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Prevalence of Iron Deficiency and Iron Deficiency Anemia in Strenuously Training Male Army Recruits
Conclusion: We report a high prevalence of anemia, ID, and IDA among young healthy males participating in prolonged strenuous training programs. These findings can be partly explained by the physiological changes associated with strenuous physical activity. Further investigations aiming to develop specific diagnostic guidelines for this unique population are warranted.Acta Haematol 2018;139:141 –147 (Source: Acta Haematologica)
Source: Acta Haematologica - February 23, 2018 Category: Hematology Source Type: research

Incidence, Survival, and Risk Factors for Adults with Acute Myeloid Leukemia Not Otherwise Specified and Acute Myeloid Leukemia with Recurrent Genetic Abnormalities: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database, 2001 –2013
Conclusion: Our findings highlight the divergent outcomes of patients with AML and the importance of using the WHO classification system and demographic factors to gauge their prognosis.Acta Haematol 2018;139:115 –127 (Source: Acta Haematologica)
Source: Acta Haematologica - February 16, 2018 Category: Hematology Source Type: research

Incidence, Survival, and Risk Factors for Adults with Acute Myeloid Leukemia Not Otherwise Specified and Acute Myeloid Leukemia with Recurrent Genetic Abnormalities: Analysis of the Surveillance, Epidemiology, and End Results (SEER) Database, 2001-2013.
CONCLUSION: Our findings highlight the divergent outcomes of patients with AML and the importance of using the WHO classification system and demographic factors to gauge their prognosis. PMID: 29455198 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - February 16, 2018 Category: Hematology Authors: Song X, Peng Y, Wang X, Chen Y, Jin L, Yang T, Qian M, Ni W, Tong X, Lan J Tags: Acta Haematol Source Type: research

No Mutation Left Behind: The Impact of Reporting Recurrent Genetic Abnormalities on Outcomes of Patients with Acute Myeloid Leukemia
Acta Haematol 2018;139:128 –130 (Source: Acta Haematologica)
Source: Acta Haematologica - February 14, 2018 Category: Hematology Source Type: research

Whither the Bone Marrow Transplantation in Multiple Myeloma?
Acta Haematol 2018;139:131 –131 (Source: Acta Haematologica)
Source: Acta Haematologica - February 14, 2018 Category: Hematology Source Type: research

Quercetin Therapy for Selected Patients with PIM1 Kinase-Positive Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Pilot Study
We reported that PIM1 kinase is expressed in the lymphocytes of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Quercetin, a naturally occurring flavonoid, is a dietary supplement and inhibits many kinases, including PIM1, in vitro. Under an Institutional Review Board-approved protocol, we performed an open-label, single-arm pilot study to evaluate the antitumor activity of quercetin in patients with CLL/SLL. Q-ForceTM chews were administered orally, 500 mg twice daily, for 3 months. Eligible patients had failed prior therapies, had had no other standard treatment, or refused other therap...
Source: Acta Haematologica - February 14, 2018 Category: Hematology Source Type: research

Quercetin Therapy for Selected Patients with PIM1 Kinase-Positive Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Pilot Study.
We reported that PIM1 kinase is expressed in the lymphocytes of patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). Quercetin, a naturally occurring flavonoid, is a dietary supplement and inhibits many kinases, including PIM1, in vitro. Under an Institutional Review Board-approved protocol, we performed an open-label, single-arm pilot study to evaluate the antitumor activity of quercetin in patients with CLL/SLL. Q-ForceTM chews were administered orally, 500 mg twice daily, for 3 months. Eligible patients had failed prior therapies, had had no other standard treatment, or refused other therap...
Source: Acta Haematologica - February 14, 2018 Category: Hematology Authors: Baron BW, Thirman MJ, Giurcanu MC, Baron JM Tags: Acta Haematol Source Type: research

Whither the Bone Marrow Transplantation in Multiple Myeloma?
GJ PMID: 29444503 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - February 14, 2018 Category: Hematology Authors: Ruiz-Argüelles GJ Tags: Acta Haematol Source Type: research

No Mutation Left Behind: The Impact of Reporting Recurrent Genetic Abnormalities on Outcomes of Patients with Acute Myeloid Leukemia.
PMID: 29444505 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - February 14, 2018 Category: Hematology Authors: Brunner AM Tags: Acta Haematol Source Type: research

Plasma Cell Disorders and Dialysis-Dependent Renal Failure: Safety and Efficacy of Autologous Stem Cell Transplantation
Acta Haematol 2018;139:101 –103 (Source: Acta Haematologica)
Source: Acta Haematologica - February 7, 2018 Category: Hematology Source Type: research

Autologous Hematopoietic Cell Transplantation for Dialysis-Dependent Myeloma: More Efficient, Less Toxic
Acta Haematol 2018;139:104 –105 (Source: Acta Haematologica)
Source: Acta Haematologica - February 7, 2018 Category: Hematology Source Type: research

Plasma Cell Disorders and Dialysis-Dependent Renal Failure: Safety and Efficacy of Autologous Stem Cell Transplantation.
PMID: 29414797 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - February 7, 2018 Category: Hematology Authors: Martini F, Buda G, Orciuolo E, Galimberti S, Mazziotta F, Petrini M Tags: Acta Haematol Source Type: research

Autologous Hematopoietic Cell Transplantation for Dialysis-Dependent Myeloma: More Efficient, Less Toxic.
PMID: 29414800 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - February 7, 2018 Category: Hematology Authors: Amit O, Ram R Tags: Acta Haematol Source Type: research

Placenta-Derived Decidua Stromal Cells for Hemorrhagic Cystitis after Stem Cell Transplantation.
CONCLUSIONS: Based on this pilot study, we started a randomized, placebo-controlled double-blind study using 2 doses of 1 × 106 DSCs/kg suspended in albumin for treatment of early HC. PMID: 29408819 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - February 7, 2018 Category: Hematology Authors: Aronsson-Kurttila W, Baygan A, Moretti G, Remberger M, Khoein B, Moll G, Sadeghi B, Ringdén O Tags: Acta Haematol Source Type: research

Two for One: B-Cell Lymphomas with Features of Marginal and Follicular Lymphomas
We report 2 cases of lymphomas which harbor both the t(14;18)(q32;q21) translocation and MALT gene upregulation. Patients presented with numerous circulating atypical lymphocytes. Lymph node biopsy in both cases on HE staining demonstrated vague nodularity readily highlighted by CD10, CD23, or BCL6. Staining with CD20 and BCL2 demonstrated monotonous diffuse effacement of normal architecture with tumor cells without obvious follicular structures. Morphologically, tumor cells were consistent with centrocytes. Bone marrow biopsy demonstrated a combined peritrabecular and interstitial distribution of the tumor cells. These ca...
Source: Acta Haematologica - February 6, 2018 Category: Hematology Source Type: research

Placenta-Derived Decidua Stromal Cells for Hemorrhagic Cystitis after Stem Cell Transplantation
Conclusions: Based on this pilot study, we started a randomized, placebo-controlled double-blind study using 2 doses of 1 × 106 DSCs/kg suspended in albumin for treatment of early HC.Acta Haematol 2018;139:106-114 (Source: Acta Haematologica)
Source: Acta Haematologica - February 6, 2018 Category: Hematology Source Type: research

Two for One: B-Cell Lymphomas with Features of Marginal and Follicular Lymphomas.
We report 2 cases of lymphomas which harbor both the t(14;18)(q32;q21) translocation and MALT gene upregulation. Patients presented with numerous circulating atypical lymphocytes. Lymph node biopsy in both cases on HE staining demonstrated vague nodularity readily highlighted by CD10, CD23, or BCL6. Staining with CD20 and BCL2 demonstrated monotonous diffuse effacement of normal architecture with tumor cells without obvious follicular structures. Morphologically, tumor cells were consistent with centrocytes. Bone marrow biopsy demonstrated a combined peritrabecular and interstitial distribution of the tumor cells. These ca...
Source: Acta Haematologica - February 6, 2018 Category: Hematology Authors: Glazyrin A, Patel C, Kujtan L, Madhusudhana S Tags: Acta Haematol Source Type: research

Contents Vol. 138, 2017
Acta Haematol 2017;138:I-IV (Source: Acta Haematologica)
Source: Acta Haematologica - February 2, 2018 Category: Hematology Source Type: research

Comparative Analysis of miRNA Expression Profiles of Multiple Myeloma with 1q21 Gains and Normal FISH
Conclusions: The identified set of miRNAs can serve as biomarkers for distinguishing MM with 1q21 gains from MM with normal FISH.Acta Haematol 2018;139:96 –100 (Source: Acta Haematologica)
Source: Acta Haematologica - February 2, 2018 Category: Hematology Source Type: research

Acknowledgement to Referees
Acta Haematol 2017;138:233 –234 (Source: Acta Haematologica)
Source: Acta Haematologica - February 2, 2018 Category: Hematology Source Type: research

Comparative Analysis of miRNA Expression Profiles of Multiple Myeloma with 1q21 Gains and Normal FISH.
Abstract BACKGROUND: Multiple myeloma (MM) with 1q21 gains invariably has a poor prognosis. Many recent studies have reported the relationship between micro (mi)RNA expression and MM prognosis. However, there is little information on the association between miRNA alterations and 1q21 gains. METHODS: We compared the miRNA expression profiles of MM with 1q21 gains and MM with normal fluorescence in situ hybridisation (FISH) by gene expression array. Differentially expressed miRNAs were identified using Affymetrix TAC software. Thresholds were defined as a false discovery rate
Source: Acta Haematologica - February 2, 2018 Category: Hematology Authors: Cui Y, Liu Y, Wang D, Liu Y, Liu L, Fang B Tags: Acta Haematol Source Type: research

Acute Pancreatitis Associated with Ixazomib in a Multiple Myeloma Patient.
CONCLUSIONS: Practitioners should include acute pancreatitis as part of their differential diagnosis in patients on ixazomib treatment who present with gastrointestinal symptoms. PMID: 29402766 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - February 2, 2018 Category: Hematology Authors: Steiner RE, Orlowski RZ, Lee HC Tags: Acta Haematol Source Type: research

Marked Elevation of Serum Hyaluronic Acid in Patients Exhibiting Late-Phase Ascites after Allogeneic Hematopoietic Stem Cell Transplantation
Acta Haematol 2018;139:81 –83 (Source: Acta Haematologica)
Source: Acta Haematologica - February 1, 2018 Category: Hematology Source Type: research

Low Expression of < b > < i > FUS1 < /i > < /b > Is Negatively Correlated with miR-378 and May Predict Adverse Prognoses in Acute Myeloid Leukemia
In this study, we aimed to investigate the expression status of theFUS1 gene in acute myeloid leukemia (AML), as well as its clinical significance. We further explored the correlation between the expression of FUS1 andmiR-378 in AML. We detected expression of theFUS1 transcript in bone marrow mononuclear cells from 23 controls and 158 newly diagnosed AML patients by real-time quantitative polymerase chain reaction. DownregulatedFUS1 expression was found in 139 out of 158 (87.97%) AML cases; this rate was significantly lower than that in all 23 controls (p = 0.012). Receiver operating characteristic curve analysis revealed ...
Source: Acta Haematologica - February 1, 2018 Category: Hematology Source Type: research

Low Expression of FUS1 Is Negatively Correlated with miR-378 and May Predict Adverse Prognoses in Acute Myeloid Leukemia.
In this study, we aimed to investigate the expression status of the FUS1 gene in acute myeloid leukemia (AML), as well as its clinical significance. We further explored the correlation between the expression of FUS1 and miR-378 in AML. We detected expression of the FUS1 transcript in bone marrow mononuclear cells from 23 controls and 158 newly diagnosed AML patients by real-time quantitative polymerase chain reaction. Downregulated FUS1 expression was found in 139 out of 158 (87.97%) AML cases; this rate was significantly lower than that in all 23 controls (p = 0.012). Receiver operating characteristic curve analysis revea...
Source: Acta Haematologica - February 1, 2018 Category: Hematology Authors: Tang X, Zhou J, Zhang J, Zhou LY, Zhai LL, Vanessa ME, Yi J, Yi YY, Lin J, Deng ZQ Tags: Acta Haematol Source Type: research

Marked Elevation of Serum Hyaluronic Acid in Patients Exhibiting Late-Phase Ascites after Allogeneic Hematopoietic Stem Cell Transplantation.
PMID: 29393098 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - February 1, 2018 Category: Hematology Authors: Hosoi H, Mushino T, Nishikawa A, Murata S, Kuriyama K, Yamashita Y, Kobata H, Ooiwa T, Hanaoka N, Tamura S, Sonoki T Tags: Acta Haematol Source Type: research

Diffusion-Weighted and Perfusion-Weighted MRI to Evaluate Therapeutic Response in Lymphoma: A Comparison with FDG-PET/CT.
PMID: 29393082 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - January 26, 2018 Category: Hematology Authors: Calistri L, Puccini B, Berti V, Grazzini G, Nardi C, Rigacci L, Colagrande S Tags: Acta Haematol Source Type: research

Primary Liver Diffuse Large B-Cell Lymphoma following Complete Response for Hepatitis C Infection after Direct Antiviral Therapy.
We present the case of a 55-year-old man with chronic hepatitis C infection and liver cirrhosis who received antiviral therapy with sofosbuvir and ribavirin and achieved a sustained complete virological response. One year after successful therapy, there was an unexplained decline of his liver function and atypical liver nodularity, which led to the diagnosis of a primary liver diffuse large B-cell lymphoma. DISCUSSION: We review the evidence supporting possible mechanisms of lymphomagenesis after successful hepatitis C therapy, particularly involving late "second-hit" mutations after viral-induced DNA damage...
Source: Acta Haematologica - January 26, 2018 Category: Hematology Authors: Andrade XA, Paz LH, Nassar M, Oramas DM, Fuentes HE, Kovarik P, Mishra S, Singh A Tags: Acta Haematol Source Type: research

Routine Screening for KIT M541L Is Not Warranted in the Diagnostic Work-Up of Patients with Hypereosinophilia.
PMID: 29393093 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - January 26, 2018 Category: Hematology Authors: Hoade Y, Metzgeroth G, Schwaab J, Reiter A, Cross NCP Tags: Acta Haematol Source Type: research

Diffusion-Weighted and Perfusion-Weighted MRI to Evaluate Therapeutic Response in Lymphoma: A Comparison with FDG-PET/CT
Acta Haematol 2018;139:74-76 (Source: Acta Haematologica)
Source: Acta Haematologica - January 25, 2018 Category: Hematology Source Type: research

Routine Screening for < b > < i > KIT < /i > < /b > M541L Is Not Warranted in the Diagnostic Work-Up of Patients with Hypereosinophilia
Acta Haematol 2018;139:71-73 (Source: Acta Haematologica)
Source: Acta Haematologica - January 25, 2018 Category: Hematology Source Type: research

Primary Liver Diffuse Large B-Cell Lymphoma following Complete Response for Hepatitis C Infection after Direct Antiviral Therapy
We present the case of a 55-year-old man with chronic hepatitis C infection and liver cirrhosis who received antiviral therapy with sofosbuvir and ribavirin and achieved a sustained complete virological response. One year after successful therapy, there was an unexplained decline of his liver function and atypical liver nodularity, which led to the diagnosis of a primary liver diffuse large B-cell lymphoma.Discussion: We review the evidence supporting possible mechanisms of lymphomagenesis after successful hepatitis C therapy, particularly involving late “second-hit” mutations after viral-induced DNA damage and...
Source: Acta Haematologica - January 25, 2018 Category: Hematology Source Type: research

Molecular Genetic Mechanisms of Hereditary Spherocytosis: Current Perspectives
With the widespread use of genetic diagnostic technologies, many novel mutations have been identified in hereditary spherocytosis (HS)-related genes, includingSPTA1,SPTB,ANK1,SLC4A1, andEPB42. However, mutations in HS-related genes are dispersed and nonspecific in the diagnosis of some HS patients, indicating significant heterogeneity in the molecular deficiency of HS. It is necessary to provide the molecular and genetic characteristics of these 5 genes for clinicians to examine HS. Here, we reviewed the recent proposed molecular genetic mechanisms of HS.Acta Haematol 2018;139:60 –66 (Source: Acta Haematologica)
Source: Acta Haematologica - January 22, 2018 Category: Hematology Source Type: research

Acute Pancreatitis Associated with Ixazomib in a Multiple Myeloma Patient
Conclusions: Practitioners should include acute pancreatitis as part of their differential diagnosis in patients on ixazomib treatment who present with gastrointestinal symptoms.Acta Haematol 2018;139:67-70 (Source: Acta Haematologica)
Source: Acta Haematologica - January 22, 2018 Category: Hematology Source Type: research

Second Autologous Hematopoietic Stem Cell Transplant as Salvage Therapy for Relapsed Multiple Myeloma: A Global Treatment Option for Eligible Patients
Acta Haematol 2018;139:45 –46 (Source: Acta Haematologica)
Source: Acta Haematologica - January 19, 2018 Category: Hematology Source Type: research

Elevations of Thrombotic Biomarkers in Hemoglobin H Disease
Conclusion: This observation indicates blood coagulation, endothelial injury, chronic low-grade inflammation, platelet activation, and thrombin generation are present in Hb H disease; these findings merit further assessment in a larger prospective cohort to establish possible links with thrombotic manifestations.Acta Haematol 2018;139:47 –51 (Source: Acta Haematologica)
Source: Acta Haematologica - January 19, 2018 Category: Hematology Source Type: research

Utility of Routine Surveillance Imaging for Hodgkin Disease following Autologous Transplant: Experiences from a Single Institution
Discussion: In our review, most patients with HD after auto-HCT were diagnosed radiologically. Patients whose relapse was diagnosed clinically were likely to be detected earlier and have a shorter OS. Patients with aggressive disease may be detected when clinically relevant, regardless of scanning. Routine scanning may not be necessary in the majority of patients with HD following auto-HCT.Acta Haematol 2018;139:52-57 (Source: Acta Haematologica)
Source: Acta Haematologica - January 17, 2018 Category: Hematology Source Type: research

Utility of Routine Surveillance Imaging for Hodgkin Disease following Autologous Transplant: Experiences from a Single Institution.
DISCUSSION: In our review, most patients with HD after auto-HCT were diagnosed radiologically. Patients whose relapse was diagnosed clinically were likely to be detected earlier and have a shorter OS. Patients with aggressive disease may be detected when clinically relevant, regardless of scanning. Routine scanning may not be necessary in the majority of patients with HD following auto-HCT. PMID: 29339629 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - January 17, 2018 Category: Hematology Authors: Mohyuddin GR, Clark AE, Roller J, Shune L, Lin T, Dunavin N, Dias A, Ganguly S, Abhyankar S, McGuirk J, Singh A Tags: Acta Haematol Source Type: research

Significance of Salvage Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma: A Nationwide Retrospective Study in Japan.
Abstract Autologous stem cell transplantation (ASCT) has been employed for patients with relapsed multiple myeloma (MM) after up-front ASCT. The present retrospective study aimed to examine the survival benefit from salvage ASCT. Among 446 patients with relapsed MM after up-front single ASCT, 70 patients received salvage ASCT, the employment of which reduced the risk of mortality after relapse (p = 0.041). Using the parameters before initial ASCT, the advantage of salvage ASCT compared to standard therapy was confirmed in the subgroup with an international staging system stage of I or II (p = 0.040), good performa...
Source: Acta Haematologica - January 17, 2018 Category: Hematology Authors: Muta T, Miyamoto T, Kamimura T, Kanda Y, Nohgawa M, Ueda Y, Iwato K, Sasaki O, Mori T, Uchida N, Iida S, Fukuda T, Atsuta Y, Sunami K Tags: Acta Haematol Source Type: research

Monoclonal Gammopathy Responsive to Decitabine Given for Acute Myeloid Leukemia in a Frail Patient
Acta Haematol 2018;139:58-59 (Source: Acta Haematologica)
Source: Acta Haematologica - January 16, 2018 Category: Hematology Source Type: research

Significance of Salvage Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma: A Nationwide Retrospective Study in Japan
Autologous stem cell transplantation (ASCT) has been employed for patients with relapsed multiple myeloma (MM) after up-front ASCT. The present retrospective study aimed to examine the survival benefit from salvage ASCT. Among 446 patients with relapsed MM after up-front single ASCT, 70 patients received salvage ASCT, the employment of which reduced the risk of mortality after relapse (p = 0.041). Using the parameters before initial ASCT, the advantage of salvage ASCT compared to standard therapy was confirmed in the subgroup with an international staging system stage of I or II (p = 0.040), good performance status (PS;p =...
Source: Acta Haematologica - January 16, 2018 Category: Hematology Source Type: research

A Novel Mutation of the δ-Globin Gene in an Asymptomatic 30-Year-Old Female.
A Novel Mutation of the δ-Globin Gene in an Asymptomatic 30-Year-Old Female. Acta Haematol. 2018 Jan 13;139(1):33-34 Authors: Di Bella C, Pugliatti F, La Rosa MA, Cara S, Capra AP, Rigoli L PMID: 29332098 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - January 13, 2018 Category: Hematology Authors: Di Bella C, Pugliatti F, La Rosa MA, Cara S, Capra AP, Rigoli L Tags: Acta Haematol Source Type: research

A Novel Mutation of the δ-Globin Gene in an Asymptomatic 30-Year-Old Female
Acta Haematol 2018;139:33-34 (Source: Acta Haematologica)
Source: Acta Haematologica - January 12, 2018 Category: Hematology Source Type: research

Perianal Infections in the Phase before Engraftment after Allogeneic Hematopoietic Stem Cell Transplantations: A Study of the Incidence, Risk Factors, and Clinical Outcomes.
In this study, we aimed to investigate the incidence, risk factors, and clinical outcomes of perianal infections during the pre-engraftment phase after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Consecutive patients who underwent non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology from January 1 to December 31, 2016 were enrolled (n = 646). Ninety-nine patients were found to have perianal infections during the pre-engraftment phase, and 80 were found to have neutropenia on perianal infection diagnosis. The cumulative incidence of perianal infection during the pre-engraftment ...
Source: Acta Haematologica - January 11, 2018 Category: Hematology Authors: Mo XD, Yan X, Hu W, Zhang XH, Xu LP, Wang Y, Xu XD, Wang LN, He XX, Yan CH, Chen H, Chen YH, Liu KY, Huang XJ Tags: Acta Haematol Source Type: research

Clinical Course and Outcome of Childhood Acquired Platelet Dysfunction with Eosinophilia
Acquired platelet dysfunction with eosinophilia (APDE) is a syndrome which manifests as a transient state of platelet dysfunction in the presence of eosinophilia. The aim of this work was to study the clinical course and outcomes of children diagnosed with APDE. The hospital records of children with APDE were retrospectively reviewed and a total of 69 children were included. The mean (standard deviation) age at diagnosis was 6.9 (3.1) years. All of the patients presented with ecchymoses on the extremities, body, and face. None had serious bleeding symptoms. Platelet counts were within the normal range but all of the patien...
Source: Acta Haematologica - January 10, 2018 Category: Hematology Source Type: research

Perianal Infections in the Phase before Engraftment after Allogeneic Hematopoietic Stem Cell Transplantations: A Study of the Incidence, Risk Factors, and Clinical Outcomes
In this study, we aimed to investigate the incidence, risk factors, and clinical outcomes of perianal infections during the pre-engraftment phase after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Consecutive patients who underwent non-T-cell-depleted allo-HSCT at the Peking University Institute of Hematology from January 1 to December 31, 2016 were enrolled (n = 646). Ninety-nine patients were found to have perianal infections during the pre-engraftment phase, and 80 were found to have neutropenia on perianal infection diagnosis. The cumulative incidence of perianal infection during the pre-engraftment p...
Source: Acta Haematologica - January 10, 2018 Category: Hematology Source Type: research

Association of Soluble Interleukin-2 Receptor and C-Reactive Protein with the Efficacy of Bendamustine Salvage Treatment for Indolent Lymphomas and Mantle Cell Lymphoma.
Abstract Bendamustine has demonstrated favourable efficacy in relapsed or refractory indolent lymphoma and mantle cell lymphoma. We retrospectively evaluated the pre-treatment clinical and laboratory factors and their correlation with the clinical outcome of these lymphomas. We analysed 53 patients who had been treated with bendamustine alone (n = 6) or rituximab plus bendamustine (n = 47). The overall response rate was 81.1%, with a complete response (CR) rate of 39.6%. The CR rate was significantly low in patients who had elevated levels of soluble interleukin-2 receptor (p = 0.024) and C-reactive protein (CRP; ...
Source: Acta Haematologica - January 5, 2018 Category: Hematology Authors: Kawaguchi Y, Nakamaki T, Abe M, Baba Y, Murai S, Watanuki M, Arai N, Fujiwara S, Kabasawa N, Tsukamoto H, Uto Y, Ariizumi H, Yanagisawa K, Hattori N, Harada H, Saito B Tags: Acta Haematol Source Type: research

Reduced Protein C Global Assay Levels in Infertile Women with in vitro Fertilization Failure: A Pilot Study.
In this study, we assessed protein C in infertile women with a history of IVF failure who were undergoing ART. We examined 45 healthy fertile women who conceived naturally, and 45 infertile women with 2 or more implantation failures undergoing ART. Both protein C and activated protein C resistance (APC-R) were evaluated. The results showed that mean protein C expressed as a normalized ratio (PCAT-NR) was significantly lower in the study group compared to the control group (0.76 ± 0.15 vs. 0.91 ± 0.14, respectively; p = 0.0001). Follow-up on ART outcomes showed that women who failed ART had significantly lower...
Source: Acta Haematologica - January 5, 2018 Category: Hematology Authors: El Masry S, Azzam H, Youssef H, Othman M, Awad M Tags: Acta Haematol Source Type: research

Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults.
Abstract BACKGROUND: Iron food fortification and oral iron formulations are frequently limited by poor absorption, resulting in the widespread use of high-dose oral iron, which is poorly tolerated. METHODS: We evaluated novel iron-denatured whey protein (Iron-WP) microspheres on reactive oxygen species (ROS) and viability in gut epithelial (HT29) cells. We compared iron absorption from Iron-WP versus equimolar-dose (25 mg elemental iron) ferrous sulphate (FeSO4) in a prospective, randomised, cross-over study in fasting volunteers (n = 21 per group) dependent on relative iron depletion (a ferritin level ≤/&...
Source: Acta Haematologica - January 5, 2018 Category: Hematology Authors: Wang J, Radics G, Whelehan M, OʼDriscoll A, Healy AM, Gilmer JF, Ledwidge M Tags: Acta Haematol Source Type: research

Amegakaryocytic Thrombocytopenia and Subsequent Aplastic Anemia Associated with Apparent Epstein-Barr Virus Infection.
Abstract Acquired amegakaryocytic thrombocytopenia (AAT), a rare entity characterized by severe thrombocytopenia and the absence of megakaryocytes in the bone marrow, may mimic or precede the diagnosis of aplastic anemia (AA). Here, we describe a patient who presented with apparent Epstein-Barr virus (EBV)-associated immune thrombocytopenia resistant to several lines of therapies, which was in fact a form of AAT with some features of AA. He eventually responded to therapy with eltrombopag, cyclosporine A (CSA), and antithymocyte globulin (ATG) and recovered completely. EBV infection is known to cause a variety of ...
Source: Acta Haematologica - January 5, 2018 Category: Hematology Authors: Levy I, Laor R, Jiries N, Bejar J, Polliack A, Tadmor T Tags: Acta Haematol Source Type: research