Fluoroquinolone Prophylaxis During Conventional Chemotherapy or Hematopoietic Stem Cell Transplantation for Acute Leukemia - Pros and Cons
This article reviews the pros and cons of FQ prophylaxis mainly in patients with AL. Most current guidelines do not support universal prophylaxis but rather recommend a selective approach, weighing the benefits against the risks. This recommendation is based on the lack of mortality benefit reported in more recent meta-analyses. FQ prophylaxis was demonstrated to reduce bacteremia and febrile neutropenia episodes, although mostly in trials performed in low resistance settings (<20%), whereas current FQ resistance rates may reach 30-60%. Other disadvantages of FQ include potential adverse events, antibiotic resistance de...
Source: Acta Haematologica - November 21, 2023 Category: Hematology Authors: Tomer Hoffman Alaa Atamna Vladislav Litchevsky Irina Amitai Dafna Yahav Source Type: research
The role of hepcidin and an oral iron absorption test in identifying the root cause of iron-restricted anemia
CONCLUSION: OIAT differentiates between classical IDA and other types of anemia caused by abnormalities in iron absorption or systemic iron availability. Additionally, elevated hepcidin in patients with oral iron malabsorption could indicate IRIDA.PMID:37972576 | DOI:10.1159/000535275 (Source: Acta Haematologica)
Source: Acta Haematologica - November 16, 2023 Category: Hematology Authors: Roberta Loveikyte Yascha van den Berg Andrea van der Meulen-de Jong Lodewijk Thomas Vlasveld Source Type: research
The role of hepcidin and an oral iron absorption test in identifying the root cause of iron-restricted anemia
CONCLUSION: OIAT differentiates between classical IDA and other types of anemia caused by abnormalities in iron absorption or systemic iron availability. Additionally, elevated hepcidin in patients with oral iron malabsorption could indicate IRIDA.PMID:37972576 | DOI:10.1159/000535275 (Source: Acta Haematologica)
Source: Acta Haematologica - November 16, 2023 Category: Hematology Authors: Roberta Loveikyte Yascha van den Berg Andrea van der Meulen-de Jong Lodewijk Thomas Vlasveld Source Type: research
The role of hepcidin and an oral iron absorption test in identifying the root cause of iron-restricted anemia
CONCLUSION: OIAT differentiates between classical IDA and other types of anemia caused by abnormalities in iron absorption or systemic iron availability. Additionally, elevated hepcidin in patients with oral iron malabsorption could indicate IRIDA.PMID:37972576 | DOI:10.1159/000535275 (Source: Acta Haematologica)
Source: Acta Haematologica - November 16, 2023 Category: Hematology Authors: Roberta Loveikyte Yascha van den Berg Andrea van der Meulen-de Jong Lodewijk Thomas Vlasveld Source Type: research
The role of hepcidin and an oral iron absorption test in identifying the root cause of iron-restricted anemia
CONCLUSION: OIAT differentiates between classical IDA and other types of anemia caused by abnormalities in iron absorption or systemic iron availability. Additionally, elevated hepcidin in patients with oral iron malabsorption could indicate IRIDA.PMID:37972576 | DOI:10.1159/000535275 (Source: Acta Haematologica)
Source: Acta Haematologica - November 16, 2023 Category: Hematology Authors: Roberta Loveikyte Yascha van den Berg Andrea van der Meulen-de Jong Lodewijk Thomas Vlasveld Source Type: research
Tumor lysis syndrome is associated with worse outcomes in adult patients with acute lymphoblastic leukemia
CONCLUSION: TLS was identified in almost a third of ALL patients during induction therapy. Different thresholds for LDH value and WBC count as well as other variables that could identify patients at risk to developing this complication, which is associated with shorter OS. C-TLS confers a higher risk for mortality during induction.PMID:37963436 | DOI:10.1159/000534453 (Source: Acta Haematologica)
Source: Acta Haematologica - November 14, 2023 Category: Hematology Authors: Fausto A Rios-Olais Fernando Gil-Lopez Analy Mora-Ca ñas Roberta Demichelis-G ómez Source Type: research
Tumor lysis syndrome is associated with worse outcomes in adult patients with acute lymphoblastic leukemia
CONCLUSION: TLS was identified in almost a third of ALL patients during induction therapy. Different thresholds for LDH value and WBC count as well as other variables that could identify patients at risk to developing this complication, which is associated with shorter OS. C-TLS confers a higher risk for mortality during induction.PMID:37963436 | DOI:10.1159/000534453 (Source: Acta Haematologica)
Source: Acta Haematologica - November 14, 2023 Category: Hematology Authors: Fausto A Rios-Olais Fernando Gil-Lopez Analy Mora-Ca ñas Roberta Demichelis-G ómez Source Type: research
A Rare Clinical Case of Secondary Central Nervous System Involvement without Transformation in Hairy Cell Leukemia: Case Report and Literature Review
Conclusion We report a case of a rare clinical presentation of SCNSI in HCL with literature review.PMID:37952510 | DOI:10.1159/000535066 (Source: Acta Haematologica)
Source: Acta Haematologica - November 12, 2023 Category: Hematology Authors: Kenichi Ito Kunihiko Harada Yoshihito Uchino Kazuhiko Hirano Naohiro Sekiguchi Source Type: research
A Rare Clinical Case of Secondary Central Nervous System Involvement without Transformation in Hairy Cell Leukemia: Case Report and Literature Review
Conclusion We report a case of a rare clinical presentation of SCNSI in HCL with literature review.PMID:37952510 | DOI:10.1159/000535066 (Source: Acta Haematologica)
Source: Acta Haematologica - November 12, 2023 Category: Hematology Authors: Kenichi Ito Kunihiko Harada Yoshihito Uchino Kazuhiko Hirano Naohiro Sekiguchi Source Type: research
A Rare Clinical Case of Secondary Central Nervous System Involvement without Transformation in Hairy Cell Leukemia: Case Report and Literature Review
Conclusion We report a case of a rare clinical presentation of SCNSI in HCL with literature review.PMID:37952510 | DOI:10.1159/000535066 (Source: Acta Haematologica)
Source: Acta Haematologica - November 12, 2023 Category: Hematology Authors: Kenichi Ito Kunihiko Harada Yoshihito Uchino Kazuhiko Hirano Naohiro Sekiguchi Source Type: research
Shikonin exerts an anti-leukemia effect against FLT3-ITD mutated acute myeloid leukemia cells via targeting FLT3 tyrosine kinase and its downstream pathways
CONCLUSION: The findings of this study indicate that SHK is a promising drug for the treatment of FLT3-ITD mutated AML.PMID:37926079 | DOI:10.1159/000534101 (Source: Acta Haematologica)
Source: Acta Haematologica - November 5, 2023 Category: Hematology Authors: Mu-Nan Zhao Long Su Fei Song Zhi-Feng Wei Tian-Xue Qin Yun-Wei Zhang Wei Li Su-Jun Gao Source Type: research
Shikonin exerts an anti-leukemia effect against FLT3-ITD mutated acute myeloid leukemia cells via targeting FLT3 tyrosine kinase and its downstream pathways
CONCLUSION: The findings of this study indicate that SHK is a promising drug for the treatment of FLT3-ITD mutated AML.PMID:37926079 | DOI:10.1159/000534101 (Source: Acta Haematologica)
Source: Acta Haematologica - November 5, 2023 Category: Hematology Authors: Mu-Nan Zhao Long Su Fei Song Zhi-Feng Wei Tian-Xue Qin Yun-Wei Zhang Wei Li Su-Jun Gao Source Type: research
Shikonin exerts an anti-leukemia effect against FLT3-ITD mutated acute myeloid leukemia cells via targeting FLT3 tyrosine kinase and its downstream pathways
CONCLUSION: The findings of this study indicate that SHK is a promising drug for the treatment of FLT3-ITD mutated AML.PMID:37926079 | DOI:10.1159/000534101 (Source: Acta Haematologica)
Source: Acta Haematologica - November 5, 2023 Category: Hematology Authors: Mu-Nan Zhao Long Su Fei Song Zhi-Feng Wei Tian-Xue Qin Yun-Wei Zhang Wei Li Su-Jun Gao Source Type: research
Shikonin exerts an anti-leukemia effect against FLT3-ITD mutated acute myeloid leukemia cells via targeting FLT3 tyrosine kinase and its downstream pathways
CONCLUSION: The findings of this study indicate that SHK is a promising drug for the treatment of FLT3-ITD mutated AML.PMID:37926079 | DOI:10.1159/000534101 (Source: Acta Haematologica)
Source: Acta Haematologica - November 5, 2023 Category: Hematology Authors: Mu-Nan Zhao Long Su Fei Song Zhi-Feng Wei Tian-Xue Qin Yun-Wei Zhang Wei Li Su-Jun Gao Source Type: research
Shikonin exerts an anti-leukemia effect against FLT3-ITD mutated acute myeloid leukemia cells via targeting FLT3 tyrosine kinase and its downstream pathways
CONCLUSION: The findings of this study indicate that SHK is a promising drug for the treatment of FLT3-ITD mutated AML.PMID:37926079 | DOI:10.1159/000534101 (Source: Acta Haematologica)
Source: Acta Haematologica - November 5, 2023 Category: Hematology Authors: Mu-Nan Zhao Long Su Fei Song Zhi-Feng Wei Tian-Xue Qin Yun-Wei Zhang Wei Li Su-Jun Gao Source Type: research
