Effects of the PREMEN-CALM ® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study
J Diet Suppl. 2024 Jan 11:1-17. doi: 10.1080/19390211.2023.2301398. Online ahead of print.ABSTRACTPremenstrual syndrome is a common disorder in women of reproductive age characterized by a variety of cyclical symptoms with a great impact on their lifestyle. Available pharmacological options include both antidepressants and oral contraceptives, both of which have side effects, are expensive and not always effective. Vitamins, minerals and plant extracts have been proven to alleviate the symptomatology of the premenstrual syndrome. For this reason, the purpose of this study was to test the effectiveness of a commercial phyto...
Source: Journal of Dietary Supplements - January 12, 2024 Category: Nutrition Authors: Andrea Herrera Miriam Al Adib Ana Beatriz Rodr íguez Cristina Carrasco Source Type: research
Genetically predicted circulating concentrations of micronutrients and risk of hypertensive disorders of pregnancy: a Mendelian randomization study
ConclusionThere is no strong evidence to support the causation between circulating micronutrients and hypertensive disorder during pregnancy. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - January 9, 2024 Category: OBGYN Source Type: research
Vitamin B < sub > 6 < /sub > : a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 19;67. doi: 10.29219/fnr.v67.10259. eCollection 2023.ABSTRACTPyridoxal 5´-phosphate (PLP) is the main form of vitamin B6 in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B6 and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vita...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Anne-Lise Bj ørke-Monsen Per Magne Ueland Source Type: research
Vitamin B < sub > 6 < /sub > : a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 19;67. doi: 10.29219/fnr.v67.10259. eCollection 2023.ABSTRACTPyridoxal 5´-phosphate (PLP) is the main form of vitamin B6 in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B6 and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vita...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Anne-Lise Bj ørke-Monsen Per Magne Ueland Source Type: research
Vitamin B < sub > 6 < /sub > : a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 19;67. doi: 10.29219/fnr.v67.10259. eCollection 2023.ABSTRACTPyridoxal 5´-phosphate (PLP) is the main form of vitamin B6 in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B6 and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vita...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Anne-Lise Bj ørke-Monsen Per Magne Ueland Source Type: research
Vitamin B < sub > 6 < /sub > : a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 19;67. doi: 10.29219/fnr.v67.10259. eCollection 2023.ABSTRACTPyridoxal 5´-phosphate (PLP) is the main form of vitamin B6 in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B6 and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vita...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Anne-Lise Bj ørke-Monsen Per Magne Ueland Source Type: research
Vitamin B < sub > 6 < /sub > : a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 19;67. doi: 10.29219/fnr.v67.10259. eCollection 2023.ABSTRACTPyridoxal 5´-phosphate (PLP) is the main form of vitamin B6 in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B6 and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vita...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Anne-Lise Bj ørke-Monsen Per Magne Ueland Source Type: research
Vitamin B < sub > 6 < /sub > : a scoping review for Nordic Nutrition Recommendations 2023
Food Nutr Res. 2023 Dec 19;67. doi: 10.29219/fnr.v67.10259. eCollection 2023.ABSTRACTPyridoxal 5´-phosphate (PLP) is the main form of vitamin B6 in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B6 and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vita...
Source: Food and Nutrition Research - January 8, 2024 Category: Nutrition Authors: Anne-Lise Bj ørke-Monsen Per Magne Ueland Source Type: research
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
Bioorg Chem. 2023 Dec 30;143:107077. doi: 10.1016/j.bioorg.2023.107077. Online ahead of print.ABSTRACTCancer stands as one of the deadliest diseases, ranking second in terms of its global impact. Despite the presence of numerous compelling theories concerning its origins, none have succeeded in fully elucidating the intricate nature of this ailment. Among the prevailing concerns in today's world, breast cancer proliferation remains a significant issue, particularly affecting females. The abnormal proliferation of the PI3K pathway emerges as a prominent driver of breast cancer, underscoring its role in cellular survival and...
Source: Bioorganic Chemistry - January 4, 2024 Category: Chemistry Authors: Rahul Dubey Anushka Sharma Shankar Gupta G D Gupta Vivek Asati Source Type: research
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
Bioorg Chem. 2023 Dec 30;143:107077. doi: 10.1016/j.bioorg.2023.107077. Online ahead of print.ABSTRACTCancer stands as one of the deadliest diseases, ranking second in terms of its global impact. Despite the presence of numerous compelling theories concerning its origins, none have succeeded in fully elucidating the intricate nature of this ailment. Among the prevailing concerns in today's world, breast cancer proliferation remains a significant issue, particularly affecting females. The abnormal proliferation of the PI3K pathway emerges as a prominent driver of breast cancer, underscoring its role in cellular survival and...
Source: Bioorganic Chemistry - January 4, 2024 Category: Chemistry Authors: Rahul Dubey Anushka Sharma Shankar Gupta G D Gupta Vivek Asati Source Type: research
Systemic effects of hypophosphatasia characterization of two novel variants in the ALPL gene
ConclusionsThe two new mutations have been classified as pathogenic. At the clinical level, this study suggests that both mutations not only lead to pathognomonic symptoms of the disease, but may also play a role at the systemic level. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 3, 2024 Category: Endocrinology Source Type: research
Discovery and characterization of natural product luteolin as an effective inhibitor of human pyridoxal kinase
In this study, we present the discovery of a novel PDXK inhibitor, luteolin, through a high-throughput screening approach based on enzyme activity. Luteolin, a natural product, exhibits micromolar-level affinity for PDXK and effectively inhibits the enzyme's activity in vitro. Our crystal structures reveal that luteolin occupies the ATP binding pocket through hydrophobic interactions and a weak hydrogen bonding pattern, displaying reversible characteristics as confirmed by biochemical assays. Moreover, luteolin disrupts vitamin B6 metabolism by targeting PDXK, thereby inhibiting the proliferation of leukemia cells. This re...
Source: Bioorganic Chemistry - December 27, 2023 Category: Chemistry Authors: Yunmei Zhu Guangsen Bao Gaolin Zhu Kai Zhang Sanyong Zhu Junchi Hu Jia He Wei Jiang Jianjun Fan Yongjun Dang Source Type: research
Discovery and characterization of natural product luteolin as an effective inhibitor of human pyridoxal kinase
In this study, we present the discovery of a novel PDXK inhibitor, luteolin, through a high-throughput screening approach based on enzyme activity. Luteolin, a natural product, exhibits micromolar-level affinity for PDXK and effectively inhibits the enzyme's activity in vitro. Our crystal structures reveal that luteolin occupies the ATP binding pocket through hydrophobic interactions and a weak hydrogen bonding pattern, displaying reversible characteristics as confirmed by biochemical assays. Moreover, luteolin disrupts vitamin B6 metabolism by targeting PDXK, thereby inhibiting the proliferation of leukemia cells. This re...
Source: Bioorganic Chemistry - December 27, 2023 Category: Chemistry Authors: Yunmei Zhu Guangsen Bao Gaolin Zhu Kai Zhang Sanyong Zhu Junchi Hu Jia He Wei Jiang Jianjun Fan Yongjun Dang Source Type: research
Methionine gamma lyase: Structure-activity relationships and therapeutic applications
Biochim Biophys Acta Proteins Proteom. 2023 Dec 24:140991. doi: 10.1016/j.bbapap.2023.140991. Online ahead of print.ABSTRACTMethionine gamma lyase (MGL) is a bacterial and plant enzyme that catalyzes the conversion of methionine in methanthiol, 2-oxobutanoate and ammonia. The enzyme belongs to fold type I of the pyridoxal 5'-dependent family. The catalytic mechanism and the structure of wild type MGL and variants were determined in the presence of the natural substrate as well as of many sulfur-containing derivatives. Structure-function relationship studies were pivotal for MGL exploitation in the treatment of cancer, bact...
Source: Biochimica et Biophysica Acta - December 26, 2023 Category: Biochemistry Authors: Samanta Raboni Serena Faggiano Stefano Bettati Andrea Mozzarelli Source Type: research
