A Randomized, Adaptive, Dose-Ranging, Open-Label Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis
Conditions: Pulmonary Tuberculosis Interventions: Drug: Isoniazid; Drug: Rifampicin; Drug: Pyrazinamide; Drug: Ethambutol; Drug: Bedaquiline; Drug: Pretomanid; Drug: Linezolid; Drug: TBI-223; Drug: Sutezolid Sponsors: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 5, 2024 Category: Research Source Type: clinical trials

Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial
DiscussionThis internally controlled study of shortened treatment for pre-XDR TB will provide urgently needed data and evidence for clinical and policy decision-making around the treatment of pre-XDR TB with a four-drug, all-oral, shortened regimen.Trial registrationClinicalTrials.Gov NCT03896685. Registered on 1 April 2018; the record was last updated for study protocol version 4.3 on 17 March 2023. (Source: Trials)
Source: Trials - November 30, 2023 Category: Research Source Type: clinical trials

Adjunctive Clindamycin Versus Linezolid for β-lactam Treated Patients With Invasive Group A Streptococcal Infections
Conditions: Streptococcal Sepsis; Invasive Group A Beta-Haemolytic Streptococcal Disease; Necrotizing Soft Tissue Infection; Infection, Bloodstream; Infection, Bacterial; Streptococcal Toxic Shock Syndrome Interventions: Drug: Linezolid; Drug: Clindamycin Sponsors: National Institutes of Health Clinical Center (CC); Emory University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 10, 2023 Category: Research Source Type: clinical trials

Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB
Conditions: Pulmonary Tuberculosis Interventions: Drug: GSK3036656; Drug: BTZ-043; Drug: Bedaquiline (B); Drug: Delamanid (D); Drug: Pretomanid (Pa); Drug: Moxifloxacin (M); Drug: Linezolid (L); Drug: Pyrazinamide (Z); Drug: Rifampicin (R); Drug: Isoniazid (H); Drug: Ethambutol (E) Sponsors: University College, London; Radboud University Medical Center; London School of Hygiene and Tropical Medicine; University of Oxford; Research Center Borstel; Lygature; TASK Applied Science; Vita-Salute San Raffaele University; Helmholtz Zentrum Munchen; KNCV Tuberculosis Foundation; Critical Path Institute; European Lung Foundation; In...
Source: ClinicalTrials.gov - November 2, 2023 Category: Research Source Type: clinical trials

Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis :Contizolid and Dlamanid Cohort
Conditions: Pulmonary Tuberculosis; Rifampicin-resistant Tuberculosis Interventions: Drug: Bedaquiline; Drug: Delamanid; Drug: Contezolid; Drug: Levofloxacin; Drug: Moxifloxacin; Drug: Clofazimine; Drug: Linezolid; Drug: Cycloserine; Drug: Prothionamide; Drug: Pyrazinamide; Drug: Para-Aminosalicylic Acid; Drug: Ethambutol Sponsors: Beijing Chest Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 13, 2023 Category: Research Source Type: clinical trials

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary Tuberculosis
Conditions:   Pulmonary TB;   Pulmonary Tuberculosis;   Drug Sensitive Tuberculosis Interventions:   Drug: TBAJ-876;   Drug: Pretomanid;   Drug: Linezolid;   Drug: Bedaquiline;   Drug: HRZE;   Drug: HR Sponsor:   Global Alliance for TB Drug Development Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 28, 2023 Category: Research Source Type: clinical trials

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, With Pretomanid and Linezolid in Adults With Drug-sensitive Pulmonary Tuberculosis
Conditions: Pulmonary TB; Pulmonary Tuberculosis; Drug Sensitive Tuberculosis Interventions: Drug: TBAJ-876; Drug: Pretomanid; Drug: Linezolid; Drug: Bedaquiline; Drug: HRZE; Drug: HR Sponsors: Global Alliance for TB Drug Development Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 28, 2023 Category: Research Source Type: clinical trials

Comparing Oral Versus Parenteral Antimicrobial Therapy
Conditions:   Endovascular Infection;   Bone and Joint Infection;   Skin and Soft Tissue Infection;   Pulmonary Infection;   Gastrointestinal Infection;   Genitourinary Infection Interventions:   Drug: Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid;   Drug: Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem Sponsor:   West Virginia University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 7, 2023 Category: Research Source Type: clinical trials