Immunological Changes in Monocyte Subsets and Their Association With Foxp3+ Regulatory T Cells in HIV-1-Infected Individuals With Syphilis: A Brief Research Report

In this study, we investigated the immunological changes in the levels of monocytes and Tregs and the associations between these cell types in HIV-1-infected MSM with syphilis. Methods Study Participants We enrolled 81 participants in this study. These individuals were assigned to four groups on the basis of serologic testing and HIV-1 results, namely, the rapid plasma reagin (RPR+) group, the CHI group, the CHI&RPR+ group, and the healthy control group. HIV-1 infection status was determined with the HIV-1/2 antigen/antibody combo enzyme immunoassay (Beijing Wantai Biological Medical Company, Beijing, China). Positive results were confirmed by western blotting for HIV-1/2 (HIV Blot 2.0 MP Diagnostics, Singapore). Participants who had been infected for more than 180 days were considered to have CHI. The diagnosis of syphilis was based on a compatible history and the results of rapid plasma regain (RPR) tests (Shanghai Kehua Company, China) and T. pallidum particle agglutination assays (TPPA) (Fujirebio Diagnostics, Inc., Japan). Patients with a latent syphilis infection are defined as those lacking clinical manifestations with the pathogen detected by serologic testing who acquired the infection within the preceding year (39). Twenty-five participants who had been diagnosed with HIV-1 infection for at least 1.5 years (median: 2.1 years, range: 1.5–2.8 years) before enrollment comprised the CHI group. None of these individuals was on ART, and all had high viral loads,...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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CONCLUSIONS The network pharmacology analysis reveals the molecular biological mechanism of Artemisia annua anti-NSCLC via multiple active components, multi-channels, and multi-targets. This suggests that Artemisia annua might be developed as a promising anti-NSCLC drug. PMID: 32474568 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2), the cause of coronavirus disease 2019 (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS–CoV-2, nor therapy for those who develop COVID-19. Immune (i.e., “convalescent”) plasma refers to plasma that is collected from individuals following resolution of infection and development of antibodies. Passive antibody administration through transfusion of convalescent plasma may offer the only short-term strategy for conferring immediate immunity to susceptib...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Dalton Trans., 2020, Accepted Manuscript DOI: 10.1039/D0DT01365J, PerspectiveLuiz Gonzaga Fran ça de França Lopes, Edinilton Muniz Carvalho, Eduardo Henrique Silva Sousa Medicinal inorganic chemists have provided many strategies to tackle a myriad of diseases, pushing forward the frontiers of pharmacology. As an example, the fight against tuberculosis (TB), an infectious bacterial... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Dr Fauci says he hasn ’t spoken to Trump in two weeks; New Zealand to consider easing restrictions earlier than planned; Mexico deaths pass 10,000. Follow the latest updatesSingapore reopens schoolsUK: Critics round on No 10 over ‘ridiculous’ rules for 14-day quarantineAustralia coronavirus updates – liveCoronavirus latest: at a glanceSee all our coronavirus coverage6.46amBSTTheAssociated Pressis carrying a report that says Chinese officials sat on releasing the genetic map, or genome, of the coronavirus for over a week after multiple government labs had fully decoded it, not sharing details key to ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Infectious diseases Science Microbiology Medical research UK news US news Australia news Source Type: news
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesivir for MERS-CoV infection in macaques (PNAS) ChAdOX1 vaccination for SARS-CoV-2 in macaques ...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
[WHO] Geneva/Brazzaville/Kinshasa -The Government of the Democratic Republic of the Congo (DRC) announced today that a new outbreak of Ebola virus disease is occurring in Wangata health zone, Mbandaka, in Équateur province. The announcement comes as a long, difficult and complex Ebola outbreak in eastern DRC is in its final phase, while the country also battles COVID-19 and the world's largest measles outbreak.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
BACKGROUND: The United States (US) and Canada are in the midst of an opioid overdose epidemic. Many people who use illicit drugs (PWUD) do not call an emergency number 911 at the scene of an overdose due to fear of arrest. In the US and Canada, when an ind...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
[DW] Following four deaths in western Congo, 1,000km from the ongoing outbreak, authorities have reported a new Ebola epidemic. "COVID-19 is not the only health threat people face," WHO chief Tedros said.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Ian Sample talks to Prof Carl Heneghan about the uncertainties in predicting future outbreaks of Covid-19 and what we can do to prevent themContinue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Coronavirus outbreak Infectious diseases Medical research Microbiology World news Health Society Source Type: news
Hi all, The CDC recommends the first immunization for live vaccines (s.a. MMR, Varicella) begin at 12 months of age. However, rotavirus is also a live vaccine but is administered at 2, 4, and 6 months, and is never administered after 8 months. I know that the rotavirus vaccine decreases the severity of illness if it is contracted and prevents most rotavirus cases in the US, but theoretically, why would this work before the immune system has matured enough?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Clinical Rotations Source Type: forums
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