The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study
ConclusionsVidofludimus demonstrated a positive safety profile, making it a promising candidate for the treatment of a variety of immune-related diseases.Trial RegistrationsClinicalTrials.gov identifier: NCT01010581. (Source: Drugs in R&D)
Source: Drugs in R&D - October 16, 2019 Category: Drugs & Pharmacology Source Type: research

Are Standard Doses of Renally-Excreted Antiretrovirals in Older Patients Appropriate: A PBPK Study Comparing Exposures in the Elderly Population With Those in Renal Impairment
ConclusionComparison of the exposure in the elderly with exposure observed in patients with different levels of renal impairment, indicated that a dosage adjustment may not be required in elderly patients on lamivudine, emtricitabine and the majority of the patients on tenofovir. Clinical trials to verify these predictions are essential. (Source: Drugs in R&D)
Source: Drugs in R&D - October 10, 2019 Category: Drugs & Pharmacology Source Type: research

Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice
ConclusionPDE4 is overexpressed in AD skin compared with normal skin, and inflammatory gene expression by human keratinocytes and mouse dermatitis can be modulated by apremilast. (Source: Drugs in R&D)
Source: Drugs in R&D - October 9, 2019 Category: Drugs & Pharmacology Source Type: research

Prediction of Drug –Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation
ConclusionOur results appear to indicate that pharmacodynamics may play a more important role than PKs in causing DDIs between opioids and benzodiazepines. This study also demonstrated that molecular modeling can be a very useful tool to mitigate the problem of “missing metabolic reaction parameters” in PK modeling and simulation. (Source: Drugs in R&D)
Source: Drugs in R&D - September 3, 2019 Category: Drugs & Pharmacology Source Type: research

Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age
ConclusionsSAM has high bioavailability that is comparable following sublingual and oral administration and is not subject to extensive first-pass metabolism. The PK of orally administered SAM are not affected by food or age. (Source: Drugs in R&D)
Source: Drugs in R&D - August 29, 2019 Category: Drugs & Pharmacology Source Type: research

Vasodepressor Effects of Adenosine in the Cat are Independent of Cyclooxygenase, Potassium Channels, and Nitric Oxide Pathways
ConclusionsVasodepressor effects of adenosine are species specific, and this species specificity will impact the development of future testing and treatments for pulmonary arterial hypertension. Clinical studies are warranted to see if adenosine moieties could play a therapeutic role in patients with pulmonary arterial hypertension and/or other pulmonary pathogeneses. (Source: Drugs in R&D)
Source: Drugs in R&D - August 26, 2019 Category: Drugs & Pharmacology Source Type: research

Amount of Cycloserine Emanating from Terizidone Metabolism and Relationship with Hepatic Function in Patients with Drug-Resistant Tuberculosis
ConclusionsCycloserine is not interchangeable with terizidone, as amounts are lower than expected. Cycloserine may be a predisposing factor to the development of hyperbilirubinaemia, as CLm/F is affected by hepatic function. (Source: Drugs in R&D)
Source: Drugs in R&D - August 8, 2019 Category: Drugs & Pharmacology Source Type: research

Correction to: Safety and Efficacy of 0.5% Carbomer 980 Gel for Treatment of Symptoms of Common Cold: Results of 2 Randomized Trials
The original publication of the article contained the following errors. (Source: Drugs in R&D)
Source: Drugs in R&D - July 20, 2019 Category: Drugs & Pharmacology Source Type: research

Impact of Primary Tumour Location and Early Tumour Shrinkage on Outcomes in Patients with RAS Wild-Type Metastatic Colorectal Cancer Following First-Line FOLFIRI Plus Panitumumab
ConclusionsThis analysis has confirmed a prognostic effect of primary tumour location in patients withRAS wild-type metastatic colorectal cancer receiving first-line panitumumab plus FOLFIRI. Early tumour shrinkage was associated with improved progression-free survival irrespective of tumour location. In right-sided disease, early tumour shrinkage may identify a subgroup of patients who might respond to panitumumab.ClinicalTrials.gov identifierNCT00508404. (Source: Drugs in R&D)
Source: Drugs in R&D - July 12, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics of Sublingual Buprenorphine Tablets Following Single and Multiple Doses in Chinese Participants With and Without Opioid Use Disorder
ConclusionsThe present data suggest that buprenorphine/naloxone pharmacokinetic profiles in Chinese participants are consistent, overall, with those in Western populations, supporting no differences in dosing.Clinical Trial RegistrationThe protocols were registered on the official website of the China Food and Drug Administration (CFDA):http://www.chinadrugtrials.org.cn/; Registration numbers CTR20132963 (RB-CN-10-0012), CTR20140153 (RB-CN-10-0015). (Source: Drugs in R&D)
Source: Drugs in R&D - June 13, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Age Among Elderly Cancer Patients on Breakthrough Pain Management with Sublingual Fentanyl Tablets
AbstractIntroductionSublingual fentanyl tablets (SFTs) have been shown to be a safe and effective option in controlling breakthrough cancer pain (BTcP). However, further examination is required to investigate the use of SFTs among the elderly. The aim of this study was to examine the influence of age in BTcP management with SFTs in the elderly population.MethodsWe performed subgroup analyses of a recently completed trial in two subsets of individuals: patients aged 65 –74 years (low age group) and patients ≥ 75 years (high age group). Pain intensity (PI), onset of pain relief, frequency and...
Source: Drugs in R&D - June 8, 2019 Category: Drugs & Pharmacology Source Type: research

Elderly Bleeding Risk of Direct Oral Anticoagulants in Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Cohort Studies
AbstractIntroductionThe 2014 American Heart Association (AHA)/American College of Cardiology (ACC)/Heart Rhythm Society (HRS) guidelines recommend anticoagulation to reduce clot formation and the risk of thromboembolic events in patients with atrial fibrillation but does not specify guidelines for the elderly population. Direct oral anticoagulants (DOACs) are newer US FDA-approved alternatives to warfarin and include dabigatran, rivaroxaban, apixaban and edoxaban. The efficacy of DOACs is heavily researched, but few studies have evaluated their bleeding risk.ObjectivesThis systematic review and meta-analysis investigates w...
Source: Drugs in R&D - May 24, 2019 Category: Drugs & Pharmacology Source Type: research

Timing of GLP-1 Receptor Agonist Initiation for Treatment of Type 2 Diabetes in the UK
ConclusionsResults suggest that treatment intensification is often delayed despite consistently poor glycaemic control for more than 12  months, contrary to treatment guideline recommendations. Findings from this study highlight that some T2DM patients may benefit from more rapid treatment intensification, which could improve glycaemic control and reduce the risk for many short- and long-term health complications. (Source: Drugs in R&D)
Source: Drugs in R&D - May 21, 2019 Category: Drugs & Pharmacology Source Type: research

Neuropsychiatric Symptoms in Dementia: Considerations for Pharmacotherapy in the USA
AbstractDementia affects all domains of cognition. The relentless progression of the disease after diagnosis is associated with a 98% incidence of neuropsychiatric symptoms (NPS) at some point in the disease, including depression, psychosis, agitation, aggression, apathy, sleep disturbances, and disinhibition. These symptoms can be severe and lead to excess morbidity and mortality. The purpose of this article was to describe current literature on the medication management of NPS of dementia and highlight approaches to and concerns about the pharmacological treatment of NPS in the USA. Guidelines and expert opinion favor no...
Source: Drugs in R&D - May 16, 2019 Category: Drugs & Pharmacology Source Type: research

Towards a Generic Tool for Prediction of Meropenem Systemic and Infection-Site Exposure: A Physiologically Based Pharmacokinetic Model for Adult Patients with Pneumonia
ConclusionsWe successfully developed a physiologically based pharmacokinetic model for meropenem in adult patients to be used as a basis for prediction of concentrations in different groups of patients, and eventually for effective dose individualisation in different subgroups of the population. (Source: Drugs in R&D)
Source: Drugs in R&D - May 14, 2019 Category: Drugs & Pharmacology Source Type: research

A Novel, Dose-Adjusted Tacrolimus Trough-Concentration Model for Predicting and Estimating Variance After Kidney Transplantation
ConclusionThis is the first known application of a functional regression model to assess complex relationships between TTC and dose in a real clinical setting. This new method has applicability in future clinical trials including real-world data sets due to flexibility of the nonparametric modeling approach. (Source: Drugs in R&D)
Source: Drugs in R&D - May 9, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of the New Oral Anticoagulants and Warfarin in Patients with Atrial Fibrillation and Valvular Heart Disease: Systematic Review and Meta-Analysis
ConclusionsThe efficacy and safety of NOACs as thromboprophylaxis for AF and VHD are similar to those of warfarin. (Source: Drugs in R&D)
Source: Drugs in R&D - May 4, 2019 Category: Drugs & Pharmacology Source Type: research

Safety and Efficacy of 0.5% Carbomer 980 Gel for Treatment of Symptoms of Common Cold: Results of 2 Randomized Trials
ConclusionWhile 0.5% carbomer 980 gel nasal spray demonstrated good local nasal tolerability in healthy volunteers, the spray did not significantly impact the course of infection or resolution of cold symptoms in subjects with common cold. (Source: Drugs in R&D)
Source: Drugs in R&D - April 19, 2019 Category: Drugs & Pharmacology Source Type: research

Bortezomib for the Treatment of Hematologic Malignancies: 15 Years Later
AbstractBortezomib is a dipeptidyl boronic acid that selectively inhibits the ubiquitin proteasome pathway, which plays a role in the degradation of many intracellular proteins. It is the first-in-class selective and reversible inhibitor of the 26S proteasome, with antiproliferative and antitumor activity. It exerts its anti-neoplastic action mainly via the inhibition of the nuclear factor- κB pathway components associated with cell proliferation, apoptosis, and angiogenesis. The drug has revolutionized the treatment of multiple myeloma and, more recently, mantle cell lymphoma. In 2003, bortezomib received accelerate...
Source: Drugs in R&D - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration
ConclusionDDRs and Src are other potential co-targets with Abl in neurodegeneration. (Source: Drugs in R&D)
Source: Drugs in R&D - March 27, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Food on the Bioavailability of Amphetamine in Healthy Adults After Administration of SHP465 Mixed Amphetamine Salts Extended-Release Capsules
ConclusionsThese findings demonstrate SHP465 mixed amphetamine salts capsules can be swallowed whole with or without food or the capsule contents can be sprinkled on applesauce. (Source: Drugs in R&D)
Source: Drugs in R&D - March 26, 2019 Category: Drugs & Pharmacology Source Type: research

Ulcerative Colitis: Shifting Sands
AbstractUlcerative colitis (UC) is a chronic inflammatory bowel disease associated with considerable disease burden. We review some current misconceptions about UC in adults with the aim of optimizing care for patients. Although UC and Crohn ’s disease (CD) are considered discrete diseases, distinctions between them are not always clear-cut and phenotypes may change over time. Patient management should take into account disease manifestations, disease severity and extent, and response to prior treatments. Although disease extent often defines severity, distal UC is not always less disabling than extensive disease as ...
Source: Drugs in R&D - March 2, 2019 Category: Drugs & Pharmacology Source Type: research

S-1 in Patients with Advanced Esophagogastric Adenocarcinoma: Results from the Safety Compliance Observatory on Oral fluoroPyrimidines (SCOOP) Study
ConclusionThe overall relative dose intensity was 70%. In a real-world setting, patients with advanced esophagogastric adenocarcinoma tolerated S-1 treatment well with high compliance rates. The SCOOP study provides valuable information on S-1 relative dose intensity that can be used for treatment decision making. (Source: Drugs in R&D)
Source: Drugs in R&D - March 1, 2019 Category: Drugs & Pharmacology Source Type: research

Assessing the Extended In-Use Stability of the Infliximab Biosimilar PF-06438179/GP1111 Following Preparation for Intravenous Infusion
ConclusionsPhysicochemical and biological analyses demonstrated that the infliximab biosimilar PF-SZ-IFX was not affected by extended storage of the diluted preparations used for intravenous infusion. (Source: Drugs in R&D)
Source: Drugs in R&D - February 27, 2019 Category: Drugs & Pharmacology Source Type: research

Inhaled Loxapine for the Management of Acute Agitation in Bipolar Disorder and Schizophrenia: Expert Review and Commentary in an Era of Change
AbstractAgitation is a common and costly phenomenon associated with a number of psychiatric conditions including schizophrenia and bipolar disorder. Early identification and prompt intervention to relieve the symptoms of agitation are essential to avoid symptomatic escalation and emergence of aggressive behaviour. Recent consensus guidelines emphasise the need for non-coercive management strategies to protect the therapeutic alliance between patients and their healthcare providers —an alliance that is critical for the effective management of chronic psychiatric conditions. Rapid symptom relief and de-escalation of ag...
Source: Drugs in R&D - February 5, 2019 Category: Drugs & Pharmacology Source Type: research

Should Cytochrome P450 Inducers be Used to Accelerate Clearance of Brodifacoum from Poisoned Patients?
AbstractA recent multi-state outbreak of life-threatening bleeding following inhalation of synthetic cannabinoids has been attributed to contamination with the long-acting anticoagulant rodenticide (LAAR) brodifacoum, a second-generation, highly potent, long-acting derivative of the commonly used blood thinner warfarin. While long-term treatment with high-dose vitamin K1 restores coagulation, it does not affect brodifacoum metabolism or clearance, and, consequently, brodifacoum remains in the human body for several months, thereby predisposing to risk of bleeding recurrence and development of coagulation-independent injury...
Source: Drugs in R&D - January 28, 2019 Category: Drugs & Pharmacology Source Type: research

Monitoring the Efficacy and Safety of Artemisinin-Based Combination Therapies: A Review and Network Meta-analysis of Antimalarial Therapeutic Efficacy Trials in Cameroon
ConclusionACTs are still effective and safe in Cameroon; however, there are insufficient data on their efficacy, safety and tolerability, therefore more RCTs should be conducted, including novel ACTs. (Source: Drugs in R&D)
Source: Drugs in R&D - January 17, 2019 Category: Drugs & Pharmacology Source Type: research

Assessment of Taste and Grittiness of Riomet ® ER Strawberry, Riomet ® ER Grape, Riomet ® Cherry, and Metformin Immediate-Release Tablets in Healthy Subjects
ConclusionsAll Riomet® formulations were significantly preferred overall to metformin IR crushed tablets. Both the strawberry and the grape flavors of Riomet® ER tended to be preferred to Riomet® Cherry. (Source: Drugs in R&D)
Source: Drugs in R&D - January 16, 2019 Category: Drugs & Pharmacology Source Type: research

Post-Marketing Surveillance of Silodosin in Patients with Benign Prostatic Hyperplasia and Poor Response to Existing Alpha-1 Blockers: The SPLASH Study
ConclusionsThis post-marketing analysis indicates that switching to silodosin from tamsulosin or naftopidil significantly improved symptoms associated with BPH, and silodosin was well tolerated in Japanese patients. (Source: Drugs in R&D)
Source: Drugs in R&D - January 3, 2019 Category: Drugs & Pharmacology Source Type: research

Suvorexant (Belsomra ® Tablets 10, 15, and 20 mg): Japanese Drug-Use Results Survey
ConclusionThis survey was an exploratory observational study without a control group; the interpretation of results may require the consideration of factors that may have caused bias in the results, such as demographic characteristics and effects of other drugs. However, the results suggest that suvorexant can be a useful drug in daily clinical practice for treating insomnia. (Source: Drugs in R&D)
Source: Drugs in R&D - December 14, 2018 Category: Drugs & Pharmacology Source Type: research

Post Hoc Analysis of the CONFIDENCE II, PROTECT I, SHAKE THE HABIT I and SHAKE THE HABIT II Observational Studies in Mild to Moderate Hypertensive Patients Treated with Perindopril and Atorvastatin Concomitantly
AbstractBackground and ObjectivesManagement of hypertension and dyslipidemia is important when considering cardiovascular disease risk; however, achievement of optimal lipid and blood pressure (BP) targets in clinical practice remains inadequate. This analysis sought to estimate the frequency, effectiveness, and safety of co-administrated atorvastatin and perindopril in routine care.MethodsWe conducted a post hoc analysis of four Canadian, prospective, multi-center, observational studies assessing real-life effectiveness and safety of perindopril  + atorvastatin in mild-to-moderate hypertensive patients with ...
Source: Drugs in R&D - November 17, 2018 Category: Drugs & Pharmacology Source Type: research

Is Conversion from Mycophenolate Mofetil to Enteric-Coated Mycophenolate Sodium Justifiable for Gastrointestinal Quality of Life?
ConclusionThere was a high risk of bias across the 29 studies investigating conversion from MMF to EC-MPS for potential improvement in GI-related quality of life. The consolidated results of the three studies with low risk of bias suggest no evidence to convert patients stabilised on MMF. If a patient experiences GI-related adverse events whilst taking MMF, other methods should be explored before conversion to EC-MPS. (Source: Drugs in R&D)
Source: Drugs in R&D - November 13, 2018 Category: Drugs & Pharmacology Source Type: research

Acknowledgement to Referees
(Source: Drugs in R&D)
Source: Drugs in R&D - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Budesonide in the Treatment of Eosinophilic Esophagitis: Updated Systematic Review and Meta-Analysis of Randomized and Non-Randomized Studies
AbstractBackground and ObjectiveEosinophilic esophagitis (EE) is an immune/antigen-driven inflammation that causes esophageal dysfunction. Budesonide has shown promising effect in the management of EE in multiple studies, and we therefore conducted this systematic review/meta-analysis to assess budesonide efficacy and safety in order to provide more updated and robust evidence.MethodsIn April 2018, we conducted a systematic electronic search through four databases: PubMed, Scopus, Web of Science (ISI), and Cochrane Central. All original studies reporting the efficacy of budesonide in the treatment of EE were included in ou...
Source: Drugs in R&D - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

Two Glucose-Lowering Mechanisms of Canagliflozin Depending on Body Weight Changes in Drug-Na ïve Subjects with Type 2 Diabetes
AbstractObjectivesThe aim of this study was to investigate the relations between the changes in body weight and those of glycemic and non-glycemic parameters in drug-na ïve subjects with type 2 diabetes mellitus (T2DM) treated with canagliflozin monotherapy.MethodsSubjects received 50 –100 mg/day canagliflozin monotherapy for 3 months (n = 36), and were then divided into two groups: (1) those who lost weight [changes in (Δ)BMI ≤ − 0.45,p   − 0.45,p  = non-significant: Group N(eutral),n = 16]. At 3&n...
Source: Drugs in R&D - October 15, 2018 Category: Drugs & Pharmacology Source Type: research

Isavuconazole Kinetic Exploration for Clinical Practice
ConclusionsCollecting one blood sample just before the first maintenance dose to make an early estimation of the patient ’s most likely pharmacokinetic profile is one method of identifying patients with outlier pharmacokinetic behavior. (Source: Drugs in R&D)
Source: Drugs in R&D - October 10, 2018 Category: Drugs & Pharmacology Source Type: research

Rivaroxaban versus Warfarin in Patients with Mechanical Heart Valve: Rationale and Design of the RIWA Study
DiscussionWarfarin and similar VKAs are standard therapy for patients with an MHV. Even with the appropriate use of therapy, the incidence of thromboembolic events is high at 1 –4% per year. Furthermore, bleeding risk is significant, ranging from 2 to 9% per year. The new frontier to be overcome in relation to use of the new oral anticoagulants is undoubtedly in patients with MHV. A significant portion of people with MHV worldwide will benefit if noninferiority of these new agents is confirmed.Trial RegistrationClinicalTrials.gov identifier:NCT03566303. Recruitment Status: Recruiting. First Posted: 25 June 2018. Last...
Source: Drugs in R&D - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Treatment of Disfiguring Cutaneous Lesions in Neurofibromatosis-1 with Everolimus: A Phase II, Open-Label, Single-Arm Trial
ConclusionsAlthough this was a small, exploratory trial that was not powered for significance, the reduction in surface volume observed in this study is noteworthy assuming that the natural course for untreated lesions is to maintain or increase in volume. Future studies are needed with larger study populations that incorporate longer durations of treatment and better standardization of volumetric measurements.Trial Registration ClinicalTrials.gov Identifier: NCT02332902 (Source: Drugs in R&D)
Source: Drugs in R&D - October 3, 2018 Category: Drugs & Pharmacology Source Type: research

Rovalpituzumab Tesirine: A Novel DLL3-Targeting Antibody –Drug Conjugate
AbstractSmall cell lung cancer (SCLC) comprises about 15% of all cases of lung cancer. In recent years, owing to a change in the epidemiology of smoking habits, the incidence of the tumor has decreased; however, it remains a significant challenge to global health. While the tumor has a favorable initial response to chemoradiation, relapse is invariable, and second-line regimens may be intolerable given the severity of side effects. For patients with tumors resistant to second-line regimens, no current standard regimens exist. Rovalpituzumab tesirine is a novel antibody –drug conjugate, targeting delta-like protein 3,...
Source: Drugs in R&D - September 19, 2018 Category: Drugs & Pharmacology Source Type: research

Critical Review of the Use of Second-Generation Antipsychotics in Obsessive –Compulsive and Related Disorders
AbstractCurrently, all second-generation antipsychotics are approved for schizophrenia. Many are also approved for bipolar disorder, with some also approved as adjunctive treatment for depression and autism-related irritability. Second-generation antipsychotics are increasingly being prescribed for indications other than those approved by the Food and Drug Administration, such as in dementia, anxiety, and post-traumatic stress disorder to name a few. Obsessive –compulsive and related disorders are a group of disorders characterized by preoccupation and repetitive behaviors. According to the latest edition of the Diag...
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

The Effectiveness of Intravenous Golimumab Administered Directly After Infliximab in Rheumatoid Arthritis Patients
This study examined the utilization and effectiveness of intravenous golimumab within a real-world population of patients with RA switching directly from infliximab, a potent anti-TNF.MethodsPatient charts (n = 113) were collected from five US-based rheumatology practices. Patient demographics, treatment characteristics, infliximab and intravenous golimumab utilization data, and Clinical Disease Activity Index (CDAI), Patient Global Assessment (PtGA), Physician Global Assessment (PhGA), and Routine Assessment of Patient Index Data (RAPID3) scores were extracted from charts. The effectiveness of intravenous go...
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of Cardiovascular Disease Risk in HIV-1 –Infected Patients Treated with Darunavir
ConclusionsThis comprehensive review of Janssen-sponsored clinical trial, post-marketing, and epidemiological data does not suggest that CVD should be considered an important risk for users of darunavir. (Source: Drugs in R&D)
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

Population Pharmacokinetic Modelling of Ceftazidime and Avibactam in the Plasma and Epithelial Lining Fluid of Healthy Volunteers
ConclusionsThis compartmental modelling analysis suggests ELF exposures of both ceftazidime and avibactam exceed levels required for efficacy in plasma. (Source: Drugs in R&D)
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

Comments on: “In Vitro Safety Pharmacology Profiling of Topical α-Adrenergic Agonist Treatments for Erythema of Rosacea”
(Source: Drugs in R&D)
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

Risks and Benefits of Sodium Polystyrene Sulfonate for Hyperkalemia in Patients on Maintenance Hemodialysis
ConclusionsOur results indicate that Na-resin exhibited an advantage in treating hyperkalemia when used in small amounts. However, when prescribing an ion-exchange resin at a higher dose, physicians should select the type and amount of resin according to the sodium and/or calcium load in each case. (Source: Drugs in R&D)
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

New Insights on the Pharmacokinetics of Ulifloxacin After Administration of Prulifloxacin in Patients with Mild, Moderate and Severe Renal Impairment
ConclusionOur data show that prulifloxacin is a safe quinolone and is well tolerated in both subjects with normal renal function and patients with impaired renal function, requiring a minimal dosage adjustment only in patients with severe renal impairment. (Source: Drugs in R&D)
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

Correction to: Evaluation of Cardiovascular Disease Risk in HIV ‑1–Infected Patients Treated with Darunavir
In the original publication of the article, Table  2 has been published incorrectly. (Source: Drugs in R&D)
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research

Octreotide Use in Neonates: A Case Series
ConclusionOctreotide was used safely as an adjunctive therapy for the treatment of chylothorax and chylous ascites in neonates. However, larger prospective controlled trials are required to establish the optimal dose, time of initiation, duration and efficacy of octreotide therapy in neonates. (Source: Drugs in R&D)
Source: Drugs in R&D - September 1, 2018 Category: Drugs & Pharmacology Source Type: research