Burden of Treatment-Induced Peripheral Neuropathy in Patients with Multiple Myeloma in Sweden
Conclusions: Effective MM treatments associated with a reduced incidence of TIPN could result in decreased healthcare expenditure.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - February 25, 2021 Category: Hematology Source Type: research

Deoxycytidine Kinase ( < b > < i > DCK < /i > < /b > ) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine
Resistance to cytarabine is an important cause of therapy failure in persons with acute myeloid leukemia (AML). Deoxycytidine kinase, encoded byDCK, catalyzes phosphorylation of cytarabine to cytarabine monophosphate, a necessary step for eventual incorporation of cytarabine triphosphate into DNA and for clinical efficacy. WhetherDCK mutations make AML cells resistant to cytarabine is controversial. We studiedDCK mutations and messenger RNA (mRNA) concentrations in leukemia cells from 10 subjects with AML who received cytarabine-based therapy and relapsed and in 2 artificially induced cytarabine-resistant AML cell lines.DC...
Source: Acta Haematologica - February 24, 2021 Category: Hematology Source Type: research

Deoxycytidine Kinase (DCK) Mutations in Human Acute Myeloid Leukemia Resistant to Cytarabine
Acta Haematol. 2021 Feb 24:1-8. doi: 10.1159/000513696. Online ahead of print.ABSTRACTResistance to cytarabine is an important cause of therapy failure in persons with acute myeloid leukemia (AML). Deoxycytidine kinase, encoded by DCK, catalyzes phosphorylation of cytarabine to cytarabine monophosphate, a necessary step for eventual incorporation of cytarabine triphosphate into DNA and for clinical efficacy. Whether DCK mutations make AML cells resistant to cytarabine is controversial. We studied DCK mutations and messenger RNA (mRNA) concentrations in leukemia cells from 10 subjects with AML who received cytarabine-based ...
Source: Acta Haematologica - February 24, 2021 Category: Hematology Authors: Biao Wu Zhengwei Jenny Mao Zhi Wang Pin Wu Hongyu Huang Wenjun Zhao Lei Zhang Zhou Zhang Hongchao Yin Robert Peter Gale Bin Yin Source Type: research

Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells
Normal human bone marrow cells are critical for studies of hematopoiesis and as controls to assess toxicity. As cells from commercial vendors are expensive, many laboratories resort to cancer-free bone marrow specimens obtained during staging or to umbilical cord blood cells, which may be abnormal or reflect a much younger age group compared to the disease samples under study. We piloted the use of femoral heads as an alternative and inexpensive source of normal bone marrow. Femoral heads were obtained from 21 successive patients undergoing elective hip arthroplasty. Mononuclear cells (MNCs) were purified with Ficoll, and ...
Source: Acta Haematologica - January 7, 2021 Category: Hematology Source Type: research

Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells
Acta Haematol. 2021 Jan 7:1-7. doi: 10.1159/000511953. Online ahead of print.ABSTRACTNormal human bone marrow cells are critical for studies of hematopoiesis and as controls to assess toxicity. As cells from commercial vendors are expensive, many laboratories resort to cancer-free bone marrow specimens obtained during staging or to umbilical cord blood cells, which may be abnormal or reflect a much younger age group compared to the disease samples under study. We piloted the use of femoral heads as an alternative and inexpensive source of normal bone marrow. Femoral heads were obtained from 21 successive patients undergoin...
Source: Acta Haematologica - January 7, 2021 Category: Hematology Authors: Anthony D Pomicter Phillip M Clair Dongqing Yan William L Heaton Anna M Eiring Michael B Anderson Stephen M Richards Jeremy Gililland Thomas O'Hare Michael W Deininger Source Type: research

Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells
Acta Haematol. 2021 Jan 7:1-7. doi: 10.1159/000511953. Online ahead of print.ABSTRACTNormal human bone marrow cells are critical for studies of hematopoiesis and as controls to assess toxicity. As cells from commercial vendors are expensive, many laboratories resort to cancer-free bone marrow specimens obtained during staging or to umbilical cord blood cells, which may be abnormal or reflect a much younger age group compared to the disease samples under study. We piloted the use of femoral heads as an alternative and inexpensive source of normal bone marrow. Femoral heads were obtained from 21 successive patients undergoin...
Source: Acta Haematologica - January 7, 2021 Category: Hematology Authors: Anthony D Pomicter Phillip M Clair Dongqing Yan William L Heaton Anna M Eiring Michael B Anderson Stephen M Richards Jeremy Gililland Thomas O'Hare Michael W Deininger Source Type: research

Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells.
Abstract Normal human bone marrow cells are critical for studies of hematopoiesis and as controls to assess toxicity. As cells from commercial vendors are expensive, many laboratories resort to cancer-free bone marrow specimens obtained during staging or to umbilical cord blood cells, which may be abnormal or reflect a much younger age group compared to the disease samples under study. We piloted the use of femoral heads as an alternative and inexpensive source of normal bone marrow. Femoral heads were obtained from 21 successive patients undergoing elective hip arthroplasty. Mononuclear cells (MNCs) were purified...
Source: Acta Haematologica - January 7, 2021 Category: Hematology Authors: Pomicter AD, Clair PM, Yan D, Heaton WL, Eiring AM, Anderson MB, Richards SM, Gililland J, O'Hare T, Deininger MW Tags: Acta Haematol Source Type: research

Parvovirus B19 as a Possible Cause of Skin Rash after Allogeneic Transplantation?
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - December 21, 2020 Category: Hematology Source Type: research

Parvovirus B19 as a Possible Cause of Skin Rash after Allogeneic Transplantation?
PMID: 33348335 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - December 21, 2020 Category: Hematology Authors: Fuji S Tags: Acta Haematol Source Type: research

Cytokine and Gene Expression Profiling in Patients with < b > < i > HFE < /i > < /b > -Associated Hereditary Hemochromatosis according to Genetic Profile
Conclusion: Different disease signatures may characterize HH patients according to theirHFE genetic profile. Studies on larger populations, including analyses at protein level, are necessary to confirm these findings.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - December 16, 2020 Category: Hematology Source Type: research

Cytokine and Gene Expression Profiling in Patients with HFE-Associated Hereditary Hemochromatosis according to Genetic Profile.
CONCLUSION: Different disease signatures may characterize HH patients according to their HFE genetic profile. Studies on larger populations, including analyses at protein level, are necessary to confirm these findings. PMID: 33326952 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - December 16, 2020 Category: Hematology Authors: Grønlien HK, Christoffersen TE, Nystrand CF, Garabet L, Syvertsen T, Moe MK, Olstad OK, Jonassen CM Tags: Acta Haematol Source Type: research

Management and Outcome of Venous Thrombosis in Patients with Myeloproliferative Neoplasms: Data from the Israeli MPN Working Group
The BCR-ABL-negative myeloproliferative neoplasms (MPN) are associated with high incidence of venous thrombosis and a significant rate of recurrent events, but there is no consensus regarding their management. In this retrospective study, we analyzed 96 patients with MPN-related venous thrombosis. The index venous thrombosis occurred at a median age of 58 years (IQR 37 –71), with 58% of the events involving unusual sites. Patients who were on antiplatelet agents at the time of index thrombosis tended to be older than patients who were not receiving antiplatelets at the time of index thrombosis. The majority of index ...
Source: Acta Haematologica - December 14, 2020 Category: Hematology Source Type: research

Management and Outcome of Venous Thrombosis in Patients with Myeloproliferative Neoplasms: Data from the Israeli MPN Working Group.
Abstract The BCR-ABL-negative myeloproliferative neoplasms (MPN) are associated with high incidence of venous thrombosis and a significant rate of recurrent events, but there is no consensus regarding their management. In this retrospective study, we analyzed 96 patients with MPN-related venous thrombosis. The index venous thrombosis occurred at a median age of 58 years (IQR 37-71), with 58% of the events involving unusual sites. Patients who were on antiplatelet agents at the time of index thrombosis tended to be older than patients who were not receiving antiplatelets at the time of index thrombosis. The majorit...
Source: Acta Haematologica - December 14, 2020 Category: Hematology Authors: Gutwein O, Lavi N, Barzilai M, Shacham-Abulafia A, Leader A, Chubar E, Dally N, Shapira S, Mishchenko E, Ellis M, Koren-Michowitz M Tags: Acta Haematol Source Type: research

Phase II, Multicenter, Single-Arm, Open-Label Study to Evaluate the Efficacy and Safety of Panobinostat in Combination with Bortezomib and Dexamethasone in Japanese Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma
Conclusion: The study met the primary objective with 48.4% CR + nCR rate. The AEs associated with the combination treatment were safely managed using the existing AE management guidelines, including dose interruption/modification and/or supportive medical intervention. This treatment regimen is an effective option with a favorable benefit/risk profile for Japanese patients with relapsed/refractory MM.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - December 4, 2020 Category: Hematology Source Type: research

Phase II, Multicenter, Single-Arm, Open-Label Study to Evaluate the Efficacy and Safety of Panobinostat in Combination with Bortezomib and Dexamethasone in Japanese Patients with Relapsed or Relapsed-and-Refractory Multiple Myeloma.
CONCLUSION: The study met the primary objective with 48.4% CR + nCR rate. The AEs associated with the combination treatment were safely managed using the existing AE management guidelines, including dose interruption/modification and/or supportive medical intervention. This treatment regimen is an effective option with a favorable benefit/risk profile for Japanese patients with relapsed/refractory MM. PMID: 33279887 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - December 4, 2020 Category: Hematology Authors: Suzuki K, Sunami K, Matsumoto M, Maki A, Shimada F, Suzuki K, Shimizu K Tags: Acta Haematol Source Type: research

Prognostic Impact of Peripheral Blood T-Cell Subsets at the Time of Diagnosis on Survival in Patients with Diffuse Large B-Cell Lymphoma
Conclusion: This study showed an association between circulating lymphocyte subsets including Th cells, Tregs, and NK cells and clinical outcomes in DLBCL; however, further confirmation is needed via prospective trials.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - December 3, 2020 Category: Hematology Source Type: research

Antigen Expression Varies Significantly between Molecular Subgroups of Acute Myeloid Leukemia Patients: Clinical Applicability Is Hampered by Establishment of Relevant Cutoffs
Conclusion: The value of immunophenotypes as surrogate markers for mutational status in AML seems limited when employing CD123 and CLEC12A in combination with CD34 and CD117. Defining relevant cutoffs for given markers is challenging and hampered by variation between laboratories and patient groups.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - December 3, 2020 Category: Hematology Source Type: research

Role of Inherited Thrombophilia Risk Factors in Patients with CKD-5 Receiving Haemodialysis
Conclusion: The FVL mutation may act as a risk factor for CKD. This study increases our understanding of molecular mechanisms in the pathogenesis of CKD of unknown aetiology. Τhe presence of thrombophilic mutations did not affect the overall survival of patients with CKD-5. This finding probably reflects the effect of medical care on patient outcomes.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - December 3, 2020 Category: Hematology Source Type: research

Prognostic Impact of Peripheral Blood T-Cell Subsets at the Time of Diagnosis on Survival in Patients with Diffuse Large B-Cell Lymphoma.
Abstract INTRODUCTION: The effects of lymphocyte subtypes, including helper (Th), natural killer (NK), and regulatory (Treg) cells, and other T-cell subtypes on treatment outcomes in diffuse large B-cell lymphoma (DLBCL) patients are not clearly established. METHODS: Among 151 consecutive patients diagnosed with DLBCL, we collected peripheral blood samples at diagnosis from 91 patients who received at least 1 cycle of R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab) chemotherapy and analyzed lymphocyte subsets by flow cytometry. RESULTS: DLBCL patients had a higher propo...
Source: Acta Haematologica - December 3, 2020 Category: Hematology Authors: Shin HJ, Kim DY, Chung J, Shin KH, Lee H Tags: Acta Haematol Source Type: research

Antigen Expression Varies Significantly between Molecular Subgroups of Acute Myeloid Leukemia Patients: Clinical Applicability Is Hampered by Establishment of Relevant Cutoffs.
CONCLUSION: The value of immunophenotypes as surrogate markers for mutational status in AML seems limited when employing CD123 and CLEC12A in combination with CD34 and CD117. Defining relevant cutoffs for given markers is challenging and hampered by variation between laboratories and patient groups. PMID: 33271547 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - December 3, 2020 Category: Hematology Authors: Herborg LL, Nederby L, Brøndum RF, Hansen M, Hokland P, Roug AS Tags: Acta Haematol Source Type: research

Role of Inherited Thrombophilia Risk Factors in Patients with CKD-5 Receiving Haemodialysis.
CONCLUSION: The FVL mutation may act as a risk factor for CKD. This study increases our understanding of molecular mechanisms in the pathogenesis of CKD of unknown aetiology. Τhe presence of thrombophilic mutations did not affect the overall survival of patients with CKD-5. This finding probably reflects the effect of medical care on patient outcomes. PMID: 33271555 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - December 3, 2020 Category: Hematology Authors: Liapi D, Sfiridaki A, Livadiotaki A, Alegakis A, Stylianou K, Manika I, Renieri V, Daphnis E, Alexandrakis M Tags: Acta Haematol Source Type: research

Contents Vol. 143, 2020
Acta Haematol 2020;143:I –VI (Source: Acta Haematologica)
Source: Acta Haematologica - December 1, 2020 Category: Hematology Source Type: research

Acknowledgement to Referees
Acta Haematol 2020;143:605 –606 (Source: Acta Haematologica)
Source: Acta Haematologica - December 1, 2020 Category: Hematology Source Type: research

The Role of Iron Staining in Myelodysplastic Syndromes: A Treasure Trove of Information
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - November 30, 2020 Category: Hematology Source Type: research

Erratum
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - November 30, 2020 Category: Hematology Source Type: research

The Role of Iron Staining in Myelodysplastic Syndromes: A Treasure Trove of Information.
PMID: 33254167 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 30, 2020 Category: Hematology Authors: Marchi G, Busti F, Girelli D Tags: Acta Haematol Source Type: research

Consolidation Treatment for Primary Central Nervous System Lymphoma: Which Modality for Whom?
Primary central nervous system lymphoma is a rare aggressive disease that largely affects elderly patients and is associated with poor prognosis. The optimal treatment approach is not yet defined and it consists of induction and consolidation phases. The combination of high-dose (HD) methotrexate-based chemotherapy followed by whole-brain radiotherapy (WBRT) prolongs the median progression-free survival (PFS) and overall survival 2- to 3-fold as compared to WBRT alone but is associated with significant delayed neurotoxicity. Alternative strategies are being investigated in order to improve disease outcomes and spare patien...
Source: Acta Haematologica - November 26, 2020 Category: Hematology Source Type: research

Consolidation Treatment for Primary Central Nervous System Lymphoma: Which Modality for Whom?
Abstract Primary central nervous system lymphoma is a rare aggressive disease that largely affects elderly patients and is associated with poor prognosis. The optimal treatment approach is not yet defined and it consists of induction and consolidation phases. The combination of high-dose (HD) methotrexate-based chemotherapy followed by whole-brain radiotherapy (WBRT) prolongs the median progression-free survival (PFS) and overall survival 2- to 3-fold as compared to WBRT alone but is associated with significant delayed neurotoxicity. Alternative strategies are being investigated in order to improve disease outcome...
Source: Acta Haematologica - November 26, 2020 Category: Hematology Authors: Bairey O, Shargian-Alon L, Siegal T Tags: Acta Haematol Source Type: research

Discontinuation of Maintenance Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia outside of Transplant
Conclusion: TKI discontinuation outside of HSCT in Ph-positive ALL in the setting of compelling toxicity may be safe only among a highly selected group of patients with deep and prolonged DMR undergoing close and frequent monitoring. Validation of these findings in prospective clinical trials is highly needed.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - November 25, 2020 Category: Hematology Source Type: research

Current Treatment of Refractory/Relapsed Chronic Lymphocytic Leukemia: A Focus on Novel Drugs
Recently, the use of novel targeted drugs has changed the treatment paradigms in chronic lymphocytic leukemia (CLL). Among the several drugs used for the management of relapsed/refractory (R/R) CLL, Bruton tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphatidylinositol 3-kinase inhibitors (idelalisib and duvelisib), B-cell lymphoma 2 inhibitor (venetoclax), and novel CD20 monoclonal antibodies have demonstrated the greatest improvements in survival among R/R CLL patients. However, patients with relapsed but asymptomatic CLL do not need immediate alternative treatment and should be observed until evident sign...
Source: Acta Haematologica - November 25, 2020 Category: Hematology Source Type: research

Absolute Immature Platelet Counts Suggest Platelet Production Suppression during Complicated Relapsing Thrombotic Thrombocytopenic Purpura
Absolute immature platelet counts (A-IPC) aid in diagnosis and treatment follow-up in thrombotic thrombocytopenic purpura (TTP). A-IPC was used to follow a patient on mycophenolate mofetil (MMF) maintenance therapy treated with a prolonged therapeutic plasma exchange (TPE) regimen for relapsing TTP. On admission, the platelet (PLT) count was 95 × 109/L declining to 14 × 109/L in 5 days. Daily TPE was initiated for suspected TTP, and MMF was discontinued. A-IPC and PLT count were 1 × 109/L and 14 × 109/L, respectively, prior to first TPE. A-IPC improved to 3.2 × 109/L with 1 TPE, and on day 5, ...
Source: Acta Haematologica - November 25, 2020 Category: Hematology Source Type: research

Discontinuation of Maintenance Tyrosine Kinase Inhibitors in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia outside of Transplant.
Abstract BACKGROUND: The addition of tyrosine kinase inhibitors (TKIs) to chemotherapy has dramatically improved outcomes of patients with Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). When allogeneic hematopoietic stem cell transplant (HSCT) is performed, maintenance TKI is generally given for a fixed duration. However, the optimal duration of TKI outside of HSCT remains unknown, and the common practice is to continue indefinitely. Here, we report characteristics and outcomes of 9 patients treated with chemotherapy + TKI without HSCT and later discontinued TKI. METHODS: Among 188 ...
Source: Acta Haematologica - November 25, 2020 Category: Hematology Authors: Samra B, Kantarjian HM, Sasaki K, Alotaibi AS, Konopleva M, O'Brien S, Ferrajoli A, Garris R, Nunez CA, Kadia TM, Short NJ, Jabbour E Tags: Acta Haematol Source Type: research

Current Treatment of Refractory/Relapsed Chronic Lymphocytic Leukemia: A Focus on Novel Drugs.
Abstract Recently, the use of novel targeted drugs has changed the treatment paradigms in chronic lymphocytic leukemia (CLL). Among the several drugs used for the management of relapsed/refractory (R/R) CLL, Bruton tyrosine kinase inhibitors (ibrutinib and acalabrutinib), phosphatidylinositol 3-kinase inhibitors (idelalisib and duvelisib), B-cell lymphoma 2 inhibitor (venetoclax), and novel CD20 monoclonal antibodies have demonstrated the greatest improvements in survival among R/R CLL patients. However, patients with relapsed but asymptomatic CLL do not need immediate alternative treatment and should be observed ...
Source: Acta Haematologica - November 25, 2020 Category: Hematology Authors: Smolewski P, Robak T Tags: Acta Haematol Source Type: research

Absolute Immature Platelet Counts Suggest Platelet Production Suppression during Complicated Relapsing Thrombotic Thrombocytopenic Purpura.
Abstract Absolute immature platelet counts (A-IPC) aid in diagnosis and treatment follow-up in thrombotic thrombocytopenic purpura (TTP). A-IPC was used to follow a patient on mycophenolate mofetil (MMF) maintenance therapy treated with a prolonged therapeutic plasma exchange (TPE) regimen for relapsing TTP. On admission, the platelet (PLT) count was 95 × 109/L declining to 14 × 109/L in 5 days. Daily TPE was initiated for suspected TTP, and MMF was discontinued. A-IPC and PLT count were 1 × 109/L and 14 × 109/L, respectively, prior to first TPE. A-IPC improved to 3.2 × 109/L with 1 T...
Source: Acta Haematologica - November 25, 2020 Category: Hematology Authors: Kundrapu S, Reeves HM, Maitta RW Tags: Acta Haematol Source Type: research

Total Platelet Transcriptomics and Its Network Analysis by RNA-Seq and miRNA-Seq and PCA Application in Essential Thrombocythaemia
Differentiating the aetiology of thrombocytosis is limited yet crucial in patients with essential thrombocythaemia (ET). MicroRNAs (miRNAs) regulate haematopoiesis and lineage commitment; aberrant expression of miRNAs plays an important role in myeloproliferative neoplasms. However, the miRNA profile has been poorly explored in ET patients compared to patients with reactive thrombocytosis (RT). A total of 9 samples, including 5 ET patient samples, 2 RT patient samples, and 2 healthy control samples, were analysed in this study. We produced 81.43 million reads from transcripts and 59.60 million reads from small RNAs. We gen...
Source: Acta Haematologica - November 23, 2020 Category: Hematology Source Type: research

Total Platelet Transcriptomics and Its Network Analysis by RNA-Seq and miRNA-Seq and PCA Application in Essential Thrombocythaemia.
Abstract Differentiating the aetiology of thrombocytosis is limited yet crucial in patients with essential thrombocythaemia (ET). MicroRNAs (miRNAs) regulate haematopoiesis and lineage commitment; aberrant expression of miRNAs plays an important role in myeloproliferative neoplasms. However, the miRNA profile has been poorly explored in ET patients compared to patients with reactive thrombocytosis (RT). A total of 9 samples, including 5 ET patient samples, 2 RT patient samples, and 2 healthy control samples, were analysed in this study. We produced 81.43 million reads from transcripts and 59.60 million reads from ...
Source: Acta Haematologica - November 23, 2020 Category: Hematology Authors: Moon KC, Gim JA, Kim DS, Choi CW, Yoon J, Yoon SY Tags: Acta Haematol Source Type: research

Association between Platelet-Associated Immunoglobulin G Levels and Response to Corticosteroid Therapy in Patients with Newly Diagnosed Immune Thrombocytopenia
Conclusion: Our data suggested that PA-IgG at diagnosis could offer a useful predictor of response to first-line corticosteroid therapy for ITP.Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - November 20, 2020 Category: Hematology Source Type: research

Hematological Manifestations among Patients with Rheumatic Diseases
Background: Rheumatic diseases have many hematological manifestations. Blood dyscrasias and other hematological abnormalities are sometimes the first sign of rheumatic disease. In addition, novel antirheumatic biological agents may cause cytopenias.Summary: The aim of this review was to discuss cytopenias caused by systemic lupus erythematosus and antirheumatic drugs, Felty ’s syndrome in rheumatoid arthritis, and autoimmune hemolytic anemia, thrombosis, and thrombotic microangiopathies related to rheumatological conditions such as catastrophic antiphospholipid syndrome and scleroderma renal crisis.Key Message: The d...
Source: Acta Haematologica - November 20, 2020 Category: Hematology Source Type: research

Current Understandings of Myeloid Differentiation Inducers in Leukemia Therapy
Differentiation therapy using all-trans retinoic acid for acute promyelocytic leukemia (APL) is well established. Several attempts have been made to treat non-APL, AML patients by employing differentiation inducers, such as hypomethylating agents (HMAs), and low-dose cytarabine (Ara-C) (LDAC), with encouraging results. Other than HMAs and LDAC, various inducers of myeloid cell differentiation have been identified. This review describes and categorizes these inducers, which include glycosylation modifiers, epigenetic modifiers, vitamin derivatives, cytokines, and chemotherapeutic agents. Some of these inducers are currently...
Source: Acta Haematologica - November 20, 2020 Category: Hematology Source Type: research

Association between Platelet-Associated Immunoglobulin G Levels and Response to Corticosteroid Therapy in Patients with Newly Diagnosed Immune Thrombocytopenia.
CONCLUSION: Our data suggested that PA-IgG at diagnosis could offer a useful predictor of response to first-line corticosteroid therapy for ITP. PMID: 33221796 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 20, 2020 Category: Hematology Authors: Saburi M, Ogata M, Soga Y, Satou T, Itani K, Kohno K, Nakayama T Tags: Acta Haematol Source Type: research

Hematological Manifestations among Patients with Rheumatic Diseases.
Abstract BACKGROUND: Rheumatic diseases have many hematological manifestations. Blood dyscrasias and other hematological abnormalities are sometimes the first sign of rheumatic disease. In addition, novel antirheumatic biological agents may cause cytopenias. SUMMARY: The aim of this review was to discuss cytopenias caused by systemic lupus erythematosus and antirheumatic drugs, Felty's syndrome in rheumatoid arthritis, and autoimmune hemolytic anemia, thrombosis, and thrombotic microangiopathies related to rheumatological conditions such as catastrophic antiphospholipid syndrome and scleroderma renal crisis. ...
Source: Acta Haematologica - November 20, 2020 Category: Hematology Authors: Klein A, Molad Y Tags: Acta Haematol Source Type: research

Current Understandings of Myeloid Differentiation Inducers in Leukemia Therapy.
Abstract Differentiation therapy using all-trans retinoic acid for acute promyelocytic leukemia (APL) is well established. Several attempts have been made to treat non-APL, AML patients by employing differentiation inducers, such as hypomethylating agents (HMAs), and low-dose cytarabine (Ara-C) (LDAC), with encouraging results. Other than HMAs and LDAC, various inducers of myeloid cell differentiation have been identified. This review describes and categorizes these inducers, which include glycosylation modifiers, epigenetic modifiers, vitamin derivatives, cytokines, and chemotherapeutic agents. Some of these indu...
Source: Acta Haematologica - November 20, 2020 Category: Hematology Authors: Takahashi S Tags: Acta Haematol Source Type: research

Myeloid Neoplasms with Eosinophilia: Rare Entities with Emerging Diagnostic and Therapeutic Challenges
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - November 18, 2020 Category: Hematology Source Type: research

Myeloid Neoplasms with Eosinophilia: Rare Entities with Emerging Diagnostic and Therapeutic Challenges.
PMID: 33207337 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 18, 2020 Category: Hematology Authors: Benevolo G, Urbino I Tags: Acta Haematol Source Type: research

Adherence to Immunization: Rebuttal of Vaccine Hesitancy
Immunizations have been saving the lives of millions of people since they were first used by Edward Jenner in 1796, and new vaccines are being developed all the time. Hopefully, a new vaccine for coronavirus disease 2019 (COVID-19) will be developed in the near future, and perhaps even one for human immunodeficiency virus. Although the effectiveness of vaccinations has been proven over the years and adverse effects to currently available vaccinations are extremely rare, many people continue to defer immunizations for themselves and their families. According to the World Health Organization (WHO), this phenomenon, known as ...
Source: Acta Haematologica - November 17, 2020 Category: Hematology Source Type: research

Adherence to Immunization: Rebuttal of Vaccine Hesitancy.
Abstract Immunizations have been saving the lives of millions of people since they were first used by Edward Jenner in 1796, and new vaccines are being developed all the time. Hopefully, a new vaccine for coronavirus disease 2019 (COVID-19) will be developed in the near future, and perhaps even one for human immunodeficiency virus. Although the effectiveness of vaccinations has been proven over the years and adverse effects to currently available vaccinations are extremely rare, many people continue to defer immunizations for themselves and their families. According to the World Health Organization (WHO), this phe...
Source: Acta Haematologica - November 17, 2020 Category: Hematology Authors: Etzioni-Friedman T, Etzioni A Tags: Acta Haematol Source Type: research

Is G-CSF Dangerous in COVID-19: Why Not Use GM-CSF?
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - November 6, 2020 Category: Hematology Source Type: research

Is G-CSF Dangerous in COVID-19: Why Not Use GM-CSF?
PMID: 33161397 [PubMed - as supplied by publisher] (Source: Acta Haematologica)
Source: Acta Haematologica - November 6, 2020 Category: Hematology Authors: Lazarus HM, Gale RP Tags: Acta Haematol Source Type: research

The Reality of Pixantrone in Real Life
Acta Haematol (Source: Acta Haematologica)
Source: Acta Haematologica - October 20, 2020 Category: Hematology Source Type: research