Potential for the Repurposing of Adamantane Antivirals for COVID-19
AbstractSeveral adamantanes have established actions against coronaviruses. Amantadine, rimantadine, bananins and the structurally related memantine are effective against human respiratory coronavirus HCoV-OC43, bovine coronavirus and severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and a spiroadamantane amine is effective against the coronavirus strain 229E. Molecular docking studies suggest that amantadine may block the viral E protein channel, leading to impaired viral propagati on. Additionally, amantadine analogues may inhibit entry of the virus into the host cell by increasing the pH of the endosomes a...
Source: Drugs in R&D - June 21, 2021 Category: Drugs & Pharmacology Source Type: research
Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model
ConclusionsIn patients receiving landiolol for coronary computed tomography angiography, deterioration in hemodynamic parameters due to anaphylactic shock can be mitigated by increasing the doses of epinephrine and glucagon. Clinicians should thus prepare appropriate amounts of epinephrine and glucagon prior to coronary computed tomography angiography. (Source: Drugs in R&D)
Source: Drugs in R&D - June 14, 2021 Category: Drugs & Pharmacology Source Type: research
Vaccinations in Patients Receiving Systemic Drugs for Skin Disorders: What Can We Learn for SARS-Cov-2 Vaccination Strategies?
AbstractLarge-scale vaccination strategies are currently being deployed against severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2). Whether systemic medication for skin diseases affects the efficacy of vaccination and whether temporary interruption or extension of the dosing interval is necessary is under debate. Most immunomodulating/immunosuppressive drugs only affect vaccine-induced immune responses to a limited or moderate extent, preserving sufficient immunity in most patients. Mycophenolate mofetil, Janus kinase inhibitors, and rituximab require a more cautious approach, and judicious timing of vaccination ...
Source: Drugs in R&D - June 9, 2021 Category: Drugs & Pharmacology Source Type: research
Effect of Sevelamer and Nicotinamide on Albumin Carbamylation in Patients with End-Stage Kidney Disease
ConclusionsOur results confirmed the presence of carbamylated albumin in patients with end-stage kidney disease and demonstrated the presence of carbamylation beyond the LRVP residues. The results also demonstrated the lack of impact of sevelamer or nicotinamide on albumin carbamylation levels. Therapeutic strategies to lower carbamylation load should probably be focused on direct anti-carbamylation processes and/or potentially anti-inflammatory therapies. (Source: Drugs in R&D)
Source: Drugs in R&D - June 8, 2021 Category: Drugs & Pharmacology Source Type: research
Correction to: Standardization and Chemical Characterization of Intravenous Therapy in Adult Patients: A Step Further in Medication Safety
A correction to this paper has been published: https://doi.org/10.1007/s40268-021-00347-2 (Source: Drugs in R&D)
Source: Drugs in R&D - June 7, 2021 Category: Drugs & Pharmacology Source Type: research
Population Pharmacokinetic Model of N-acetylmannosamine (ManNAc) and N-acetylneuraminic acid (Neu5Ac) in Subjects with GNE Myopathy
ConclusionsThis population pharmacokinetic model can be used to evaluate ManNAc dosing regimens and to calculate Neu5Ac production and exposure following oral administration of ManNAc in subjects with GNE myopathy. (Source: Drugs in R&D)
Source: Drugs in R&D - June 1, 2021 Category: Drugs & Pharmacology Source Type: research
Population Pharmacokinetic Analysis of Rivipansel in Healthy Subjects and Subjects with Sickle Cell Disease
ConclusionsThe pharmacokinetics of rivipansel was well characterized by a two-compartment population pharmacokinetic model. Our results illustrate the important role of simulations in optimizing a potential drug dosing regimen for patients with sickle cell disease and progressive renal impairment. (Source: Drugs in R&D)
Source: Drugs in R&D - May 16, 2021 Category: Drugs & Pharmacology Source Type: research
Population Pharmacokinetic Model of N -acetylmannosamine (ManNAc) and N -acetylneuraminic acid (Neu5Ac) in Subjects with GNE Myopathy
ConclusionsThis population pharmacokinetic model can be used to evaluate ManNAc dosing regimens and to calculate Neu5Ac production and exposure following oral administration of ManNAc in subjects with GNE myopathy. (Source: Drugs in R&D)
Source: Drugs in R&D - April 24, 2021 Category: Drugs & Pharmacology Source Type: research
Ammonia Removal by Metabolic Scavengers for the Prevention and Treatment of Hepatic Encephalopathy in Cirrhosis
AbstractEffective lowering of circulating ammonia is the mainstay strategy in the prevention and treatment of hepatic encephalopathy in cirrhosis and there is increasing interest in agents with the metabolic potential for the active removal of ammonia by the liver and skeletal muscle by agents includingl-ornithinel-aspartate, branched-chain amino acids, as well as the re-purposing of benzoate and phenylacetate currently employed for the control of hyperammonaemia in congenital urea-cycle enzymopathies. Based upon results of multiple systematic reviews with meta-analyses,l-ornithinel-aspartate demonstrably lowers circulatin...
Source: Drugs in R&D - April 22, 2021 Category: Drugs & Pharmacology Source Type: research
Comparative Efficacy of Fentanyl and Morphine in Patients with or At Risk for Acute Respiratory Distress Syndrome: A Propensity Score-Matched Cohort Study
ConclusionsBoth fentanyl and morphine were independent risk factors for worse outcomes in patients with or at risk for ARDS. Compared with morphine, fentanyl may be preferred in these patients. (Source: Drugs in R&D)
Source: Drugs in R&D - April 19, 2021 Category: Drugs & Pharmacology Source Type: research
Clinical Pharmacokinetics of Oral Sodium Selenite and Dosing Implications in the Treatment of Patients with Metastatic Cancer
DiscussionThe population model described the pharmacokinetic data well. Three regimens (33 mg daily, 11 mg BID, 5.5 mg TID) achieved in vitro target selenite levels after one dose. The model and optimal sampling times may inform future studies evaluating the efficacy of selenite for metastatic cancer treatment. (Source: Drugs in R&D)
Source: Drugs in R&D - April 17, 2021 Category: Drugs & Pharmacology Source Type: research
Impact of the Epithelial Lining Fluid Milieu on Amikacin Pharmacodynamics Against Pseudomonas aeruginosa
ConclusionsOur findings indicate that simulating the epithelial lining fluid antagonises amikacin-mediated killing ofP. aeruginosa, even at the high concentrations achieved following nebulised administration. (Source: Drugs in R&D)
Source: Drugs in R&D - April 2, 2021 Category: Drugs & Pharmacology Source Type: research
Incident Gallstones During Somatostatin Analog Treatment are Associated with Acute Biliary Complications Especially After Discontinuation
ConclusionsTreatment with a somatostatin analog leads to the formation of multiple, small gallstones that are associated with severe complications, especially after discontinuation of therapy.Clinical Trial Registry Website and Trial NumberClinicalTrials.gov (https://clinicaltrials.gov); NCT01616927. (Source: Drugs in R&D)
Source: Drugs in R&D - March 29, 2021 Category: Drugs & Pharmacology Source Type: research
A Review on the Efficacy and Safety of Oral Semaglutide
AbstractThere are numerous treatment options currently available for patients with type 2 diabetes mellitus; however, a multitude of patients continue to have inadequately controlled glycemic levels with their current antihyperglycemic regimen. Furthermore, the American Diabetes Association guidelines increasingly highlight the importance of multifactorial management and optimizing medication regimens that include cardiovascular, renal, and/or weight benefits in patients with type 2 diabetes mellitus. Glucagon-like peptide-1 receptor agonists belong to a novel class of type 2 diabetes mellitus agents that are becoming incr...
Source: Drugs in R&D - March 26, 2021 Category: Drugs & Pharmacology Source Type: research
Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination
ConclusionOur study shows that transcriptome analysis can be used to validate the choice of receptor targets and guide the design of novel multi-specific molecules. The inherent modularity of the AffiMab format renders it readily applicable to other receptor targets. (Source: Drugs in R&D)
Source: Drugs in R&D - March 15, 2021 Category: Drugs & Pharmacology Source Type: research
