A case report of Chronic myelogenous leukemia presenting as blastic crisis with a T-cell acute lymphoblastic leukemia phenotype: Awareness of a rare entity
Acta Haematol. 2023 Aug 9. doi: 10.1159/000529911. Online ahead of print.ABSTRACTChronic Myelogenous leukemia at blast crisis with a T-cell phenotype (T-ALL CML-BC ) at diagnosis, without any prior history of CML is extremely rare. After the introduction of TKIs, CML patients have a median survival comparable to general population and accelerated/blast crisis are rarely encountered. Most CML patients (80%) transform into AML and the rest into B-ALL. Anecdotal cases of Ph+ T-ALL, either de novo or in the context of CML BC have been reported .Left shift in the blood, the presence of splenomegaly/extramedullary infiltration a...
Source: Acta Haematologica - August 9, 2023 Category: Hematology Authors: Maria Efstathopoulou Katerina Zoi Marina P Siakantaris Daphne Koumbi Anna Zannou Evangelia-Faidra Triantafyllou Gerassimos Tsourouflis Eleftheria Lakiotaki Theodoros Vassilakopoulos Maria K Angelopoulou Source Type: research

The impact of thrombocytopenia and lymphopenia on mortality in patients infected with Influenza virus - a retrospective cohort study
Conclusion Patients hospitalized with seasonal influenza and thrombocytopenia < 100K/mL on admission, have an increased 30-days all-cause mortality.PMID:37557088 | DOI:10.1159/000533466 (Source: Acta Haematologica)
Source: Acta Haematologica - August 9, 2023 Category: Hematology Authors: Adi Sherban Ragda Hussen Anat Gafter-Gvili Alla Atamna Jihad Bishara Pia Raanani Kim Ben Tikva Kagan Tomer Avni Source Type: research

Consensus statements highlight the need of harmonizing CLL management worldwide
Acta Haematol. 2023 Aug 7. doi: 10.1159/000533349. Online ahead of print.NO ABSTRACTPMID:37549650 | DOI:10.1159/000533349 (Source: Acta Haematologica)
Source: Acta Haematologica - August 7, 2023 Category: Hematology Authors: Stefano Molica Marco Rossi David Allsup Source Type: research

Consensus statements highlight the need of harmonizing CLL management worldwide
Acta Haematol. 2023 Aug 7. doi: 10.1159/000533349. Online ahead of print.NO ABSTRACTPMID:37549650 | DOI:10.1159/000533349 (Source: Acta Haematologica)
Source: Acta Haematologica - August 7, 2023 Category: Hematology Authors: Stefano Molica Marco Rossi David Allsup Source Type: research

Consensus statements highlight the need of harmonizing CLL management worldwide
Acta Haematol. 2023 Aug 7. doi: 10.1159/000533349. Online ahead of print.NO ABSTRACTPMID:37549650 | DOI:10.1159/000533349 (Source: Acta Haematologica)
Source: Acta Haematologica - August 7, 2023 Category: Hematology Authors: Stefano Molica Marco Rossi David Allsup Source Type: research

Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research

Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research

Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research

Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research

Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research

Busulfan for allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia: A retrospective study
Discussion In children with SAA undergoing allo-HSCT, conditioning regimen with Bu + Flu + Cy + ATG-F is capable of enhancing the myeloablation effect, promoting donor hematopoietic stem cell engraftment, and reducing the graft failure rate. Furthermore, it does not increase the incidence of complications, including GVHD.PMID:37524052 | DOI:10.1159/000531687 (Source: Acta Haematologica)
Source: Acta Haematologica - July 31, 2023 Category: Hematology Authors: Yingjian Si Rongmu Luo Maoquan Qin Zhenlan Du Xiaomei Zhang Ya Wang Wei Chen Wenjing Gu Guosheng Xing Lingsong Dou Wei Cao Zhichun Feng Source Type: research

Clinical outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome
CONCLUSION: Patients with MF/SS do not necessarily have worse COVID-19 outcomes compared to the general population.PMID:37517402 | DOI:10.1159/000531831 (Source: Acta Haematologica)
Source: Acta Haematologica - July 30, 2023 Category: Hematology Authors: Ilana Levy Yurkovski Lior Rokach Guy Melamed Hillel Alapi Sivan Gazit Tal Patalon Tamar Tadmor Source Type: research

Clinical outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome
CONCLUSION: Patients with MF/SS do not necessarily have worse COVID-19 outcomes compared to the general population.PMID:37517402 | DOI:10.1159/000531831 (Source: Acta Haematologica)
Source: Acta Haematologica - July 30, 2023 Category: Hematology Authors: Ilana Levy Yurkovski Lior Rokach Guy Melamed Hillel Alapi Sivan Gazit Tal Patalon Tamar Tadmor Source Type: research

Immune dysfunction and infection - interaction between CLL and treatment A reflection on current treatment paradigms and unmet needs
Acta Haematol. 2023 Jul 27. doi: 10.1159/000533234. Online ahead of print.ABSTRACTBackground Chronic lymphocytic leukemia (CLL) is a hematological malignancy characterized by immune dysfunction, which significantly contributes to increased morbidity and mortality due to infections. Summary Advancement in therapeutic strategies based on combination chemoimmunotherapy and targeted treatment have increased life expectancy for patients affected by CLL. However, mortality and morbidity due to infection showed no improvement over the last decades. Although therapy options are highly efficient in targeting leukemic cells, several...
Source: Acta Haematologica - July 27, 2023 Category: Hematology Authors: Ernesto Gargiulo Rebecca Svanberg Teglgaard Tereza Faitov รก Carsten Utoft Niemann Source Type: research

Erratum
Acta Haematol. 2023;146(2):172. doi: 10.1159/000529163. Epub 2023 Jan 24.NO ABSTRACTPMID:37497945 | DOI:10.1159/000529163 (Source: Acta Haematologica)
Source: Acta Haematologica - July 27, 2023 Category: Hematology Source Type: research