Chemotherapy-initiated cysteine-rich protein 61 decreases acute B-lymphoblastic leukemia chemosensitivity

CONCLUSION: DNR induces Cyr61 production in B-ALL cells, and increased Cyr61 levels reduce the chemosensitivity of B-ALL cells. Consequently, targeting Cyr61 or related ATM signaling pathway may present a promising treatment strategy to enhance the chemosensitivity of patients with B-ALL.PMID:38530432 | DOI:10.1007/s00432-024-05692-8

Source: Cell Research - March 26, 2024 Category: Cytology Authors: Pengchong Shi Zhen Lin Yanfang Song Zhaozhong Li Menglu Zeng Li Luo Yingping Cao Xianjin Zhu Source Type: research