Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines
In conclusion, our study suggested that high cytoplasmic BRCA1 protein levels could be considered as a potential predictive marker for response to chemotherapy in both sporadic and hereditary BC. Tumors with either BRCAness phenotype or germlineBRCA1 mutation are both aggressive BCs associated with poor prognosis and could both be subjected to targeted therapies againstBRCA1-mutated BC in future clinical management strategies. (Source: Drugs in R&D)
Source: Drugs in R&D - September 6, 2017 Category: Drugs & Pharmacology Source Type: research
Boceprevir and Antiretroviral Pharmacokinetic Interactions in HIV/HCV Co-infected Persons: AIDS Clinical Trials Group Study A5309s
ConclusionsEffects of BOC on ARV PK in these HIV/HCV co-infected individuals were similar to prior studies in healthy volunteers. However, some differences in the effects of ARV on BOC PK were observed, indicating the magnitude of interactions may differ in HCV-infected individuals versus healthy volunteers. Findings highlight the need to conduct interaction studies with HCV therapies in the population likely to receive the combination. (Source: Drugs in R&D)
Source: Drugs in R&D - September 5, 2017 Category: Drugs & Pharmacology Source Type: research
Benzodiazepines and Z-Drugs: An Updated Review of Major Adverse Outcomes Reported on in Epidemiologic Research
This article provides an overview and interpretation on the current state of evidence regarding each of these associations and proposes what gaps in the evidence for drug-exposure –harm associations need to be addressed in the future for the purpose of evaluating causality of harm as it relates to these drugs. (Source: Drugs in R&D)
Source: Drugs in R&D - September 1, 2017 Category: Drugs & Pharmacology Source Type: research
Longitudinal Assessment of the Effect of Atrasentan on Thoracic Bioimpedance in Diabetic Nephropathy: A Randomized, Double-Blind, Placebo-Controlled Trial
ConclusionsWe conclude that thoracic bioimpedance did not reflect changes in weight gain or edema with atrasentan treatment in this study. However, the sample size was small, and it may be of interest to explore the use of thoracic bioimpedance in a larger population to understand its potential clinical use in monitoring fluid retention in patients with chronic kidney disease who receive ET receptor antagonists. (Source: Drugs in R&D)
Source: Drugs in R&D - August 22, 2017 Category: Drugs & Pharmacology Source Type: research
The EGFR Inhibitor Gefitinib Enhanced the Response of Human Oral Squamous Cell Carcinoma to Cisplatin In Vitro
ConclusionThus, in OSCC cells in vitro, inhibition of EGFR activity with gefitinib enhances the apoptotic effect of cisplatin. This has potential implications for enhancement of cisplatin effectiveness in tumors that over-express the EGFR. (Source: Drugs in R&D)
Source: Drugs in R&D - August 21, 2017 Category: Drugs & Pharmacology Source Type: research
Methodological Study of Vancomycin Dosing in Elderly Patients Using Actual Serum Creatinine Versus Rounded Serum Creatinine
ConclusionUsing actual SCr to perform vancomycin dosing calculations more accurately predicted measured vancomycin troughs than using an SCr rounded to 1 mg/dL. In our sex-specific analysis, using actual SCr resulted in more accurate trough projections for both males and females than using a rounded SCr. (Source: Drugs in R&D)
Source: Drugs in R&D - August 16, 2017 Category: Drugs & Pharmacology Source Type: research
Does Dose Modification Affect Efficacy of First-Line Pazopanib in Metastatic Renal Cell Carcinoma?
ConclusionsOur results may suggest that patients with mRCC receiving a lower dose of first-line pazopanib might not have a meaningful progression-free survival advantage compared with those receiving a standard dose. These data highlight that proper management of treatment-related side effects may lead to optimal drug exposure. (Source: Drugs in R&D)
Source: Drugs in R&D - August 11, 2017 Category: Drugs & Pharmacology Source Type: research
Differences in Dihydrotetrabenazine Isomer Concentrations Following Administration of Tetrabenazine and Valbenazine
ConclusionsBased on relative abundance and potency, [+]- β-HTBZ appears to be the primary contributor to VMAT2 inhibition by TBZ, a finding in contrast with the generally held assertion that [+]-α-HTBZ is the major contributor. [−]-α-HTBZ, the other abundant TBZ metabolite, has much lower VMAT2 inhibitory potency than [+]-β-HTBZ, but increased affin ity for other CNS targets, which may contribute to off-target effects of TBZ. In contrast, pharmacological activity for VBZ is derived primarily from [+]-α-HTBZ. Individual HTBZ isomer concentrations provide a more clinically relevant endpoint for assessing on- and off-t...
Source: Drugs in R&D - August 3, 2017 Category: Drugs & Pharmacology Source Type: research
A Randomized, Open-Label, Two-Way Crossover, Single-Dose Bioequivalence Study of Temozolomide 200 mg/m 2 (Dralitem ® vs. Temodal ® Capsules) in Patients with Primary Tumors of the Central Nervous System Under Fasting Conditions
ConclusionsTemozolomide Dralitem® capsules, 20, 100 and 250 mg, were bioequivalent to Temodal® capsules under fasting conditions in patients with CNS primary tumors, supporting that they are therapeutic equivalents.ClinicalTrials.gov Identifier: NCT02343081. (Source: Drugs in R&D)
Source: Drugs in R&D - July 29, 2017 Category: Drugs & Pharmacology Source Type: research
Impact of Genetic Polymorphisms on Phenytoin Pharmacokinetics and Clinical Outcomes in the Middle East and North Africa Region
ConclusionsCYP2C9 decrease-of-function alleles altered phenytoin pharmacokinetics in patients originating from the Middle East and North Africa region. The impacts ofCYP2C19 and multidrug resistance protein 1 C3435T variants on phenytoin pharmacokinetic and clinical outcomes are unclear and require further investigation. Future research should focus on the clinical outcomes associated with phenytoin therapy.PROSPERO 2017: CRD42017057850 (Source: Drugs in R&D)
Source: Drugs in R&D - July 26, 2017 Category: Drugs & Pharmacology Source Type: research
Breakthrough Pain Management with Sublingual Fentanyl Tablets in Patients with Cancer: Age Subgroup Analysis of a Multicenter Prospective Study
ConclusionAge subgroup analyses suggest that SFTs are an effective and safe treatment for the management of BTP in cancer patients of all ages. SFTs may offer a well-tolerated and efficient option to control cancer BTP in the elderly. (Source: Drugs in R&D)
Source: Drugs in R&D - July 25, 2017 Category: Drugs & Pharmacology Source Type: research
Eslicarbazepine Acetate: A New Improvement on a Classic Drug Family for the Treatment of Partial-Onset Seizures
AbstractEslicarbazepine acetate is a new anti-epileptic drug belonging to the dibenzazepine carboxamide family that is currently approved as adjunctive therapy and monotherapy for partial-onset (focal) seizures. The drug enhances slow inactivation of voltage-gated sodium channels and subsequently reduces the activity of rapidly firing neurons. Eslicarbazepine acetate has few, but some, drug –drug interactions. It is a weak enzyme inducer and it inhibits cytochrome P450 2C19, but it affects a smaller assortment of enzymes than carbamazepine. Clinical studies using eslicarbazepine acetate as adjunctive treatment or monothe...
Source: Drugs in R&D - July 24, 2017 Category: Drugs & Pharmacology Source Type: research
Effectiveness and Safety of Switching from Innovator Infliximab to Biosimilar CT-P13 in Inflammatory Rheumatic Diseases: A Real-World Case Study
ConclusionsCT-P13 was equally effective as infliximab RP in this real-world study. CT-P13 is a valid, lower-cost alternative for patients currently receiving RP. (Source: Drugs in R&D)
Source: Drugs in R&D - June 30, 2017 Category: Drugs & Pharmacology Source Type: research
Lipophilicity Influences Drug Binding to α1-Acid Glycoprotein F1/S Variants But Not to the A Variant
ConclusionsWe were able to develop a simple screening method for determining individual α1-acid glycoprotein variants to which drugs would bind. The binding of drugs to F1/S variants may be determined mainly by drug lipophilicity. (Source: Drugs in R&D)
Source: Drugs in R&D - June 23, 2017 Category: Drugs & Pharmacology Source Type: research
Comparative Effect of Calcium Channel Blockers on Glomerular Function in Hypertensive Patients with Diabetes Mellitus
ConclusionsOur findings suggest that monotherapy with an L-, L/T-, L/N/T-, or L/N-type CCB may have little influence on renal function parameters and may be safely used in hypertensive patients with diabetes. (Source: Drugs in R&D)
Source: Drugs in R&D - June 3, 2017 Category: Drugs & Pharmacology Source Type: research
