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Prevalence and genetic characteristics of Staphylococcus aureus isolates from cell phones of medical students from Iran
Acta Microbiol Immunol Hung. 2024 Apr 15. doi: 10.1556/030.2024.02193. Online ahead of print.ABSTRACTAlthough mobile phones as a rapid communication vehicle can lead to improved quality of healthcare, they can also facilitate the transmission of pathogens to patients. This current research focuses on genetic diversity, and genes involved in resistance and biofilm production of Staphylococcus aureus isolates from mobile phones of medical students. Antibiotic resistance profiling and polymerase chain reaction (PCR) amplification of antibiotic resistance and biofilm-related genes were investigated and statistically analyzed. ...
Source: Acta Microbiologica et Immunologica Hungarica - April 15, 2024 Category: Microbiology Authors: Fatemeh Behrouzmanesh Sahar Ahmad Samali Rozhin Nasehi Ali Shivaee Mehdi Goudarzi Source Type: research

Successful treatment of penicillin-resistant pneumococcal meningitis following ventriculoperitoneal shunt in congenital hydrocephalus: A case report on the efficacy of linezolid
Asian J Surg. 2024 Apr 9:S1015-9584(24)00639-0. doi: 10.1016/j.asjsur.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38599973 | DOI:10.1016/j.asjsur.2024.04.007 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 10, 2024 Category: Surgery Authors: Jun Wei Junjie Ning Source Type: research

Assessing potential drug-drug interactions between clofazimine and other frequently used agents to treat drug-resistant tuberculosis
Antimicrob Agents Chemother. 2024 Apr 10:e0158323. doi: 10.1128/aac.01583-23. Online ahead of print.ABSTRACTClofazimine is included in drug regimens to treat rifampicin/drug-resistant tuberculosis (DR-TB), but there is little information about its interaction with other drugs in DR-TB regimens. We evaluated the pharmacokinetic interaction between clofazimine and isoniazid, linezolid, levofloxacin, and cycloserine, dosed as terizidone. Newly diagnosed adults with DR-TB at Klerksdorp/Tshepong Hospital, South Africa, were started on the then-standard treatment with clofazimine temporarily excluded for the initial 2 weeks. Pha...
Source: Antimicrobial Agents and Chemotherapy - April 10, 2024 Category: Microbiology Authors: Allan Kengo Firdaus Nabeemeeah Paolo Denti Ryan Sabet Gifty Okyere-Manu Pattamukkil Abraham Lubbe Weisner Modiehi Helen Mosala Sibongile Tshabalala Janine Scholefield Juan Eduardo Resendiz-Galvan Neil A Martinson Ebrahim Variava Source Type: research

Novel six-month all oral treatment of pre-extensively drug-resistant tuberculosis in Canada: New treatment options present new implementation challenges
Can Commun Dis Rep. 2023 Jan 5;49(1):15-20. doi: 10.14745/ccdr.v49i01a04. eCollection 2023 Jan 5.ABSTRACTDrug-resistant tuberculosis (TB) is a major global health challenge in part because there are fewer effective treatments and these treatments have been prolonged and more toxic. The evidence base for more effective, shorter, standardized treatments is evolving rapidly. Herein, we report the first case of pre-extensively drug-resistant pulmonary TB treated with a novel six-month all oral bedaquiline, pretomanid and linezolid (BPaL) regimen in Canada. Recent clinical trial data supporting BPaL therapy is presented in the ...
Source: Can Commun Dis Rep - March 29, 2024 Category: Infectious Diseases Authors: William Connors Cesilia Nishi Inna Sekirov Victoria Cook James Johnston Source Type: research

Nocardiosis in kidney transplant recipients: A tertiary care center experience
CONCLUSION: Nocardia may cause a late-manifesting infection beyond the traditional window. The cotrimoxazole prophylaxis may not be sufficient for Nocardia prevention.PMID:38537681 | DOI:10.1016/j.trim.2024.102041 (Source: Transplant Immunology)
Source: Transplant Immunology - March 27, 2024 Category: Transplant Surgery Authors: Rungmei Marak None Abdullah Manas Behera Anupma Kaul Dharmendra Bhaduaria Narayan Prasad Manas Patel Ravi Kushwaha Monika Yachha Source Type: research

The Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus Before and After the COVID-19 Pandemic in a Tertiary Saudi Hospital
CONCLUSION: It was concluded that the prevalence rates of MRSA have not increased in 2020 when compared to 2019. Vancomycin, linezolid, trimethoprim-sulfamethoxazole, and doxycycline remain susceptible to the positive collected MRSA strains. There was no significant difference between the prevalence and antimicrobial resistance rates of MRSA between 2019 and 2020. Continued research efforts are needed to address this persistent public health threat. Strategies to control the spread of MRSA should include early detection of MRSA and surveillance, even during pandemics.PMID:38529437 | PMC:PMC10962010 | DOI:10.7759/cureus.548...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Omar B Ahmed Fayez S Bahwerth Radi Alsafi Eman A Elsebaei Gamal T Ebid Abdulrhaman Theyab Hamza Assaggaf Source Type: research

Whole genome sequencing and molecular epidemiology of methicillin-resistant Staphylococcus aureus isolated from patients with bacteraemia in Slovenia
ConclusionThis study demonstrates that bacteraemia in central Slovenia is caused by diverse MRSA lineages. Identification of newly emerged lineages should be followed in the future to detect changes in the molecular epidemiology of MRSA in our country. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 22, 2024 Category: Microbiology Source Type: research

Recent advances in the exploration of oxazolidinone scaffolds from compound development to antibacterial agents and other bioactivities
Eur J Med Chem. 2024 Mar 13;269:116326. doi: 10.1016/j.ejmech.2024.116326. Online ahead of print.ABSTRACTBacterial infections cause a variety of life-threatening diseases, and the continuous evolution of drug-resistant bacteria poses an increasing threat to current antimicrobial regimens. Gram-positive bacteria (GPB) have a wide range of genetic capabilities that allow them to adapt to and develop resistance to practically all existing antibiotics. Oxazolidinones, a class of potent bacterial protein synthesis inhibitors with a unique mechanism of action involving inhibition of bacterial ribosomal translation, has emerged a...
Source: European Journal of Medicinal Chemistry - March 21, 2024 Category: Chemistry Authors: Maxwell Ampomah-Wireko Shengcong Chen Ruirui Li Chen Gao Meng Wang Ye Qu Hongtao Kong Lauraine Nininahazwe En Zhang Source Type: research

Comparison of two acquisition modes in mass spectrometry for quantification of 12 antibiotics, including beta-lactams, linezolid, fluoroquinolones and clindamycin: Multiple reactions monitoring (MRM) and fullMS/dd-MS < sup > 2 < /sup >
Anal Biochem. 2024 Mar 19:115507. doi: 10.1016/j.ab.2024.115507. Online ahead of print.ABSTRACTThe quantification of antibiotics, using mass spectrometry, for monitoring therapeutic drugs is a key benefit in infection management for many hospitals. After an easy work-up of plasma samples, analysis were performed using both We aimed to evaluate the differences and agreements between the two widely used acquisition modes: MRM for the triple quadrupole spectrometer and fullMS/ddMS2 for the HRMS to quantify twelve antibiotics. Comparison between the two acquisition modes were performed. Validation parameters and sample values ...
Source: Analytical Biochemistry - March 21, 2024 Category: Biochemistry Authors: Catherine Feliu Celine Konecki Damien Vautier Jessica Rogier Claire Gozalo Yoann Cazaubon Zoubir Djerada Source Type: research