Department of Defense Doubles Cancer Research Funding in 2015
Doctors and researchers seeking a cure for mesothelioma will soon be able to tap into millions of dollars set aside by the U.S. Department of Defense for cancer research. The Office of Congressionally Directed Medical Research Programs (CDMRP) invested $50 million in the Peer Reviewed Cancer Research Program (PRCRP) for 2015 — an amount that doubles the money awarded to the program last year. With the additional funding, asbestos-related cancer researchers can extend current studies and launch new ones to improve traditional treatments, introduce emerging therapies or test new cancer drugs. Funding in 2014 was $25 million. Researchers hold out hope that their military-focused programs will develop the medical advancements that extend life expectancy or develop a cure for U.S. service members and families affected by mesothelioma. Former service members are a prime demographic for development of the rare and fatal cancer. CDMRP spokeswoman Gail Whitehead told Asbestos.com that applicants seeking funding under the 2015 cycle must send in their applications in the fall. Winners for that round will be announced in 2016. The cancer program and CDMRP are funded through the Defense Department. Since its inception, the program has provided nearly $3 million to fund mesothelioma research, according to CDMRP documents. The Peer Reviewed Medical Research Program, also part of CDMRP, pumped $7.7 million into mesothelioma research projects from 2008 to 2010. Ongoing Mesothelioma...
ConclusionsFOSL1 is an independent prognostic biomarker of GC. Detecting FOSL1 expression could help stratify GC patients with high-risk and guide the precious treatment.
In this study, we aimed to investigate the role of IL-6/Stat3 signaling pathway in human endometrial cancer cells invasion and migration. We demonstrated that Stat3 is activated in endometrial cancer cell lines. To investigate the role of Stat3 in endometrial cancer invasive capacity, we used Stat3 inhibitor Stattic and found that Stattic significantly inhibited the migration and invasion of endometrial cancer cells elevated by IL-6. Furthermore, we showed that Stat3 inhibitor significantly decreased the expression of MMP2 enhanced by IL-6, indicating that IL-6 promoted endometrial cancer invasion and migration by Stat3-in...
Publication date: Available online 19 March 2019Source: Pathology - Research and PracticeAuthor(s): Xiaobo He, Ying ShuAbstractIncreasing evidence has shown that dysregulation of mircoRNA (miRNA) is linked to the development and progression of human cancer, including gastric cancer (GC). In the current study, by analysing the GEO database (GSE78091), we found that miR-660 was significantly downregulated in GC. Consistently, quantitative real-time PCR (qRT-PCR) results showed that miR-660 was dramatically decreased in GC tissues and cell lines. Importantly, low miR-660 expression was closely related to larger tumor size (P&...
ConclusionsThe results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients.
Conclusions: DIM is a very rare tumour. The global survival is excellent. Conservative treatment with PT is an efficient alternative to enucleation and allows good local tumour control. Cataract and glaucoma are the main radiation-related complications, but the corneal status was excellent due to the stem cell harvest prior to radiotherapy.Ocul Oncol Pathol
Conclusion: There are no relevant differences between men and women in ocular or patient survival after brachytherapy for uveal melanoma.Ocul Oncol Pathol
Conclusions: Conjunctival melanocytic lesions suspicious for melanocytoma should be bleached to evaluate their cytologic features. CD68 can be helpful in identifying heavily pigmented melanomacrophages which may mimic a melanocytoma. As conjunctival melanocytomas are extremely rare, their pathogenesis may be different from that of other conjunctival nevi.Ocul Oncol Pathol
In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases.
This article discusses a quality improvement project across four NP-owned primary care clinics in which all clinical staff received an educational intervention focused on best vaccination practices and Medicare billing strategies. This project yielded improved vaccination rates in the older adult patient population over a 3-month period.
In states that legalized medical marijuana, there was a 4.8 percent decrease in reported pain for conditions that qualified for pot treatment (cancer, arthritis, glaucoma and pain), compared to states without medical marijuana.
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