Clofazimine-associated enteropathy
A 36-year-old man presented to the gastroenterology department because he had experienced intermittent abdominal pain for 1 year. He had received a diagnosis of multidrug-resistant pulmonary tuberculosis 2 years earlier and had received a drug regimen containing clofazimine, linezolid, protionamide, cycloserine, pyrazinamide, and moxifloxacin for 19 months. The abdominal pain occurred after he had been taking clofazimine for 7 months. Physical examination showed skin darkening. Laboratory results showed no abnormalities. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - January 29, 2024 Category: Gastroenterology Authors: Jixin Zhang, Jinpei Dong Tags: At the focal point Source Type: research

Drug recommendation for optimization on treatment outcome for MDR/RR-TB based on a multi-center, large scale, retrospective cohort study in China
CONCLUSIONS: The recommendation order for the treatment of MDR/RR-TB is Bdq, Lzd, and Cs. FQs were decreased in use intensity. Injection drugs, whether Amk or Cm, are not recommended.PMID:38251634 | DOI:10.1080/14787210.2024.2303032 (Source: Expert Review of Anti-Infective Therapy)
Source: Expert Review of Anti-Infective Therapy - January 22, 2024 Category: Infectious Diseases Authors: Lin Fan Ming Yang Yu-Tong Han Fei Ren Hua Wang Jin-Bao Ma Guo-Hui Zhu Yan-Jun Xiong Xin-Xin Fan Su-Xia Chen Hao-Yu Wu Wen-Wen Sun Shao-Jun Zhang Hui Ke Xiao-Hong Cheng Biao Xu Yu Chen Chang Chen Source Type: research

Hematological adverse events associated with anti-MRSA agents: a real-world analysis based on FAERS
This study investigated the patterns of hematological adverse events related to daptomycin (DAP), tigecycline (TIG), vancomycin (VAN) and linezolid (LIN) in the FDA Adverse Event Reporting System (FAERS). Adverse event associations were analyzed through calculating reporting odds ratio (ROR), proportional reporting ratio (PRR), multiple gamma Poisson shrinkage (MGPS), and Bayesian confidence propagation neural network (BCPNN). A comprehensive descriptive analysis was also conducted considering factors such as age, gender, daily dose, cumulative dose, and time to onset. The leading hematologic adverse events were eosinophil...
Source: Expert Opinion on Drug Safety - January 22, 2024 Category: Drugs & Pharmacology Authors: Xiuheng Yu Xiaodan Zhou Min Li Yu Zhao Source Type: research

Genomic characterization of vancomycin-resistant Enterococcus faecium clonal complex 17 isolated from urine in tertiary hospitals in Northeastern Thailand
This study investigated VREfm isolates from rural tertiary hospitals in Northeastern Thailand based both antibiotic susceptibility testing and whole-genome sequencing. All isolates showed resistance to vancomycin, ampicillin, erythromycin, tetracycline, ciprofloxacin, norfloxacin, and rifampin. Nitrofurantoin and tigecycline resistance were also observed in nearly all isolates. Conversely, all isolates remained susceptible to chloramphenicol, daptomycin, and linezolid. Genomic characterization revealed that all VREfm isolates belonged to clonal complex 17 (CC17), primarily consisting of sequence type (ST) 80, followed by S...
Source: Frontiers in Microbiology - January 19, 2024 Category: Microbiology Source Type: research

Towards a better detection of patients at-risk of linezolid toxicity in clinical practice: a prospective study in three Belgian hospital centers
Conclusion: Our work supports the necessity of establishing guidelines for dose adjustment in patients with renal insufficiency and the systematic use of TDM in patients at-risk in order to keep trough values ≤8 mg/L. The Buzelé predictive score (if ≥7) may help to detect these at-risk patients, and pop-PK models can estimate trough levels based on plasma samples collected at varying times, reducing the logistical burden of TDM in clinical practice. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 19, 2024 Category: Drugs & Pharmacology Source Type: research

Preclinical toxicity evaluation of novel antibacterial contezolid acefosamil in rats and dogs
AbstractContezolid acefosamil (CZA) is an intravenous prodrug of oxazolidinone antibiotic contezolid (CZD). It is being developed to treat infections due to Gram-positive bacteria including multidrug-resistant pathogens, while addressing myelosuppression and neurotoxicity limitations associated with long-term use of this class of antibiotics. In vivo, CZA is rapidly deacylated into its first metabolite MRX-1352, which is then dephosphorylated to release active drug CZD. Four-week repeat-dose toxicity studies of intravenous CZA were conducted in Sprague –Dawley rats (40, 80, and 160/120 mg/kg/dose twice a day [BID]) and...
Source: Journal of Applied Toxicology - January 18, 2024 Category: Toxicology Authors: Wen Wang, Zhengyao Li, Mikhail F. Gordeev, Hong Yuan Tags: RESEARCH ARTICLE Source Type: research

Cost-effectiveness of linezolid to ventilator-associated pneumonia in Colombia
Ventilator-associated pneumonia (VAP) is a prominent cause of morbidity and mortality in intensive care unit (ICU) patients. Due to the increase in Methicillin resistant Staphylococcus aureus infection, it is ... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 18, 2024 Category: Infectious Diseases Authors: Jefferson Antonio Buend ía, Diana Guerrero Patiño and Andrés Felipe Zuluaga Salazar Tags: Research Source Type: research

High Gastrointestinal Colonization Rate of Vancomycin-Resistant < em > Enterococci < /em > among Hospitalized Patients: Potential Source for Resistant Gene
CONCLUSIONS: In our study, high proportion of vancomycin-resistant Enterococci was found. Previous exposure to antibiotics and hospital stay were significant factors for VRE gut colonization. The isolated Enterococci showed variable degrees of resistance to commonly prescribed antibiotics which leads to a worldwide problem multidrug resistance. Therefore, periodic surveillance on antimicrobial resistance pattern, adhering to rational use of antibiotics, and implementing infection prevention protocols may reduce colonization by VRE.PMID:38226181 | PMC:PMC10789508 | DOI:10.1155/2024/6430026 (Source: International Journal of Microbiology)
Source: International Journal of Microbiology - January 16, 2024 Category: Microbiology Authors: Techilo Habtemariam Mengesha Musa Mohammed Ali Mulugeta Mengistu Demissie Assegu Fenta Source Type: research

Off-label oritavancin treatment outcome and molecular characterization of a vancomycin- and linezolid-resistant Enterococcus faecium causing liver abscesses
Among vancomycin-resistantEnterococcus faecium (VRE) strains, linezolid resistance (LR) is increasing. Long-acting oritavancin is active against Staphylococci and Enterococci, even for those displaying LR, and despite its approval for acute skin/soft tissue infections, off-label uses have been already described.1,2 (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - January 16, 2024 Category: Microbiology Source Type: research

Comorbidity of Mitral Valve Stenosis with Influenza in Pregnancy, A Case Report
Adv Biomed Res. 2023 Nov 29;12:252. doi: 10.4103/abr.abr_104_23. eCollection 2023.ABSTRACTIn this case, a 44-year-old pregnant woman at a gestational age of 28 weeks and 6 days with symptoms of cold, shortness of breath, and cough since a week ago. She had received remdesivir ampoule, Tamiflu tablet, meropenem and linezolid, and dexamethasone. She received oxygen through a 14-liter reservoir bag mask and hydrocortisone, heparin, and ceftriaxone. Nine hours after hospitalization, the patient suffered a cardiorespiratory arrest, resuscitation was performed, and the patient was intubated. Emergency cesarean section was done i...
Source: Biomed Res - January 9, 2024 Category: Research Authors: Minoo Movahedi Maryam Goharian Azita Kabiri Shadi Zamansaraei Source Type: research

Liquid chromatography-tandem mass spectrometry methods for quantification of total and free antibiotic concentrations in serum and exudate from patients with post-sternotomy deep sternal wound infection receiving negative pressure wound therapy
CONCLUSION: This method can accurately quantify the total and free concentrations of 16 antibiotics. Comparison of concentration ratios between serum and exudates allows for monitoring individual antibiotics' penetration capacity in patients receiving NPWT.PMID:38185284 | DOI:10.1016/j.cca.2023.117704 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 7, 2024 Category: Chemistry Authors: Hana Brozmanov á Pavel Šištík Jana Ďuricová Ivana Kac ířová Kl ára Kaňková Martin Kolek Source Type: research

Liquid chromatography-tandem mass spectrometry methods for quantification of total and free antibiotic concentrations in serum and exudate from patients with post-sternotomy deep sternal wound infection receiving negative pressure wound therapy
CONCLUSION: This method can accurately quantify the total and free concentrations of 16 antibiotics. Comparison of concentration ratios between serum and exudates allows for monitoring individual antibiotics' penetration capacity in patients receiving NPWT.PMID:38185284 | DOI:10.1016/j.cca.2023.117704 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 7, 2024 Category: Chemistry Authors: Hana Brozmanov á Pavel Šištík Jana Ďuricová Ivana Kac ířová Kl ára Kaňková Martin Kolek Source Type: research

Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis
Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 5, 2024 Category: Infectious Diseases Authors: Yuan Li, Guohua Lei, Weijie Dong, Tinglong Lan, Jun Fan and Shibing Qin Tags: Research Source Type: research

High prevalence of heteroresistance in < i > Staphylococcus aureus < /i > is caused by a multitude of mutations in core genes
by Sheida Heidarian, Andrei Guliaev, Herv é Nicoloff, Karin Hjort, Dan I. Andersson Heteroresistance (HR) is an enigmatic phenotype where, in a main population of susceptible cells, small subpopulations of resistant cells exist. This is a cause for concern, as this small subpopulation is difficult to detect by standard antibiotic susceptibility tests, and upon antibiotic exposure the resistant subpopulation may increase in frequency and potentially lead to treatment complications or failure. Here, we determined the prevalence and mechanisms of HR for 40 clinicalStaphylococcus aureus isolates, against 6 clinically importa...
Source: PLoS Biology: Archived Table of Contents - January 4, 2024 Category: Biology Authors: Sheida Heidarian Source Type: research