Population pharmacokinetics of antibacterial agents in the older population: a literature review
Expert Rev Clin Pharmacol. 2023 Dec 22. doi: 10.1080/17512433.2023.2295009. Online ahead of print.ABSTRACTINTRODUCTION: Older individuals face an elevated risk of developing bacterial infections. The optimal use of antibacterial agents in this population is challenging because of age-related physiological alterations, changes in pharmacokinetics (PK) and pharmacodynamics (PD), and the presence of multiple underlying diseases. Therefore, population pharmacokinetics (PPK) studies are of great importance for optimizing individual treatments and prompt identification of potential risk factors.AREA COVERED: Our search involved ...
Source: Pharmacological Reviews - December 22, 2023 Category: Drugs & Pharmacology Authors: Hui-Xin Liu Bo-Hao Tang John van den Anker Guo-Xiang Hao Wei Zhao Yi Zheng Source Type: research

Population pharmacokinetics of antibacterial agents in the older population: a literature review
Expert Rev Clin Pharmacol. 2023 Dec 22. doi: 10.1080/17512433.2023.2295009. Online ahead of print.ABSTRACTINTRODUCTION: Older individuals face an elevated risk of developing bacterial infections. The optimal use of antibacterial agents in this population is challenging because of age-related physiological alterations, changes in pharmacokinetics (PK) and pharmacodynamics (PD), and the presence of multiple underlying diseases. Therefore, population pharmacokinetics (PPK) studies are of great importance for optimizing individual treatments and prompt identification of potential risk factors.AREA COVERED: Our search involved ...
Source: Expert Review of Clinical Pharmacology - December 22, 2023 Category: Drugs & Pharmacology Authors: Hui-Xin Liu Bo-Hao Tang John van den Anker Guo-Xiang Hao Wei Zhao Yi Zheng Source Type: research

Population pharmacokinetics of antibacterial agents in the older population: a literature review
Expert Rev Clin Pharmacol. 2023 Dec 22. doi: 10.1080/17512433.2023.2295009. Online ahead of print.ABSTRACTINTRODUCTION: Older individuals face an elevated risk of developing bacterial infections. The optimal use of antibacterial agents in this population is challenging because of age-related physiological alterations, changes in pharmacokinetics (PK) and pharmacodynamics (PD), and the presence of multiple underlying diseases. Therefore, population pharmacokinetics (PPK) studies are of great importance for optimizing individual treatments and prompt identification of potential risk factors.AREA COVERED: Our search involved ...
Source: Pharmacological Reviews - December 22, 2023 Category: Drugs & Pharmacology Authors: Hui-Xin Liu Bo-Hao Tang John van den Anker Guo-Xiang Hao Wei Zhao Yi Zheng Source Type: research

Population pharmacokinetics of antibacterial agents in the older population: a literature review
Expert Rev Clin Pharmacol. 2023 Dec 22. doi: 10.1080/17512433.2023.2295009. Online ahead of print.ABSTRACTINTRODUCTION: Older individuals face an elevated risk of developing bacterial infections. The optimal use of antibacterial agents in this population is challenging because of age-related physiological alterations, changes in pharmacokinetics (PK) and pharmacodynamics (PD), and the presence of multiple underlying diseases. Therefore, population pharmacokinetics (PPK) studies are of great importance for optimizing individual treatments and prompt identification of potential risk factors.AREA COVERED: Our search involved ...
Source: Expert Review of Clinical Pharmacology - December 22, 2023 Category: Drugs & Pharmacology Authors: Hui-Xin Liu Bo-Hao Tang John van den Anker Guo-Xiang Hao Wei Zhao Yi Zheng Source Type: research

Fosfomycin Enhances the Inhibition Ability of Linezolid Against Biofilms of Vancomycin-Resistant Enterococcus faecium in vitro
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - December 19, 2023 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Membrane vesicles derived from Enterococcus faecalis promote the co-transfer of important antibiotic resistance genes located on both plasmids and chromosomes
ConclusionsTo our knowledge, this is the first report of MV-mediated co-transfer of ARG-carrying plasmids and transposons in the Gram-positive bacteriumE. faecium. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - December 18, 2023 Category: Microbiology Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2023 Category: Respiratory Medicine Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: Respiratory Care)
Source: Respiratory Care - December 15, 2023 Category: Respiratory Medicine Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - December 15, 2023 Category: Intensive Care Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2023 Category: Respiratory Medicine Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: Respiratory Care)
Source: Respiratory Care - December 15, 2023 Category: Respiratory Medicine Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - December 15, 2023 Category: Intensive Care Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2023 Category: Respiratory Medicine Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - December 15, 2023 Category: Intensive Care Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 15, 2023 Category: Respiratory Medicine Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research