A high performance liquid chromatography - Tandem mass spectrometry assay for therapeutic drug monitoring of 10 drug compounds commonly used for antimicrobial therapy in plasma and serum of critically ill patients: Method optimization, validation, cross-validation and clinical application
CONCLUSION: The established multiplex method covers major drug classes with documented dosing challenges, provides a reliable basis for the implementation of high-throughput TDM, and its application confirmed the clinical impact of TDM in a real-world setting.PMID:38677452 | DOI:10.1016/j.cca.2024.119690 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 27, 2024 Category: Chemistry Authors: Sylvia Karin Neef Anna-Diana Hinderer Wassim Arbash Fritz S örgel Christian Wunder Matthias Schwab Ute Hofmann Source Type: research
Adverse reactions caused by high serum concentration of linezolid: Two case reports and literature review
The relationship between drug concentrations and adverse drug reactions in patients. Key Clinical MessageLinezolid is a potent oxazolidinone for the treatment of various gram-positive bacterial infections. However, the drug can cause potential adverse reactions such as thrombocytopenia, hyperlactacidemia and serotonin syndrome, which warrant consideration by the medical team when planning treatment. The existing literature has reported some adverse reactions caused by linezolid, but most of these are based on clinical characteristics and simple treatment measures. Two cases of linezolid overdose resulting in thrombocytopen...
Source: Clinical Case Reports - April 27, 2024 Category: General Medicine Authors: Renzhu Liu,
Lu Xiao,
Can Xiao,
Wencan Li,
Xiang Liu Tags: CASE REPORT Source Type: research
Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
Euro Surveill. 2024 Apr;29(17). doi: 10.2807/1560-7917.ES.2024.29.17.2400211.ABSTRACTThe BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on nation...
Source: Euro Surveill - April 26, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp Suzanne Edwards Giorgi Kuchukhidze Stefan Kr öger Brit H äcker Stela Bivol Askar Yedilbayev Source Type: research
Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
Euro Surveill. 2024 Apr;29(17). doi: 10.2807/1560-7917.ES.2024.29.17.2400211.ABSTRACTThe BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on nation...
Source: Euro Surveill - April 26, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp Suzanne Edwards Giorgi Kuchukhidze Stefan Kr öger Brit H äcker Stela Bivol Askar Yedilbayev Source Type: research
Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
Euro Surveill. 2024 Apr;29(17). doi: 10.2807/1560-7917.ES.2024.29.17.2400211.ABSTRACTThe BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on nation...
Source: Euro Surveill - April 26, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp Suzanne Edwards Giorgi Kuchukhidze Stefan Kr öger Brit H äcker Stela Bivol Askar Yedilbayev Source Type: research
Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
Euro Surveill. 2024 Apr;29(17). doi: 10.2807/1560-7917.ES.2024.29.17.2400211.ABSTRACTThe BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on nation...
Source: Euro Surveill - April 26, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp Suzanne Edwards Giorgi Kuchukhidze Stefan Kr öger Brit H äcker Stela Bivol Askar Yedilbayev Source Type: research
Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
Euro Surveill. 2024 Apr;29(17). doi: 10.2807/1560-7917.ES.2024.29.17.2400211.ABSTRACTThe BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on nation...
Source: Euro Surveill - April 26, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp Suzanne Edwards Giorgi Kuchukhidze Stefan Kr öger Brit H äcker Stela Bivol Askar Yedilbayev Source Type: research
Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
Euro Surveill. 2024 Apr;29(17). doi: 10.2807/1560-7917.ES.2024.29.17.2400211.ABSTRACTThe BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on nation...
Source: Euro Surveill - April 26, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp Suzanne Edwards Giorgi Kuchukhidze Stefan Kr öger Brit H äcker Stela Bivol Askar Yedilbayev Source Type: research
Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
The BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on national and supranational level are needed to guarantee universal access. (Source: Eurosurveillance)
Source: Eurosurveillance - April 25, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp, Suzanne Edwards, Giorgi Kuchukhidze, Stefan Kr öger, Brit Häcker, Stela Bivol and Askar Yedilbayev Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research
