Two weeks to bowel cancer?
There’s no doubt antibiotics have saved a lot of lives. But because they’ve been overprescribed for so many years we’ve ended up with a slew of health problems. For one thing, overuse of antibiotics wreaks havoc on your microbiome… That’s your body’s ecosystem. Your microbiome has 100 trillion or so bacteria, viruses and fungi. It affects just about every organ and body system. Some of these gut bugs cause disease and infection. But other good bacteria are called “probiotics.” They boost your immune system. They help you digest your food and turn it into vitamins. But in your gut, antibiotics kill off good bacteria along with the bad. When that happens, your immune system gets weak. Your risk of obesity and heart disease goes up. So do rates of allergies, asthma, autism and autoimmune diseases.1 And now shocking new research says antibiotics can even spike your risk of bowel cancer. And it can happen in just two weeks! A study in the journal Gut looked at data from 16,000 women over 60 years old. They were part of the famous Nurses Health Study.2 Results showed that taking antibiotics increased their risk of getting adenomas or polyps. These are growths on the lining of the bowel that can become cancerous. Women who took antibiotics in their 20s and 30s for as little as 15 days to two months increased their risk by up to 36%. It was worse for those who took these drugs in their 40s and 50s for longer periods of time....
ConclusionIn conclusion, hypothalamic Pomc as well as Mc4r, both of which are reduced in type 1 diabetic mice, are required for normal counterregulatory responses to hypoglycemia. Therefore, enhancing MC4R function may improve hypoglycemia counterregulation in diabetes.Graphical abstract
Antonella Stoppacciaro, Serena Di Vito, Patrizia Filetici
In this study, a PEG-modified liposome was developed for efficiently encapsulating CBZ, thus enhancing its specific tumor inhibition effect and reducing the systemic toxicity. It was found that the loading efficiency of CBZ into the liposome could be improved with the increase of lipophilic materials, as it could be over 80% under the weight ratio of 20:1 (total lipid: CBZ). The diameter of CBZ loaded liposome (CBZ@Lipo) was ∼100 nm. And the liposome suspending in aqueous medium was stable at 4 °C for at least one month, according to the change of its size distribution. The killing ability of CBZ@Lipo to cancer cel...
Publication date: Available online 19 November 2018Source: Journal of Herbal MedicineAuthor(s): Andrew Croaker, Graham J. King, John H. Pyne, Shailendra Anoopkumar-Dukie, Lei LiuAbstractBlack salve, used as an alternative skin cancer therapy, contains both herbal and chemical constituents, including extracts of the rhizomes of Sanguinaria canadensis and zinc chloride. Black salves may be ordered online and have been associated with cases of extensive tissue necrosis and treatment failures that have resulted in patient fatalities. Despite these adverse outcomes and continued use by patients, black salve products have not be...
Conclusion: In the most compromised lung cancer patients, VATS sublobar resection might be the best option.
Conclusions: Our study suggests that the evaluation of lymph nodes via groin dissections in groin sarcomas in the Asian population should be based primarily on clinical and radiologic evidence. Regional lymph node dissection seems to confer OS benefit in patients with these high-risk tumors and can improve local control of disease.
Conclusions: Cure with a microscopically positive margin was suboptimal (71%) despite patients having classic-histology papillary and follicular carcinoma, favorable stage, and moderate-dose I-131 therapy.
Conclusions: These results affirm that patients with OMCC have extended OS periods and that stereotactic body radiotherapy offers strong local control in these settings. We show that even in the oligometastatic setting those with right-sided primary tumors have worse outcomes relative to those with left-sided or rectal primary tumors. This suggests more aggressive treatment may be needed for those with oligometastatic right-sided colorectal cancer.
Conclusions: About 25% of patients with PC treated without adjuvant RT develop LRRO as initial failure. The only independent predictor of LRRO was positive margin, while elevated postoperative CA 19-9 and pLN+ were associated with predicting MR and overall survival. These data may help determine which patients benefit from intensification of local therapy with radiation.
This study investigated the addition of celecoxib, a selective COX-2 inhibitor, to the irinotecan, 5-fluorouracil, and leucovorin (IFL) regimen for patients with previously untreated metastatic CRC. Patients and Methods: Forty-seven patients enrolled in this single-arm phase II study received celecoxib at 400 mg orally twice daily in combination with weekly irinotecan (125 mg/m2), 5-fluorouracil (500 mg/m2), and leucovorin (20 mg/m2) for 4 weeks every 6 weeks. The primary endpoint was response rate (RR) as measured by Response Evaluation Criteria in Solid Tumors. The protocol was amended midw...
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