Association between < em > MTHFR C677T < /em > Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
CONCLUSIONS: Our findings suggested that the TT genotype and T allele of MTHFR C677T polymorphism were independently associated with an insufficient Hcy lowering treatment effect in stroke patients with HHcy.PMID:38287840 | DOI:10.31083/j.jin2301003 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 30, 2024 Category: Neuroscience Authors: Zhi-Can Li Min Huang Qing-Yang Yao Cai-Hong Lin Bing-Cong Hong Jie-Hua Wang Zedan Zhang Source Type: research
Association between < em > MTHFR C677T < /em > Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
CONCLUSIONS: Our findings suggested that the TT genotype and T allele of MTHFR C677T polymorphism were independently associated with an insufficient Hcy lowering treatment effect in stroke patients with HHcy.PMID:38287840 | DOI:10.31083/j.jin2301003 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 30, 2024 Category: Neuroscience Authors: Zhi-Can Li Min Huang Qing-Yang Yao Cai-Hong Lin Bing-Cong Hong Jie-Hua Wang Zedan Zhang Source Type: research
Association between < em > MTHFR C677T < /em > Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
CONCLUSIONS: Our findings suggested that the TT genotype and T allele of MTHFR C677T polymorphism were independently associated with an insufficient Hcy lowering treatment effect in stroke patients with HHcy.PMID:38287840 | DOI:10.31083/j.jin2301003 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 30, 2024 Category: Neuroscience Authors: Zhi-Can Li Min Huang Qing-Yang Yao Cai-Hong Lin Bing-Cong Hong Jie-Hua Wang Zedan Zhang Source Type: research
Association between < em > MTHFR C677T < /em > Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
CONCLUSIONS: Our findings suggested that the TT genotype and T allele of MTHFR C677T polymorphism were independently associated with an insufficient Hcy lowering treatment effect in stroke patients with HHcy.PMID:38287840 | DOI:10.31083/j.jin2301003 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 30, 2024 Category: Neuroscience Authors: Zhi-Can Li Min Huang Qing-Yang Yao Cai-Hong Lin Bing-Cong Hong Jie-Hua Wang Zedan Zhang Source Type: research
Association between < em > MTHFR C677T < /em > Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia
CONCLUSIONS: Our findings suggested that the TT genotype and T allele of MTHFR C677T polymorphism were independently associated with an insufficient Hcy lowering treatment effect in stroke patients with HHcy.PMID:38287840 | DOI:10.31083/j.jin2301003 (Source: Journal of Integrative Neuroscience)
Source: Journal of Integrative Neuroscience - January 30, 2024 Category: Neuroscience Authors: Zhi-Can Li Min Huang Qing-Yang Yao Cai-Hong Lin Bing-Cong Hong Jie-Hua Wang Zedan Zhang Source Type: research
Decreased hepatic enzymes reflect the decreased vitamin B6 levels in Parkinson's disease patients
Serum vitamin B6 level was strongly correlated with total levodopa dose in PD patients. AbstractThe study aims to investigate the vitamin B6 levels in Parkinson's disease (PD) patients and their association with liver enzymes and evaluate how much dysregulation is associated with levodopa dose. Furthermore, to evaluate the effect of Opicapone, a catechol-o-methyl-transferase inhibitor, on vitamin B6 levels by monitoring the AST and ALT levels in patients treated with Levodopa –Carbidopa Intestinal Gel Infusion (LCIG). For these aims, serum vitamin B6 levels were measured (PD,n = 72 and controls,n = 31). The vitam...
Source: Pharmacology Research and Perspectives - January 30, 2024 Category: Drugs & Pharmacology Authors: Kensuke Ikenaka,
Yuta Kajiyama,
C ésar Aguirre,
Chi‐Jing Choong,
Seira Taniguchi,
Junko Doi,
Nan Wang,
Takahiro Ajiki,
Kotaro Ogawa,
Keita Kakuda,
Yasuyoshi Kimura,
Hideki Mochizuki Tags: ORIGINAL ARTICLE Source Type: research
Enhanced Physical Stability of L-Ascorbic Acid in an Ionic Liquid
Chem Pharm Bull (Tokyo). 2024 Jan 26. doi: 10.1248/cpb.c23-00861. Online ahead of print.ABSTRACTIonic liquid (IL) technology was used to enhance the stability of L-ascorbic acid (AA). Pyridoxine was selected as the counter cation for anionic AA in IL. After AA was dissolved in water at 40°C, its ratio decreased to 3.2% after 7 days. In contrast, the IL formulation showed negligible degradation, with almost no loss of AA even after 28 days. These results suggest that the use of IL enhances the stability of AA.PMID:38281765 | DOI:10.1248/cpb.c23-00861 (Source: Chemical and Pharmaceutical Bulletin)
Source: Chemical and Pharmaceutical Bulletin - January 28, 2024 Category: Drugs & Pharmacology Authors: Takeshi Oshizaka Issei Takeuchi Katsuya Mukae Kenji Mori Kenji Sugibayashi Source Type: research
Development of chromatographic methods to determine multivitamins formulation depending on their solubility and polarity: comparative study using three greenness assessment tools
High performance liquid chromatography is one of the techniques of choice for the separation and quantitative determination of drugs in mixture form. Ipriflavone, ascorbic acid, pyridoxine, vitamin D3, and lys... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - January 27, 2024 Category: Chemistry Authors: Sara Abdel Basset Galal, Eman Saad Elzanfaly, Emad Mohamed Hussien, Enas Abdel Hakim Amer and Hala Elsayed Zaazaa Tags: Research Source Type: research
A synthetic microbial consortium protects against obesity by regulating vitamin B6 metabolism
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - January 25, 2024 Category: Microbiology Authors: Xiuzhao ChenMengxue GaoLina WangGuifen QiangYili WuHe HuangGuangbo Kanga Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University Source Type: research
Identification of the pyridoxal 5 ′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase
AbstractAdequate levels of pyridoxal 5 ′-phosphate (PLP), the catalytically active form of vitamin B6, and its proper distribution in the body are essential for human health. The PLP recycling pathway plays a crucial role in these processes and its defects cause severe neurological diseases. The enzyme pyridox(am)ine 5 ′-phosphate oxidase (PNPO), whose catalytic action yields PLP, is one of the key players in this pathway. Mutations in the gene encoding PNPO are responsible for a severe form of neonatal epilepsy. Recently, PNPO has also been described as a potential target for chemotherapeutic agents. Our labora tory h...
Source: Protein Science - January 23, 2024 Category: Biochemistry Authors: Anna Barile,
Claudio Graziani,
Lorenzo Antonelli,
Alessia Parroni,
Annarita Fiorillo,
Martino Luigi di Salvo,
Andrea Ilari,
Alessandra Giorgi,
Serena Rosignoli,
Alessandro Paiardini,
Roberto Contestabile,
Angela Tramonti Tags: RESEARCH ARTICLE Source Type: research
Genome analysis of “Candidatus Aschnera chinzeii,” the bacterial endosymbiont of the blood-sucking bat fly Penicillidia jenynsii (Insecta: Diptera: Nycteribiidae)
In this study, we report the first complete genome sequence of Aschnera from the bristled bat fly Penicillidia jenynsii. The Aschnera genome consisted of a 748,020 bp circular chromosome and a 18,747 bp circular plasmid. The chromosome encoded 603 protein coding genes (including 3 pseudogenes), 33 transfer RNAs, and 1 copy of 16S/23S/5S ribosomal RNA operon. The plasmid contained 10 protein coding genes, whose biological function was elusive. The genome size, 0.77 Mbp, was drastically reduced in comparison with 4–6 Mbp genomes of free-living γ-proteobacteria. Accordingly, the Aschnera genome was devoid of many important...
Source: Frontiers in Microbiology - January 22, 2024 Category: Microbiology Source Type: research
Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants
Mutations in alanine:glyoxylate aminotransferase (AGT) leading to protein misfolding cause primary hyperoxaluria type I (PH1). Here, we use hydrogen-deuterium exchange to characterize the structural dynamics of AGT variants. These dynamics are heterogeneously distributed across the structure and different functional sites. Disease-associated variants show local destabilization. Our work provides novel insight into the pathogenic mechanisms causing PH1. Primary hyperoxaluria type I (PH1) is caused by deficient alanine:glyoxylate aminotransferase (AGT) activity. PH1-causing mutations in AGT lead to protein mistargeting and a...
Source: FEBS Letters - January 20, 2024 Category: Biochemistry Authors: Pavla Vankova,
Juan Luis Pacheco ‐Garcia,
Dmitry S. Loginov,
Atanasio Gómez‐Mulas,
Alan Kádek,
José Manuel Martín‐Garcia,
Eduardo Salido,
Petr Man,
Angel L. Pey Tags: Research Article Source Type: research
Enzymatic properties of ornithine decarboxylase from Clostridium aceticum DSM1496
In this study, we expressed ODC derived fromC. aceticum DSM1496 inEscherichia coli BL21 (DE3) and thoroughly examined its enzymatic properties. The enzyme has a molecular weight of 55.27 kDa and uses pyridoxal-5′-phosphate (PLP) as a coenzyme with aKm = 0.31 mM. ODC exhibits optimal activity at pH 7.5, and it maintains high stability even at pH 4.5. The peak reaction temperature for ODC is 30°C. Besides, it can be influenced by certain metal ions such as Mn2+. Althoughl-ornithine serves as the preferred substrate for ODC, the enzyme also decarboxylatesl-arginine andl-lysine simultaneously. The results indicate that...
Source: Biotechnology and Applied Biochemistry - January 16, 2024 Category: Biochemistry Authors: Qian Tan,
Linbo Gou,
Tai ‐Ping Fan,
Yujie Cai Tags: ORIGINAL ARTICLE Source Type: research
