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Liquid chromatography-tandem mass spectrometry methods for quantification of total and free antibiotic concentrations in serum and exudate from patients with post-sternotomy deep sternal wound infection receiving negative pressure wound therapy
CONCLUSION: This method can accurately quantify the total and free concentrations of 16 antibiotics. Comparison of concentration ratios between serum and exudates allows for monitoring individual antibiotics' penetration capacity in patients receiving NPWT.PMID:38185284 | DOI:10.1016/j.cca.2023.117704 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - January 7, 2024 Category: Chemistry Authors: Hana Brozmanov á Pavel Šištík Jana Ďuricová Ivana Kac ířová Kl ára Kaňková Martin Kolek Source Type: research

Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis
Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - January 5, 2024 Category: Infectious Diseases Authors: Yuan Li, Guohua Lei, Weijie Dong, Tinglong Lan, Jun Fan and Shibing Qin Tags: Research Source Type: research

High prevalence of heteroresistance in < i > Staphylococcus aureus < /i > is caused by a multitude of mutations in core genes
by Sheida Heidarian, Andrei Guliaev, Herv é Nicoloff, Karin Hjort, Dan I. Andersson Heteroresistance (HR) is an enigmatic phenotype where, in a main population of susceptible cells, small subpopulations of resistant cells exist. This is a cause for concern, as this small subpopulation is difficult to detect by standard antibiotic susceptibility tests, and upon antibiotic exposure the resistant subpopulation may increase in frequency and potentially lead to treatment complications or failure. Here, we determined the prevalence and mechanisms of HR for 40 clinicalStaphylococcus aureus isolates, against 6 clinically importa...
Source: PLoS Biology: Archived Table of Contents - January 4, 2024 Category: Biology Authors: Sheida Heidarian Source Type: research

Second-line anti-tuberculosis drug exposure thresholds predictive of adverse events in multidrug-resistant tuberculosis treatment
Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem [1]. The introduction of new (bedaquiline) and repurposed drugs (linezolid and clofazimine) is expected to improve treatment outcomes [2], but adverse events (AEs) related to these drugs have been frequently reported during the long-term MDR-TB treatment [3]. As many as 8.4% of patients with MDR-TB experienced serious AEs, including corrected QT interval by Fridericia's formula (QTcF) above 500ms, bone marrow suppression, peripheral neuropathy, and kidney/liver failure, resulting in treatment failure, as well as major morbidity and even death [...
Source: International Journal of Infectious Diseases - January 2, 2024 Category: Infectious Diseases Authors: Sainan Wang, Lina Davies Forsman, Chunhua Xu, Haoyue Zhang, Yue Zhu, Ge Shao, Shanshan Wang, Jiayi Cao, Haiyan Xiong, Katarina Niward, Thomas Sch ön, Judith Bruchfeld, Limei Zhu, Jan-Willem Alffenaar, Yi Hu Source Type: research

Second-line antituberculosis drug exposure thresholds predictive of adverse events in multidrug-resistant tuberculosis treatment
Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem [1]. The introduction of new (bedaquiline) and repurposed drugs (linezolid and clofazimine) is expected to improve treatment outcomes [2], but adverse events (AEs) related to these drugs have been frequently reported during the long-term MDR-TB treatment [3]. As many as 8.4% of patients with MDR-TB experienced serious AEs, including corrected QT interval by Fridericia's formula (QTcF) above 500 ms, bone marrow suppression, peripheral neuropathy, and kidney/liver failure, resulting in treatment failure, as well as major morbidity and even death ...
Source: International Journal of Infectious Diseases - January 2, 2024 Category: Infectious Diseases Authors: Sainan Wang, Lina Davies Forsman, Chunhua Xu, Haoyue Zhang, Yue Zhu, Ge Shao, Shanshan Wang, Jiayi Cao, Haiyan Xiong, Katarina Niward, Thomas Sch ön, Judith Bruchfeld, Limei Zhu, Jan-Willem Alffenaar, Yi Hu Source Type: research

Linezolid/Meropenem
(Source: Reactions Weekly)
Source: Reactions Weekly - January 1, 2024 Category: Drugs & Pharmacology Source Type: research

Comparison of the incidence of nausea and vomiting between linezolid and vancomycin using claims database: a retrospective cohort study
ConclusionThis study clarified the relationship between linezolid and nausea and vomiting using a Japanese claims database. Further studies are required to elucidate the unknown mechanisms of linezolid-induced nausea and vomiting. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 29, 2023 Category: Drugs & Pharmacology Source Type: research

Urinary tract infection associated with bacteremia caused by vancomycin ‐resistant enterococcus following continent urinary diversion
Miami pouch in the right lower abdomen is dilated because of incomplete intermittent self-catheterization. It caused pyelonephritis and bacteremia by vancomycin-resistant enterococcus. Key Clinical MessageEven in a country where vancomycin –resistant enterococcus is rare, multidrug-resistant organism precautions are necessary when admitting patients with a history of medical exposure in other countries. On admission, screening is necessary and if infection is confirmed, a multidisciplinary approach involving different specialists is required.AbstractThe patient was a 49-year-old Japanese female living in the United State...
Source: Clinical Case Reports - December 28, 2023 Category: General Medicine Authors: Kai Morishita, Soichiro Kashiwabara, Yuki Matsumoto, Atsuhiro Mizushima, Kaori Hara, Toshihiko Agatsuma, Yuji Mimura, Hideyoshi Matsumura, Hiroya Mizusawa Tags: CASE REPORT Source Type: research

Linezolid and vancomycin for nosocomial infections in pediatric patients: a systematic review
CONCLUSION: Both linezolid and vancomycin showed good efficacy in the treatment of bacterial infections caused by resistant Gram-positive bacteria in hospitalized children. However, linezolid stands out regarding its pharmacological safety. Importantly, to strengthen this conclusion, further clinical trials are needed to provide additional evidence.PMID:38145631 | DOI:10.1016/j.jped.2023.08.011 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - December 25, 2023 Category: Pediatrics Authors: Bruno Russo Porchera Carolina Moraes da Silva Rayssa Pinheiro Miranda Ant ônio Rafael Quadros Gomes Pedro Henrique Dos Santos Fernandes Camili Giseli Oliveira de Menezes Paula do Socorro de Oliveira da Costa Laurindo Maria Fani Dolabela Heliton Patrick C Source Type: research