Post-surgical Thyroid Bed Pyoderma Gangrenosum Mimicking Recurrent Papillary Thyroid Carcinoma

Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG. Introduction Papillary thyroid carcinoma (PTC), the main variant of differentiated thyroid carcinoma (DTC), is the most common thyroid cancer, accounting for 70–80% of all thyroid carcinomas and occurring predominantly in women, generally with a good prognosis (1). PTC is characterized by a steady and continuous increase in the incidence rate, which has more than doubled within the past three decades all over the world (2). Pyoderma gangrenosum (PG) is a rare chronic-relapsing inflammatory disease clinically characterized by single or multiple skin ulcers with undermined erythematous-violaceous borders usually developing on the lower extremities (3). It is nowadays regarded as autoinflammatory in origin and classified in the spectrum of the so-called neutrophilic dermatoses, which are a group of conditions hallmarked by accumulation of mature neutrophils in the skin (4–6). Albeit rarely, in this disease almost any organ system can be involved by sterile neutrophilic infiltrates, with the lungs being the most commonly affected site (3, 4). This condition may be idiopathic or associated with underlying...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research