haematologica - May 17, 2019 Category: Hematology Source Type: research

C-X-C Chemokine Receptor 4 in Diffuse Large B Cell Lymphoma: Achievements and Challenges.
Abstract Diffuse large B cell lymphoma (DLBCL), an aggressive cancer of the B cells, is the most common subtype of non-Hodgkin lymphoma (NHL) worldwide. In China, the cases of DLBCL increase yearly. C-X-C chemokine receptor 4 (CXCR4) has been implicated in the migration and trafficking of malignant B cells in several hematological malignancies, and only a few reports have been published on the role of CXCR4 in the metastasis of DLBCL. This review summarizes the relevant perspectives on the functional mechanism, prognostic significance, and therapeutic applications of the CXCL12/CXCR4 axis in DLBCL, in particular D...
Source: Acta Haematologica - May 16, 2019 Category: Hematology Authors: Du H, Gao L, Luan J, Zhang H, Xiao T Tags: Acta Haematol Source Type: research

Responses to Dasatinib as a Second- and Third-Line Tyrosine Kinase Inhibitor in Chronic Phase Chronic Myeloid Leukaemia Patients.
Abstract We retrospectively evaluated the efficacy and safety of dasatinib among 48 Chinese patients with chronic phase chronic myeloid leukaemia. The proportions of patients achieving the optimal molecular responses at 3, 6, and 12 months, a major molecular response (MMR) rate and a complete cytogenetic response (CCyR) rate were 87.0, 87.0, 72.2, 45.8, and 72.7% for patients with dasatinib as second-line therapy, and 34.8, 34.8, 33.3, 20.8, and 46.2% as third-line therapy, respectively. A BCR-ABL1 transcript level on the International Scale (BCR-ABL1IS) of ≤10% at the initiation of -dasatinib treatment wa...
Source: Acta Haematologica - May 16, 2019 Category: Hematology Authors: Tan J, Xue M, Pan J, Cen J, Qi X, Liu P, Zhao X, Wu P, Wang Q, Liu D, Liu Y, Chen S, Wang Z Tags: Acta Haematol Source Type: research

Contents Vol. 141, 2019
Acta Haematol 2019;141:I –IV (Source: Acta Haematologica)
Source: Acta Haematologica - May 15, 2019 Category: Hematology Source Type: research

Prelims
Acta Haematol 2019;142:1 –3 (Source: Acta Haematologica)
Source: Acta Haematologica - May 15, 2019 Category: Hematology Source Type: research