Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury
CONCLUSIONS: Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.PMID:38099833 | DOI:10.1164/rccm.202306-0974OC (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - December 15, 2023 Category: Intensive Care Authors: Johannes Geilen Matthias Kainz Bernhard Zapletal Asami Naka Johanna Tichy Walter J äger Michaela B öhmdorfer Markus Zeitlinger Marcus J Schultz Tanja Stamm Valentin Ritschl Silvana Geleff Edda Tschernko Source Type: research

The prevalence of Staphylococcus aureus and the emergence of livestock-associated MRSA CC398 in pig production in eastern China
This study investigated the prevalence of MRSA in pig production in Eastern China and determined the genomic characteristics of pig-associated MRSA isolates by whole-genome sequencing (WGS). A total of 1,318 samples were collected from pig farms and pig slaughterhouses, and 150 S. aureus were identified, including 63 MRSA isolates and 87 MSSA isolates. MRSA was detected in all pig farms and pig slaughterhouses. The antimicrobial susceptibility test revealed that all MRSA isolates were multidrug-resistant. The WGS and MLST analysis demonstrated that 56 MRSA isolates belonged to clonal complex (CC) 398, and seven MRSA isolat...
Source: Frontiers in Microbiology - December 15, 2023 Category: Microbiology Source Type: research

Antibacterial activity of < em > Hypericum perforatum < /em > L. (St. John's wort) extracts against Gram-positive bacteria and characterisation of its secondary metabolites
This study aimed to determine the secondary metabolite profiles and antibacterial activity of H. perforatum L extracts against Gram-positive clinical isolates. The plant materials (Sample A and Sample B) were macerated with n-hexane, ethyl acetate and methanol (MeOH). The antibacterial activitiy of plant extracts and routinely used antibiotics were tested against Gram-positive bacteria. The secondary metabolite profiles of Sample A were determined by LC-Q-TOF-MS. The MIC values for n-hexane and ethyl acetate extracts of Sample A were lower than the susceptibility breakpoints of most broad-spectrum antibiotics (e.g. vancomy...
Source: Natural Product Research - December 14, 2023 Category: Biochemistry Authors: Ozgul Kisa Lutfiye Oksuz Huseyin Servi Ayhan Ibrahim Aysal Source Type: research

The role of long-acting antibiotics in the clinical practice: a narrative review
DISCUSSION: Registration studies confirmed non-inferiority of long-acting glycopeptides to standard of care in ABSSSI (dalbavancin DISCOVER 1 and 2: 79.7% clinical success in the dalbavancin group and 79.8% in the vancomycin-linezolid group; oritavancin SOLO I: 82,3% clinical success in the oritavancin group versus 78,9% for the vancomycin group; SOLO II: 80,1% clinical success versus 82,9%). Large cohorts have confirmed similar success rates in ABSSSI treatment in real-world practice. Evidence for off-label indications is still rather scarce but promising, especially in bone and joint infections therapy for both dalbavanc...
Source: Infezioni in Medicina - December 11, 2023 Category: Infectious Diseases Authors: Giulia Micheli Marta Chiuchiarelli Francesco Taccari Massimo Fantoni Source Type: research