Examining the Correlation of Lymphangiogenesis Biomarkers with Clinical Condition in Age-Related Macular Degeneration (AMD)
Exp Eye Res. 2024 Apr 12:109891. doi: 10.1016/j.exer.2024.109891. Online ahead of print.ABSTRACTThe aim of this study is to investigate the relationship between age-related macular degeneration (AMD) and lymphangiogenesis biomarkers, namely LYVE-1, Podoplanin, VEGF-C, VEGFR-2 and VEGFR-3. This prospective and interventional study includes 30 patients with AMD which may be dry or wet type and 30 controls for whom vitrectomy and phacoemulsification was indicated due to additional pathologies (epiretinal membrane, macular hole, retinal detachment, and cataract). 0.1-0,2 ml of aqueous humor and 0.5-1 ml of vitreous sample was ...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Bagim Aycin Cakir Ince Murat Kucukevcilioglu Cigdem Yucel Ali Hakan Durukan Source Type: research
Possible Retinotoxicity of Long-term Vardenafil Treatment
Exp Eye Res. 2024 Apr 12:109890. doi: 10.1016/j.exer.2024.109890. Online ahead of print.ABSTRACTPhosphodiesterase (PDE) inhibitors - such as vardenafil - are used primarily for treating erectile dysfunction via increasing cyclic guanosine monophosphate (cGMP) levels. Recent studies have also demonstrated their significant cardioprotective effects in several diseases, including diabetes, upon long-term, continuous application. However, PDE inhibitors are not specific for PDE5 and also inhibit the retinal isoform. A sustained rise in cGMP in photoreceptors is known to be toxic; therefore, we hypothesized that long-term varde...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Klaudia Szab ó Bulcs ú Dékány Anna Énzsöly Rozina Ida Hajd ú Lenke Korn élia Laurik-Feuerstein Arnold Szab ó Tam ás Radovits Csaba M átyás Attila Ol áh Kriszti án András Kovács Ágoston Szél G ábor Márk Somfai Ákos Lukáts Source Type: research
Sustained Release Formulation of Hydroxypropyl- β-cyclodextrin Eye Drops Using Xanthan Gum
Chem Pharm Bull (Tokyo). 2024;72(4):381-384. doi: 10.1248/cpb.c24-00059.ABSTRACTBietti's crystalline dystrophy (BCD) is an autosomal recessive chorioretinal degeneration caused by mutations in the CYP4V2 gene. It is characterized by cholesterol accumulation and crystal-like deposits in the retinas. Hydroxypropyl-β-cyclodextrin (HP-β-CyD) exerts therapeutic effects against BCD by reducing lysosomal dysfunction and inhibiting cytotoxicity in induced pluripotent stem cell (iPSC)-RPE cells established from patient-derived iPS cells. However, the ocular retention of HP-β-CyD is low and needs to be improved. Therefore, this s...
Source: Chemical and Pharmaceutical Bulletin - April 14, 2024 Category: Drugs & Pharmacology Authors: Taishi Higashi Taito Goto Risako Onodera Tatsunori Hirotsu Hanako Ohashi Ikeda Keiichi Motoyama Source Type: research
Possible Retinotoxicity of Long-term Vardenafil Treatment
Exp Eye Res. 2024 Apr 12:109890. doi: 10.1016/j.exer.2024.109890. Online ahead of print.ABSTRACTPhosphodiesterase (PDE) inhibitors - such as vardenafil - are used primarily for treating erectile dysfunction via increasing cyclic guanosine monophosphate (cGMP) levels. Recent studies have also demonstrated their significant cardioprotective effects in several diseases, including diabetes, upon long-term, continuous application. However, PDE inhibitors are not specific for PDE5 and also inhibit the retinal isoform. A sustained rise in cGMP in photoreceptors is known to be toxic; therefore, we hypothesized that long-term varde...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Klaudia Szab ó Bulcs ú Dékány Anna Énzsöly Rozina Ida Hajd ú Lenke Korn élia Laurik-Feuerstein Arnold Szab ó Tam ás Radovits Csaba M átyás Attila Ol áh Kriszti án András Kovács Ágoston Szél G ábor Márk Somfai Ákos Lukáts Source Type: research
Examining the Correlation of Lymphangiogenesis Biomarkers with Clinical Condition in Age-Related Macular Degeneration (AMD)
Exp Eye Res. 2024 Apr 12:109891. doi: 10.1016/j.exer.2024.109891. Online ahead of print.ABSTRACTThe aim of this study is to investigate the relationship between age-related macular degeneration (AMD) and lymphangiogenesis biomarkers, namely LYVE-1, Podoplanin, VEGF-C, VEGFR-2 and VEGFR-3. This prospective and interventional study includes 30 patients with AMD which may be dry or wet type and 30 controls for whom vitrectomy and phacoemulsification was indicated due to additional pathologies (epiretinal membrane, macular hole, retinal detachment, and cataract). 0.1-0,2 ml of aqueous humor and 0.5-1 ml of vitreous sample was ...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Bagim Aycin Cakir Ince Murat Kucukevcilioglu Cigdem Yucel Ali Hakan Durukan Source Type: research
Examining the correlation of lymphangiogenesis biomarkers with clinical condition in Age-Related Macular Degeneration (AMD)
Exp Eye Res. 2024 Apr 13;243:109891. doi: 10.1016/j.exer.2024.109891. Online ahead of print.ABSTRACTThe aim of this study is to investigate the relationship between age-related macular degeneration (AMD) and lymphangiogenesis biomarkers, namely LYVE-1, Podoplanin, VEGF-C, VEGFR-2 and VEGFR-3. This prospective and interventional study includes 30 patients with AMD which may be dry or wet type and 30 controls for whom vitrectomy and phacoemulsification was indicated due to additional pathologies (epiretinal membrane, macular hole, retinal detachment, and cataract). 0.1-0,2 ml of aqueous humor and 0.5-1 ml of vitreous sample ...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Bagim Aycin Cakir Ince Murat Kucukevcilioglu Cigdem Yucel Ali Hakan Durukan Source Type: research
Possible retinotoxicity of long-term vardenafil treatment
Exp Eye Res. 2024 Apr 13;243:109890. doi: 10.1016/j.exer.2024.109890. Online ahead of print.ABSTRACTPhosphodiesterase (PDE) inhibitors - such as vardenafil - are used primarily for treating erectile dysfunction via increasing cyclic guanosine monophosphate (cGMP) levels. Recent studies have also demonstrated their significant cardioprotective effects in several diseases, including diabetes, upon long-term, continuous application. However, PDE inhibitors are not specific for PDE5 and also inhibit the retinal isoform. A sustained rise in cGMP in photoreceptors is known to be toxic; therefore, we hypothesized that long-term v...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Klaudia Szab ó Bulcs ú Dékány Anna Énzsöly Rozina Ida Hajd ú Lenke Korn élia Laurik-Feuerstein Arnold Szab ó Tam ás Radovits Csaba M átyás Attila Ol áh Kriszti án András Kovács Ágoston Szél G ábor Márk Somfai Ákos Lukáts Source Type: research
Accumulation of Microvascular Target Organ Damage in Systemic Lupus Erythematosus Patients Is Associated with Increased Cardiovascular Risk
Conclusions: Our study showed for the first time that SLE patients exhibit a greater number of cases of TOD. The accumulation of TOD was associated with increased CV risk. Clinicians dealing with SLE should be aware and seek microvascular alterations.PMID:38610905 | DOI:10.3390/jcm13072140 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nikolaos Koletsos Antonios Lazaridis Areti Triantafyllou Panagiota Anyfanti Stamatina Lamprou Anastasia Stoimeni Nikolaos G Papadopoulos Evaggelia-Evdoxia Koravou Eugenia Gkaliagkousi Source Type: research
Late-onset Kjellin syndrome: Diagnosis of SPG11 on fundus examination
CONCLUSION: Careful ophthalmological examination prompted the diagnosis and guided molecular testing. This case underlines the importance of a neuro-ophthalmologic assessment in patients with SPG.PMID:38613257 | DOI:10.1177/11206721241247418 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 13, 2024 Category: Opthalmology Authors: Vincent Brock Anna Wissocq Nicolas Geoffre Caroline Marks Vincent Canel Vincent Huin Vasily M Smirnov Source Type: research
Accumulation of Microvascular Target Organ Damage in Systemic Lupus Erythematosus Patients Is Associated with Increased Cardiovascular Risk
Conclusions: Our study showed for the first time that SLE patients exhibit a greater number of cases of TOD. The accumulation of TOD was associated with increased CV risk. Clinicians dealing with SLE should be aware and seek microvascular alterations.PMID:38610905 | PMC:PMC11012611 | DOI:10.3390/jcm13072140 (Source: Atherosclerosis)
Source: Atherosclerosis - April 13, 2024 Category: Cardiology Authors: Nikolaos Koletsos Antonios Lazaridis Areti Triantafyllou Panagiota Anyfanti Stamatina Lamprou Anastasia Stoimeni Nikolaos G Papadopoulos Evaggelia-Evdoxia Koravou Eugenia Gkaliagkousi Source Type: research
Late-onset Kjellin syndrome: Diagnosis of SPG11 on fundus examination
CONCLUSION: Careful ophthalmological examination prompted the diagnosis and guided molecular testing. This case underlines the importance of a neuro-ophthalmologic assessment in patients with SPG.PMID:38613257 | DOI:10.1177/11206721241247418 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 13, 2024 Category: Opthalmology Authors: Vincent Brock Anna Wissocq Nicolas Geoffre Caroline Marks Vincent Canel Vincent Huin Vasily M Smirnov Source Type: research
Association between the arm-to-choroidal circulation time and clinical profile in patients with polypoidal choroidal vasculopathy
ConclusionPatients with PCV and ACT>20 s are more likely to experience exudative change recurrence in the retina during treatment because they have more polypoidal lesions. (Source: Japanese Journal of Ophthalmology)
Source: Japanese Journal of Ophthalmology - April 13, 2024 Category: Opthalmology Source Type: research
Diagnosis of retinal damage using Resnet rescaling and support vector machine (Resnet-RS-SVM): a case study from an Indian hospital
ConclusionThe findings demonstrate the effectiveness of the ResNet-RS-SVM model in accurately identifying retinal damage in diverse datasets collected from multiple eye hospitals in India. This approach presents a promising advancement in computer-aided diagnosis for improving the detection and management of retinal diseases. (Source: International Ophthalmology)
Source: International Ophthalmology - April 13, 2024 Category: Opthalmology Source Type: research
Case report: The role of hypertension retinopathy graduation in the management of systemic cardiovascular disease
J Family Med Prim Care. 2024 Feb;13(2):787-791. doi: 10.4103/jfmpc.jfmpc_1772_22. Epub 2024 Mar 6.ABSTRACTModerate to severe hypertensive retinopathies are more likely to correlate with uncontrolled blood pressure in all ages. Mild microvascular changes are expected with natural aging and are therefore more concerning in patients younger than 40. Risk assessment is subsequently determined based on blood pressure measurements and patient symptoms. The goal of this paper is to discuss current opinions regarding the role of grading hypertensive retinopathy in the risk assessment of systemic cardiovascular disease in the conte...
Source: Primary Care - April 12, 2024 Category: Primary Care Authors: Kathryn Kosteva Evan J Kaufman Alicia Kinch Source Type: research
Promotion of 14-3-3 ζ/Heme Oxygenase-1 Axis on Endotoxin-Induced Uveitis and Microglia Ferroptosis in Mice
CONCLUSION: The study provides valuable insights into the mechanisms underlying uveitis and highlights the potential of the 14-3-3ζ/HO-1 axis as a therapeutic target for the disease. Further research in this area could lead to the development of preventive and therapeutic strategies for uveitis.PMID:38607656 | DOI:10.1080/09273948.2024.2328784 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 12, 2024 Category: Allergy & Immunology Authors: Mohan Li Sijia Gao Yu Wen Liang Yong Liming Tao Source Type: research
