A systematic efficacy analysis of tuberculosis treatment with BPaL ‐containing regimens using a multiscale modeling approach
In this study, we present a unique framework that uses a primate granuloma modeling approach to screen many combination regimens that are currently under clinical and experimental exploration and assesses their efficacies to inform future studies. We tested well-studied regimens such as HRZE and BPaL to evaluate the validity and accuracy of our framework. We also simulated additional promising combination regimens that have not been sufficiently studied clinically or experimentally, and we provide a pipeline for regimen ranking based on their efficacies in granulomas. Furthermore, we showed a correlation between simulation rankings and new marmoset data rankings, providing evidence for the credibility of our framework. This framework can be adapted to any TB regimen and can rank any number of single or combination regimens.
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Maral Budak,
Laura E. Via,
Danielle M. Weiner,
Clifton E. Barry III,
Pariksheet Nanda,
Gabrielle Michael,
Khisimuzi Mdluli,
Denise Kirschner Tags: ARTICLE Source Type: research
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