Paracentral acute middle maculopathy and cotton wool spots in a patient with ocular migraine: A case report
In this study, we report paracentral acute middle maculopathy (PAMM) and cotton wool spots (CWS) in a patient with ocular migraine. A 74-year-old man presented with persistent paracentral scotoma in the right eye that began a week prior. His visual acuity was 20/25 in the right eye and 20/40 in the left. Dilated fundoscopy revealed CWS in the right eye. Spectral-domain optical coherence tomography (SD-OCT) showed hyper-reflective bands in the inner nuclear layer corresponding to parafoveal lesions seen on near-infrared imaging in the right eye consistent with the diagnosis of PAMM. Further laboratory studies were unremarka...
Source: European Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: MacGregor N Hall Arash Maleki Source Type: research
Telemedicine Screening for Eye Disorders in Federally Qualified Health Centers: Relationship to Vision-Targeted Health-Related Quality of Life
Conclusion: Vision-targeted, health-related quality of life in our FQHC settings was related to the visual acuity impairment and the diagnosis of diabetic retinopathy but was also influenced by a variety of sociodemographic factors.PMID:38662523 | DOI:10.1089/tmj.2023.0695 (Source: Rural Remote Health)
Source: Rural Remote Health - April 25, 2024 Category: Rural Health Authors: Thomas A Swain Gerald McGwin Christopher A Girkin Cynthia Owsley Source Type: research
Scoping review of non-surgical treatment options for macular holes
This study conducted a comprehensive literature review and analysis of non-surgical MH management.A systematic literature search was conducted on PubMed, Embase, Scopus, and the Cochrane Library from January 1, 1973, to September 13, 2023. Treatments included laser therapy, carbonic anhydrase inhibitors (CAIs), non-steroidal anti-inflammatories (NSAIDs), steroids (topical, subtenons, peribulbar, intravitreal), intravitreal gas, anti-vascular endothelial growth factors (VEGF) and ocriplasmin injections. (Source: Survey of Ophthalmology)
Source: Survey of Ophthalmology - April 25, 2024 Category: Opthalmology Authors: Yong Min Lee, Bobak Bahrami, Dinesh Selva, Robert J Casson, Weng Onn Chan Tags: Review article Source Type: research
Genetic Prediction of Micronutrient Levels and the Risk of Colorectal Polyps: A Mendelian Randomization Study
Previous epidemiological and experimental studies have yielded conflicting results regarding the influence of human micronutrient levels on the risk of colorectal polyps (CP). In our study, we conducted a two-sample Mendelian randomization (MR) investigation to probe the link between 13 human micronutrients (calcium, selenium, magnesium, phosphorus, folate, vitamins B-6, B-12, C, D, beta-carotene, iron, zinc, and copper) and the genetic susceptibility to CP. (Source: Clinical Nutrition)
Source: Clinical Nutrition - April 25, 2024 Category: Nutrition Authors: Siyao Lv, Yunyi Ding, Junli Huang, Yixin He, Ruijie Xie, Xiaohong Shi, Wei Ye Source Type: research
Contribution of systemic factors on macular vessel density: a sex-specific population-based study
ConclusionsThis large cross-sectional study shows that older age and type 2 diabetes mellitus are associated with lower superficial and deep retinal capillary vessel density in men. This may help clinicians better understand how systemic factors influence retinal vessel density in different genders and future studies can ascertain more potential sex differences. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 25, 2024 Category: Opthalmology Source Type: research
miR-199a-5p modulates choroidal neovascularization by regulating Wnt7b/Wnt/ β-catenin signaling pathway
In conclusion, overexpression of miR-199a-5p inhibited t he angiogenesis of HRMEC by regulating Wnt7b/Wnt/β-catenin signaling pathway, which may serve as a promising therapy target of CNV. (Source: Journal of Molecular Histology)
Source: Journal of Molecular Histology - April 25, 2024 Category: Laboratory Medicine Source Type: research
Targeting inflammasomes and pyroptosis in retinal diseases-molecular mechanisms and future perspectives
Prog Retin Eye Res. 2024 Apr 22:101263. doi: 10.1016/j.preteyeres.2024.101263. Online ahead of print.ABSTRACTRetinal diseases encompass various conditions associated with sight-threatening immune responses and are leading causes of blindness worldwide. These diseases include age-related macular degeneration, diabetic retinopathy, glaucoma and uveitis. Emerging evidence underscores the vital role of the innate immune response in retinal diseases, beyond the previously emphasized T-cell-driven processes of the adaptive immune system. In particular, pyroptosis, a newly discovered programmed cell death process involving inflam...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Yimeng Sun Fan Li Yunfei Liu Dijie Qiao Xinyu Yao Guei-Sheung Liu Dequan Li Chuanle Xiao Tao Wang Wei Chi Source Type: research
Autonomous artificial intelligence versus teleophthalmology for diabetic retinopathy
Conclusions: The comparison between the diagnosis provided by artificial intelligence based automated software and the reference clinical diagnosis showed that they can work at a level of sensitivity that is similar to that achieved by experts.PMID:38656241 | DOI:10.1177/11206721241248856 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 24, 2024 Category: Opthalmology Authors: Donatella Musetti Carlo Alberto Cutolo Monica Bonetto Mauro Giacomini Davide Maggi Giorgio Luciano Viviani Ilaria Gandin Carlo Enrico Traverso Massimo Nicol ò Source Type: research
SUMOylation of GMFB regulates its stability and function in retinal pigment epithelial cells under hyperglycemia
CONCLUSIONS: This work provides novel insight into the role of SUMOylated GMFB in RPE cells and provides a novel therapeutic target for diabetic retinopathy (DR).PMID:38657921 | DOI:10.1016/j.ijbiomac.2024.131678 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 24, 2024 Category: Biochemistry Authors: Wan Sun Juan Wang Caiying Liu Furong Gao Qingjian Ou Haibin Tian Jingying Xu Jieping Zhang Jiao Li Jie Xu Song Jia Jingfa Zhang GuoTong Xu Jian Huang Caixia Jin Lixia Lu Source Type: research
Comparison of B-Scan ultrasonography, ultra-widefield fundus imaging, and indirect ophthalmoscopy in detecting retinal breaks in cataractous eyes
Eye, Published online: 24 April 2024; doi:10.1038/s41433-024-03093-2Comparison of B-Scan ultrasonography, ultra-widefield fundus imaging, and indirect ophthalmoscopy in detecting retinal breaks in cataractous eyes (Source: Eye)
Source: Eye - April 24, 2024 Category: Opthalmology Authors: Ao Miao Jie Xu Kai Wei Peimin Lin Liangliang Niu Yumeng Shi Dongjin Qian Yi Lu Yongxiang Jiang Tianyu Zheng Source Type: research
Short-term Aronia melanocarpa extract supplementation improves cognitive performance: a randomized, double-blind, placebo-controlled cross-over study in healthy young adults
ConclusionShort-term AME supplementation beneficially affected cognitive performance as attention and psychomotor speed improved. Serum BDNF concentrations were increased, but vascular function markers were not affected.Clinical trial registrationThe study was registered on Clinical Trials under NCT03793777 on January 4th, 2019. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 24, 2024 Category: Nutrition Source Type: research
Serum vitamins and homocysteine levels in autoimmune liver disease: A systematic review and meta ‐analysis
ConclusionMost vitamins are deficient in AILD, so appropriate vitamin supplementation should be necessary. Further studies with larger sample sizes are needed to validate these findings. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 23, 2024 Category: Allergy & Immunology Authors: Jiahuan Li,
Shan Tian,
Bai Ci,
Yuwen Xi,
Xiaoling Deng Tags: REVIEW ARTICLE Source Type: research
Increased glutamatergic neurotransmission between the retinohypothalamic tract and the suprachiasmatic nucleus of old mice
J Neurosci Res. 2024 Apr;102(4):e25331. doi: 10.1002/jnr.25331.ABSTRACTCircadian rhythms synchronize to light through the retinohypothalamic tract (RHT), which is a bundle of axons coming from melanopsin retinal ganglion cells, whose synaptic terminals release glutamate to the ventral suprachiasmatic nucleus (SCN). Activation of AMPA-kainate and NMDA postsynaptic receptors elicits the increase in intracellular calcium required for triggering the signaling cascade that ends in phase shifts. During aging, there is a decline in the synchronization of circadian rhythms to light. With electrophysiological (whole-cell patch-clam...
Source: Cell Research - April 23, 2024 Category: Cytology Authors: J Manuel Herrera-Zamora Fernando Osuna-Lopez Miriam E Reyes-M éndez Ramon E Valadez-Lemus Enrique A S ánchez-Pastor Ricardo A Navarro-Polanco Eloy G Moreno-Galindo Javier Alamilla Source Type: research
Bioactive compounds from Morchella esculenta as potential inhibitors of RNA-binding protein La in ovarian cancer: a molecular modeling and quantum mechanics approach
In Silico Pharmacol. 2024 Apr 20;12(1):32. doi: 10.1007/s40203-024-00202-7. eCollection 2024.ABSTRACTLa protein is significantly expressed in various malignant tumors, including ovarian cancer (OC), which is related to the poor response to platinum-based chemotherapy. Thus, inhibiting La protein could control the expression of the potential downstream genes involved in promoting proliferation and chemotherapy resistance to OC, which could serve as a therapeutic intervention. Through a molecular docking approach, 12 compounds from Morchella esculenta were screened against the crystal structure of La protein and four hit com...
Source: Cancer Control - April 23, 2024 Category: Cancer & Oncology Authors: Gbenga Dairo Matthew N Ward Mette Soendergaard John J Determan Source Type: research
Molecular mechanism of high glucose-induced mitochondrial DNA damage in retinal ganglion cells
Cell Mol Biol (Noisy-le-grand). 2024 Mar 31;70(3):219-224. doi: 10.14715/cmb/2024.70.3.33.ABSTRACTMitochondrial DNA damage in retinal ganglion cells (RGCs) may be closely related to lesions of glaucoma. RGCs were cultured with different concentrations of glucose and grouped into 3 groups, namely normal control (NC) group, Low-Glu group, and High-Glu group. Cell viability was measured with cell counting kit-8, and cell apoptosis was measured using flow cytometry. The DNA damage was measured with comet assay, and the morphological changes of damaged mitochondria in RGCs were observed using TEM. Western blot analyzed the expr...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Jinzi Zhou Fenghua Chen Aimin Yan Xiaobo Xia Source Type: research
