Linezolid-Induced Thrombocytopenia in Patients with Renal Impairment: A Case Series, Review and Dose Advice

ConclusionRe-evaluation of the current dose advice is necessary. We advocate for a standard dose reduction to 50% after 2  days of standard dosing for all patients with an estimated glomerular filtration of<60  mL/min/1.73 m2. Besides this, therapeutic drug monitoring and thrombocytes monitoring may be executed weekly when patients have renal impairment or other risk factors for developing linezolid-induced thrombocytopenia.
Source: Drugs in R&D - Category: Drugs & Pharmacology Source Type: research