Marijuana Eases Pain, But Jury's Out On Other Health Benefits, Scientists Say

Marijuana has proved to be a powerful aid in easing chronic pain and helping battle nausea, but results are mixed or largely inconclusive on other health benefits, as well as detriments, according to a massive new scientific review of cannabis studies. The report, released Thursday by the National Academies of Science, Engineering, and Medicine, analyzes an astounding 10,000 scientific studies on the drug. “The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research” concludes that marijuana definitely provides some health benefits, though other claims about the drug are far less clear. The scientists note that much information could be determined if researchers didn’t have to battle restrictions caused by federal classification of cannabis as a Schedule 1 drug, meaning it “currently” has “no accepted medical use and a high potential for abuse.” “It is often difficult for researchers to gain access to the quantity, quality, and type of cannabis product necessary to address specific research questions on the health effects of cannabis use,” conclude the authors, a panel of experts led by Harvard public health researcher Marie McCormack.  Federal attitude aside, more than half of all U.S. states have legalized marijuana for medical use, and eight (plus the District of Columbia) have legalized the drug for recreational use. The major conclusions in the st...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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AbstractLong-term sequel of acute COVID-19, commonly referred to as long COVID, has affected millions of patients worldwide. Long COVID patients display persistent or relapsing and remitting symptoms that include fatigue, breathlessness, cough, myalgia, arthralgia, sleep disturbance, cognitive impairment and skin rashes. Due to the shared clinical features, laboratory and imaging findings, long COVID could mimic rheumatic disease posing a diagnostic challenge. Our comprehensive literature review will help rheumatologist to be aware of long COVID manifestations and differentiating features from rheumatic diseases to ensure ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsImprovement was seen in most patients. One year after the start of treatment, more than half of the patients were untreated and around one-third in remission. Residual symptoms and deficits were common regardless of treatment.
Source: Journal of Neurology - Category: Neurology Source Type: research
ConclusionsIn this updated systematic review and meta-analysis, uterine exteriorization was associated with an increased risk of IONV but no significant change in perioperative hemoglobin decrease compared within situ repair.Study registrationPROSPERO (CRD42020190074); registered 5 July 2020.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
ConclusionsGiven the perceived benefits of regional over general anesthesia, approximately half of the members of three regional anesthesia societies seem to have expanded their use of regional anesthesia techniques during the initial surge of the COVID-19 pandemic.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
ConclusionPlastic bronchitis can present in adult patients and be life-threatening when associated with acute respiratory failure. We report an unusual case of an adult patient treated with veno-venous ECMO for plastic bronchitis following cardiac surgery. Use of ECMO support while providing airway cleaning can be lifesaving in patients with respiratory failure secondary to plastic bronchitis.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
“For me, my own personal stories of opioid patients come to mind, including one who keyed my car when I stopped prescribing his opioid after an acute injury. I think of some local opioid overdose deaths in my community. I would love to hear what other doctors and clinicians have to say about these issues,Read more …Coal mining culture and the opioid crisis [PODCAST] originally appeared
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Podcast Pain Management Source Type: blogs
AbstractSynaptic plasticity, the substrate for learning, has been established in neural reward circuits and might involve in the learning of addictive behaviors. Long-term exposure to addictive drugs caused long-lasting memories of the drug experience. The main clinical problem that involves the persistence of addiction is a relapse that is resulted from the exposure to cues of the drug experience. Persistent forms of synaptic plasticity are associated with some of the behavioral effects of addictive drugs. Here, we present the underlying mechanisms of plasticity induced by different brain reward circuitry. Therefore, we f...
Source: Neurological Sciences - Category: Neurology Source Type: research
Oncogene, Published online: 22 January 2022; doi:10.1038/s41388-021-02150-4Role of Nischarin in the pathology of diseases: a special emphasis on breast cancer
Source: Oncogene - Category: Cancer & Oncology Authors: Source Type: research
ConclusionGenerally, our study established the gut microbiome-based signature for liver cancer prediction and screening and revealed that gut microbiome characteristic in primary liver cancer was correlated with adverse inflammatory response markers in liver cancer.
Source: Hepatology International - Category: Infectious Diseases Source Type: research
ConclusionOur data emphasize that metabolic dysfunction has a significant impact on hepatocarcinogenesis in patients with NAFLD. Moreover, coexisting multiple metabolic risk factors would dampen the risk of developing HCC in patients with NAFLD. Closely tracing HCC formation through laboratory examination or imaging is crucial in these patients.
Source: Hepatology International - Category: Infectious Diseases Source Type: research
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