Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013 –2020
ConclusionSignificant heterogeneity in ACD and prescription of different antibiotic classes as well as high prescription rates for cephalosporins and an increased use of reserve antibiotics indicate improvable antibiotic prescribing quality. AMS programs should urgently prioritize these issues to reduce antimicrobial resistance. (Source: Infection)
Source: Infection - November 2, 2023 Category: Infectious Diseases Source Type: research

Cefazolin/levofloxacin/linezolid
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2023 Category: Drugs & Pharmacology Source Type: research

Epidemiology of Nontuberculous Mycobacteria in Tuberculosis suspects, Southwest of China, 2017-2022
ConclusionThe NTM isolation rate in Southwest China has risen in recent years, primarily among elderly patients with a high HIV co-infection rate. The main NTM isolates were MAC and M. chelonae/M. abscessus. Amikacin, moxifloxacin, clarithromycin, and linezolid exhibited strong antibacterial activity against SGM, while amikacin and linezolid displayed relatively better antibacterial activity against RGM. The prevalence of NTM infection may be positively associated with regional economic development and health conditions. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - October 31, 2023 Category: Microbiology Source Type: research

Prevalence and antibacterial resistance patterns of uropathogenic staphylococci in Casablanca, Morocco
Conclusions: The prevalence and antibacterial resistance patterns of uropathogenic staphylococci in this study, with a high percentage of methicillin resistance, require careful consideration of antimicrobial therapy for staphylococcal UTIs. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - October 31, 2023 Category: Infectious Diseases Authors: Rafik Aniba, Abouddihaj Barguigua, Asmaa Dihmane, Ghizlane Momen, Kaotar Nayme, Mohammed Timinouni Source Type: research

Hybrid surgical treatment of a complicated intralobar sequestration in a young adult.
Conclusion: To our knowledge this is the first published case report of an ILS receiving direct supply by four aberrant arteries. It supports emerging cases demonstrating accumulating benefits and improved outcomes of endoluminal aortic stenting followed by surgery in selected ILS patient population. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Lioumpas, D., Tzatzadaki, E., Michelis, S., Theodorou, A., Gkantinas, G., Fergadis, E., Trimandili, M., Fachouridis, T., Metaxas, E., Stamatatos, I., Benakis, G., Samiotis, I., Katsantonis, A., Theoni, K., Antoniadis, A., Zaragkas, S., Tzatzadakis, N. Tags: Thoracic surgery Source Type: research

Programmatic management of bedaquiline-pretomanid-linezolid regimens in Georgia.
Conclusion: BPaL regimens showed excellent efficacy and good safety in program settings in Georgia. Urgent need to develop rapid tests for new drugs to avoid delaying adequate treatment. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Kiria, N., Avaliani, Z., Togonidze, T., Mikiashvili, L. Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research

Real-life experience using intravenous Fosfomycin in patients with Cystic Fibrosis and non-Cystic Fibrosis bronchiectasis
Conclusions: ivFO proved to be effective in PEx in pwCF and pwNCFB even after repeated courses. Treatment was well tolerated, with fewer side effects than in previous literature, despite an older population. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Riberi, L., Valsecchi, L., Falco, A., Scopelliti, N., Mossetto, C., Soccal, S., Demichelis, S., Perboni, A., Messore, B. Tags: Adult CF Source Type: research

Frequency of serious adverse events on therapy with modified fully oral shorter treatment regimens (mSTR) for MDR/RR-TB
Conclusion: SAE occur during mSTR, but rarely lead to treatment discontinuation. Proper SAE monitoring and management are essential for any TB response. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Gurbanova, E., Yatskevich, N., Yedilbayev, A., Korotych, O., Hovhannesyan, A., Tyshko, M., Dankova, N., Skrahina, A. Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research

Beta-lactamase activity is a biomarker for the prediction of the efficacy of antimicrobial therapy.
Conclusion: The conclusion argues for the necessity of determining the level of beta-lactamase activity in biological substrates in order to predict the efficacy of successful treatment with first-line BLA within the framework of evidence-based medicine. The evaluation of the BLA level will allow for a reduction of up to 30% in the unjustified use of BLAs. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Mukhsinov, F., Liverko, I. Tags: General practice and primary care Source Type: research

Linezolid-induced peripheral neuropathy in patients receiving MDR-TB treatment
Conclusion: These findings emphasise the need for close monitoring of side effects and careful consideration of treatment duration is required when using linezolid in the treatment of TB. Therapeutic drug monitoring may allow for dose reductions in the future. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Skyllberg, E., Young, R., Sharma, A., Chen, C., Tiberi, S., White, V., Kunst, H. Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research

Seventeen drugs, one sample: analyzing multiple anti-TB drugs simultaneously using one method
In conclusion, we developed a method to analyze 17 anti-TB drugs simultaneously in one sample of plasma, serum or saliva: all first-line, BPaLM, and 9m all oral regimen for MDR/RR-TB drugs, and 63% of the longer MDR-TB regimen drugs. This method will save time and will further optimize therapeutic drug monitoring. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Bolhuis, M. S., Jongedijk, E. M., Akkerman, O. W., Touw, D. J., Sturkenboom, M. G. G. Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research

Tuberculous meningoencephalitis complicate with mielitis
Conclusions: Patients with myelitis often have poor outcomes. In the presented case, the patient had a favorable clinical response to the treatment, but despite the correctly administered antituberculous treatment, the inflammation in the CSF continues to persist. Further research on the pathogenesis of TB myelitis will be helpful to provide potential effective therapy to these patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Caliman-Sturdza, O. A. Tags: Tuberculosis and non-tuberculous mycobacterial diseases Source Type: research