A 10-year retrospective study of methicillin-resistant Staphylococcus aureus from burn wound infection in southeast China from 2013 to 2022
ConclusionST239-III (70%) was the predominant clone found in MRSA from burn wound infection among burn patients in southeast China. ST239-III was less found from 2018 to 2022. A higher diversity of MRSA clones was observed in these recent 5 years than that from 2013 to 2017. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - December 1, 2023 Category: Microbiology Source Type: research

Risk exploration and prediction model construction for linezolid-resistant Enterococcus faecalis based on big data in a province in southern China
ConclusionE. faecalis linezolid-resistant rates varied by specimen site, geographic region, GDP level, facility level, and the number of beds. At the same time, community-acquiredE. faecalis with linezolid resistance should be monitored closely. We can use the prediction model to guide clinical medication and take timely prevention and control measures. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - November 30, 2023 Category: Microbiology Source Type: research

Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels
ConclusionPrescribers need to be vigilant about drugs that can raise serotonin concentration or influence serotonergic neurotransmission, also when using drugs with less well-known risk for serotonin syndrome, like linezolid and triptans. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - November 30, 2023 Category: Drugs & Pharmacology Source Type: research

Linezolid dose adjustment according to therapeutic drug monitoring helps reach the goal concentration in severe patients, and the oldest seniors benefit more
The elderly with severe infection increased dramatically in intensive care unit (ICU). Proper antimicrobial therapy help improve the prognosis. Linezolid, as an antimicrobial drug, is commonly utilized to trea... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Ying Xu, Xilan Yang, Pei Liang and Chen Qu Tags: Research Source Type: research

Guiding pragmatic treatment choices for rifampicin-resistant tuberculosis in the absence of second-line drug susceptibility testing
Extract With recent expansion in the use of bedaquiline and limited access to accurate drug susceptibility testing (DST), we read with concern of examples of the high prevalence of bedaquiline resistance detected in Mycobacterium tuberculosis isolates [1]. Choosing the most effective regimen for treatment of drug-resistant tuberculosis (TB) is crucially important [2] and requires accurate and timely DST. In the past decade, there has been wide roll-out of rapid molecular tests that can identify M. tuberculosis and mutations conferring rifampicin resistance (RR). However, for potent second-line drugs, such as fluoroquinolon...
Source: European Respiratory Journal - November 29, 2023 Category: Respiratory Medicine Authors: Achar, J., Seddon, J. A., Knight, G. M., Dodd, P. J., Esmail, H., Hughes, J., McQuaid, C. F. Tags: Respiratory infections and tuberculosis Research Letters Source Type: research

Postoperative wound infection by nontuberculous mycobacteria; case series in Dhaka Medical College Hospital of Bangladesh
Key Clinical MessageThe incidence of nontuberculous mycobacterial (NTM) infections after operations is increasing in Bangladesh but data regarding clinical presentation, diagnosis, treatment, and prognosis after treatment are lacking. In this case series, three patients having persistent serous discharge from incision wound after operation were studied. Discharge from wounds were collected, wet film microscopy was performed for pus cells and fungus, Gram stain, Ziehl-Neelsen (ZN) stain, culture in routine culture media and Lowenstein-Jensen (LJ) media, Xene-Xpert for mycobacterium tuberculosis (MTB), polymerase chain react...
Source: Clinical Case Reports - November 28, 2023 Category: General Medicine Authors: Kakali Halder, Nusrat Noor Tanni, Rubaiya Binte Kabir, Maherun Nesa, Md. Faizur Rahman, Rizwana Zaman, Farjana Binte Habib, Noor ‐E‐Jannat Tania, Md. Asaduzzaman, Azmeri Haque, Akteruzzaman Chowdhury, Avizit Sarker, Nadira Akter, Mahbuba Tags: CASE SERIES Source Type: research

Antibiotic therapy in reconstructive surgery of deep sternal wound infections
CONCLUSION: There is no evidence of benefit from antibiotic therapy over 14 days, whereas multidrug resistance increases with prolonged antibiotic use. In the absence of infectious agents or clinical signs of inflammation, surgical treatment without additional antibiotic treatment is effective.Linezolid is a suitable antibiotic in the treatment of gram-positive infections which are the most frequent in DSWI.PMID:38007643 | DOI:10.3233/CH-238121 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 26, 2023 Category: Hematology Authors: P Unbehaun L Prantl S Langer N Spindler Source Type: research

Antibiotic therapy in reconstructive surgery of deep sternal wound infections
CONCLUSION: There is no evidence of benefit from antibiotic therapy over 14 days, whereas multidrug resistance increases with prolonged antibiotic use. In the absence of infectious agents or clinical signs of inflammation, surgical treatment without additional antibiotic treatment is effective.Linezolid is a suitable antibiotic in the treatment of gram-positive infections which are the most frequent in DSWI.PMID:38007643 | DOI:10.3233/CH-238121 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 26, 2023 Category: Hematology Authors: P Unbehaun L Prantl S Langer N Spindler Source Type: research

Antibiotic therapy in reconstructive surgery of deep sternal wound infections
CONCLUSION: There is no evidence of benefit from antibiotic therapy over 14 days, whereas multidrug resistance increases with prolonged antibiotic use. In the absence of infectious agents or clinical signs of inflammation, surgical treatment without additional antibiotic treatment is effective.Linezolid is a suitable antibiotic in the treatment of gram-positive infections which are the most frequent in DSWI.PMID:38007643 | DOI:10.3233/CH-238121 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 26, 2023 Category: Hematology Authors: P Unbehaun L Prantl S Langer N Spindler Source Type: research

Antibiotic therapy in reconstructive surgery of deep sternal wound infections
CONCLUSION: There is no evidence of benefit from antibiotic therapy over 14 days, whereas multidrug resistance increases with prolonged antibiotic use. In the absence of infectious agents or clinical signs of inflammation, surgical treatment without additional antibiotic treatment is effective.Linezolid is a suitable antibiotic in the treatment of gram-positive infections which are the most frequent in DSWI.PMID:38007643 | DOI:10.3233/CH-238121 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 26, 2023 Category: Hematology Authors: P Unbehaun L Prantl S Langer N Spindler Source Type: research

Antibiotic therapy in reconstructive surgery of deep sternal wound infections
CONCLUSION: There is no evidence of benefit from antibiotic therapy over 14 days, whereas multidrug resistance increases with prolonged antibiotic use. In the absence of infectious agents or clinical signs of inflammation, surgical treatment without additional antibiotic treatment is effective.Linezolid is a suitable antibiotic in the treatment of gram-positive infections which are the most frequent in DSWI.PMID:38007643 | DOI:10.3233/CH-238121 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - November 26, 2023 Category: Hematology Authors: P Unbehaun L Prantl S Langer N Spindler Source Type: research

Brain abscess caused by Porphyromonas gingivalis and Eubacterium nodatum mimicking acute stroke
We described a case of a 65-year-old man with a brain abscess caused by Porphyromonas gingivalis and Eubacterium nodatum. The patient presented right central facial nerve palsy, mutism and right hemiparesis at the examination. The patient underwent a left frontal craniotomy with evacuation of the brain abscess. Specimens were collected for microbiological analysis and intravenous treatment was started with levetiracetam, dexamethasone, meropenem (1 g/8 h) and linezolid (600 mg/12 h). After identification of anaerobic bacteria the antibiotic treatment was changed to piperacillin/tazobactam (4 g/0,5 g/8 h), fulfilling 8 week...
Source: Anaerobe - November 25, 2023 Category: Microbiology Authors: Domingo Fern ández Vecilla Mary Paz Roche Matheus Mikel Urrutikoetxea Guti érrez Gotzon Iglesias Hidalgo Cristina Aspichueta Vivanco Jos é Luis Díaz de Tuesta Del Arco Source Type: research

Brain abscess caused by Porphyromonas gingivalis and Eubacterium nodatum mimicking acute stroke
We described a case of a 65-year-old man with a brain abscess caused by Porphyromonas gingivalis and Eubacterium nodatum. The patient presented right central facial nerve palsy, mutism and right hemiparesis at the examination. The patient underwent a left frontal craniotomy with evacuation of the brain abscess. Specimens were collected for microbiological analysis and intravenous treatment was started with levetiracetam, dexamethasone, meropenem (1 g/8 h) and linezolid (600 mg/12 h). After identification of anaerobic bacteria the antibiotic treatment was changed to piperacillin/tazobactam (4 g/0,5 g/8 h), fulfilling 8 week...
Source: Anaerobe - November 25, 2023 Category: Microbiology Authors: Domingo Fern ández Vecilla Mary Paz Roche Matheus Mikel Urrutikoetxea Guti érrez Gotzon Iglesias Hidalgo Cristina Aspichueta Vivanco Jos é Luis Díaz de Tuesta Del Arco Source Type: research

Brain abscess caused by Porphyromonas gingivalis and Eubacterium nodatum mimicking acute stroke
We described a case of a 65-year-old man with a brain abscess caused by Porphyromonas gingivalis and Eubacterium nodatum. The patient presented right central facial nerve palsy, mutism and right hemiparesis at the examination. The patient underwent a left frontal craniotomy with evacuation of the brain abscess. Specimens were collected for microbiological analysis and intravenous treatment was started with levetiracetam, dexamethasone, meropenem (1 g/8 h) and linezolid (600 mg/12 h). After identification of anaerobic bacteria the antibiotic treatment was changed to piperacillin/tazobactam (4 g/0,5 g/8 h), fulfilling 8 week...
Source: Anaerobe - November 25, 2023 Category: Microbiology Authors: Domingo Fern ández Vecilla Mary Paz Roche Matheus Mikel Urrutikoetxea Guti érrez Gotzon Iglesias Hidalgo Cristina Aspichueta Vivanco Jos é Luis Díaz de Tuesta Del Arco Source Type: research