Associaton of Retinol Binding Protein 4 (RBP4) Levels With Hyperuricemia: A Cross-Sectional Study in a Chinese Population
ConclusionsRBP4 is strongly associated with hyperuricemia, and its predictive value was higher than that of traditional predictors. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - June 29, 2022 Category: Endocrinology Source Type: research

miRNA-124 regulates palmitic acid-induced epithelial-mesenchymal transition and cell migration in human retinal pigment epithelial cells by targeting LIN7C
Exp Ther Med. 2022 Jun 1;24(1):481. doi: 10.3892/etm.2022.11408. eCollection 2022 Jul.ABSTRACTThe present study revealed that palmitic acid (PA) treatment induced epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells, which are involved in the progression of proliferative vitreoretinopathy (PVR). ARPE-19 cells were treated with PA followed by miRNA screening and EMT marker detection using qRT-PCR. Then, miR-124 mimic or inhibitor was transfected into ARPE-19 cells to explore the role of miR-124 on the EMT of ARPE-19 cells using transwell assay. The underlying mechanism of miRNA were predicted by...
Source: Experimental and Therapeutic Medicine - June 28, 2022 Category: General Medicine Authors: Xiao-Dong Han Xu-Guang Jiang Min Yang Wen-Jun Chen Li-Gang Li Source Type: research

Heme oxygenase-1 gene rs2071746 polymorphism in retinal vein occlusion
CONCLUSION: The rs2071746 polymorphism does not seem to be a major risk factor for the presence of RVO.PMID:35762119 | DOI:10.1080/13816810.2022.2092754 (Source: Ophthalmic Genetics)
Source: Ophthalmic Genetics - June 28, 2022 Category: Opthalmology Authors: Laura Posch-Pertl Wolfgang List Monja Michelitsch Silke Pinter-Hausberger Bujar Berisha Florian Posch Lorenz Kloeckl Wilfried Renner Martin Weger Source Type: research

Differentiation and Maturation Effect of All-trans Retinoic Acid on Cultured Fetal RPE and Stem Cell-Derived RPE Cells for Cell-Based Therapy
CONCLUSIONS: Differences in protein and gene expression among three RPE types exist. ATRA can increase RPE markers, CRPs gene expression in fRPE and stem cell-derived RPE. These can be used to guide the standard of screening RPE cells for clinical translational cell therapy.PMID:35763026 | DOI:10.1080/02713683.2022.2079144 (Source: Cell Research)
Source: Cell Research - June 28, 2022 Category: Cytology Authors: Tingyu Yan Na Yang Wei Hu Xinxin Zhang Xuedong Li Youjin Wang Jun Kong Source Type: research

Optical Coherence Tomography Angiography in Chiasmitis
A 29-year-old girl presented complaining of acute bilateral visual loss associated with mild headache and retrobulbar pain. She was diagnosed with chiasmal optic neuritis caused by multiple sclerosis. Her visual acuity and visual field defect promptly improved after steroid therapy. However optical coherence tomography angiography showed a progressive reduction of superficial capillary plexus density of the retina and optic nerve consistent with the progressive impairment of the retinal ganglionar cell layer. Contrary to chiasmal compression, in chiasmal optic neuritis, the superficial capillary plexus density reduction is...
Source: Case Reports in Ophthalmology - June 28, 2022 Category: Opthalmology Source Type: research

Bacillary Layer Detachment in an Atypical Case of Central Serous Chorioretinopathy Associated with High Hyperopia
A 16-year-old boy with elevated hyperopia presented to the office with a 24-h history of bilateral blurred vision, mainly of the left eye, and bilateral central serous chorioretinopathy. He showed a clinically recognizable bacillary layer detachment in one eye and excellent multimodal diagnostic image correlation, with the best-corrected visual acuity as 20/400. He had bilateral serous retinal detachment, as confirmed by optical coherence tomography. Laser photocoagulation was performed with good results, and reestablishment of the foveal anatomical structure was documented 16 days after treatment.Case Rep Ophthalmol 2022;...
Source: Case Reports in Ophthalmology - June 28, 2022 Category: Opthalmology Source Type: research

GSE201254 Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells [1]
Contributors : Anne Jacobi ; Nicholas M Tran ; Wenjun Yan ; Inbal Benhar ; Feng Tian ; Rebecca Schaffer ; Zhigang He ; Joshua SanesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeurons of the central nervous system (CNS) display only a limited ability to survive and regenerate their axons after an injury. In mice, 85% of retinal ganglion cells (RGCs) die within 2 weeks of axotomy by optic nerve crush (ONC) and only few survivors regenerate axons. In the past years, a multitude of interventions have been identified to improve RGC survival and regeneration after an injury, howe...
Source: GEO: Gene Expression Omnibus - June 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE202154 Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells [2]
Contributors : Anne Jacobi ; Nicholas M Tran ; Wenjun Yan ; Inbal Benhar ; Feng Tian ; Rebecca Schaffer ; Zhigang He ; Joshua SanesSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusNeurons of the central nervous system (CNS) display only a limited ability to survive and regenerate their axons after an injury. In mice, 85% of retinal ganglion cells (RGCs) die within 2 weeks of axotomy by optic nerve crush (ONC) and only few survivors regenerate axons. In the past years, a multitude of interventions have been identified to improve RGC survival and regeneration after an injury, howe...
Source: GEO: Gene Expression Omnibus - June 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

GSE202155 Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - June 28, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Genetics of Inherited Retinal Diseases in Understudied Ethnic Groups in Italian Hospitals
Conclusion: Though limited by the relatively low number of patients, the present paper paints a picture of the clinical and genetic features of IRD patients from understudied ethnic groups referred to Italian specialized hospitals and extended the epidemiological studies on underrepresented world regional areas. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - June 28, 2022 Category: Genetics & Stem Cells Source Type: research

Reduced blood flow by laser speckle flowgraphy after 125I-plaque brachytherapy for uveal melanoma
To determine whether reductions in retinal and choroidal blood flow measured by laser speckle flowgraphy are detected after 125I-plaque brachytherapy for uveal melanoma. (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - June 28, 2022 Category: Opthalmology Authors: Michelle R. Tamplin, Jui-Kai Wang, Anthony H. Vitale, Ryuya Hashimoto, Mona K. Garvin, Elaine M. Binkley, Daniel E. Hyer, John M. Buatti, H. Culver Boldt, Randy H. Kardon and Isabella M. Grumbach Tags: Research Source Type: research

Health technology assessment of new retinal treatments; the need to capture healthcare capacity issues
Eye, Published online: 28 June 2022; doi:10.1038/s41433-022-02149-5Health technology assessment of new retinal treatments; the need to capture healthcare capacity issues (Source: Eye)
Source: Eye - June 28, 2022 Category: Opthalmology Authors: Richard Gale Oliver Cox Craig Keenan Usha Chakravarthy Source Type: research

Linear interactions between intraocular, intracranial pressure, and retinal vascular pulse amplitude in the fourier domain
by Anmar Abdul-Rahman, William Morgan, Ying Jo Khoo, Christopher Lind, Allan Kermode, William Carroll, Dao-Yi Yu PurposeTo compare the retinal vascular pulsatile characteristics in subjects with normal (ICPn) and high (ICPh) intracranial pressure and quantify the interactions between intraocular pressure, intracranial pressure, and retinal vascular pulse amplitude in the Fourier domain. Materials and methodsTwenty-one subjects were examined using modified photoplethysmography with simultaneous ophthalmodynamometry. A harmonic regression model was fitted to each pixel in the time-series, and used to quantify the retinal vas...
Source: PLoS One - June 28, 2022 Category: Biomedical Science Authors: Anmar Abdul-Rahman Source Type: research

Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images
Comput Math Methods Med. 2022 Jun 15;2022:9409749. doi: 10.1155/2022/9409749. eCollection 2022.ABSTRACTThe aim of this study was to investigate the characteristics of macular and optic disc parameters in children with amblyopic and nonamblyopic eyes, using fundus images under optical coherence tomography (OCT). 36 patients with anisometropic amblyopia were selected in the experimental group, and another 36 healthy volunteers were selected in the control group, OCT examinations were performed in all groups, and the mean diopter, mean corrected visual acuity (CVA), mean axial length, mean optic disc retinal nerve fiber layer...
Source: Computational and Mathematical Methods in Medicine - June 27, 2022 Category: Statistics Authors: Dan Zhu Qiang Sun Hong Yang Yangcheng Zou Chunmei Liu Yan Xu Source Type: research

The Analysis of Potential Diagnostic and Therapeutic Targets for the Occurrence and Development of Gastric Cancer Based on Bioinformatics
CONCLUSION: This study identified new potential molecular targets closely related to gastric cancer occurrence and development via mining public data using bioinformatics analysis methods.PMID:35756405 | PMC:PMC9232307 | DOI:10.1155/2022/4321466 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - June 27, 2022 Category: Statistics Authors: Chuan Ding Qiqi Zhang Xinying Jiang Diandian Wei Shu Xu Qingdai Li Meng Wu Hongbin Wang Source Type: research