Lipophilicity Influences Drug Binding to α1-Acid Glycoprotein F1/S Variants But Not to the A Variant

ConclusionsWe were able to develop a simple screening method for determining individual α1-acid glycoprotein variants to which drugs would bind. The binding of drugs to F1/S variants may be determined mainly by drug lipophilicity.

http://link.springer.com/10.1007/s40268-017-0193-9

Source: Drugs in R&D - June 23, 2017 Category: Drugs & Pharmacology Source Type: research