Methionine gamma lyase: Structure-activity relationships and therapeutic applications
Biochim Biophys Acta Proteins Proteom. 2023 Dec 24:140991. doi: 10.1016/j.bbapap.2023.140991. Online ahead of print.ABSTRACTMethionine gamma lyase (MGL) is a bacterial and plant enzyme that catalyzes the conversion of methionine in methanthiol, 2-oxobutanoate and ammonia. The enzyme belongs to fold type I of the pyridoxal 5'-dependent family. The catalytic mechanism and the structure of wild type MGL and variants were determined in the presence of the natural substrate as well as of many sulfur-containing derivatives. Structure-function relationship studies were pivotal for MGL exploitation in the treatment of cancer, bact...
Source: Biochimica et Biophysica Acta - December 26, 2023 Category: Biochemistry Authors: Samanta Raboni Serena Faggiano Stefano Bettati Andrea Mozzarelli Source Type: research
New copper(II) and oxidovanadium(IV) complexes with a vitamin B6 Schiff base: mechanism of action and synergy studies on 2D and 3D human osteosarcoma cell models
Dalton Trans., 2024, Advance Article DOI: 10.1039/D3DT02964F, PaperLucia M. Balsa, Valeria Ferretti, Marco Sottile, Patrique Nunes, Jo ão Costa Pessoa, Isabel Correia, Ignacio E. León Decoding novel therapies using novel V and Cu complexes against human osteosarcoma. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - December 19, 2023 Category: Chemistry Authors: Lucia M. Balsa Source Type: research
Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study
Nutrients. 2023 Nov 30;15(23):4981. doi: 10.3390/nu15234981.ABSTRACTSeveral risk factors, including nutritional/lifestyle ones, play a role in gastric cancer etiology. Further interactions with mental health have also been emphasized. We hypothesized that individuals with mental disorders would exhibit compromised nutrient intake, increasing their risk of gastric cancer. The state of mental health was evaluated in 82 patients with gastric cancer and 95 healthy controls using the 21-item Depression-Anxiety-Stress Scale. The participants' dietary intakes were evaluated by a 168-item food frequency questionnaire. Based on ful...
Source: Cancer Control - December 9, 2023 Category: Cancer & Oncology Authors: Farhad Vahid Wena Rahmani Sayed Hossein Davoodi Torsten Bohn Source Type: research
Trimethylamine N-oxide, β-alanine, tryptophan index, and vitamin B6-related dietary patterns in association with stroke risk
The aim of this study was to examine the associations of dietary patterns derived by reduced-rank regression (RRR) model reflecting variation in novel biomarkers (trimethylamine N-oxide, β-alanine, tryptophan index, and vitamin B6) with stroke risk. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 8, 2023 Category: Nutrition Authors: Dong Liu, Siyue Tan, Zhengyuan Zhou, Shujun Gu, Hui Zuo Source Type: research
New copper(II) and oxidovanadium(IV) complexes with a vitamin B6 Schiff base: mechanism of action and synergy studies on 2D and 3D human osteosarcoma cell models.
We report the synthesis, characterization and anticancer activity of a new Schiff base (H2L) derived from the condensation of pyridoxamine with pyridoxal and its novel copper(II) and oxidovanadium(IV) complexes: [Cu(HL)Cl]... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - December 5, 2023 Category: Chemistry Authors: Lucia M Balsa Source Type: research
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial
This study presents one prespecified outcome from the randomized controlled NiPPeR trial, aiming to identify longitudinal patterns of maternal vitamin status from preconception, through early and late pregnancy, to 6 months postdelivery, and determine the influence of vitamin supplementation. Methods and findingsIn the NiPPeR trial, 1,729 women (from the United Kingdom, Singapore, and New Zealand) aged 18 to 38 years and planning conception were randomized to receive a standard vitamin supplement (control;n = 859) or an enhanced vitamin supplement (intervention;n = 870) starting in preconception and continued throughout pr...
Source: PLoS Medicine - December 5, 2023 Category: Internal Medicine Authors: Keith M. Godfrey Source Type: research
GSE191212 Engineering class-B vitamin biosynthesis in Saccharomyces cerevisiae
Contributors : Anna K Wronska ; Thomas Perli ; Marcel van den Broek ; Jean-Marc DaranSeries Type : Expression profiling by high throughput sequencingOrganism : Saccharomyces cerevisiaeSaccharomyces cerevisiae is bradytroph for class B vitamins, it means that yeast cells exhibit slower growth in the absence of an external source of these metabolites. Alleviating these nutritional requirements for optimal growth performance would represent a valuable phenotypic characteristic for industrial strains since this would result in cheaper processes that would also be less susceptible to contaminations. In the present study, sub...
Source: GEO: Gene Expression Omnibus - December 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Saccharomyces cerevisiae Source Type: research
The impacts of pharmacological drugs on vitamin B6, B9 and B12 intakes and levels among uk adults: National diet and nutrition survey rolling programme (NDNS) (2008 –2017).
This study has assessed the effects of drugs on vitamins B6, B9 and B12 status (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: A. Alsaeedi, S. Welham Source Type: research
Erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin inhibit cytopathic effect, papain-like protease, and MPRO enzymes of SARS-CoV-2
ConclusionThe IC50 for all the drugs, except ivermectin, was at the clinically achievable plasma concentration in humans, which supports a possible role for the drugs in the management of COVID-19. The lack of inhibition of CPE by ivermectin at clinical concentrations could be part of the explanation for its lack of effectiveness in clinical trials. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - November 27, 2023 Category: Microbiology Source Type: research
Sociodemographic, lifestyle, and environmental determinants of vitamin D levels in pregnant women in Spain
CONCLUSIONS: This comprehensive study shows that younger age, higher body mass index, higher deprived areas, higher air pollution and lower UV rays and humidity are associated with lower 25(OH)D3 levels.PMID:37984291 | DOI:10.1016/j.envint.2023.108293 (Source: Environment International)
Source: Environment International - November 20, 2023 Category: Environmental Health Authors: Maria Llopis Paula Sol Ventura Nicolai Brachowicz J úlia Sangüesa Mario Murcia Maria-Jose Lopez-Espinosa Gonzalo Garc ía-Baquero Aitana Lertxundi Martine Vrijheid Maribel Casas Paula Petrone Source Type: research
Crystal structure of an aspartate aminotransferase Lpg0070 from Legionella pneumophila
Biochem Biophys Res Commun. 2023 Nov 10;689:149230. doi: 10.1016/j.bbrc.2023.149230. Online ahead of print.ABSTRACTLegionella pneumophila aspartate aminotransferase (Lpg0070) is a member of the transaminase and belongs to the pyridoxal 5'-phosphate (PLP)-dependent superfamily. It is responsible for the transfer of α-amino between aspartate and α-ketoglutarate to form glutamate and oxaloacetate. Here, we report the crystal structure of Lpg0070 at the resolution of 2.14 Å and 1.7 Å, in apo-form and PLP-bound, respectively. Our structural analysis revealed the specific residues involved in the PLP binding and free form ag...
Source: Biochemical and Biophysical Research communications - November 20, 2023 Category: Biochemistry Authors: Yongshan Gao Xiaowen Yang Lan Hua Min Wang Qing Ge Weiqiang Wang Na Wang Jinming Ma Honghua Ge Source Type: research
Research on sweat metabolomics of athlete ’s fatigue induced by high intensity interval training
Conclusion: The change of hypoxanthine concentration in sweat can be used as a good biomarker for the diagnosis of exercise-induced fatigue, while the change of pyruvate content in sweat can be used as a discriminant index for the energy metabolism mode of the body before and after exercise. The main metabolic pathways involved in differential metabolites produced before and after HIIT exercise-induced fatigue are purine metabolism and amino acid metabolism. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - November 15, 2023 Category: Physiology Source Type: research
Gestational diabetes induced by low vitamin-B6
Endocrinology. 2023 Nov 10:bqad171. doi: 10.1210/endocr/bqad171. Online ahead of print.NO ABSTRACTPMID:37951839 | DOI:10.1210/endocr/bqad171 (Source: Endocrinology)
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Ricardo Augusto Leoni De Sousa Ricardo Cardoso Cassilhas Source Type: research
Gestational diabetes induced by low vitamin-B6
Endocrinology. 2023 Nov 10:bqad171. doi: 10.1210/endocr/bqad171. Online ahead of print.NO ABSTRACTPMID:37951839 | DOI:10.1210/endocr/bqad171 (Source: Endocrinology)
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Ricardo Augusto Leoni De Sousa Ricardo Cardoso Cassilhas Source Type: research
Gestational diabetes induced by low vitamin-B6
Endocrinology. 2023 Nov 10:bqad171. doi: 10.1210/endocr/bqad171. Online ahead of print.NO ABSTRACTPMID:37951839 | DOI:10.1210/endocr/bqad171 (Source: Endocrinology)
Source: Endocrinology - November 11, 2023 Category: Endocrinology Authors: Ricardo Augusto Leoni De Sousa Ricardo Cardoso Cassilhas Source Type: research
