Impact of Etoposide on BRCA1 Expression in Various Breast Cancer Cell Lines

In conclusion, our study suggested that high cytoplasmic BRCA1 protein levels could be considered as a potential predictive marker for response to chemotherapy in both sporadic and hereditary BC. Tumors with either BRCAness phenotype or germlineBRCA1 mutation are both aggressive BCs associated with poor prognosis and could both be subjected to targeted therapies againstBRCA1-mutated BC in future clinical management strategies.
Source: Drugs in R&D - Category: Drugs & Pharmacology Source Type: research