Recent Advances in the Diagnosis, Risk Stratification, and Management of Systemic Light-Chain Amyloidosis
The term amyloidosis refers to a group of disorders in which protein fibrils accumulate in certain organs, disrupt their tissue architecture, and impair the function of the effected organ. The clinical manifestations and prognosis vary widely depending on the specific type of the affected protein. Immunoglobulin light-chain (AL) amyloidosis is the most common form of systemic amyloidosis, characterized by deposition of a misfolded monoclonal light-chain that is secreted from a plasma cell clone. Demonstrating amyloid deposits in a tissue biopsy stained with Congo red is mandatory for the diagnosis. Novel agents (proteasome...
Source: Acta Haematologica - January 16, 2019 Category: Hematology Source Type: research

Recent Advances in the Diagnosis, Risk Stratification, and Management of Systemic Light-Chain Amyloidosis.
Abstract The term amyloidosis refers to a group of disorders in which protein fibrils accumulate in certain organs, disrupt their tissue architecture, and impair the function of the effected organ. The clinical manifestations and prognosis vary widely depending on the specific type of the affected protein. Immunoglobulin light-chain (AL) amyloidosis is the most common form of systemic amyloidosis, characterized by deposition of a misfolded monoclonal light-chain that is secreted from a plasma cell clone. Demonstrating amyloid deposits in a tissue biopsy stained with Congo red is mandatory for the diagnosis. Novel ...
Source: Acta Haematologica - January 16, 2019 Category: Hematology Authors: Vaxman I, Gertz M Tags: Acta Haematol Source Type: research

Top 100 Most Influential Articles in the Field of Myeloid Neoplasms: A Bibliometric Study
Conclusion: Our analysis sheds light on the quality of work and driving trends, listing the most cited and impactful guideline articles within this field and aiding clinicians.Acta Haematol 2019;141:68 –78 (Source: Acta Haematologica)
Source: Acta Haematologica - January 13, 2019 Category: Hematology Source Type: research

Autoimmune Cytopenias Occurring after Treatment with Chemoimmunotherapy for Non-Hodgkin Lymphomas
We examined NHL patients with autoimmune cytopenia and all patients were treated with rituximab-containing therapy. The present results showed reversed imbalances in helper/suppressor T-cell populations, and an immune system imbalance may have contributed to immunological abnormalities. Although the relationship between imbalances in helper/suppressor T-cell populations and the development of auto-antibody production after chemotherapies currently remains unclear, the immunosuppressive effects of immunochemotherapy may be a contributing factor. The long-term monitoring of T-cell populations after immunochemotherapies is im...
Source: Acta Haematologica - January 13, 2019 Category: Hematology Source Type: research

Efficacy of Gemcitabine as Salvage Therapy for Relapsed and Refractory Aggressive Non-Hodgkin Lymphoma
Gemcitabine-based salvage therapy is considered an effective treatment for relapsed and refractory Non-Hodgkin ’s lymphoma (NHL). We analyzed the outcome of 41 consecutive NHL patients treated with gemcitabine-based regimens between January 2007 and October 2015. Twenty-eight males and 13 females (median age 66.4 years) were included. The median follow-up from gemcitabine initiation was 7.3 months. Thirty patients (73%) had B-cell, and eleven (27%) had T-cell, lymphoma. All patients received a median of 2 prior regimens, of which at least 1 was anthracycline based. Twenty-eight patients (78%) received full-dose while...
Source: Acta Haematologica - January 13, 2019 Category: Hematology Source Type: research

Gemcitabine: End of a Chemotherapy ’s Era?
Acta Haematol 2019;141:91 –92 (Source: Acta Haematologica)
Source: Acta Haematologica - January 13, 2019 Category: Hematology Source Type: research

Autoimmune Cytopenias Occurring after Treatment with Chemoimmunotherapy for Non-Hodgkin Lymphomas.
We examined NHL patients with autoimmune cytopenia and all patients were treated with rituximab-containing therapy. The present results showed reversed imbalances in helper/suppressor T-cell populations, and an immune system imbalance may have contributed to immunological abnormalities. Although the relationship between imbalances in helper/suppressor T-cell populations and the development of auto-antibody production after chemotherapies currently remains unclear, the immunosuppressive effects of immunochemotherapy may be a contributing factor. The long-term monitoring of T-cell populations after immunochemotherapies is im...
Source: Acta Haematologica - January 10, 2019 Category: Hematology Authors: Oka S, Nohgawa M Tags: Acta Haematol Source Type: research

Gemcitabine: End of a Chemotherapy's Era?
PMID: 30630165 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - January 10, 2019 Category: Hematology Authors: Smith SD Tags: Acta Haematol Source Type: research

Efficacy of Gemcitabine as Salvage Therapy for Relapsed and Refractory Aggressive Non-Hodgkin Lymphoma.
Abstract Gemcitabine-based salvage therapy is considered an effective treatment for relapsed and refractory Non-Hodgkin's lymphoma (NHL). We analyzed the outcome of 41 consecutive NHL patients treated with gemcitabine-based regimens between January 2007 and October 2015. Twenty-eight males and 13 females (median age 66.4 years) were included. The median follow-up from gemcitabine initiation was 7.3 months. Thirty patients (73%) had B-cell, and eleven (27%) had T-cell, lymphoma. All patients received a median of 2 prior regimens, of which at least 1 was anthracycline based. Twenty-eight patients (78%) received full...
Source: Acta Haematologica - January 10, 2019 Category: Hematology Authors: Zlotnick M, Avigdor A, Ribakovsky E, Nagler A, Kedmi M Tags: Acta Haematol Source Type: research

Top 100 Most Influential Articles in the Field of Myeloid Neoplasms: A Bibliometric Study.
CONCLUSION: Our analysis sheds light on the quality of work and driving trends, listing the most cited and impactful guideline articles within this field and aiding clinicians. PMID: 30616235 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - January 7, 2019 Category: Hematology Authors: Iqbal U, Rehan A, Akmal M, Jamali M, Iqbal A, Khan BA, Wasif KU, Rivera E, Khan M Tags: Acta Haematol Source Type: research

Is BK Virus-Associated Cystitis a Generalized Epithelial Disease?
BK polyomavirus-associated haemorrhagic cystitis (BKHC) is a complication after allogeneic stem cell transplantation, which can occur in 5 –60% of the cases. BK viruria alone can also occur in up to 100%. BKHC can lead to severe morbidity in stem cell-transplanted patients, but data about this disease is limited. Consequently, we conducted a prospective unicentric non-interventional trial on BKHC as well as BK viruria after first adu lt allogeneic stem cell transplantation with a follow-up time of 1 year after inpatient treatment. Between November 2013 and December 2015, we were able to include 40 adult patients with...
Source: Acta Haematologica - January 3, 2019 Category: Hematology Source Type: research

Is BK Virus-Associated Cystitis a Generalized Epithelial Disease?
r W Abstract BK polyomavirus-associated haemorrhagic cystitis (BKHC) is a complication after allogeneic stem cell transplantation, which can occur in 5-60% of the cases. BK viruria alone can also occur in up to 100%. BKHC can lead to severe morbidity in stem cell-transplanted patients, but data about this disease is limited. Consequently, we conducted a prospective unicentric non-interventional trial on BKHC as well as BK viruria after first adult allogeneic stem cell transplantation with a follow-up time of 1 year after inpatient treatment. Between November 2013 and December 2015, we were able to include 40 adult...
Source: Acta Haematologica - January 3, 2019 Category: Hematology Authors: Schneidewind L, Neumann T, Zimmermann K, Weigel M, Schmidt CA, Krüger W Tags: Acta Haematol Source Type: research

Ankyrin Mutations in Hereditary Spherocytosis
Acta Haematol 2019;141:63 –64 (Source: Acta Haematologica)
Source: Acta Haematologica - January 2, 2019 Category: Hematology Source Type: research

Ankyrin Mutations in Hereditary Spherocytosis.
PMID: 30602149 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - January 2, 2019 Category: Hematology Authors: Agarwal AM Tags: Acta Haematol Source Type: research

Acknowledgement to Referees
Acta Haematol 2018;140:250 –252 (Source: Acta Haematologica)
Source: Acta Haematologica - December 7, 2018 Category: Hematology Source Type: research

Contents Vol. 140, 2018
Acta Haematol 2018;140:I –IV (Source: Acta Haematologica)
Source: Acta Haematologica - December 7, 2018 Category: Hematology Source Type: research

Hemophagocytic Lymphohistiocytosis during the Postpartum Stage of Pregnancy: A Report of Eight Cases
Haemophagocytic lymphohistiocytosis (HLH) is a rare and severe clinical syndrome that can be classified as either primary or secondary. Secondary HLH can be triggered by a variety of diseases. Pregnancy-related HLH has already been observed clinically. However, most of these cases occur during pregnancy. Considering that the periods before and after delivery have different clinical features, we presented the first case series of HLH that presented during the postpartum stage of pregnancy. From these cases, we concluded that postpartum HLH is a common form of pregnancy-related HLH. Patients with postpartum HLH may suffer mo...
Source: Acta Haematologica - December 7, 2018 Category: Hematology Source Type: research

Postpartum Hemophagocytic Lymphohystiocytosis: A New Entity Is Born
Acta Haematol 2019;141:61 –62 (Source: Acta Haematologica)
Source: Acta Haematologica - December 7, 2018 Category: Hematology Source Type: research

Postpartum Hemophagocytic Lymphohystiocytosis: A New Entity Is Born.
PMID: 30537710 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - December 7, 2018 Category: Hematology Authors: Pasvolsky O, Leader A Tags: Acta Haematol Source Type: research

Hemophagocytic Lymphohistiocytosis during the Postpartum Stage of Pregnancy: A Report of Eight Cases.
Abstract Haemophagocytic lymphohistiocytosis (HLH) is a rare and severe clinical syndrome that can be classified as either primary or secondary. Secondary HLH can be triggered by a variety of diseases. Pregnancy-related HLH has already been observed clinically. However, most of these cases occur during pregnancy. Considering that the periods before and after delivery have different clinical features, we presented the first case series of HLH that presented during the postpartum stage of pregnancy. From these cases, we concluded that postpartum HLH is a common form of pregnancy-related HLH. Patients with postpartum...
Source: Acta Haematologica - December 7, 2018 Category: Hematology Authors: Song Y, Wang JS, Wang YN, Wang Z Tags: Acta Haematol Source Type: research

Analysis of Efficacy and Prognostic Factors of CLAG Treatment in Chinese Patients with Refractory or Relapsed Acute Myeloid Leukemia
Conclusion: CLAG was effective and well tolerated for R/R AML. BM blasts ≥42.1%, age ≥60 years, high risk stratification, and second or higher salvage therapy were independent factors for a poor prognosis.Acta Haematol 2019;141:43 –53 (Source: Acta Haematologica)
Source: Acta Haematologica - December 5, 2018 Category: Hematology Source Type: research

Factors Involved in the Selection of Treatment in Patients with Hematological Malignancies
Acta Haematol 2019;141:54 (Source: Acta Haematologica)
Source: Acta Haematologica - December 5, 2018 Category: Hematology Source Type: research

Analysis of Efficacy and Prognostic Factors of CLAG Treatment in Chinese Patients with Refractory or Relapsed Acute Myeloid Leukemia.
CONCLUSION: CLAG was effective and well tolerated for R/R AML. BM blasts ≥42.1%, age ≥60 years, high risk stratification, and second or higher salvage therapy were independent factors for a poor prognosis. PMID: 30517910 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - December 5, 2018 Category: Hematology Authors: Wang L, Xu J, Tian X, Lv T, Yuan G Tags: Acta Haematol Source Type: research

Factors Involved in the Selection of Treatment in Patients with Hematological Malignancies.
GJ PMID: 30517914 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - December 5, 2018 Category: Hematology Authors: Ruiz-Argüelles GJ Tags: Acta Haematol Source Type: research

Effectiveness and Safety of Deferasirox in Thalassemia with Iron Overload: A Meta-Analysis
In this study, a systematic meta-analysis was performed to assess the effectiveness and safety of DFX in the treatment of thalassemia with iron overload. We performed a systematic electronic literature search for randomized controlled studies of DFX in the Embase, Medline, Cochrane, and Chinese Biomedical Literature (CBM) databases from January 1990 to May 2018. Particular attention was paid to mortality, serum ferritin (SF), liver iron concentration (LIC), myocardial iron concentration, and adverse events (AEs). Six studies comparing DFX with deferoxamine (DFO) and placebo were enrolled. DFX was not better than DFO in low...
Source: Acta Haematologica - November 30, 2018 Category: Hematology Source Type: research

Long-Term Follow-Up of a Case with Dyskeratosis Congenita Caused by NHP2-V126M/X154R Mutation: Genotype-Phenotype Association
Dyskeratosis congenita (DC) is a rare inherited syndrome characterized by classical mucocutaneous features and the presence of other clinical features including bone marrow failure, pulmonary fibrosis, liver cirrhosis, and a predisposition to cancer. The symptoms develop at various ages and may manifest over time. Gene mutations associated with DC, such as DC1, TERC, TERT, TINF2, NHP2, NOP10, ACD, CTC1, NAF1, PARN, POT1, RTEL1, STN1, and WRAP53, have been identified in about 70% of patients. Since the number of patients with DC is small and the effect of genetic pathogenic variant may affect the phenotype, we wanted to pre...
Source: Acta Haematologica - November 23, 2018 Category: Hematology Source Type: research

Long-Term Follow-Up of a Case with Dyskeratosis Congenita Caused by NHP2-V126M/X154R Mutation: Genotype-Phenotype Association.
u İ, Ören H Abstract Dyskeratosis congenita (DC) is a rare inherited syndrome characterized by classical mucocutaneous features and the presence of other clinical features including bone marrow failure, pulmonary fibrosis, liver cirrhosis, and a predisposition to cancer. The symptoms develop at various ages and may manifest over time. Gene mutations associated with DC, such as DC1, TERC, TERT, TINF2, NHP2, NOP10, ACD, CTC1, NAF1, PARN, POT1, RTEL1, STN1, and WRAP53, have been identified in about 70% of patients. Since the number of patients with DC is small and the effect of genetic pathogenic variant may af...
Source: Acta Haematologica - November 23, 2018 Category: Hematology Authors: Erdem M, Tüfekçi Ö, Yılmaz Ş, Alacacıoğlu İ, Ören H Tags: Acta Haematol Source Type: research

Unique Case of Myeloproliferative Neoplasm with Two Rare Clonal Abnormalities: Rare < b > < i > JAK2 < /i > < /b > Exon 12 < b > < i > < /i > < /b > Mutation and Rare e14a3 (b3a3) BCR/ABL Fusion Transcript
We describe clinical and laboratory features, bone marrow pathology, treatment, and overall outcome.Acta Haematol 2019;141:23 –27 (Source: Acta Haematologica)
Source: Acta Haematologica - November 21, 2018 Category: Hematology Source Type: research

Unique Case of Myeloproliferative Neoplasm with Two Rare Clonal Abnormalities: Rare JAK2 Exon 12 Mutation and Rare e14a3 (b3a3) BCR/ABL Fusion Transcript.
We describe clinical and laboratory features, bone marrow pathology, treatment, and overall outcome. PMID: 30463063 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 21, 2018 Category: Hematology Authors: Swaminathan M, Patel KP, Huynh-Lu J, Tang G, Zuo Z, Miranda R, Verstovsek S Tags: Acta Haematol Source Type: research

The Onset of Monoclonal and Oligoclonal Gammopathies Is a Good Prognostic Factor after Allogeneic Stem Cell Transplantation
Acta Haematol 2019;141:7 –11 (Source: Acta Haematologica)
Source: Acta Haematologica - November 15, 2018 Category: Hematology Source Type: research

Allogenic Stem Cell Transplantation and the Subsequent Paraproteinemia: A Benign Altered B-Cell Homeostasis?
Acta Haematol 2019;141:12 –13 (Source: Acta Haematologica)
Source: Acta Haematologica - November 15, 2018 Category: Hematology Source Type: research

Spontaneous Regression of Hodgkin Lymphoma: Case Report and Review of the Literature
We describe a 32-year-old woman with spontaneous regression of HL and review the literature. The patient presented with cervical lymphadenopathy and was diagnosed with stage IIA classical HL. The patient refused to receive any treatment for her disease. Positron emission tomography/computed tomography carried out 2 years later showed complete regression of the lymphadenopathy, without pathological uptake of fluorodeoxyglucose. At the last follow-up, 3.5 years after the initial presentation, the patient is with no evidence of disease. During workup for the HL, concomitant papillary thyroid carcinoma was diagnosed, for which...
Source: Acta Haematologica - November 15, 2018 Category: Hematology Source Type: research

Immune Mediated Cerebellar Ataxia: An Unknown Manifestation of Graft-versus-Host Disease
We describe a middle-aged woman with chronic GVHD after allo-HCT who presented with a rapidly progressive cerebellar syndrome. Thorough investigation revealed only cerebellar atrophy on brain imaging and positive anti-GAD65 antibodies in serum and cerebrospinal fluid suggesting the diagnosis of anti-GAD antibody-associated cerebellar ataxia. Despite prompt treatment with high-dose corticosteroids, intravenous immunoglobulins, and rituximab, the patient ’s condition rapidly deteriorated, and she died 4 months later. This case suggests that anti-GAD antibody-associated cerebellar ataxia may be a rare manifestation of c...
Source: Acta Haematologica - November 15, 2018 Category: Hematology Source Type: research

Allogenic Stem Cell Transplantation and the Subsequent Paraproteinemia: A Benign Altered B-Cell Homeostasis?
PMID: 30439698 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 15, 2018 Category: Hematology Authors: Widmer CC Tags: Acta Haematol Source Type: research

The Onset of Monoclonal and Oligoclonal Gammopathies Is a Good Prognostic Factor after Allogeneic Stem Cell Transplantation.
PMID: 30439709 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 15, 2018 Category: Hematology Authors: Iovino L, Mazziotta F, Buda G, Orciuolo E, Caracciolo F, Pelosini M, Morganti R, Galimberti S, Benedetti E, Petrini M Tags: Acta Haematol Source Type: research

Immune Mediated Cerebellar Ataxia: An Unknown Manifestation of Graft-versus-Host Disease.
We describe a middle-aged woman with chronic GVHD after allo-HCT who presented with a rapidly progressive cerebellar syndrome. Thorough investigation revealed only cerebellar atrophy on brain imaging and positive anti-GAD65 antibodies in serum and cerebrospinal fluid suggesting the diagnosis of anti-GAD antibody-associated cerebellar ataxia. Despite prompt treatment with high-dose corticosteroids, intravenous immunoglobulins, and rituximab, the patient's condition rapidly deteriorated, and she died 4 months later. This case suggests that anti-GAD antibody-associated cerebellar ataxia may be a rare manifestation of chronic ...
Source: Acta Haematologica - November 15, 2018 Category: Hematology Authors: Shargian-Alon L, Raanani P, Rozovski U, Siegal T, Yust-Katz S, Yeshurun M Tags: Acta Haematol Source Type: research

Spontaneous Regression of Hodgkin Lymphoma: Case Report and Review of the Literature.
We describe a 32-year-old woman with spontaneous regression of HL and review the literature. The patient presented with cervical lymphadenopathy and was diagnosed with stage IIA classical HL. The patient refused to receive any treatment for her disease. Positron emission tomography/computed tomography carried out 2 years later showed complete regression of the lymphadenopathy, without pathological uptake of fluorodeoxyglucose. At the last follow-up, 3.5 years after the initial presentation, the patient is with no evidence of disease. During workup for the HL, concomitant papillary thyroid carcinoma was diagnosed, for which...
Source: Acta Haematologica - November 15, 2018 Category: Hematology Authors: Pasvolsky O, Berger T, Bernstine H, Hayman L, Raanani P, Vidal L Tags: Acta Haematol Source Type: research

Multiparameter Flow Cytometry Identification of Neoplastic Subclones: A New Biomarker in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma
Multiparameter flow cytometry (MFC)-based clonality assessment is a powerful method of diagnosis and follow-up in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). However, the relevance of intraclonal heterogeneity in immunophenotypic studies remains poorly understood. The main objective of this work was to characterize the different immunophenotypic subclones in MGUS and MM patients and to investigate their correlation with disease stages. An 8-color MFC protocol with 17 markers was used to identify the subclones within the neoplastic compartment of 56 MGUS subjects, 151 newly diagnosed...
Source: Acta Haematologica - November 14, 2018 Category: Hematology Source Type: research

Multiparameter Flow Cytometry Identification of Neoplastic Subclones: A New Biomarker in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma.
ez-Miñano C, De Paz F, Verdú-Belmar J, Marco P, Matutes E Abstract Multiparameter flow cytometry (MFC)-based clonality assessment is a powerful method of diagnosis and follow-up in monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). However, the relevance of intraclonal heterogeneity in immunophenotypic studies remains poorly understood. The main objective of this work was to characterize the different immunophenotypic subclones in MGUS and MM patients and to investigate their correlation with disease stages. An 8-color MFC protocol with 17 markers was used to identif...
Source: Acta Haematologica - November 14, 2018 Category: Hematology Authors: Tarín F, López-Castaño F, García-Hernández C, Beneit P, Sarmiento H, Manresa P, Alda O, Villarrubia B, Blanes M, Bernabéu J, Amorós C, Sánchez-Sánchez S, Fernández-Miñano C, De Paz F, Verdú-Belmar J, Marco P, Matutes E Tags: Acta Haematol Source Type: research

Bortezomib Comes to the Rescue: Comment on the Article by Nachmias et al. Entitled “A Bortezomib-Based Protocol Induces a High Rate of CR with Minor Toxicity in Adult Patients with Relapsed/Refractory ALL”
Acta Haematol 2018;140:247 –249 (Source: Acta Haematologica)
Source: Acta Haematologica - November 13, 2018 Category: Hematology Source Type: research

Bortezomib Comes to the Rescue: Comment on the Article by Nachmias et al. Entitled "A Bortezomib-Based Protocol Induces a High Rate of CR with Minor Toxicity in Adult Patients with Relapsed/Refractory ALL".
Bortezomib Comes to the Rescue: Comment on the Article by Nachmias et al. Entitled "A Bortezomib-Based Protocol Induces a High Rate of CR with Minor Toxicity in Adult Patients with Relapsed/Refractory ALL". Acta Haematol. 2018 Nov 13;140(4):247-249 Authors: Messinger YH, Bostrom BC PMID: 30423549 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 13, 2018 Category: Hematology Authors: Messinger YH, Bostrom BC Tags: Acta Haematol Source Type: research

Joint Mobility and Physical Function of Danish Hemophilia Patients: A Three-Wave Panel Study Spanning 24 Years
Conclusions: Significant improvements in joint mobility and physical function have occurred over the last 24 years, but PWH #x3e; 35 years still experience a decline in these areas with age. This decline underscores the importance of life-long treatment and continuous rehabilitation of PWH.Acta Haematol 2018;140:240 –246 (Source: Acta Haematologica)
Source: Acta Haematologica - November 8, 2018 Category: Hematology Source Type: research

Joint Mobility and Physical Function of Danish Hemophilia Patients: A Three-Wave Panel Study Spanning 24 Years.
CONCLUSIONS: Significant improvements in joint mobility and physical function have occurred over the last 24 years, but PWH> 35 years still experience a decline in these areas with age. This decline underscores the importance of life-long treatment and continuous rehabilitation of PWH. PMID: 30408776 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 8, 2018 Category: Hematology Authors: Schnohr C, Bacher T, Andersen T, Lehrmann L, Funding E, Poulsen LH, Holm KB, Bjorner JB Tags: Acta Haematol Source Type: research

< b > < i > JAK2 < /i > < /b > < sup > V617F < /sup > , < b > < i > CALR < /i > < /b > , and < b > < i > MPL < /i > < /b > Mutations and Bone Marrow Histology in Patients with Essential Thrombocythaemia
Conclusions: Distinct morphological patterns were associated with gene mutations in ET, supporting the classification of ET into different subtypes.Acta Haematol 2018;140:234 –239 (Source: Acta Haematologica)
Source: Acta Haematologica - November 7, 2018 Category: Hematology Source Type: research

JAK2V617F, CALR, and MPL Mutations and Bone Marrow Histology in Patients with Essential Thrombocythaemia.
CONCLUSIONS: Distinct morphological patterns were associated with gene mutations in ET, supporting the classification of ET into different subtypes. PMID: 30404086 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 7, 2018 Category: Hematology Authors: Pich A, Riera L, Francia di Celle P, Beggiato E, Benevolo G, Godio L Tags: Acta Haematol Source Type: research

Successful Decitabine Treatment in Unfit, Elderly Patients with Acute Myeloid Leukemia following Chronic Myeloproliferative Neoplasm
Acta Haematol 2018;140:231 –233 (Source: Acta Haematologica)
Source: Acta Haematologica - November 1, 2018 Category: Hematology Source Type: research

Successful Decitabine Treatment in Unfit, Elderly Patients with Acute Myeloid Leukemia following Chronic Myeloproliferative Neoplasm.
PMID: 30384359 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 1, 2018 Category: Hematology Authors: Abruzzese E, Trawinska MM, Neri B, Bondanini F, Fratoni S, Tendas A, Scaramucci L, Siniscalchi A, Giovannini M, Palumbo R, de Fabritiis P, Niscola P Tags: Acta Haematol Source Type: research

Coagulation Disturbances in Patients with Argininemia
Conclusions: Argininemia patients should be investigated for coagulation disorders even if there is no apparent liver dysfunction or major bleeding symptoms.Acta Haematol 2018;140:221 –225 (Source: Acta Haematologica)
Source: Acta Haematologica - October 24, 2018 Category: Hematology Source Type: research

Unmet Needs and Therapeutic Strategies in Cardio-Hemato-Oncology
This article aims to shed light on this field – providing some examples of therapies with cardiotoxic potential as well as the cardiologist’s approach to patient assessment before, during, and after therapy.Acta Haematol 2018;140:226 –230 (Source: Acta Haematologica)
Source: Acta Haematologica - October 24, 2018 Category: Hematology Source Type: research

Coagulation Disturbances in Patients with Argininemia.
CONCLUSIONS: Argininemia patients should be investigated for coagulation disorders even if there is no apparent liver dysfunction or major bleeding symptoms. PMID: 30355940 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - October 24, 2018 Category: Hematology Authors: Kiykim E, Zubarioglu T, Cansever MS, Celkan T, Häberle J, Aktuglu Zeybek AC Tags: Acta Haematol Source Type: research