Interleukin-4 protects retinal ganglion cells and promotes axon regeneration
The preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in the management of various vision-threatening disorders. Therefore, we investigate the e... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 22, 2024 Category: Molecular Biology Authors: Zhaoyang Zuo, Bin Fan, Ziyuan Zhang, Yang Liang, Jing Chi and Guangyu Li Tags: Research Source Type: research
Management of macula-on giant retinal tear detachments – outcome of pars-plana-vitrectomy with silicone oil versus gas tamponade
To compare the outcome of eyes with a macula-on giant retinal tear (GRT) detachment treated with pars-plana-vitrectomy (PPV) depending on the used endotamponade. (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - April 22, 2024 Category: Opthalmology Authors: Teresa Barth, Viola Radeck, Maria-Andreea Gamulescu, Horst Helbig and David M ärker Tags: Research Source Type: research
Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway
NADPH oxidase (NOX), a primary source of endothelial reactive oxygen species (ROS), is considered a key event in disrupting the integrity of the blood-retinal barrier. Abnormalities in neurovascular-coupled im... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 22, 2024 Category: Neurology Authors: Xin Shi, Panpan Li, Marc Herb, Hanhan Liu, Maoren Wang, Xiaosha Wang, Yuan Feng, Tim van Beers, Ning Xia, Huige Li and Verena Prokosch Tags: Research Source Type: research
Photocoagulation or sham laser in addition to conventional anti-VEGF therapy in macular edema associated with TelCaps due to diabetic macular edema or retinal vein occlusion (TalaDME): a study protocol for a multicentric, French, two-group, non-commercial, active-control, observer-masked, non-inferiority, randomized controlled clinical trial
Macular edema (ME) results from hyperpermeability of retinal vessels, leading to chronic extravasation of plasma components into the retina and hence potentially severe visual acuity loss. Current standard of ... (Source: Trials)
Source: Trials - April 22, 2024 Category: General Medicine Authors: B énédicte Dupas, Daniela Castro-Farias, Jean-François Girmens, Ali Eginay, Aude Couturier, Frederic Villeroy, Marie-Noëlle Delyfer, Catherine Creuzot-Garcher, Audrey Giocanti-Auregan, Laurence Béral, Carl Arndt, Charles Mesnard, Eric Vicaut, Philipp Tags: Study protocol Source Type: research
The Role of Optical Coherence Tomography Angiography in Glaucoma
Semin Ophthalmol. 2024 Apr 20:1-12. doi: 10.1080/08820538.2024.2343049. Online ahead of print.ABSTRACTGlaucoma is the leading cause of irreversible vision loss and comprises a group of chronic optic neuropathies characterized by progressive retinal ganglion cell (RGC) loss. Various etiologies, including impaired blood supply to the optic nerve, have been implicated for glaucoma pathogenesis. Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality for visualizing the ophthalmic microvasculature. Using blood flow as an intrinsic contrast agent, it distinguishes blood vessels from the surrounding ti...
Source: Seminars in Ophthalmology - April 21, 2024 Category: Opthalmology Authors: Maximilian Braun Chhavi Saini Jessica A Sun Lucy Q Shen Source Type: research
Vitamin A and bronchopulmonary dysplasia: the next steps
Lancet Respir Med. 2024 Apr 18:S2213-2600(24)00108-5. doi: 10.1016/S2213-2600(24)00108-5. Online ahead of print.NO ABSTRACTPMID:38643781 | DOI:10.1016/S2213-2600(24)00108-5 (Source: Respiratory Care)
Source: Respiratory Care - April 21, 2024 Category: Respiratory Medicine Authors: Abhijeet Rakshasbhuvankar J Jane Pillow Source Type: research
Early postnatal high-dose fat-soluble enteral vitamin A supplementation for moderate or severe bronchopulmonary dysplasia or death in extremely low birthweight infants (NeoVitaA): a multicentre, randomised, parallel-group, double-blind, placebo-controlled, investigator-initiated phase 3 trial
Lancet Respir Med. 2024 Apr 18:S2213-2600(24)00073-0. doi: 10.1016/S2213-2600(24)00073-0. Online ahead of print.ABSTRACTBACKGROUND: Vitamin A plays a key role in lung development, but there is no consensus regarding the optimal vitamin A dose and administration route in extremely low birthweight (ELBW) infants. We aimed to assess whether early postnatal additional high-dose fat-soluble enteral vitamin A supplementation versus placebo would lower the rate of moderate or severe bronchopulmonary dysplasia or death in ELBW infants receiving recommended basic enteral vitamin A supplementation.METHODS: This prospective, multicen...
Source: Respiratory Care - April 21, 2024 Category: Respiratory Medicine Authors: Sascha Meyer Johannes Bay Axel R Franz Harald Erhardt Lars Klein Jutta Petzinger Christoph Binder Susanne Kirschenhofer Anja Stein Britta H üning Axel Heep Eva Cloppenburg Julia Muyimbwa Torsten Ott Julia Sandk ötter Norbert Teig Susanne Wiegand Michael Source Type: research
Ferulic acid in synergy with retinol alleviates oxidative injury of HaCaT cells during UVB-induced photoaging
Aging (Albany NY). 2024 Apr 18;16. doi: 10.18632/aging.205749. Online ahead of print.ABSTRACTApplication of retinol (Vitamin A, VA) in skincare is limited for instability, poor water solubility, and skin intolerance that combats skin aging. We employed computer-aided virtual screening and cell experiments with transcriptomics, thereby unveiling the comprehensive gene expression and regulation pathway of photoaging HaCaT cell treated with ferulic acid (FA) in synergizing with VA. Through network pharmacology analysis, the combined use of VA and FA exhibited highly correlated cross-targets with skin aging acting on EGFR, PTP...
Source: Aging - April 21, 2024 Category: Biomedical Science Authors: Peng Shu Jiaxin Mo Zunjiang Li Mingjie Li Wei Zhu Zhiyun Du Source Type: research
Genes, Vol. 15, Pages 516: Syndromic Retinitis Pigmentosa: A 15-Patient Study
This study reviewed the clinical data of 15 patients with syndromic retinitis pigmentosa from a Rare Disease Reference Center in Brazil and the results of their next-generation sequencing tests. Five males and ten females participated, with the mean ages for ocular disease onset, fundoscopic diagnosis, and molecular evaluation being 9, 19, and 29 years, respectively. Bardet–Biedl syndrome (n = 5) and Usher syndrome (n = 3) were the most frequent diagnoses, followed by other rare conditions. Among the patients, fourteen completed molecular studies, with three negative results and eleven revealing findings in k...
Source: Genes - April 20, 2024 Category: Genetics & Stem Cells Authors: Ianne Pessoa Holanda Priscila Hae Hyun Rim Rare Genomes Project Consortium Rare Genomes Project Consortium Mara Sanches Guaragna Vera L úcia Gil-da-Silva-Lopes Carlos Eduardo Steiner Tags: Case Report Source Type: research
Polymeric Propranolol Nanoparticles for Intraocular Delivery: Formulation, Characterization, and Vitreous Pharmacokinetics
CONCLUSION: PLGA NPs can prolong the existence of propranolol in both vitreous and posterior ocular tissues, and thus, may provide an effective approach in treatment of posterior segment neovascularization.PMID:38638633 | PMC:PMC11022021 | DOI:10.18502/jovr.v19i1.15436 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Farkhondeh Chaharband Reyhaneh Varshochian Rassoul Dinarvand Hamideh Sabbaghi Mozhgan Rezaei Kanavi Narsis Daftarian Ramin Nourinia Source Type: research
Internal Limiting Peeling in Conjunction with Subretinal Injection of a Balanced Salt Solution in the Macular Region to Treat Refractory Diabetic Macular Edema
CONCLUSION: Subretinal injection of BSS can be an effective treatment for refractory DME and is recommended for clinical use.PMID:38639628 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Ziqing Mao Zhipeng You Source Type: research
Internal Limiting Peeling in Conjunction with Subretinal Injection of a Balanced Salt Solution in the Macular Region to Treat Refractory Diabetic Macular Edema
CONCLUSION: Subretinal injection of BSS can be an effective treatment for refractory DME and is recommended for clinical use.PMID:38639628 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Ziqing Mao Zhipeng You Source Type: research
Dark Adaptometry and Optical Coherence Tomography Angiography in Huntington Disease
CONCLUSION: This study suggests that changes in retinal biomarkers may exist in patients with HD and that additional investigations using multimodal techniques are warranted.PMID:38638627 | PMC:PMC11022016 | DOI:10.18502/jovr.v19i1.15422 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - April 19, 2024 Category: Opthalmology Authors: Aaditya Shah Spencer Fuller Susan Criswell Rajendra S Apte Source Type: research
Application of Nanoscopic Quantum Systems in Retinal Restoration
J Ophthalmic Vis Res. 2024 Mar 14;19(1):1-3. doi: 10.18502/jovr.v19i1.15415. eCollection 2024 Jan-Mar.NO ABSTRACTPMID:38638632 | PMC:PMC11022022 | DOI:10.18502/jovr.v19i1.15415 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - April 19, 2024 Category: Opthalmology Authors: Hadi Mohammadi Hashem Rafii-Tabar Source Type: research
Polymeric Nanoparticles for Retinal Drug Delivery
J Ophthalmic Vis Res. 2024 Mar 14;19(1):4-5. doi: 10.18502/jovr.v19i1.15417. eCollection 2024 Jan-Mar.NO ABSTRACTPMID:38638631 | PMC:PMC11022025 | DOI:10.18502/jovr.v19i1.15417 (Source: Journal of Ophthalmic and Vision Research)
Source: Journal of Ophthalmic and Vision Research - April 19, 2024 Category: Opthalmology Authors: Mazda Rad-Malekshahi Source Type: research
