Androgen Deficiency and Phosphodiesterase Type 5 Expression Changes in Aging Male: Therapeutic Implications

Conclusions Aging leads to a progressive decrease in androgen production that, in turn, leads to the development of LOH, defined by significant low T serum levels (in the lowest quartile) in the presence of signs and symptoms of hypogonadism (51). LOH could be due to both testicular and hypothalamic-pituitary dysfunction (32), and ED is one of its main symptoms. ED in LOH is linked to increased oxidative stress, subclinical inflammation, and subsequent endothelial dysfunction (101). In elderly men, it has been shown that LOH is also linked to lower cAMP pool and to an alteration of the cGMP signaling pathway. PDE5 gene lower expression is associated to aging and hypogonadism at the corpus cavernosum level. TRT is able to restore the expression of PDE5 gene and this effect is initially attributed to a direct regulation of the gene expression by T (38). Subsequently, this hypothesis was not confirmed, and the authors hypothesized that the lower expression of PDE5 in hypogonadism was due to the decreased smooth muscle cell content in corpora cavernosa. Therefore, T could able to increase PDE5 content by reversing these anatomical changes (39). Anyway, the increased PDE5 gene expression explains the reason for the possible failure of PDE5i administration in hypogonadal patients with ED. The timing of treatment with T and PDE5is in patients with hypogonadism and ED is a matter of debate (102). The initial approach to patients with ED encompasses the use of PDE5is (72) (Figure 2...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research

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AbstractCohen syndrome (CS) is an autosomal recessive congenital disorder, characterized by hypotonia, intellectual disability, developmental delay, microcephaly, progressive retinopathy, neutropenia, truncal obesity, joint laxity, characteristic facial, ophthalmic, oral and appendage abnormalities, and an over friendly behavior. It has been linked to mutations in theVPS13B gene. The main purpose of this study was to determine the genetic cause of CS in an Indian family. Whole exome sequencing (WES) was used to identify the genetic cause of CS in the family. The WES analysis identified a homozygous novel duplication mutati...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
Authors: Carapetis JR, Brown A PMID: 32652580 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Authors: Bondy SC, Campbell A Abstract Melatonin is well known as a neuroendocrine hormone that promotes sleep. However, the many other attributes of melatonin are less apparent and not as widely appreciated. The purpose of this review is to summarize the qualities of melatonin relating to immune function. The relevance of melatonin in partially or wholly restoring optimal function in a series of disorders related to immune dysfunction is addressed. This includes the potential relief of both autoimmune diseases and many other ailments involving abnormal immune responses, including the overall diminished effectivene...
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
CONCLUSION: Our modified U-Net with attention unit achieves significantly higher results in terms of Dice score and classification accuracy. The computed BMD and T-score values of the proposed method are also compared with the respective clinical reports for validation. Hence, using the digitized X-Ray images can be used to detect osteoporosis efficiently and accurately. PMID: 32651352 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
Conclusion: The risk of fetal cardiac remodeling is higher in pregnancies conceived by ICSI and independent from fetal size and Doppler. The magnitude of these changes is affected by the type of ICSI technique and is higher in pregnancies conceived by fresh embryos.Fetal Diagn Ther
Source: Fetal Diagnosis and Therapy - Category: Perinatology & Neonatology Source Type: research
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Source: Journal of Theoretical Biology - Category: Biology Source Type: research
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Authors: Skewes MC, Gonzalez VM, Gameon JA, FireMoon P, Salois E, Rasmus SM, Lewis JP, Gardner SA, Ricker A, Reum M Abstract American Indian and Alaska Native (AI/AN) communities experience notable health disparities associated with substance use, including disproportionate rates of accidents/injuries, diabetes, liver disease, suicide, and substance use disorders. Effective treatments for substance use are needed to improve health equity for AI/AN communities. However, an unfortunate history of unethical and stigmatizing research has engendered distrust and reluctance to participate in research among many Native co...
Source: American Journal of Community Psychology - Category: Psychiatry Tags: Am J Community Psychol Source Type: research
Lactation boosts the quantity and quality of insulin-producing beta cells in the pancreas, likely reducing a woman ’s risk of developing type 2 diabetes.
Source: The Scientist - Category: Science Tags: The Literature Source Type: news
Breastfeeding reduces type 2 diabetes risk by boosting beta cells.
Source: The Scientist - Category: Science Tags: Infographics Source Type: news
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