Sustained Response to Ruxolitinib of Eosinophilia-Associated Myeloproliferative Neoplasm with Translocation t(8;9)(p21;p24)
Acta Haematol. 2023 Aug 10:1-4. doi: 10.1159/000510281. Online ahead of print.ABSTRACTThe translocation t(8;9) produces the fusion gene PCM1-JAK2, resulting in the continuous activation of the JAK2 tyrosine kinase. Myelodysplastic/myeloproliferative neoplasms are the most common disease with t(8;9)/PCM1-JAK2. Individuals with this abnormality have similar features, and JAK2 kinase inhibitor (ruxolitinib) is an effective treatment of the condition. The long-term remission results of ruxolitinib are varied. It is important to determine the response to ruxolitinib. Here, we describe a patient who has been diagnosed with eosin...
Source: Acta Haematologica - August 10, 2023 Category: Hematology Authors: Ping Cai Suhui Liu Lijuan Duan Li Huo Depei Wu Suning Chen Ruyu Yang Xiaofei Yang Source Type: research
Sustained Response to Ruxolitinib of Eosinophilia-Associated Myeloproliferative Neoplasm with Translocation t(8;9)(p21;p24)
Acta Haematol. 2023 Aug 10:1-4. doi: 10.1159/000510281. Online ahead of print.ABSTRACTThe translocation t(8;9) produces the fusion gene PCM1-JAK2, resulting in the continuous activation of the JAK2 tyrosine kinase. Myelodysplastic/myeloproliferative neoplasms are the most common disease with t(8;9)/PCM1-JAK2. Individuals with this abnormality have similar features, and JAK2 kinase inhibitor (ruxolitinib) is an effective treatment of the condition. The long-term remission results of ruxolitinib are varied. It is important to determine the response to ruxolitinib. Here, we describe a patient who has been diagnosed with eosin...
Source: Acta Haematologica - August 10, 2023 Category: Hematology Authors: Ping Cai Suhui Liu Lijuan Duan Li Huo Depei Wu Suning Chen Ruyu Yang Xiaofei Yang Source Type: research
Sustained Response to Ruxolitinib of Eosinophilia-Associated Myeloproliferative Neoplasm with Translocation t(8;9)(p21;p24)
Acta Haematol. 2023 Aug 10:1-4. doi: 10.1159/000510281. Online ahead of print.ABSTRACTThe translocation t(8;9) produces the fusion gene PCM1-JAK2, resulting in the continuous activation of the JAK2 tyrosine kinase. Myelodysplastic/myeloproliferative neoplasms are the most common disease with t(8;9)/PCM1-JAK2. Individuals with this abnormality have similar features, and JAK2 kinase inhibitor (ruxolitinib) is an effective treatment of the condition. The long-term remission results of ruxolitinib are varied. It is important to determine the response to ruxolitinib. Here, we describe a patient who has been diagnosed with eosin...
Source: Acta Haematologica - August 10, 2023 Category: Hematology Authors: Ping Cai Suhui Liu Lijuan Duan Li Huo Depei Wu Suning Chen Ruyu Yang Xiaofei Yang Source Type: research
A case report of Chronic myelogenous leukemia presenting as blastic crisis with a T-cell acute lymphoblastic leukemia phenotype: Awareness of a rare entity
Acta Haematol. 2023 Aug 9. doi: 10.1159/000529911. Online ahead of print.ABSTRACTChronic Myelogenous leukemia at blast crisis with a T-cell phenotype (T-ALL CML-BC ) at diagnosis, without any prior history of CML is extremely rare. After the introduction of TKIs, CML patients have a median survival comparable to general population and accelerated/blast crisis are rarely encountered. Most CML patients (80%) transform into AML and the rest into B-ALL. Anecdotal cases of Ph+ T-ALL, either de novo or in the context of CML BC have been reported .Left shift in the blood, the presence of splenomegaly/extramedullary infiltration a...
Source: Acta Haematologica - August 9, 2023 Category: Hematology Authors: Maria Efstathopoulou Katerina Zoi Marina P Siakantaris Daphne Koumbi Anna Zannou Evangelia-Faidra Triantafyllou Gerassimos Tsourouflis Eleftheria Lakiotaki Theodoros Vassilakopoulos Maria K Angelopoulou Source Type: research
The impact of thrombocytopenia and lymphopenia on mortality in patients infected with Influenza virus - a retrospective cohort study
Conclusion Patients hospitalized with seasonal influenza and thrombocytopenia < 100K/mL on admission, have an increased 30-days all-cause mortality.PMID:37557088 | DOI:10.1159/000533466 (Source: Acta Haematologica)
Source: Acta Haematologica - August 9, 2023 Category: Hematology Authors: Adi Sherban Ragda Hussen Anat Gafter-Gvili Alla Atamna Jihad Bishara Pia Raanani Kim Ben Tikva Kagan Tomer Avni Source Type: research
Consensus statements highlight the need of harmonizing CLL management worldwide
Acta Haematol. 2023 Aug 7. doi: 10.1159/000533349. Online ahead of print.NO ABSTRACTPMID:37549650 | DOI:10.1159/000533349 (Source: Acta Haematologica)
Source: Acta Haematologica - August 7, 2023 Category: Hematology Authors: Stefano Molica Marco Rossi David Allsup Source Type: research
Consensus statements highlight the need of harmonizing CLL management worldwide
Acta Haematol. 2023 Aug 7. doi: 10.1159/000533349. Online ahead of print.NO ABSTRACTPMID:37549650 | DOI:10.1159/000533349 (Source: Acta Haematologica)
Source: Acta Haematologica - August 7, 2023 Category: Hematology Authors: Stefano Molica Marco Rossi David Allsup Source Type: research
Consensus statements highlight the need of harmonizing CLL management worldwide
Acta Haematol. 2023 Aug 7. doi: 10.1159/000533349. Online ahead of print.NO ABSTRACTPMID:37549650 | DOI:10.1159/000533349 (Source: Acta Haematologica)
Source: Acta Haematologica - August 7, 2023 Category: Hematology Authors: Stefano Molica Marco Rossi David Allsup Source Type: research
Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research
Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research
Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research
Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research
Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research
Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research
Clinical outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome
CONCLUSION: Patients with MF/SS do not necessarily have worse COVID-19 outcomes compared to the general population.PMID:37517402 | DOI:10.1159/000531831 (Source: Acta Haematologica)
Source: Acta Haematologica - July 30, 2023 Category: Hematology Authors: Ilana Levy Yurkovski Lior Rokach Guy Melamed Hillel Alapi Sivan Gazit Tal Patalon Tamar Tadmor Source Type: research
