Endoscopic Clip Closure After Large Polyp Resection in Right Colon Reduces Bleeding Endoscopic Clip Closure After Large Polyp Resection in Right Colon Reduces Bleeding
Endoscopic clip closure after resection of large sessile polyps in the proximal colon reduced the risk of post-procedure bleeding in a multicenter randomized trial, researchers say.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - April 4, 2019 Category: Surgery Tags: Gastroenterology News Source Type: news

Embracing the Cold Snare Polypectomy Revolution Embracing the Cold Snare Polypectomy Revolution
Dr David Johnson highlights some easy-to-apply tips for using this innovative approach for resecting small colorectal polyps.Medscape Gastroenterology (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - March 29, 2019 Category: Gastroenterology Tags: Gastroenterology Commentary Source Type: news

Optical Technologies Unreliable at Diagnosing Pre-Cancerous Colorectal Polyps Optical Technologies Unreliable at Diagnosing Pre-Cancerous Colorectal Polyps
The accuracy of optical technologies in differentiating cancerous from benign tissue is"insufficient" for most routine clinical applications, including diagnosing pre-cancerous colorectal polyps, researchers say.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 15, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

A Pill, That ’s a Device, That Delivers a Drug!
Rani Therapeutics just achieved one of its most significant milestones since it was spun out of InCube Lab in 2012. The San Jose, CA-based company just finished conducting the first human study of its “robotic capsule” set to replace injections. Previously the device, which administers a pharmaceutical through a digestible pill, had been tested in more than 100 animal models. The human study was conducted at a Clinical Research Organization (CRO) in Texas under the Investigational Review Board (IRB) approval. There were two sub-groups, one cohort was fed and another fasted. Each subject ...
Source: MDDI - February 28, 2019 Category: Medical Devices Authors: Omar Ford Tags: Implants Source Type: news

Check-Cap ’ s cancer screening capsule will have U.S. study
Check-Cap (NSDQ:CHEK) said its X-ray-enabled, colorectal cancer-screening capsule will have a pilot study in the United States. The Isfiya, Israel-based startup makes the C-Scan System, an ingestible capsule used to detect precancerous polyps without the need for laxatives or an invasive procedure. The C-Scan system uses an ultra-low dose X-ray capsule, an integrated positioning, control, and recording system, and proprietary software to generate a 3D map of the inner lining of the colon. It received approval from Israel’s Ministry of Health Medical Device division (AMAR) and the CE Mark...
Source: Mass Device - February 12, 2019 Category: Medical Devices Authors: Nancy Crotti Tags: Blog Clinical Trials Implants News Well Oncology Research & Development Check-Cap FDA New York University Source Type: news

Aspirin Underused for Advanced Colorectal Polyps
Only 42.6 percent of 84 patients with biopsy - proven advanced colorectal polyps were taking aspirin (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 12, 2019 Category: Cancer & Oncology Tags: Family Medicine, Geriatrics, Gastroenterology, Internal Medicine, Oncology, Pharmacy, Journal, Source Type: news

Aspirin Can Help Prevent Colon Cancer, But Many at Risk Don't Take It
Low-dose aspirin can lower your risk for colon cancer but fewer than half the people who already have polyps aren’t taking it. (Source: WebMD Health)
Source: WebMD Health - February 12, 2019 Category: Consumer Health News Source Type: news

Aspirin Underused for Advanced Colorectal Polyps
TUESDAY, Feb. 12, 2019 -- Aspirin is underused to reduce the risk for colorectal cancer among patients with advanced colorectal polyps, according to a study recently published in The American Journal of Medicine. Noting that the U.S. Preventive... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 12, 2019 Category: Pharmaceuticals Source Type: news

Aspirin Can Help Prevent Colon Cancer, But Many at Risk Don't Take It
MONDAY, Feb. 11, 2019 -- People with colon polyps spotted during screening are at higher risk for colon cancer. But while low-dose aspirin could lower the odds for the disease, too few patients adopt the regimen, new research shows. Advanced colon... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 11, 2019 Category: General Medicine Source Type: news

Aspirin to prevent colon cancer underutilized in high-risk patients
(Florida Atlantic University) The US Preventive Services Task Force (USPSTF) concluded that aspirin reduces the risk of colorectal cancer by 40 percent as well as recurrence of advanced polyps, which are a major risk factor. To explore whether high risk patients are adhering to USPSTF guidelines, FAU researchers analyzed data from structured interviews with 84 patients and found that less than half (42.9 percent) reported taking aspirin. These findings pose major challenges that require multifactorial approaches by physicians and patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 7, 2019 Category: Cancer & Oncology Source Type: news

Fidarestat prevents high-fat diet-induced intestinal polyps in ApcMin/+ mice
(Bentham Science Publishers) Recent epidemiological and experimental studies have shown that obesity is a major risk factor for Colorectal Cancer (CRC). Regular intake of high fat-containing diet can promote obesity and metabolic syndrome by increasing the insulin resistance and inflammatory response which contribute to carcinogenesis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 18, 2019 Category: Cancer & Oncology Source Type: news

Pseudopolyps Not Associated With Greater Colorectal Cancer Risk Pseudopolyps Not Associated With Greater Colorectal Cancer Risk
Post-inflammatory polyps (PIPs) are not associated with colorectal neoplasia (CRN) in patients with inflammatory bowel disease (IBD), according to new findings.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 20, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Post-Inflammatory Polyps Not Linked to Colorectal Neoplasia
FRIDAY, Dec. 14, 2018 -- For patients with inflammatory bowel disease (IBD), post-inflammatory polyps (PIPs) are associated with greater severity and extent of colon inflammation and higher rates of colectomy, but not with development of colorectal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 14, 2018 Category: Pharmaceuticals Source Type: news

Living With Cancer: When can you stop colon cancer screening?
Colon cancer screening: At what age can you stop? People older than 75 who have been getting regular colon cancer screening since age 50 and who have had consistently negative screenings ? no polyps or colon cancer, and who are not at an increased risk of colon cancer because of family history, may not need [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - December 14, 2018 Category: Databases & Libraries Source Type: news

Colorectal Cancer Screening Pill to Be in US Pilot Study
Check-Cap is getting one step closer to having its capsule-based screening method for colorectal cancer on the U.S. market. The Isfiya, Israel-based company has received FDA conditional approval for an IDE to initiate a pilot study of the C-Scan capsule. FDA’s conditional approval of the IDE requires Check-Cap to provide additional information to the agency and the company may begin enrolling patients immediately upon approval by the study site's Institutional Review Board (IRB). The trial will consist of up to 45 patients and it will be a single-arm study. Patients who are enrolled will be those conside...
Source: MDDI - December 14, 2018 Category: Medical Devices Authors: Omar Ford Tags: Regulatory and Compliance Implants Source Type: news

Check-Cap wins conditional IDE approval for C-Scan pilot study
Check-Cap (NSDQ:CHEK) said today it won conditional approval from the FDA for its investigational device exemption application to launch a pilot study of its C-Scan system. The Israel-based company’s C-Scan system is designed as an alternative to standard colon cancer screening methods. The system uses an ingestible, ultra-low dose X-ray capsule and a wireless tracking system to return structural information on the lumen of the colon to create 2D and 3D maps. The conditional approval will require Check-Cap to provide additional information to the FDA, but will allow the company to being enrolling patients immedi...
Source: Mass Device - December 13, 2018 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Diagnostics Food & Drug Administration (FDA) Check-Cap Source Type: news

Wendy Atkin obituary
Epidemiologist whose research led to a breakthrough in bowel cancer screening programmes worldwide“Breakthrough” is an overused word when applied to medical advances. But in the case of the2010 trial of a new screening test for bowel cancer led by Wendy Atkin, professor of gastrointestinal epidemiology atImperial College London, who has died of acute myeloid leukaemia aged 71, it is fully deserved. Its impact will be felt by millions. The trial was the first in the world to show that bowel cancer – the second biggest cancer killer in the UK – could be prevented with a simple, five-minute test.The ex...
Source: Guardian Unlimited Science - November 29, 2018 Category: Science Authors: Ara Darzi Tags: Cancer research Health Medical research Science Source Type: news

Many Patients With Polyps Delay Follow-up Colonoscopy: Study
MONDAY, Nov. 26, 2018 -- Many people found to have colon polyps (adenomas) that can lead to cancer don't have follow-up colonoscopies at recommended times, a new study finds. Patients who have certain types of adenomas, or large or numerous ones,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 26, 2018 Category: General Medicine Source Type: news

Many Patients With Polyps Delay Follow-up Colonoscopy: Study
(Source: Cancercompass News: Colorectal Cancer)
Source: Cancercompass News: Colorectal Cancer - November 26, 2018 Category: Cancer & Oncology Source Type: news

Treating a rare genetic disorder that causes colon cancer in children
(University of Houston) A University of Houston pharmaceutical scientist is developing a new drug that recycles through the colon to treat children suffering with Familial Adenomatous Polyposis, a rare genetic disorder characterized by hundreds -- if not thousands -- of colorectal polyps. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 20, 2018 Category: Cancer & Oncology Source Type: news

Artificial intelligence could help doctors identify hard-to-spot colon polyps
Colon cancer is the second leading cause of cancer-related deaths in the U.S. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 10, 2018 Category: Consumer Health News Source Type: news

How AI could help doctors identify hard-to-spot colon polyps
"Colon cancer is the second-leading cause of cancer-related deaths in the U.S. but colonoscopies have been found to reduce the risk of death from the disease by 70 percent or more by detecting cancer early. But doctors don ’t always find every polyp. As a gastroenterologist, CBS News chief medical correspondent Dr. Jon LaPook knows all too well that colon polyps can be tough to spot. But a new high-tech tool may be able to help doctors spot them. " (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - November 10, 2018 Category: Consumer Health News Source Type: news

Precision medicine is not enough: Moving towards precision surveillance
(Regenstrief Institute) The interval at which an individual undergoes a repeat colonoscopy because of previous pre-cancerous polyps -- a practice known as 'surveillance' -- should be tailored to the individual and not simply be determined by the results of prior colonoscopies, according to Regenstrief Institute research scientist Thomas Imperiale, M.D. In a American Journal of Gastroenterology editorial he calls for 'precision surveillance,' a phrase he has coined to echo the personalized, targeted focus of precision medicine and application of these concepts to colon cancer screening and surveillance. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 7, 2018 Category: Cancer & Oncology Source Type: news

Higher CRC Risks in Black Americans Not Related to Biology Higher CRC Risks in Black Americans Not Related to Biology
The overall prevalence of advanced, precancerous polyps does not differ with race, but uniform screening guidelines could still leave many at increased risk for colorectal cancer (CRC).Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 6, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Racial differences in colorectal cancer incidence not due to biology
(Regenstrief Institute) A systematic review and meta-analysis from the Regenstrief Institute and Indiana University School of Medicine has found that, in spite of the higher incidence and death rate of colorectal cancer in blacks, no difference exists in the overall prevalence of advanced, precancerous polyps between average-risk blacks and whites who underwent a screening colonoscopy. These findings suggest that the age at which to begin screening need not differ based on race, provided all other factors -- access to screening, in particular -- are similar. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 23, 2018 Category: Cancer & Oncology Source Type: news

AI colonoscopies may produce smarter results, doctors say
New test uses artificial intelligence to spot polyps, where all colorectal cancers begin. Doctors hope the technology will help save lives. CBS News' Chris Martinez reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 18, 2018 Category: Consumer Health News Source Type: news

AI colonoscopies may produce smarter results, save lives, doctors say
New test uses artificial intelligence to spot polyps, where all colorectal cancers begin. CBS News' Chris Martinez reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 18, 2018 Category: Consumer Health News Source Type: news

Doctors Using Artificial Intelligence To Make Colonoscopies More Accurate
BOSTON (CBS) – Colon cancer is the second leading cause of cancer death in the United States and now doctors in California are using artificial intelligence to make colonoscopies more accurate and help save lives. AI colonoscopies would not replace routine colonoscopies, which most people need to get every 10 years starting at age 45 or 50 depending on whom you ask, but this new technology can help doctors identify polyps that they might otherwise miss. Polyps are growths that can turn into cancer but if removed early can prevent cancer from growing. The artificial intelligence uses an algorithm, analyzing 98 images ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 17, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Syndicated Local Watch Listen AI colonoscopy Cancer Dr. Mallika Marshall Source Type: news

Check-Cap touts interim post-CE Mark C-Scan study results
Check-Cap (NSDQ:CHEK) today released interim results from the post-CE Mark approval study of its C-Scan system version 3, touting the device’s ability to detect polyps in un-prepped colons. The Israel-based company’s C-Scan system is designed as an alternative to standard colon cancer screening methods. The system uses an ingestible, ultra-low dose X-ray capsule and a wireless tracking system to return structural information on the lumen of the colon to create 2D and 3D maps. The study aimed to assess the safety and clinical performance of the C-Scan system version 3 in detecting polyps, Check-cap said. Da...
Source: Mass Device - September 4, 2018 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Diagnostics Oncology Check-Cap Source Type: news

Targeting Inflammation Slows STK11 Mutation-Driven Polyp Growth
A study shows that LKB1 deficiency in T cells increases gastrointestinal polyposis development. (Source: CancerNetwork)
Source: CancerNetwork - August 14, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

AI Improves Colonoscopy Diagnostics in Prospective Trial AI Improves Colonoscopy Diagnostics in Prospective Trial
Artificial intelligence performs extremely well in the diagnosis of diminutive nonneoplastic polyps in the distal colon, allowing endoscopists to safely diagnose them and leave them alone.Medscape Medical Ethics (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 14, 2018 Category: Consumer Health News Tags: Gastroenterology News Source Type: news

LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis
Germline mutations in STK11, which encodes the tumor suppressor liver kinase B1 (LKB1), promote Peutz–Jeghers syndrome (PJS), a cancer predisposition syndrome characterized by the development of gastrointestinal (GI) polyps. Here, we report that heterozygous deletion of Stk11 in T cells (LThet mice) is sufficient to promote GI polyposis. Polyps from LThet mice, Stk11+/– mice, and human PJS patients display hallmarks of chronic inflammation, marked by inflammatory immune-cell infiltration, signal transducer and activator of transcription 3 (STAT3) activation, and increased expression of inflammatory factors asso...
Source: ScienceNOW - July 26, 2018 Category: Science Authors: Poffenberger, M. C., Metcalfe-Roach, A., Aguilar, E., Chen, J., Hsu, B. E., Wong, A. H., Johnson, R. M., Flynn, B., Samborska, B., Ma, E. H., Gravel, S.- P., Tonelli, L., Devorkin, L., Kim, P., Hall, A., Izreig, S., Loginicheva, E., Beauchemin, N., Siegel Tags: Immunology, Medicine, Diseases reports Source Type: news

Medical News Today: What to know about colon polyps
Colon polyps are common, especially in those over 50 years of age. Most colon polyps are harmless, though some can become cancerous. A doctor can diagnose colon polyps with a series of exams. Learn how they treat colon polyps and how to prevent them. Plus, use a 3-D body map to get a better picture of colon polyps. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 11, 2018 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news

A blood test for leukemia? Genetic changes in the blood can be spotted five years before
The findings by British and Canadian scientists could be a game-changer for the hard-to-treat cancer, allowing doctors to monitor patients' risks in the same way that polyps can be red flags for colon cancers. (Source: the Mail online | Health)
Source: the Mail online | Health - July 9, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Colon cancer: Scientists find new predisposition mechanism
New research finds a novel mechanism that genetically predisposes some people to the development of colon polyps and potentially cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 19, 2018 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

High BMI, Male Gender Predict Colon Polyps in Younger Patients (CME/CE)
(MedPage Today) -- Chronic kidney disease also a risk factor, study finds (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - June 7, 2018 Category: Urology & Nephrology Source Type: news

PENTAX Medical Announces U.S. Deal To Distribute Third Eye(R) Panoramic(TM) Imaging System For Colon Cancer Screening
Provides 'Panoramic' View to Detect Potentially Cancerous Polyps Standard Colonoscopes May Not See MONTVALE, N.J., May 31, 2018 -- (Healthcare Sales & Marketing Network) -- PENTAX Medical Company, a healthcare industry leader in diagnostic and therapeu... Devices, Gastroenterology, Oncology, Distribution PENTAX Medical, Avantis Medical Systems, Third Eye, colonoscopy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 31, 2018 Category: Pharmaceuticals Source Type: news

Lumendi wins FDA nod for DiLumen IS endoscopic scissors
Lumendi said today it won FDA 510(k) clearance for its DiLumen IS endolumenal interventional scissors, now indicated for cutting, dissecting and cauterizing tissue within the digestive tract during endoscopic procedures. The Westport, Conn.-based company touted the sterile, single-use disposable, monopolar electrosurgical device as the fourth it’s developed, and said that it and its recently cleared DiLumen CT are intended to help improve access and therapy in the colon and reduce the need for surgical interventions. The recently cleared C2  is a second-gen Endolumenal interventional platform designed to en...
Source: Mass Device - May 29, 2018 Category: Medical Devices Authors: Fink Densford Tags: 510(k) Endoscopic / Arthroscopic Food & Drug Administration (FDA) Regulatory/Compliance Lumendi Source Type: news

Bringing AI to Colorectal Cancer Screening
Freenome is looking to build a diagnostic test that can learn from its mistakes. The South San Francisco, CA- based company is using artificial intelligence to improve colorectal cancer screening. To do this, Freenome has initiated AI-EMERGE, a clinical study for the AI-Genomics blood test, which will collect samples from up to 3,000 patients in the U.S. and Canada. Freenome CEO, Gabe Otte said the infusion of AI is a natural step in the evolution of diagnostics that should have been taken years ago. “If you look at the traditional molecular diagnostic tests that are out there – the PSA tests for example &ndash...
Source: MDDI - May 24, 2018 Category: Medical Devices Authors: Omar Ford Tags: IVD Source Type: news

Blue dye tablet helps identify polyps during colonoscopy
(Digestive Disease Week) Ingestion of a blue dye tablet during bowel prep for colonoscopy could be a significant advance in the early detection of colorectal cancer (CRC). When used in conjunction with colonoscopy, the blue dye increased adenoma detection rate (ADR) by nearly 9 percent, according to a study scheduled for presentation at Digestive Disease Week ® (DDW) 2018. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 22, 2018 Category: Cancer & Oncology Source Type: news

Colon Polyp Type May Be Key to Cancer Risk
Their study of almost 16,000 patients who underwent colonoscopy found that the long-term risk for colon cancer was 2.5 times greater for those with advanced polyps, compared to people without such growths. (Source: WebMD Health)
Source: WebMD Health - May 16, 2018 Category: Consumer Health News Source Type: news

Colon Polyp Type May Be Key to Cancer Risk
Title: Colon Polyp Type May Be Key to Cancer RiskCategory: Health NewsCreated: 5/15/2018 12:00:00 AMLast Editorial Review: 5/16/2018 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - May 16, 2018 Category: Cancer & Oncology Source Type: news

Colon Polyp Type May Be Key to Cancer Risk
(Source: Cancercompass News: Colorectal Cancer)
Source: Cancercompass News: Colorectal Cancer - May 16, 2018 Category: Cancer & Oncology Source Type: news

Colon Polyp Type May Be Key to Cancer Risk
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 15, 2018 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Preventive Medicine, News, Source Type: news

Colon Polyp Type May Be Key to Cancer Risk
TUESDAY, May 15, 2018 -- The type of colon polyp that's spotted during a colonoscopy may help predict the likelihood of colon cancer, new research shows. These polyps -- also called adenomas -- can be labeled advanced or non-advanced, explained... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 15, 2018 Category: General Medicine Source Type: news

CRC Polyps May Allow for Immune Checkpoint Inhibitors in Premalignant Lesions
Colorectal carcinomas in LS patients appear in background of mismatch repair (MMR) deficiency, show a unique immune profile, and response to immunotherapy. (Source: CancerNetwork)
Source: CancerNetwork - May 11, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news

Check-Cap closes $20m Series C
Check-Cap (NSDQ:CHEK) said yesterday it closed an offering of Series C shares and warrants, raising approximately $20.2 million in total. In the offering, the Isfiya, Israel-based company floated approximately 3.2 million units for $5.50 per unit, with each unit in the offering consisting of a single ordinary share or ordinary share equivalent and a Series C warrant to purchase one ordinary share. The offering also included an underwriter’s option for an additional 478,407 shares and Series C warrants to purchase up to 478,407 shares, which was exercised in full, Check-Cap said. Proceeds from the round are slate...
Source: Mass Device - May 9, 2018 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Funding Roundup Wall Street Beat Check-Cap Source Type: news