Early Trauma and Cognitive Functions of Patients With Schizophrenia

Conclusion: Although a cause–effect relationship cannot be firmly stated, an association between early trauma experience and cognitive impairment such as visual memory, as well as a relationship between negative symptoms and attention domains, is suggested by our preliminary findings. Future studies with larger sample sizes and prospective design will clarify the long-term effects of early exposure to trauma and its clinical meaning in terms of developing psychotic-related illness.IntroductionMore than 75% of patients with schizophrenia show some level of cognitive impairment, leading to poor functional status and impairments in social interaction. Therefore, when there is an improvement in cognition and executive function, there is also an improvement in quality of life, social interactions, and treatment outcomes (1).Thus, cognitive performance in patients with schizophrenia may be related to the illness itself and to endophenotypes, with cognitive profiles indicating traits, which can be developed later on the course of the illness (2). This hypothesis has been supported by studies showing an overlap between cognitive deficits between SZ patients and their relatives. Patients with schizophrenia show a lower performance in neuropsychological tests when compared to both healthy controls and siblings. In addition, overlapping cognitive symptoms in patients with schizophrenia and their siblings seem to appear, with the latter exhibiting milder cognitive impairment, inclu...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research

Related Links:

BACKGROUND: To gain a better understanding of nonfatal injuries in Alaska, underutilized data sources such as workers' compensation claims must be analyzed. The purpose of the current study was to utilize workers' compensation claims data to estimate the r...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
OBJECTIVE: Although suicide is a serious public health concern for adolescents, there is a lack of studies that explore its risk factors in the Republic of Korea. The present study aims to investigate risk factors associated with suicidal behaviors in Kore...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
OBJECTIVES: Mood disorder is highly comorbid with attention deficit/hyperactivity disorder (ADHD), and comorbid ADHD symptoms are associated with suicide risk. The aim of this study was to examine the association between comorbid ADHD symptoms and the numb...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
In this study, we assess the association between polymorphism rs67920064 in ADAMTS9 gene and mandibular retrognathism in a Chinese population. MATERIAL AND METHODS Sixty participants (20 to 45 y, mean age 32.79 y) were classified into Class I or mandibular retrognathism skeletal-facial profile groups in accordance with cephalometric parameters. Thirty patients with mandibular retrognathism were assigned to the subject group; the others were assigned to the control group. Cephalometric parameters including sella-nasion A point, SN point B, condylion-gnathion (Gn), and gonion-Gn were recorded. Saliva samples from these parti...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS Male university students do not know enough about HPV infection, and males' attitudes regarding vaccination are not sufficient. Education should be provided to promote awareness of HPV-associated diseases and vaccination. PMID: 32603317 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
This study aimed to evaluate the Molecular Adsorbent Recirculating System (MARS) effectiveness in patients with alcohol-related acute-on-chronic liver failure (AoCLF) complicated with type 1 hepatorenal syndrome (HRS). So far, MARS efficacy and safety has been demonstrated in various acute liver failure scenarios. MATERIAL AND METHODS Data from 41 MARS procedures (10 patients with type 1 HRS, in the course of alcohol-related AoCLF were considered for this study. Biochemical tests of blood serum were performed before and after each procedure. The condition of patients was determined before and after the treatment with the u...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS 2D-SWE irradiation of neonatal mice for more than 10 minutes downregulated the expression of BDNF. This effect disappeared within 24 hours after the irradiation, and the 2D-SWE scan seemed not to induce neuronal apoptosis. PMID: 32601265 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS For patients with type II and III CSP, hysteroscopy and laparoscopy surgery and reversible ligation of the uterine artery achieved better clinical outcomes than hysteroscopy or curettage with respect to postoperative recovery. This could be suitable for patients with CSP and desire for fertility. PMID: 32595205 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The results of this study suggesting some novel genes may play an important role in the occurrence and progression NAFLD and AMI. But more experimental researches and clinical trials need to verify. PMID: 32594092 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Intracerebroventricular streptozotocin induces behavioral impairments and increases short‑term C3 gene expression in the hippocampus of Wistar rats. Acta Neurobiol Exp (Wars). 2020;80(2):160-171 Authors: Pfutzenreuter G, Nieradka K, Pincerati MR, da Silva IS Abstract A non‑transgenic rat model based on intracerebroventricular injection of streptozotocin (STZ) has been used as an animal model to investigate mechanisms associated to the late onset of sporadic Alzheimer's disease, such as anatomical and behavioral impairments. However, molecular aspects related to gene expression, mainly in the hippo...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
More News: Academia | Accidents | Alcoholism | Anxiety | Autism | Bipolar | Brain | Brazil Health | Child Abuse | Child Development | China Health | Clinical Trials | Depression | Education | Employment | Environmental Health | Genetics | Hyperactivity | Internal Medicine | Laboratory Medicine | Legislation | Mania | Medical Ethics | Men | Neurology | Occupational Health | Panic Disorder | PET Scan | Phobias | Portugal Health | Post Traumatic Stress Disorder | Psychiatry | Psychology | Rehabilitation | Reproduction Medicine | Schizophrenia | Sexual Abuse | Smokers | Social Anxiety Disorder | Spain Health | Statistics | Study | Substance Abuse | Substance Abuse Disorders | Switzerland Health | Universities & Medical Training