Evaluation of Fosphenytoin Therapeutic Drug Monitoring in the Neurocritical Care Unit
ConclusionThe current method of calculating a fosphenytoin reloading dose in the critically ill population does not consistently result in therapeutic concentrations. With multiple factors affecting the pharmacokinetics of critically ill patients, the creation of a new pharmacokinetic model with less emphasis on volume of distribution may more consistently result in therapeutic concentrations. (Source: Drugs in R&D)
Source: Drugs in R&D - January 9, 2020 Category: Drugs & Pharmacology Source Type: research
Extrapolation of Drug Clearance in Children ≤ 2 Years of Age from Empirical Models Using Data from Children ( & gt; 2 Years) and Adults
ConclusionsThe study indicated that simple empirical models can provide more accurate results than complex empirical models. (Source: Drugs in R&D)
Source: Drugs in R&D - December 8, 2019 Category: Drugs & Pharmacology Source Type: research
The Effect of Fluctuating Temperature on the Stability of Turoctocog Alfa for Hemophilia A
ConclusionThe results demonstrated that turoctocog alfa can be subjected to variable storage conditions, including cycling between 5 °C and ≤ 40 °C, and subsequent storage for 3 months up to 40 °C, without loss of stability. This suggests that turoctocog alfa may offer greater product storage flexibility for patients in everyday practice, with a potential reduction in wastage. (Source: Drugs in R&D)
Source: Drugs in R&D - November 27, 2019 Category: Drugs & Pharmacology Source Type: research
Acknowledgement to Referees
(Source: Drugs in R&D)
Source: Drugs in R&D - November 19, 2019 Category: Drugs & Pharmacology Source Type: research
Use of Selective Serotonin Reuptake Inhibitors and Outcomes in Stroke Rehabilitation: A Prospective Observational Pilot Cohort Study
ConclusionSSRI therapy did not improve disability and QOL in multi-ethnic Asian patients with first-ever stroke undergoing rehabilitation. (Source: Drugs in R&D)
Source: Drugs in R&D - November 17, 2019 Category: Drugs & Pharmacology Source Type: research
A Clinician ’s Guide to the Recognition and Management of Dupilumab-Associated Conjunctivitis
AbstractDupilumab, a monoclonal antibody that inhibits both interleukin (IL)-4 and IL-13 signaling, is an effective treatment option in moderate-to-severe atopic dermatitis (AD). Patients with AD are already at increased risk of developing conjunctivitis, and clinical trials and case reports have shown a greater incidence of conjunctivitis in individuals with AD treated with dupilumab. As this is one of the more commonly reported side effects of this biologic agent, it is important that clinicians are aware of this association and advise patients receiving dupilumab to report signs of conjunctivitis. This review summarizes...
Source: Drugs in R&D - November 13, 2019 Category: Drugs & Pharmacology Source Type: research
The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study
ConclusionsVidofludimus demonstrated a positive safety profile, making it a promising candidate for the treatment of a variety of immune-related diseases.Trial RegistrationsClinicalTrials.gov identifier: NCT01010581. (Source: Drugs in R&D)
Source: Drugs in R&D - October 15, 2019 Category: Drugs & Pharmacology Source Type: research
Are Standard Doses of Renally-Excreted Antiretrovirals in Older Patients Appropriate: A PBPK Study Comparing Exposures in the Elderly Population With Those in Renal Impairment
ConclusionComparison of the exposure in the elderly with exposure observed in patients with different levels of renal impairment, indicated that a dosage adjustment may not be required in elderly patients on lamivudine, emtricitabine and the majority of the patients on tenofovir. Clinical trials to verify these predictions are essential. (Source: Drugs in R&D)
Source: Drugs in R&D - October 9, 2019 Category: Drugs & Pharmacology Source Type: research
Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice
ConclusionPDE4 is overexpressed in AD skin compared with normal skin, and inflammatory gene expression by human keratinocytes and mouse dermatitis can be modulated by apremilast. (Source: Drugs in R&D)
Source: Drugs in R&D - October 8, 2019 Category: Drugs & Pharmacology Source Type: research
Prediction of Drug –Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation
ConclusionOur results appear to indicate that pharmacodynamics may play a more important role than PKs in causing DDIs between opioids and benzodiazepines. This study also demonstrated that molecular modeling can be a very useful tool to mitigate the problem of “missing metabolic reaction parameters” in PK modeling and simulation. (Source: Drugs in R&D)
Source: Drugs in R&D - September 2, 2019 Category: Drugs & Pharmacology Source Type: research
Characterization of the Pharmacokinetics of Samidorphan in Healthy Volunteers: Absolute Bioavailability and the Effect of Food and Age
ConclusionsSAM has high bioavailability that is comparable following sublingual and oral administration and is not subject to extensive first-pass metabolism. The PK of orally administered SAM are not affected by food or age. (Source: Drugs in R&D)
Source: Drugs in R&D - August 28, 2019 Category: Drugs & Pharmacology Source Type: research
Vasodepressor Effects of Adenosine in the Cat are Independent of Cyclooxygenase, Potassium Channels, and Nitric Oxide Pathways
ConclusionsVasodepressor effects of adenosine are species specific, and this species specificity will impact the development of future testing and treatments for pulmonary arterial hypertension. Clinical studies are warranted to see if adenosine moieties could play a therapeutic role in patients with pulmonary arterial hypertension and/or other pulmonary pathogeneses. (Source: Drugs in R&D)
Source: Drugs in R&D - August 25, 2019 Category: Drugs & Pharmacology Source Type: research
Amount of Cycloserine Emanating from Terizidone Metabolism and Relationship with Hepatic Function in Patients with Drug-Resistant Tuberculosis
ConclusionsCycloserine is not interchangeable with terizidone, as amounts are lower than expected. Cycloserine may be a predisposing factor to the development of hyperbilirubinaemia, as CLm/F is affected by hepatic function. (Source: Drugs in R&D)
Source: Drugs in R&D - August 7, 2019 Category: Drugs & Pharmacology Source Type: research
Correction to: Safety and Efficacy of 0.5% Carbomer 980 Gel for Treatment of Symptoms of Common Cold: Results of 2 Randomized Trials
The original publication of the article contained the following errors. (Source: Drugs in R&D)
Source: Drugs in R&D - July 19, 2019 Category: Drugs & Pharmacology Source Type: research
Impact of Primary Tumour Location and Early Tumour Shrinkage on Outcomes in Patients with RAS Wild-Type Metastatic Colorectal Cancer Following First-Line FOLFIRI Plus Panitumumab
ConclusionsThis analysis has confirmed a prognostic effect of primary tumour location in patients withRAS wild-type metastatic colorectal cancer receiving first-line panitumumab plus FOLFIRI. Early tumour shrinkage was associated with improved progression-free survival irrespective of tumour location. In right-sided disease, early tumour shrinkage may identify a subgroup of patients who might respond to panitumumab.ClinicalTrials.gov identifierNCT00508404. (Source: Drugs in R&D)
Source: Drugs in R&D - July 11, 2019 Category: Drugs & Pharmacology Source Type: research
