Over-the-Counter Medications in Pregnancy
Am Fam Physician. 2023 Oct;108(4):360-369.ABSTRACTHigh-quality research on the safety and effectiveness of over-the-counter medications in pregnancy is limited. Physicians should explore nonpharmacologic treatments before recommending medication. For nausea and vomiting in pregnancy, vitamin B6 (pyridoxine), H1 antihistamines, and ginger are safe and effective. Physicians can recommend calcium carbonate, H2 antihistamines, and proton pump inhibitors for gastroesophageal reflux disease. Osmotic laxatives, fiber preparations, and probiotics are safe and effective treatments for constipation. Many over-the-counter topical med...
Source: Pain Physician - October 16, 2023 Category: Anesthesiology Authors: Elizabeth Allison Powers Ryan Tewell Max Bayard Source Type: research
Over-the-Counter Medications in Pregnancy
Am Fam Physician. 2023 Oct;108(4):360-369.ABSTRACTHigh-quality research on the safety and effectiveness of over-the-counter medications in pregnancy is limited. Physicians should explore nonpharmacologic treatments before recommending medication. For nausea and vomiting in pregnancy, vitamin B6 (pyridoxine), H1 antihistamines, and ginger are safe and effective. Physicians can recommend calcium carbonate, H2 antihistamines, and proton pump inhibitors for gastroesophageal reflux disease. Osmotic laxatives, fiber preparations, and probiotics are safe and effective treatments for constipation. Many over-the-counter topical med...
Source: American Family Physician - October 16, 2023 Category: Primary Care Authors: Elizabeth Allison Powers Ryan Tewell Max Bayard Source Type: research
Over-the-Counter Medications in Pregnancy
Am Fam Physician. 2023 Oct;108(4):360-369.ABSTRACTHigh-quality research on the safety and effectiveness of over-the-counter medications in pregnancy is limited. Physicians should explore nonpharmacologic treatments before recommending medication. For nausea and vomiting in pregnancy, vitamin B6 (pyridoxine), H1 antihistamines, and ginger are safe and effective. Physicians can recommend calcium carbonate, H2 antihistamines, and proton pump inhibitors for gastroesophageal reflux disease. Osmotic laxatives, fiber preparations, and probiotics are safe and effective treatments for constipation. Many over-the-counter topical med...
Source: American Family Physician - October 16, 2023 Category: Primary Care Authors: Elizabeth Allison Powers Ryan Tewell Max Bayard Source Type: research
Stereoselective Synthesis of Noncanonical Amino Acids Enabled by Photoredox-Pyridoxal Radical Biocatalysis
Synfacts 2023; 19: 1142- DOI: 10.1055/s-0042-1752035 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Synfacts)
Source: Synfacts - October 14, 2023 Category: Chemistry Tags: Organo- and Biocatalysis Source Type: research
Molecules, Vol. 28, Pages 7044: Comparative Study of Augmented Classical Least Squares Models for UV Assay of Co-Formulated Antiemetics Together with Related Impurities
E. Draz
The classical least squares (CLS) model and three augmented CLS models are adopted and validated for the analysis of pyridoxine HCl (PYR), cyclizine HCl (CYC), and meclizine HCl (MEC) in a quinary mixture with two related impurities: the CYC main impurity, Benzhydrol (BEH), which has carcinogenic and hepatotoxic effects, and the MEC official impurity, 4-Chlorobenzophenone (BEP). The proposed augmented CLS models are orthogonal signal correction CLS (OSC-CLS), direct orthogonal signal correction CLS (DOSC-CLS), and net analyte processing CLS (NAP-CLS). These models were applied to quantify the three active const...
Source: Molecules - October 12, 2023 Category: Chemistry Authors: Muneera S. M. Al-Saleem Hany W. Darwish Ibrahim A. Naguib Mohammed E. Draz Tags: Article Source Type: research
The efficiency of cabergoline versus pyridoxine for lactation inhibition – a randomized controlled trial
Some mothers may seek lactation inhibition on personal, social, or medical grounds. The common drug used for lactation inhibition is cabergoline. Several adverse effects and contraindications are known for this drug. Its use is contraindicated for patients with hypertensive disorders and fibrotic, cardiac, or hepatic diseases. Pyridoxine (Vitamin B6) has also been used for this indication, with no significant adverse effects, following studies that demonstrated its efficacy. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - October 10, 2023 Category: OBGYN Authors: Adi DAYAN-SCHWARTZ, Enav YEFET, Manal MASSALHA, Sally HOSARI-MHAMEED, Chen REMER-GROSS, Eliran PASAND, Zohar NACHUM Tags: Original Research: Obstetrics Source Type: research
The efficiency of cabergoline vs pyridoxine for lactation inhibition —a randomized controlled trial
Some mothers may seek lactation inhibition on personal, social, or medical grounds. The common drug used for lactation inhibition is cabergoline. Several adverse effects and contraindications are known for this drug. Its use is contraindicated for patients with hypertensive disorders and fibrotic, cardiac, or hepatic diseases. In addition, pyridoxine (vitamin B6) has been used for this indication, with no significant adverse effect, following studies that demonstrated its efficacy. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - October 10, 2023 Category: OBGYN Authors: Adi Dayan-Schwartz, Enav Yefet, Manal Massalha, Sally Hosari-Mhameed, Chen Remer-Gross, Eliran Pasand, Zohar Nachum Tags: Original Research Source Type: research
Longitudinal metabolomics integrated with machine learning identifies novel biomarkers of gestational diabetes mellitus
CONCLUSION: We identified and characterized distinct patterns of metabolites associated with GDM throughout pregnancy, and found that allantoic acid was a potential biomarker for early diagnosis of GDM.PMID:37806596 | DOI:10.1016/j.freeradbiomed.2023.10.014 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - October 8, 2023 Category: Biology Authors: Qiuhan Lu Yue Li Dewei Ye Xiangtian Yu Wenyu Huang Shufei Zang Guozhi Jiang Source Type: research
Longitudinal metabolomics integrated with machine learning identifies novel biomarkers of gestational diabetes mellitus
CONCLUSION: We identified and characterized distinct patterns of metabolites associated with GDM throughout pregnancy, and found that allantoic acid was a potential biomarker for early diagnosis of GDM.PMID:37806596 | DOI:10.1016/j.freeradbiomed.2023.10.014 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - October 8, 2023 Category: Biology Authors: Qiuhan Lu Yue Li Dewei Ye Xiangtian Yu Wenyu Huang Shufei Zang Guozhi Jiang Source Type: research
Longitudinal metabolomics integrated with machine learning identifies novel biomarkers of gestational diabetes mellitus
CONCLUSION: We identified and characterized distinct patterns of metabolites associated with GDM throughout pregnancy, and found that allantoic acid was a potential biomarker for early diagnosis of GDM.PMID:37806596 | DOI:10.1016/j.freeradbiomed.2023.10.014 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - October 8, 2023 Category: Biology Authors: Qiuhan Lu Yue Li Dewei Ye Xiangtian Yu Wenyu Huang Shufei Zang Guozhi Jiang Source Type: research
Longitudinal metabolomics integrated with machine learning identifies novel biomarkers of gestational diabetes mellitus
CONCLUSION: We identified and characterized distinct patterns of metabolites associated with GDM throughout pregnancy, and found that allantoic acid was a potential biomarker for early diagnosis of GDM.PMID:37806596 | DOI:10.1016/j.freeradbiomed.2023.10.014 (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - October 8, 2023 Category: Biology Authors: Qiuhan Lu Yue Li Dewei Ye Xiangtian Yu Wenyu Huang Shufei Zang Guozhi Jiang Source Type: research
Prognostic Impact of Serum Homocysteine-Lowering Therapy on Patients with Hemorrhagic Stroke and Its Influence on National Institutes of Health Stroke Scale and China Stroke Scale Scores
CONCLUSIONS: High-dose folic acid, methylcobalamin, and vitamin B6 as part of serum homocysteine-lowering therapy can improve oxidative stress and vascular endothelial function in HS patients. This treatment also enhances prognosis and ameliorates neurological deficits. Therefore, it holds significant clinical potential and should be considered for broader adoption.PMID:37793337 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 4, 2023 Category: Complementary Medicine Authors: Xiangyang An Xinrui Du Bo Yang Naichi Zhai Laixian Cui Source Type: research
Predictors of hyporesponsiveness to erythropoiesis-stimulating agents in patients with non-dialysis-dependent chronic kidney disease (RADIANCE-CKD Study)
CONCLUSIONS: Our results suggest that existing risk factors and serum test items can be used to predict ESA resistance in patients with non-dialysis-dependent chronic kidney disease on ESA.PMID:37793365 | DOI:10.1159/000534438 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 4, 2023 Category: Urology & Nephrology Authors: Kaori Mase Kunihiro Yamagata Hiroyasu Yamamoto Kazuhiko Tsuruya Hiroki Hase Shinichi Nishi Masaomi Nangaku Takashi Wada Terumasa Hayashi Yukari Uemura Hideki Hirakata Source Type: research
Prognostic Impact of Serum Homocysteine-Lowering Therapy on Patients with Hemorrhagic Stroke and Its Influence on National Institutes of Health Stroke Scale and China Stroke Scale Scores
CONCLUSIONS: High-dose folic acid, methylcobalamin, and vitamin B6 as part of serum homocysteine-lowering therapy can improve oxidative stress and vascular endothelial function in HS patients. This treatment also enhances prognosis and ameliorates neurological deficits. Therefore, it holds significant clinical potential and should be considered for broader adoption.PMID:37793337 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 4, 2023 Category: Complementary Medicine Authors: Xiangyang An Xinrui Du Bo Yang Naichi Zhai Laixian Cui Source Type: research
Predictors of hyporesponsiveness to erythropoiesis-stimulating agents in patients with non-dialysis-dependent chronic kidney disease (RADIANCE-CKD Study)
CONCLUSIONS: Our results suggest that existing risk factors and serum test items can be used to predict ESA resistance in patients with non-dialysis-dependent chronic kidney disease on ESA.PMID:37793365 | DOI:10.1159/000534438 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 4, 2023 Category: Urology & Nephrology Authors: Kaori Mase Kunihiro Yamagata Hiroyasu Yamamoto Kazuhiko Tsuruya Hiroki Hase Shinichi Nishi Masaomi Nangaku Takashi Wada Terumasa Hayashi Yukari Uemura Hideki Hirakata Source Type: research
