A systematic efficacy analysis of tuberculosis treatment with BPaL ‐containing regimens using a multiscale modeling approach
In this study, we present a unique framework that uses a primate granuloma modeling approach to screen many combination regimens that are currently under clinical and experimental exploration and assesses their efficacies to inform future studies. We tested well-studied regimens such as HRZE and BPaL to evaluate the validity and accuracy of our framework. We also simulated additional promising combination regimens that have not been sufficiently studied clinically or experimentally, and we provide a pipeline for regimen ranking based on their efficacies in granulomas. Furthermore, we showed a correlation between simulation...
Source: CPT: Pharmacometrics and Systems Pharmacology - February 26, 2024 Category: Drugs & Pharmacology Authors: Maral Budak, Laura E. Via, Danielle M. Weiner, Clifton E. Barry III, Pariksheet Nanda, Gabrielle Michael, Khisimuzi Mdluli, Denise Kirschner Tags: ARTICLE Source Type: research

Assessment of Zn and Cu in piglets' liver and kidney: impact in fecal Enterococcus spp.?
Environ Sci Pollut Res Int. 2024 Feb 21. doi: 10.1007/s11356-024-32495-8. Online ahead of print.ABSTRACTZinc and copper have been used as growth promotors in alternative to antibiotics in pig's diet. The aim was the ascertainment of the Zn and Cu concentrations in piglets' liver and kidney and their impact in the reduced susceptibility to Zn, Cu, and antibiotics in enterococci, used as microbiota biomarker. Zn and Cu were determined in the livers and kidneys of 43 piglets slaughtered in Portugal, by flame atomic absorption spectrometry. Enterococci were isolated from feces for determining the identification of species (E. ...
Source: Environmental Science and Pollution Research International - February 21, 2024 Category: Environmental Health Authors: Maria M Donato Gabriela Assis Olga Cardoso B árbara Oliveiros Andreia Freitas Fernando Ramos Source Type: research

Assessment of Zn and Cu in piglets' liver and kidney: impact in fecal Enterococcus spp.?
Environ Sci Pollut Res Int. 2024 Feb 21. doi: 10.1007/s11356-024-32495-8. Online ahead of print.ABSTRACTZinc and copper have been used as growth promotors in alternative to antibiotics in pig's diet. The aim was the ascertainment of the Zn and Cu concentrations in piglets' liver and kidney and their impact in the reduced susceptibility to Zn, Cu, and antibiotics in enterococci, used as microbiota biomarker. Zn and Cu were determined in the livers and kidneys of 43 piglets slaughtered in Portugal, by flame atomic absorption spectrometry. Enterococci were isolated from feces for determining the identification of species (E. ...
Source: Environmental Science and Pollution Research International - February 21, 2024 Category: Environmental Health Authors: Maria M Donato Gabriela Assis Olga Cardoso B árbara Oliveiros Andreia Freitas Fernando Ramos Source Type: research

Prediction of risk factors for linezolid-induced thrombocytopenia based on neural network model
Conclusion: The predictive performance of the artificial neural network model is better than that of the traditional Logistic regression model, and it can well predict the risk factors of linezolid-induced thrombocytopenia. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 21, 2024 Category: Drugs & Pharmacology Source Type: research

Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis
Antimicrob Agents Chemother. 2024 Feb 20:e0156223. doi: 10.1128/aac.01562-23. Online ahead of print.ABSTRACTThe combination of bedaquiline, pretomanid, and linezolid (BPaL) has become a preferred regimen for treating multidrug- and extensively drug-resistant tuberculosis (TB). However, treatment-limiting toxicities of linezolid and reports of emerging bedaquiline and pretomanid resistance necessitate efforts to develop new short-course oral regimens. We recently found that the addition of GSK2556286 increases the bactericidal and sterilizing activity of BPa-containing regimens in a well-established BALB/c mouse model of tu...
Source: Antimicrobial Agents and Chemotherapy - February 20, 2024 Category: Microbiology Authors: Si-Yang Li Sandeep Tyagi Heena Soni Fabrice Betoudji Paul J Converse Khisimuzi Mdluli Anna M Upton Nader Fotouhi David Barros-Aguirre Llu ís Ballell Elena Jimenez-Navarro Eric L Nuermberger Source Type: research

Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis
Antimicrob Agents Chemother. 2024 Feb 20:e0156223. doi: 10.1128/aac.01562-23. Online ahead of print.ABSTRACTThe combination of bedaquiline, pretomanid, and linezolid (BPaL) has become a preferred regimen for treating multidrug- and extensively drug-resistant tuberculosis (TB). However, treatment-limiting toxicities of linezolid and reports of emerging bedaquiline and pretomanid resistance necessitate efforts to develop new short-course oral regimens. We recently found that the addition of GSK2556286 increases the bactericidal and sterilizing activity of BPa-containing regimens in a well-established BALB/c mouse model of tu...
Source: Antimicrobial Agents and Chemotherapy - February 20, 2024 Category: Microbiology Authors: Si-Yang Li Sandeep Tyagi Heena Soni Fabrice Betoudji Paul J Converse Khisimuzi Mdluli Anna M Upton Nader Fotouhi David Barros-Aguirre Llu ís Ballell Elena Jimenez-Navarro Eric L Nuermberger Source Type: research

Daptomycin plus ceftaroline salvage therapy for persistent Staphylococcus epidermidis bacteremia
Key Clinical MessageInitial antibiotics for trueStaphylococcus epidermidis bacteremia include vancomycin or linezolid, but if bacteremia persists, consideration should be made for salvage combination therapy regimes such as daptomycin with ceftaroline. (Source: Clinical Case Reports)
Source: Clinical Case Reports - February 20, 2024 Category: General Medicine Authors: Hayden Zhang, Kylie Tran, Richard Lindley, Ravindra Dotel Tags: CASE REPORT Source Type: research

Risk factors and outcome associated with the acquisition of MDR linezolid-resistant Enterococcus faecium: a report from tertiary care centre
ConclusionThis study provided insight into epidemiology of MDR LREfm in a setting where linezolid use is high. The main drivers of infections with LREfm are multiple, including use of carbapenems and linezolid. Invasive procedures and increased hospital stay facilitate spread through breach in infection control practises. As therapeutic options are limited, ongoing surveillance of LREfm and VRE is critical to guide appropriate use of linezolid and infection control policies. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - February 19, 2024 Category: Microbiology Source Type: research

Adverse drug events associated with linezolid administration: a real-world pharmacovigilance study from 2004 to 2023 using the FAERS database
Conclusion: This study reports the time to onset of adverse effects in detail at the levels of SOC and specific preferred term (PT). The results of our study provide valuable insights for optimizing the use of linezolid and reducing potential side effects, expected to facilitate the safe use of linezolid in clinical settings. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 16, 2024 Category: Drugs & Pharmacology Source Type: research

Genomic characteristics of cfr and fexA carrying Staphylococcus aureus isolated from pig carcasses in Korea
This study evaluated the genetic characteristics of linezolid-resistantStaphylococcus aureus strains isolated from pig carcasses and further clarified potential resistance and virulence mechanisms in a newly identified sequence type. Of more than 2500 strains isolated in a prior study, 15 isolated from pig carcasses exhibited linezolid resistance (minimum inhibitory concentration  ≥ 8 mg/L). The strains were characterized in detail by genomic analysis. Linezolid-resistantS. aureus strains exhibited a high degree of genetic lineage diversity, with one strain (LNZ_R_SAU_64) belonging to ST8004, which has not been repo...
Source: Veterinary Research - February 16, 2024 Category: Veterinary Research Source Type: research

Predictive Modeling of Drug-Related Adverse Events with Real-World Data: A Case Study of Linezolid Hematologic Outcomes
Clin Pharmacol Ther. 2024 Feb 12. doi: 10.1002/cpt.3201. Online ahead of print.ABSTRACTElectronic health records (EHRs) provide meaningful knowledge of drug-related adverse events (AEs) that are not captured in standard drug development and postmarketing surveillance. Using variables obtained from EHR data in the University of California San Francisco de-identified Clinical Data Warehouse, we aimed to evaluate the potential of machine learning to predict two hematological AEs, thrombocytopenia and anemia, in a cohort of patients treated with linezolid for 3 or more days. Features for model input were extracted at linezolid...
Source: Clinical Pharmacology and Therapeutics - February 12, 2024 Category: Drugs & Pharmacology Authors: Anu Patel Sarah B Doernberg Travis Zack Atul J Butte Kendra K Radtke Source Type: research

Clinical Characteristics and Drug Resistance Mechanisms of Linezolid-Non-Susceptible Enterococcus in a Tertiary Hospital in Northwest China
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - February 8, 2024 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

3D printed PLGA scaffold with nano-hydroxyapatite carrying linezolid for treatment of infected bone defects
CONCLUSION: Overall, the linezolid-loaded PLGA-HA scaffolds fabricated by 3D printing exerts significant bone repair and anti-infection effects.PMID:38320333 | DOI:10.1016/j.biopha.2024.116228 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 6, 2024 Category: Drugs & Pharmacology Authors: A Li Mu Ke Re Mu Zhi Lin Liang Linlin Chen Ai Ke Bai Er Tu Xun Mai Mai Ti Ai Li A Bu Li Ke Mu Yuan Quan Wu Source Type: research

Serotype, antibiotic susceptibility and whole-genome characterization of Streptococcus pneumoniae in all age groups living in Southwest China during 2018 –2022
ConclusionOur study provides reliable information, including the prevalence, molecular characterization and antimicrobial resistance of S. pneumoniae isolates causing pneumococcal diseases in Southwest China. The findings contribute to informed and clinical policy decisions for prevention and treatment. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - February 1, 2024 Category: Microbiology Source Type: research

Prevalence of antibiotic resistance in clinical isolates of < em > Mycobacterium kansasii < /em > : a systematic review and meta-analysis
Expert Rev Anti Infect Ther. 2024 Jan 31:1-11. doi: 10.1080/14787210.2024.2313051. Online ahead of print.ABSTRACTINTRODUCTION: The prevalence of diseases caused by non-tuberculous mycobacteria (NTM), including M. kansasii, is increasing, necessitating further information to guide prevention, control, and treatment strategies.AREAS COVERED: A comprehensive analysis of articles published until February 2023 was conducted on PubMed, Web of Science, and Scopus databases to investigate antibiotic resistance in M. kansasii species. Stata software version 17 was employed for all analyses.EXPERT OPINION: A total of 1647 articles w...
Source: Expert Review of Anti-Infective Therapy - January 31, 2024 Category: Infectious Diseases Authors: Negar Narimisa Forough Goodarzi Narjess Bostanghadiri Faramarz Masjedian Jazi Source Type: research