Proliferative vitreoretinopathy: a revised concept of retinal injury and response
Br J Ophthalmol. 2024 May 2:bjo-2023-324417. doi: 10.1136/bjo-2023-324417. Online ahead of print.ABSTRACTPrevious concepts for the pathogenesis of proliferative vitreoretinopathy (PVR) have focused on the central role of retinal pigment epithelium cells only, potentially contributing to the lack of clinical advances. More recent studies have demonstrated the essential role of retinal glial cells in the PVR healing response but failed to identify a consistent triggering mechanism.We propose a revised concept for the pathogenesis of PVR based on retinal injury and response. A posterior vitreous detachment (PVD) is invariably...
Source: The British Journal of Ophthalmology - May 2, 2024 Category: Opthalmology Authors: Alexandre Assi David Charteris Source Type: research
Predicting the cognitive impairment with multimodal ophthalmic imaging and artificial neural network for community screening
CONCLUSIONS: This study demonstrates retinal spectral signature alteration, neurodegeneration and angiopathy occur concurrently in cognitive impairment. The combination of multimodal ophthalmic imaging and BPNN can be a useful tool for predicting cognitive impairment with high performance for community screening.PMID:38697799 | DOI:10.1136/bjo-2023-323283 (Source: The British Journal of Ophthalmology)
Source: The British Journal of Ophthalmology - May 2, 2024 Category: Opthalmology Authors: Zi Jin Xuhui Chen Chunxia Jiang Ximeng Feng Da Zou Yanye Lu Jinying Li Qiushi Ren Chuanqing Zhou Source Type: research
[PERSPECTIVES] Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism
Retinitis pigmentosa is a blinding disease wherein rod photoreceptors are affected first, due to the expression of a disease gene, leading to the loss of dim light vision. In many cases, cones do not express the disease gene, yet they are also affected and eventually die, typically after most of the rods in their neighborhood have died. The cause of secondary cone death is unclear. Photoreceptors are one of the most energy-demanding cell types in the body and consume a high amount of glucose. At an early stage of degeneration, the cones appear to have a shortage of glucose to fuel their metabolism. This review focuses on g...
Source: Cold Spring Harbor perspectives in medicine - May 2, 2024 Category: Research Authors: Xue, Y., Cepko, C. L. Tags: Retinal Disorders: Genetic Approaches to Diagnosis and Treatment PERSPECTIVES Source Type: research
The role of vitamins and nutrients in rosacea
AbstractRosacea is a common inflammatory skin condition displaying symptoms like flushing, erythema, papules, and pustules. Oral antibiotics, despite long-term adverse effects, are often used due to topical treatment limitations, underscoring the need for cost-effective choices like dietary modifications. Our review investigates the role of vitamins and minerals in rosacea, and provides evidence-based recommendations for supplementation and topical treatment of these nutrients for rosacea. An online search was performed on PubMed, Web of Science, Science Direct, Google Scholar, and ClinicalTrials.gov from 1998 to 2023. Inc...
Source: Archives of Dermatological Research - May 2, 2024 Category: Dermatology Source Type: research
LUNet: deep learning for the segmentation of arterioles and venules in high resolution fundus images
This study aims to automate the segmentation of retinal arterioles and venules (A/V) from digital fundus images (DFI), as changes in the spatial distribution of retinal microvasculature are indicative of cardiovascular diseases, positioning the eyes as windows to cardiovascular health. Approach. We utilized active learning to create a new DFI dataset with 240 crowd-sourced manual A/V segmentations performed by 15 medical students and reviewed by an ophthalmologist. We then developed LUNet, a novel deep learning architecture optimized for high-resolution A/V segmentation. The LUNet model features a double dilated convolutio...
Source: Physiological Measurement - May 2, 2024 Category: Physiology Authors: Jonathan Fhima, Jan Van Eijgen, Marie-Isaline Billen Moulin-Roms ée, Heloïse Brackenier, Hana Kulenovic, Valérie Debeuf, Marie Vangilbergen, Moti Freiman, Ingeborg Stalmans and Joachim A Behar Source Type: research
The role of vitamins and nutrients in rosacea
AbstractRosacea is a common inflammatory skin condition displaying symptoms like flushing, erythema, papules, and pustules. Oral antibiotics, despite long-term adverse effects, are often used due to topical treatment limitations, underscoring the need for cost-effective choices like dietary modifications. Our review investigates the role of vitamins and minerals in rosacea, and provides evidence-based recommendations for supplementation and topical treatment of these nutrients for rosacea. An online search was performed on PubMed, Web of Science, Science Direct, Google Scholar, and ClinicalTrials.gov from 1998 to 2023. Inc...
Source: Archives of Dermatological Research - May 2, 2024 Category: Dermatology Source Type: research
CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway
This study establishes the crucial role of CD200R in HG-induced oxidative stress and identifies potential therapeutic avenues for the treatment of DR.PMID:38692160 | DOI:10.1016/j.tice.2024.102381 (Source: Tissue and Cell)
Source: Tissue and Cell - May 1, 2024 Category: Cytology Authors: Yaguang Hu Ting Wei Shan Gao Ning Gao Li Chen Qiaochu Cheng Source Type: research
Role of antioxidants in the neurobiology of drug addiction: An update
Biomed Pharmacother. 2024 Apr 30;175:116604. doi: 10.1016/j.biopha.2024.116604. Online ahead of print.ABSTRACTRelationships between protective enzymatic and non-enzymatic pro-antioxidant mechanisms and addictive substances use disorders (SUDs) are analyzed here, based on the results of previous research, as well as on the basis of our current own studies. This review introduces new aspects of comparative analysis of associations of pro-antixidant and neurobiological effects in patients taking psychoactive substances and complements very limited knowledge about relationships with SUDs from different regions, mainly Europe. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Piotr Kami ński Ma łgorzata Lorek J ędrzej Baszyński Tadeusz Tadrowski Edward Jacek Gorzela ńczyk Julia Feit Halina Tkaczenko Jakub Owoc Alina Wo źniak Natalia Kurhaluk Source Type: research
Germacrone Protects against NF- κB-Mediated Inflammatory Signaling, Apoptosis, and Retinal Ganglion Cell Survival in a Rat Glaucoma Model
Tohoku J Exp Med. 2024 May 2. doi: 10.1620/tjem.2024.J028. Online ahead of print.NO ABSTRACTPMID:38692861 | DOI:10.1620/tjem.2024.J028 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 1, 2024 Category: Research Authors: Yu Yuan Linhai Shao Source Type: research
A Visible-Light Regulated ATP Transport in Retinal-modified Pillar[6]arene Layer-by-Layer Self-assembled Sub-nanochannel
Chemistry. 2024 May 1:e202401045. doi: 10.1002/chem.202401045. Online ahead of print.ABSTRACTNatural light-responsive rhodopsins play a critical role in visual conversion, signal transduction, energy transmission, etc., which has aroused extensive interest in the past decade. Inspired by these gorgeous works of living beings, scientists have constructed various biomimetic light-responsive nanochannels to mimic the behaviors of rhodopsins. However, it is still challenging to build stimuli-responsive sub-nanochannels only regulated by visible light as the rhodopsins are always at the sub-nanometer level and regulated by visi...
Source: Chemistry - May 1, 2024 Category: Chemistry Authors: Jiaxin Quan Hewei Yan Govindasami Periyasami Haibing Li Source Type: research
CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway
This study establishes the crucial role of CD200R in HG-induced oxidative stress and identifies potential therapeutic avenues for the treatment of DR.PMID:38692160 | DOI:10.1016/j.tice.2024.102381 (Source: Tissue and Cell)
Source: Tissue and Cell - May 1, 2024 Category: Cytology Authors: Yaguang Hu Ting Wei Shan Gao Ning Gao Li Chen Qiaochu Cheng Source Type: research
Role of antioxidants in the neurobiology of drug addiction: An update
Biomed Pharmacother. 2024 Apr 30;175:116604. doi: 10.1016/j.biopha.2024.116604. Online ahead of print.ABSTRACTRelationships between protective enzymatic and non-enzymatic pro-antioxidant mechanisms and addictive substances use disorders (SUDs) are analyzed here, based on the results of previous research, as well as on the basis of our current own studies. This review introduces new aspects of comparative analysis of associations of pro-antixidant and neurobiological effects in patients taking psychoactive substances and complements very limited knowledge about relationships with SUDs from different regions, mainly Europe. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Piotr Kami ński Ma łgorzata Lorek J ędrzej Baszyński Tadeusz Tadrowski Edward Jacek Gorzela ńczyk Julia Feit Halina Tkaczenko Jakub Owoc Alina Wo źniak Natalia Kurhaluk Source Type: research
Germacrone Protects against NF- κB-Mediated Inflammatory Signaling, Apoptosis, and Retinal Ganglion Cell Survival in a Rat Glaucoma Model
Tohoku J Exp Med. 2024 May 2. doi: 10.1620/tjem.2024.J028. Online ahead of print.NO ABSTRACTPMID:38692861 | DOI:10.1620/tjem.2024.J028 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 1, 2024 Category: Research Authors: Yu Yuan Linhai Shao Source Type: research
CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway
This study establishes the crucial role of CD200R in HG-induced oxidative stress and identifies potential therapeutic avenues for the treatment of DR.PMID:38692160 | DOI:10.1016/j.tice.2024.102381 (Source: Tissue and Cell)
Source: Tissue and Cell - May 1, 2024 Category: Cytology Authors: Yaguang Hu Ting Wei Shan Gao Ning Gao Li Chen Qiaochu Cheng Source Type: research
Germacrone Protects against NF- κB-Mediated Inflammatory Signaling, Apoptosis, and Retinal Ganglion Cell Survival in a Rat Glaucoma Model
Tohoku J Exp Med. 2024 May 2. doi: 10.1620/tjem.2024.J028. Online ahead of print.NO ABSTRACTPMID:38692861 | DOI:10.1620/tjem.2024.J028 (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - May 1, 2024 Category: Research Authors: Yu Yuan Linhai Shao Source Type: research
