Use of multiple pharmacodynamic measures to deconstruct the Nix-TB regimen in a short-course murine model of tuberculosis
Antimicrob Agents Chemother. 2024 Mar 19:e0101023. doi: 10.1128/aac.01010-23. Online ahead of print.ABSTRACTA major challenge for tuberculosis (TB) drug development is to prioritize promising combination regimens from a large and growing number of possibilities. This includes demonstrating individual drug contributions to the activity of higher-order combinations. A BALB/c mouse TB infection model was used to evaluate the contributions of each drug and pairwise combination in the clinically relevant Nix-TB regimen [bedaquiline-pretomanid-linezolid (BPaL)] during the first 3 weeks of treatment at human equivalent doses. The...
Source: Antimicrobial Agents and Chemotherapy - March 19, 2024 Category: Microbiology Authors: M A Lyons A Obregon-Henao M E Ramey A A Bauman S Pauly K Rossmassler J Reid B Karger N D Walter G T Robertson Source Type: research
Prevalence of linezolid resistance in Streptococcus pneumoniae isolates: a systematic review and meta-analysis
Future Microbiology, Ahead of Print. (Source: Future Microbiology)
Source: Future Microbiology - March 18, 2024 Category: Microbiology Authors: Mohsen Heidari Shirin Dashtbin Arezoo Asadi Parisa Asadollahi Ali Khatib Mohammad Amin Ebrahimi Zahra Ghanbari Atieh Darbandi Roya Ghanavati Reza Pakzad Source Type: research
Synthesis, biological evaluation and molecular docking study of pyrimidine linked thiazolidinedione derivatives as potential antimicrobial and antitubercular agents
Bioorg Med Chem Lett. 2024 Mar 14:129707. doi: 10.1016/j.bmcl.2024.129707. Online ahead of print.ABSTRACTThe design and development of novel antimicrobial agents are highly desired to combat the emergence of medication resistance against microorganisms that cause infections. A series of new pyrimidine-linked thiazolidinedione derivatives (5a-j) were synthesized, characterized, and their antimicrobial properties assessed in the current investigation. Here, novel pyrimidine-linked thiazolidinedione compounds were designed using the molecular hybridization approach. Elemental and spectral techniques were used to determine the...
Source: Bioorganic and Medicinal Chemistry Letters - March 16, 2024 Category: Chemistry Authors: M S Raghu K C B Pradeep Kumar Yogesh Kumar M K Prashanth Fahd Alharethy Byong-Hun Jeon Source Type: research
Synthesis, biological evaluation and molecular docking study of pyrimidine linked thiazolidinedione derivatives as potential antimicrobial and antitubercular agents
Bioorg Med Chem Lett. 2024 Mar 15;103:129707. doi: 10.1016/j.bmcl.2024.129707. Online ahead of print.ABSTRACTThe design and development of novel antimicrobial agents are highly desired to combat the emergence of medication resistance against microorganisms that cause infections. A series of new pyrimidine-linked thiazolidinedione derivatives (5a-j) were synthesized, characterized, and their antimicrobial properties assessed in the current investigation. Here, novel pyrimidine-linked thiazolidinedione compounds were designed using the molecular hybridization approach. Elemental and spectral techniques were used to determine...
Source: Bioorganic and Medicinal Chemistry Letters - March 16, 2024 Category: Chemistry Authors: M S Raghu C B Pradeep Kumar K Yogesh Kumar M K Prashanth Fahd Alharethy Byong-Hun Jeon Source Type: research
A multicenter clinical epidemiology of pediatric pneumococcal meningitis in China: results from the Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) 2019 –2020
ConclusionPediatric PM is more common in children aged 3 months to < 3 years old. Intracranial complications mostly occur in children < 1 year of age with fever being the most common clinical manifestations and subdural effusion and (or) empyema and hydrocephalus being the most common complications, respectively. CSF non-culture methods can facilitate improving the detection rate of pathogenic bacteria. More than 10% of PM children had adverse outcomes. S. pneumoniae strains are susceptible to vancomycin, linezolid, ertapenem, levofloxacin, moxifloxacin, rifampicin, and chloramphenicol. (Source: Frontiers in cellular...
Source: Frontiers in cellular and infection microbiology - March 15, 2024 Category: Microbiology Source Type: research
Linezolid-Induced Thrombocytopenia in Patients with Renal Impairment: A Case Series, Review and Dose Advice
ConclusionRe-evaluation of the current dose advice is necessary. We advocate for a standard dose reduction to 50% after 2 days of standard dosing for all patients with an estimated glomerular filtration of<60 mL/min/1.73 m2. Besides this, therapeutic drug monitoring and thrombocytes monitoring may be executed weekly when patients have renal impairment or other risk factors for developing linezolid-induced thrombocytopenia. (Source: Drugs in R&D)
Source: Drugs in R&D - March 14, 2024 Category: Drugs & Pharmacology Source Type: research
< em > Mycobacterium tuberculosis < /em > Lineage Distribution Using Whole-Genome Sequencing and Bedaquiline, Clofazimine, and Linezolid Phenotypic Profiles among Rifampicin-Resistant Isolates from West Java, Indonesia
This study aimed to determine the association between the TB lineage distribution using whole-genome sequencing and bedaquiline, clofazimine, and linezolid phenotypic profile resistance among M. tuberculosisrifampicin-resistant isolates from West Java. M. tuberculosis isolates stock of the Department of Microbiology, Faculty of Medicine, Universitas Indonesia, was tested against bedaquiline, clofazimine, and linezolid using a mycobacteria growth indicator tube liquid culture. All isolates were tested for M. tuberculosis and rifampicin resistance using Xpert MTB/RIF. The DNA genome of M. tuberculosis was freshly extracted f...
Source: International Journal of Microbiology - March 12, 2024 Category: Microbiology Authors: Andriansjah Rukmana Cynthia Gozali Linda Erlina Source Type: research
Spectrum and antibiotic sensitivity of bacterial keratitis: a retrospective analysis of eight years in a Tertiary Referral Hospital in Southwest China
ConclusionThe microbial composition primarily consists of Gram-Positive cocci and Gram-Negative bacilli. Among the Gram-Positive bacteria, S. epidermidis and Streptococcus pneumoniae are the most frequently encountered, while P. aeruginosa is the predominant Gram-Negative bacteria. To combat Gram-Positive bacteria, vancomycin, linezolid, and rifampicin are considered excellent antimicrobial agents. When targeting Gram-Negative pathogens, third-generation cephalosporins exhibit superior sensitivity compared to first and second-generation counterparts. As an initial empirical treatment for severe cases of bacterial keratitis...
Source: Frontiers in cellular and infection microbiology - March 11, 2024 Category: Microbiology Source Type: research
Does selective digestive decontamination (SDD) increase antibiotic resistance? Long-term comparison of two intensive care units (with and without SDD) of the same tertiary hospital
ConclusionsSDD had neither a clinically relevant impact on emergence and spread of resistance, nor in the overall systemic antimicrobial use. The patient type rather than the SDD protocol showed to condition the ecology and therefore, the resistance rate in the ICUs. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 9, 2024 Category: Microbiology Source Type: research
Multidrug ‐resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage
This study investigated the prevalence of antibiotic resistance inEnterococcus spp. from raw and treated sewage in Bergen, Norway. We analyzed 307 Enterococcus faecium isolates from raw sewage and 185E. faecium isolates from treated sewage for antibiotic sensitivity and sequenced selected isolates (n = 25). This study found that multidrug-resistantE. faecium clones from clonal complex 17 are entering the marine environment through treated sewage. AbstractThis study aimed to understand the antibiotic resistance prevalence amongEnterococcus spp. from raw and treated sewage in Bergen city, Norway. In total, 517Enterococ...
Source: MicrobiologyOpen - March 6, 2024 Category: Microbiology Authors: Vera Radisic,
Didrik H. Grevskott,
Nadja Junghardt,
Lise Øvreås,
Nachiket P. Marathe Tags: ORIGINAL ARTICLE Source Type: research
