Risk of Adverse Events Associated with Domperidone and Metoclopramide in Gastroparesis: Systematic Review and Meta-analysis
ConclusionsThe evidence confirms concerns of cardiovascular, extrapyramidal, and endocrine AEs in patients with gastroparesis treated with domperidone and metoclopramide. Imprecise AE reporting limits firm interpretation and conclusions.RegistrationPROSPERO international prospective register of systematic reviews (registration number: CRD42021248888). (Source: Drugs in R&D)
Source: Drugs in R&D - February 7, 2023 Category: Drugs & Pharmacology Source Type: research
A Randomised Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of Palovarotene Ophthalmic Solution
ConclusionsPVO-OS was generally well tolerated at doses up to and including 0.10 mg/mL twice daily. Similar pharmacokinetic profiles were observed for the once-daily and twice-daily regimens following multiple ascending doses of PVO-OS. (Source: Drugs in R&D)
Source: Drugs in R&D - December 21, 2022 Category: Drugs & Pharmacology Source Type: research
Benefits of Hydroxychloroquine Combined with Low-Dose Aspirin on Pregnancy Outcomes and Serum Cytokines in Pregnant Women with Systemic Lupus Erythematosus
ConclusionHydroxychloroquine combined with low-dose aspirin can effectively improve the pregnancy outcomes of pregnant women with SLE by affecting the levels of T helper (Th) 2 and Th1 cytokines. (Source: Drugs in R&D)
Source: Drugs in R&D - November 30, 2022 Category: Drugs & Pharmacology Source Type: research
Analyses of Basal and Squamous Cell Carcinoma Reported as an Adverse Drug Reaction and Comparison with Cases from the Cancer Registry from Germany
ConclusionsIn Germany, drug-associated BCC and SCC occurred at a younger age than in the general population. The results underline the necessity for skin cancer screening of patients treated with immunosuppressants or with drugs with photosensitising potential. (Source: Drugs in R&D)
Source: Drugs in R&D - November 19, 2022 Category: Drugs & Pharmacology Source Type: research
Acknowledgement to Referees
(Source: Drugs in R&D)
Source: Drugs in R&D - November 17, 2022 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics, Bioequivalence and Safety of Cloperastine in Chinese Healthy Subjects Under Fasting and Postprandial Conditions
ConclusionsThe T and R preparations were bioequivalent under both conditions. Food has no significant effect on the absorption of cloperastine. Moreover, T and R preparations were well tolerated. The trial registration number (TRN) and date of registrations were CTR20212515, 13 October 2021. (Source: Drugs in R&D)
Source: Drugs in R&D - November 11, 2022 Category: Drugs & Pharmacology Source Type: research
Chinese- and French-Manufactured Immediate-Release Glucophage ® Bioequivalence: A Randomized, Open-Label, Crossover Study
ConclusionsBioequivalence between the test and reference GIR tablets was demonstrated under fasted and fed conditions and both were safe and well tolerated.Clinical Trials RegistrationThis study was registered at ClinicalTrials.gov under the identifying number NCT03393208. (Source: Drugs in R&D)
Source: Drugs in R&D - October 20, 2022 Category: Drugs & Pharmacology Source Type: research
Clinical Validation of the Covariates Pharmacokinetic Model for Propofol in an Adult Population
ConclusionsThe covariates propofol pharmacokinetic model achieved an acceptable level of predictive performance, as assessed by both arterial and venous sampling, for use in target-controlled infusion in clinical practice.Clinical Trial RegistrationNCT01492712 (15 December, 2011) (Source: Drugs in R&D)
Source: Drugs in R&D - October 7, 2022 Category: Drugs & Pharmacology Source Type: research
Quercetin Supplement to Aspirin Attenuates Lipopolysaccharide-Induced Pre-eclampsia-Like Impairments in Rats Through the NLRP3 Inflammasome
ConclusionsOur data suggested that quercetin supplementation to aspirin is more effective in attenuating symptoms of pre-eclampsia and improving pregnancy outcomes compared with quercetin or aspirin alone. Quercetin can ameliorate placental NLRP3 inflammasome activation, which might serve as an underlying mechanism for its therapeutic efficacies in pre-eclampsia. (Source: Drugs in R&D)
Source: Drugs in R&D - September 22, 2022 Category: Drugs & Pharmacology Source Type: research
Impact of Renal Function on Anti-factor Xa Activity Concentrations with Edoxaban Use in Patients with Non-valvular Atrial Fibrillation
ConclusionsCreatinine clearance tends to be negatively correlated with trough AXA concentrations in patients with non-valvular atrial fibrillation taking edoxaban, while renal function is not correlated with peak AXA concentrations. (Source: Drugs in R&D)
Source: Drugs in R&D - September 14, 2022 Category: Drugs & Pharmacology Source Type: research
Roxadustat for SARS-CoV-2 Infection: Old Signaling Raised New Hopes
(Source: Drugs in R&D)
Source: Drugs in R&D - August 25, 2022 Category: Drugs & Pharmacology Source Type: research
Novel Strategies for the Treatment of COVID-19
This article examines the rationale behind the use of these disparate agents in the treatment and prevention of adverse outcomes in patients with COVID-19 and explores how these strategies may be utilized in the future to address the severe acute respiratory syndrome coronavirus 2 pandemic. (Source: Drugs in R&D)
Source: Drugs in R&D - August 24, 2022 Category: Drugs & Pharmacology Source Type: research
Correction: The Pitfalls of Abnormal Laboratory Value Interpretation in Vaccine Clinical Trials: The Example of Asymptomatic Transient Neutropenia
(Source: Drugs in R&D)
Source: Drugs in R&D - August 22, 2022 Category: Drugs & Pharmacology Source Type: research
Risk Factors for Septic Shock After Irinotecan-Containing Chemotherapy: An Exploratory Case-Control Study
ConclusionMedical personnel involved in cancer therapy should consider the possible risk of septic shock developing due to neutropenic
enterocolitis when administering irinotecan-containing chemotherapy in patients with a history of pelvic irradiation. (Source: Drugs in R&D)
Source: Drugs in R&D - August 20, 2022 Category: Drugs & Pharmacology Source Type: research
Correction: Association between Acid-Suppressive Drugs and Clinical Outcomes in Patients with Nonvalvular Atrial Fibrillation
(Source: Drugs in R&D)
Source: Drugs in R&D - August 18, 2022 Category: Drugs & Pharmacology Source Type: research
