EphB1 causes retinal damage through inflammatory pathways in the retina and retinal M üller cells
CONCLUSIONS: EphB1 is increased in the retinas of diabetic humans and mice and in high glucose-treated Müller cells. This increase leads to inflammatory proteins. EphB1 also enhanced retinal damage in response to I/R. Taken together, inhibition of EphB1 may offer a new therapeutic option for diabetic retinopathy.PMID:38601015 | PMC:PMC11006007 (Source: Molecular Vision)
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Li Liu Youde Jiang Mohamed Al-Shabrawey Xiaobai Ren Sui Wang Jena J Steinle Source Type: research
Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy
Mol Vis. 2024 Mar 3;30:74-91. eCollection 2024.ABSTRACTSorsby fundus dystrophy (SFD) is a rare, inherited form of macular degeneration caused by mutations in the gene encoding tissue inhibitor of metalloproteinases 3 (TIMP-3). There are 21 mutations currently associated with SFD, with some variants (e.g., Ser179Cys, Tyr191Cys, and Ser204Cys) having been studied much more than others. We review what is currently known about the identified SFD variants in terms of their dimerization, metalloproteinase inhibition, and impact on angiogenesis, with a focus on disparities between reports and areas requiring further study. We als...
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Jacob H J Betts Linda Troeberg Source Type: research
EphB1 causes retinal damage through inflammatory pathways in the retina and retinal M üller cells
CONCLUSIONS: EphB1 is increased in the retinas of diabetic humans and mice and in high glucose-treated Müller cells. This increase leads to inflammatory proteins. EphB1 also enhanced retinal damage in response to I/R. Taken together, inhibition of EphB1 may offer a new therapeutic option for diabetic retinopathy.PMID:38601015 | PMC:PMC11006007 (Source: Molecular Vision)
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Li Liu Youde Jiang Mohamed Al-Shabrawey Xiaobai Ren Sui Wang Jena J Steinle Source Type: research
Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy
Mol Vis. 2024 Mar 3;30:74-91. eCollection 2024.ABSTRACTSorsby fundus dystrophy (SFD) is a rare, inherited form of macular degeneration caused by mutations in the gene encoding tissue inhibitor of metalloproteinases 3 (TIMP-3). There are 21 mutations currently associated with SFD, with some variants (e.g., Ser179Cys, Tyr191Cys, and Ser204Cys) having been studied much more than others. We review what is currently known about the identified SFD variants in terms of their dimerization, metalloproteinase inhibition, and impact on angiogenesis, with a focus on disparities between reports and areas requiring further study. We als...
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Jacob H J Betts Linda Troeberg Source Type: research
EphB1 causes retinal damage through inflammatory pathways in the retina and retinal M üller cells
CONCLUSIONS: EphB1 is increased in the retinas of diabetic humans and mice and in high glucose-treated Müller cells. This increase leads to inflammatory proteins. EphB1 also enhanced retinal damage in response to I/R. Taken together, inhibition of EphB1 may offer a new therapeutic option for diabetic retinopathy.PMID:38601015 | PMC:PMC11006007 (Source: Molecular Vision)
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Li Liu Youde Jiang Mohamed Al-Shabrawey Xiaobai Ren Sui Wang Jena J Steinle Source Type: research
Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy
Mol Vis. 2024 Mar 3;30:74-91. eCollection 2024.ABSTRACTSorsby fundus dystrophy (SFD) is a rare, inherited form of macular degeneration caused by mutations in the gene encoding tissue inhibitor of metalloproteinases 3 (TIMP-3). There are 21 mutations currently associated with SFD, with some variants (e.g., Ser179Cys, Tyr191Cys, and Ser204Cys) having been studied much more than others. We review what is currently known about the identified SFD variants in terms of their dimerization, metalloproteinase inhibition, and impact on angiogenesis, with a focus on disparities between reports and areas requiring further study. We als...
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Jacob H J Betts Linda Troeberg Source Type: research
EphB1 causes retinal damage through inflammatory pathways in the retina and retinal M üller cells
CONCLUSIONS: EphB1 is increased in the retinas of diabetic humans and mice and in high glucose-treated Müller cells. This increase leads to inflammatory proteins. EphB1 also enhanced retinal damage in response to I/R. Taken together, inhibition of EphB1 may offer a new therapeutic option for diabetic retinopathy.PMID:38601015 | PMC:PMC11006007 (Source: Molecular Vision)
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Li Liu Youde Jiang Mohamed Al-Shabrawey Xiaobai Ren Sui Wang Jena J Steinle Source Type: research
Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy
Mol Vis. 2024 Mar 3;30:74-91. eCollection 2024.ABSTRACTSorsby fundus dystrophy (SFD) is a rare, inherited form of macular degeneration caused by mutations in the gene encoding tissue inhibitor of metalloproteinases 3 (TIMP-3). There are 21 mutations currently associated with SFD, with some variants (e.g., Ser179Cys, Tyr191Cys, and Ser204Cys) having been studied much more than others. We review what is currently known about the identified SFD variants in terms of their dimerization, metalloproteinase inhibition, and impact on angiogenesis, with a focus on disparities between reports and areas requiring further study. We als...
Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Jacob H J Betts Linda Troeberg Source Type: research
Functional OCT reveals anisotropic changes of retinal flicker-evoked vasodilation
The purpose of this study is to verify the effect of anisotropic property of retinal biomechanics on vasodilation measurement. A ... (Source: Optics Letters)
Source: Optics Letters - April 11, 2024 Category: Physics Authors: Taeyoon Son Guangying Ma Xincheng Yao Source Type: research
Molecules, Vol. 29, Pages 1732: Effect of the Drying Method and Storage Conditions on the Quality and Content of Selected Bioactive Compounds of Green Legume Vegetables
This study aimed to determine the effect of the drying method (freeze-drying, air-drying), storage period (12 months), and storage conditions (2–4 °C, 18–22 °C) applied to two legume species: green beans and green peas. The raw and dried materials were determined for selected physical parameters typical of dried vegetables, contents of bioactive components (vitamin C and E, total chlorophyll, total carotenoids, β-carotene, and total polyphenols), antioxidative activity against the DPPH radical, and sensory attributes (overall quality and profiles of color, te...
Source: Molecules - April 11, 2024 Category: Chemistry Authors: Piotr G ębczyński Ma łgorzata Tabaszewska Katarzyna Kur Maria Zbylut-G órska Jacek S łupski Tags: Article Source Type: research
Solanum nigrum Toxicity and Its Neuroprotective Effect Against Retinal Ganglion Cell Death Through Modulation of Extracellular Matrix in a Glaucoma Rat Model
Journal of Ocular Pharmacology and Therapeutics, Ahead of Print. (Source: Journal of Ocular Pharmacology and Therapeutics)
Source: Journal of Ocular Pharmacology and Therapeutics - April 11, 2024 Category: Opthalmology Authors: Karan Singh Yadav Amol Chhatrapati Bisen Sharmeen Ishteyaque Isha Sharma Smriti Verma Sachin Nashik Sanap Shobhit Verma Kaveri R. Washimkar Akhilesh Kumar Vineeta Tripathi Rabi Sankar Bhatta Madhav Nilakanth Mugale Source Type: research
Understanding preferences for receiving health communications and information about clinical trials: a cross-sectional study among US adults
CONCLUSION: Effective health communication may be achieved via multiple formats shared directly by healthcare providers.PMID:38595182 | DOI:10.1080/03007995.2024.2340720 (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - April 10, 2024 Category: Research Authors: Dalia Majumdar Diane Webb Stephanie Parsons Elizabeth M Selwan-Lewis Trisha Rettig Emily Chastain Winifred Obanor Rob Birnberg Amy Kuang Source Type: research
Effect of adalimumab as an anti-inflammatory agent on gene expression of retinal pigment epithelial cells
In conclusion, despite its safety, the 2x concentration of ADA was the only dose that did not ignite the expression of any of the studied inflammatory and fibrogenesis genes. This dosage, which is roughly equal to 2 mg intravitreal dose in a clinical setting, might be referred to as a reference starting point for future in-vivo studies in ocular conditions.PMID:38599062 | DOI:10.1016/j.biopha.2024.116568 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2024 Category: Drugs & Pharmacology Authors: M Hossein Nowroozzadeh Mojtaba Yousefi Mostafa Abuali Fatemeh Sanie-Jahromi Source Type: research
